GREMLIN Database
SAD - Succinate semialdehyde dehydrogenase [NAD(P)+] Sad
UniProt: P76149 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13817
Length: 462 (451)
Sequences: 36280 (21737)
Seq/√Len: 1023.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
278_E377_K5.5081.00
222_A226_A3.4811.00
278_E375_I3.3871.00
250_E287_R3.3531.00
356_T359_M2.9561.00
281_A375_I2.9481.00
245_N277_E2.9071.00
338_E348_P2.7521.00
313_F317_D2.7351.00
39_A204_R2.7191.00
285_T373_I2.6971.00
65_R98_D2.6441.00
10_I22_V2.5661.00
254_K291_A2.5391.00
323_V347_Y2.5311.00
324_E328_A2.5171.00
39_A206_A2.4741.00
245_N279_G2.4591.00
171_L174_Q2.4571.00
67_R70_E2.4541.00
325_K360_T2.4341.00
310_M319_L2.3531.00
69_E87_R2.2611.00
27_G30_D2.2401.00
332_R354_N2.1701.00
399_T405_A2.1681.00
60_I176_F2.1461.00
320_H339_K2.1021.00
10_I19_Q2.0921.00
68_S91_A2.0621.00
125_R455_Q2.0541.00
177_K183_Q2.0511.00
320_H324_E2.0421.00
379_A404_Q2.0321.00
275_I382_A2.0221.00
56_K181_I1.9831.00
379_A407_Q1.9651.00
352_L361_A1.9381.00
325_K329_Q1.9351.00
164_N312_R1.9251.00
334_L353_A1.9071.00
327_L333_L1.9011.00
289_V293_A1.8921.00
63_A178_D1.8901.00
407_Q411_R1.8881.00
241_F256_A1.8871.00
246_D404_Q1.8791.00
320_H347_Y1.8701.00
124_Y452_C1.8681.00
283_A287_R1.8211.00
63_A179_A1.8191.00
390_E436_K1.8161.00
63_A175_V1.8051.00
275_I385_L1.8031.00
413_E435_K1.8011.00
124_Y449_H1.8011.00
201_K223_Q1.7971.00
70_E171_L1.7921.00
277_E376_A1.7811.00
36_Q204_R1.7671.00
292_A351_V1.7611.00
357_P385_L1.7281.00
249_L287_R1.7231.00
332_R353_A1.7161.00
256_A284_F1.7131.00
42_F46_R1.7101.00
360_T364_E1.7051.00
173_A188_W1.6951.00
219_A222_A1.6861.00
274_F371_A1.6831.00
63_A66_A1.6791.00
156_G185_V1.6701.00
289_V334_L1.6641.00
333_L352_L1.6631.00
62_K98_D1.6611.00
282_S375_I1.6591.00
218_A436_K1.6421.00
380_E411_R1.6331.00
281_A285_T1.6181.00
245_N404_Q1.6121.00
67_R178_D1.6101.00
97_C148_V1.6011.00
286_E290_A1.6001.00
32_E36_Q1.5991.00
381_H384_E1.5941.00
32_E202_D1.5941.00
74_M171_L1.5841.00
362_F374_T1.5691.00
261_Y292_A1.5681.00
62_K66_A1.5621.00
58_R98_D1.5491.00
395_A414_C1.5121.00
198_Q201_K1.4911.00
83_I87_R1.4891.00
76_T86_A1.4821.00
281_A353_A1.4751.00
49_N52_Y1.4731.00
377_K381_H1.4721.00
321_H360_T1.4541.00
17_G343_A1.4431.00
58_R105_P1.4401.00
69_E73_Q1.4371.00
65_R94_A1.4361.00
275_I376_A1.4291.00
52_Y55_E1.4251.00
287_R290_A1.4211.00
378_D381_H1.4141.00
331_A352_L1.4141.00
244_L376_A1.4091.00
256_A274_F1.4071.00
42_F156_G1.4031.00
283_A286_E1.4031.00
174_Q178_D1.4011.00
322_Q366_M1.4001.00
276_I284_F1.3951.00
35_L202_D1.3951.00
103_H106_A1.3911.00
30_D33_N1.3891.00
313_F345_N1.3881.00
255_A398_F1.3871.00
253_V287_R1.3861.00
132_A157_Y1.3721.00
61_G98_D1.3651.00
18_E343_A1.3621.00
244_L404_Q1.3561.00
19_Q22_V1.3521.00
97_C144_M1.3511.00
73_Q77_R1.3501.00
173_A186_Y1.3321.00
291_A294_A1.3201.00
383_L408_M1.3191.00
176_F186_Y1.3191.00
59_D62_K1.3131.00
73_Q301_R1.3091.00
221_G439_F1.3081.00
324_E327_L1.3071.00
326_T352_L1.3041.00
290_A293_A1.3021.00
71_M171_L1.2991.00
13_N16_T1.2991.00
68_S87_R1.2991.00
67_R171_L1.2811.00
295_L307_L1.2781.00
193_N197_S1.2771.00
293_A335_L1.2741.00
316_R347_Y1.2711.00
47_E411_R1.2631.00
316_R339_K1.2601.00
123_E410_A1.2571.00
35_L204_R1.2491.00
319_L368_G1.2481.00
207_A232_V1.2481.00
296_K304_E1.2441.00
381_H385_L1.2401.00
376_A385_L1.2381.00
363_R388_D1.2381.00
285_T334_L1.2371.00
143_V159_L1.2321.00
317_D321_H1.2201.00
12_I19_Q1.2181.00
329_Q360_T1.2081.00
147_A186_Y1.2051.00
184_G187_G1.2021.00
60_I175_V1.2001.00
285_T289_V1.1981.00
282_S286_E1.1971.00
67_R175_V1.1911.00
244_L408_M1.1911.00
61_G65_R1.1821.00
277_E280_I1.1811.00
277_E378_D1.1721.00
48_T52_Y1.1671.00
336_G350_T1.1661.00
132_A209_T1.1661.00
288_F371_A1.1631.00
121_V406_R1.1621.00
316_R320_H1.1621.00
60_I181_I1.1601.00
163_P192_D1.1561.00
8_H22_V1.1531.00
59_D63_A1.1511.00
60_I97_C1.1481.00
284_F288_F1.1371.00
71_M175_V1.1341.00
395_A417_V1.1291.00
124_Y454_I1.1281.00
13_N299_D1.1281.00
319_L370_V1.1271.00
357_P388_D1.1251.00
242_I408_M1.1251.00
37_L187_G1.1251.00
363_R390_E1.1201.00
15_A300_P1.1181.00
216_A219_A1.1181.00
405_A419_I1.1151.00
298_G305_N1.1141.00
131_L199_M1.1121.00
66_A178_D1.1101.00
240_P395_A1.1051.00
446_F449_H1.1041.00
329_Q359_M1.1021.00
409_A457_V1.1001.00
76_T300_P1.0991.00
313_F316_R1.0991.00
242_I382_A1.0941.00
358_E363_R1.0901.00
289_V335_L1.0821.00
163_P193_N1.0811.00
296_K306_A1.0791.00
170_Q188_W1.0751.00
110_A446_F1.0721.00
138_F267_V1.0721.00
25_W192_D1.0701.00
48_T56_K1.0681.00
248_D400_T1.0651.00
238_S272_K1.0621.00
282_S285_T1.0611.00
280_I283_A1.0611.00
43_R47_E1.0591.00
73_Q83_I1.0551.00
380_E407_Q1.0521.00
445_H449_H1.0491.00
383_L411_R1.0481.00
36_Q40_A1.0481.00
163_P194_D1.0431.00
21_S167_G1.0381.00
285_T353_A1.0371.00
35_L205_I1.0291.00
340_M348_P1.0281.00
379_A408_M1.0281.00
58_R102_E1.0241.00
129_T205_I1.0221.00
401_D404_Q1.0211.00
181_I186_Y1.0191.00
218_A228_L1.0191.00
123_E457_V1.0161.00
43_R384_E1.0101.00
290_A294_A1.0101.00
336_G348_P1.0101.00
147_A157_Y1.0081.00
293_A348_P1.0081.00
241_F271_A1.0061.00
41_G156_G1.0051.00
110_A445_H0.9961.00
337_G350_T0.9961.00
219_A223_Q0.9951.00
242_I386_A0.9941.00
127_L207_A0.9931.00
299_D302_D0.9871.00
131_L205_I0.9871.00
432_G441_R0.9861.00
221_G231_C0.9861.00
331_A359_M0.9841.00
253_V288_F0.9831.00
13_N77_R0.9831.00
192_D196_V0.9821.00
244_L379_A0.9811.00
316_R345_N0.9801.00
201_K226_A0.9761.00
446_F454_I0.9761.00
215_R219_A0.9761.00
321_H325_K0.9711.00
330_G359_M0.9711.00
213_S216_A0.9711.00
287_R291_A0.9701.00
221_G225_G0.9671.00
382_A385_L0.9641.00
253_V257_V0.9631.00
170_Q190_N0.9621.00
243_V284_F0.9611.00
43_R413_E0.9591.00
206_A413_E0.9571.00
376_A382_A0.9551.00
397_I408_M0.9531.00
326_T366_M0.9531.00
9_A25_W0.9521.00
441_R453_N0.9511.00
380_E384_E0.9481.00
17_G345_N0.9451.00
374_T385_L0.9391.00
396_T422_Y0.9391.00
355_V359_M0.9381.00
230_K453_N0.9371.00
248_D251_L0.9351.00
327_L352_L0.9341.00
125_R410_A0.9321.00
13_N18_E0.9301.00
127_L230_K0.9221.00
131_L208_V0.9221.00
376_A381_H0.9221.00
322_Q325_K0.9211.00
253_V291_A0.9211.00
127_L155_N0.9201.00
250_E283_A0.9181.00
281_A354_N0.9171.00
281_A373_I0.9151.00
322_Q360_T0.9151.00
260_R272_K0.9141.00
257_V288_F0.9131.00
252_A256_A0.9091.00
46_R413_E0.9061.00
253_V284_F0.9051.00
259_G271_A0.9051.00
208_V220_I0.9021.00
54_A101_A0.9011.00
64_L94_A0.8981.00
434_V453_N0.8951.00
77_R301_R0.8931.00
81_K89_E0.8921.00
357_P374_T0.8911.00
67_R174_Q0.8871.00
64_L93_S0.8861.00
104_G152_L0.8861.00
252_A284_F0.8841.00
93_S144_M0.8771.00
72_A87_R0.8761.00
31_I131_L0.8761.00
384_E388_D0.8741.00
59_D179_A0.8721.00
25_W195_G0.8721.00
61_G101_A0.8691.00
192_D195_G0.8691.00
54_A105_P0.8641.00
317_D320_H0.8641.00
79_M165_V0.8571.00
129_T156_G0.8571.00
395_A412_L0.8561.00
70_E73_Q0.8551.00
120_A429_V0.8531.00
249_L253_V0.8501.00
383_L387_N0.8471.00
41_G185_V0.8461.00
127_L453_N0.8451.00
39_A43_R0.8441.00
241_F398_F0.8431.00
174_Q177_K0.8431.00
319_L366_M0.8431.00
323_V370_V0.8431.00
125_R434_V0.8401.00
239_D272_K0.8391.00
319_L347_Y0.8391.00
159_L169_A0.8351.00
40_A43_R0.8321.00
57_L152_L0.8311.00
130_I207_A0.8281.00
58_R101_A0.8271.00
429_V456_T0.8241.00
200_I220_I0.8241.00
37_L184_G0.8241.00
208_V224_A0.8221.00
244_L399_T0.8171.00
50_I54_A0.8131.00
353_A375_I0.8071.00
251_L255_A0.8031.00
378_D384_E0.8021.00
221_G224_A0.7991.00
217_G235_L0.7981.00
55_E59_D0.7971.00
158_L187_G0.7961.00
143_V147_A0.7961.00
26_A34_A0.7941.00
164_N314_D0.7901.00
221_G228_L0.7891.00
240_P386_A0.7881.00
288_F351_V0.7881.00
26_A189_L0.7881.00
257_V291_A0.7871.00
323_V352_L0.7871.00
325_K328_A0.7871.00
316_R340_M0.7861.00
29_D32_E0.7851.00
402_E405_A0.7851.00
155_N452_C0.7851.00
9_A192_D0.7851.00
93_S140_L0.7831.00
297_M340_M0.7831.00
335_L351_V0.7821.00
87_R303_E0.7801.00
28_A32_E0.7771.00
26_A30_D0.7751.00
63_A67_R0.7741.00
76_T83_I0.7731.00
72_A76_T0.7731.00
313_F339_K0.7721.00
276_I280_I0.7721.00
33_N37_L0.7711.00
54_A58_R0.7711.00
244_L277_E0.7701.00
217_G233_L0.7701.00
12_I345_N0.7691.00
218_A222_A0.7681.00
15_A346_Y0.7671.00
320_H323_V0.7671.00
210_V216_A0.7621.00
149_P447_G0.7611.00
71_M140_L0.7601.00
321_H324_E0.7591.00
299_D305_N0.7581.00
224_A231_C0.7521.00
29_D33_N0.7481.00
31_I35_L0.7471.00
56_K179_A0.7441.00
72_A83_I0.7441.00
45_W185_V0.7441.00
38_A187_G0.7431.00
132_A146_G0.7431.00
20_L77_R0.7421.00
47_E410_A0.7411.00
295_L306_A0.7401.00
150_I157_Y0.7391.00
200_I223_Q0.7381.00
79_M311_A0.7361.00
286_E289_V0.7351.00
156_G187_G0.7351.00
379_A383_L0.7341.00
414_C417_V0.7331.00
81_K85_Q0.7301.00
289_V292_A0.7301.00
84_N306_A0.7291.00
352_L355_V0.7291.00
406_R410_A0.7241.00
191_A196_V0.7241.00
51_D105_P0.7231.00
246_D399_T0.7221.00
40_A44_D0.7201.00
292_A335_L0.7191.00
173_A177_K0.7181.00
200_I208_V0.7171.00
297_M307_L0.7121.00
24_P190_N0.7091.00
337_G348_P0.7061.00
277_E379_A0.7061.00
161_H190_N0.7061.00
58_R62_K0.7051.00
43_R46_R0.7051.00
181_I185_V0.7031.00
75_I78_E0.7021.00
288_F373_I0.7011.00
144_M172_I0.7011.00
198_Q219_A0.6991.00
170_Q174_Q0.6981.00
322_Q364_E0.6981.00
33_N36_Q0.6941.00
83_I301_R0.6931.00
289_V351_V0.6911.00
250_E291_A0.6911.00
121_V457_V0.6901.00
32_E204_R0.6901.00
153_A452_C0.6891.00
409_A419_I0.6891.00
140_L168_C0.6851.00
302_D305_N0.6831.00
292_A295_L0.6831.00
28_A195_G0.6811.00
214_V436_K0.6791.00
399_T404_Q0.6781.00
275_I357_P0.6781.00
176_F181_I0.6761.00
23_L166_M0.6761.00
44_D48_T0.6761.00
163_P318_E0.6731.00
222_A225_G0.6701.00
28_A198_Q0.6681.00
200_I227_A0.6671.00
12_I17_G0.6651.00
249_L280_I0.6641.00
74_M167_G0.6641.00
275_I362_F0.6631.00
159_L186_Y0.6621.00
218_A226_A0.6591.00
36_Q39_A0.6591.00
146_G442_E0.6561.00
230_K450_E0.6541.00
333_L350_T0.6541.00
357_P362_F0.6531.00
76_T301_R0.6521.00
256_A288_F0.6521.00
13_N301_R0.6521.00
274_F284_F0.6501.00
50_I104_G0.6481.00
143_V169_A0.6461.00
44_D47_E0.6461.00
194_D198_Q0.6451.00
120_A456_T0.6441.00
64_L71_M0.6421.00
417_V455_Q0.6411.00
77_R167_G0.6411.00
366_M370_V0.6391.00
46_R411_R0.6381.00
385_L388_D0.6381.00
171_L175_V0.6371.00
315_L318_E0.6371.00
243_V252_A0.6361.00
75_I89_E0.6361.00
65_R91_A0.6341.00
56_K60_I0.6331.00
81_K138_F0.6321.00
39_A42_F0.6321.00
355_V362_F0.6311.00
232_V450_E0.6311.00
64_L140_L0.6311.00
192_D197_S0.6301.00
347_Y350_T0.6281.00
164_N311_A0.6271.00
400_T403_T0.6251.00
119_Q406_R0.6251.00
45_W56_K0.6231.00
339_K348_P0.6211.00
163_P219_A0.6211.00
240_P414_C0.6211.00
37_L183_Q0.6211.00
62_K65_R0.6201.00
146_G209_T0.6201.00
64_L172_I0.6201.00
327_L338_E0.6201.00
131_L158_L0.6201.00
90_V140_L0.6191.00
257_V295_L0.6181.00
46_R125_R0.6171.00
193_N196_V0.6171.00
17_G313_F0.6151.00
312_R315_L0.6151.00
61_G94_A0.6141.00
329_Q358_E0.6131.00
134_M143_V0.6121.00
264_T307_L0.6111.00
397_I405_A0.6091.00
247_A252_A0.6091.00
71_M90_V0.6061.00
355_V361_A0.6061.00
194_D197_S0.6041.00
405_A409_A0.6041.00
132_A147_A0.6031.00
310_M315_L0.6021.00
241_F274_F0.6011.00
143_V172_I0.6011.00
90_V94_A0.6001.00
314_D317_D0.5991.00
314_D318_E0.5991.00
147_A159_L0.5991.00
297_M306_A0.5991.00
38_A156_G0.5991.00
140_L172_I0.5981.00
65_R68_S0.5971.00
331_A355_V0.5961.00
245_N376_A0.5961.00
383_L412_L0.5961.00
127_L206_A0.5941.00
402_E406_R0.5941.00
43_R411_R0.5921.00
280_I376_A0.5911.00
45_W151_I0.5901.00
413_E434_V0.5881.00
69_E83_I0.5861.00
197_S201_K0.5861.00
383_L407_Q0.5851.00
31_I196_V0.5851.00
75_I86_A0.5851.00
60_I63_A0.5841.00
276_I373_I0.5831.00
362_F385_L0.5801.00
46_R126_P0.5791.00
50_I152_L0.5771.00
207_A450_E0.5751.00
267_V270_A0.5751.00
449_H452_C0.5741.00
449_H454_I0.5721.00
310_M347_Y0.5721.00
221_G233_L0.5721.00
249_L283_A0.5691.00
38_A129_T0.5671.00
42_F185_V0.5671.00
172_I176_F0.5661.00
107_M448_L0.5651.00
130_I155_N0.5631.00
198_Q223_Q0.5631.00
253_V280_I0.5621.00
38_A158_L0.5621.00
246_D400_T0.5611.00
278_E282_S0.5581.00
278_E281_A0.5581.00
285_T351_V0.5581.00
130_I157_Y0.5561.00
34_A189_L0.5561.00
403_T407_Q0.5551.00
75_I168_C0.5551.00
158_L189_L0.5551.00
61_G97_C0.5551.00
70_E174_Q0.5531.00
73_Q76_T0.5521.00
163_P215_R0.5511.00
320_H327_L0.5511.00
11_S78_E0.5501.00
11_S21_S0.5491.00
11_S166_M0.5481.00
234_E393_L0.5481.00
120_A458_W0.5481.00
296_K302_D0.5471.00
52_Y56_K0.5461.00
89_E138_F0.5451.00
354_N375_I0.5451.00
277_E377_K0.5451.00
141_W145_R0.5441.00
412_L417_V0.5441.00
333_L336_G0.5441.00
274_F373_I0.5411.00
123_E455_Q0.5401.00
246_D401_D0.5401.00
92_K141_W0.5401.00
261_Y295_L0.5391.00
64_L97_C0.5371.00
102_E105_P0.5371.00
39_A129_T0.5371.00
130_I209_T0.5361.00
32_E35_L0.5361.00
68_S94_A0.5351.00
131_L200_I0.5341.00
403_T406_R0.5341.00
41_G44_D0.5341.00
91_A94_A0.5341.00
131_L196_V0.5331.00
111_E122_I0.5331.00
223_Q226_A0.5331.00
72_A86_A0.5331.00
107_M452_C0.5321.00
81_K86_A0.5311.00
177_K184_G0.5311.00
215_R314_D0.5301.00
37_L41_G0.5301.00
250_E253_V0.5291.00
214_V391_F0.5281.00
329_Q356_T0.5281.00
251_L254_K0.5281.00
323_V350_T0.5271.00
269_A426_D0.5271.00
129_T206_A0.5271.00
271_A396_T0.5261.00
239_D394_S0.5261.00
68_S72_A0.5261.00
326_T360_T0.5261.00
394_S418_F0.5251.00
32_E198_Q0.5241.00
225_G228_L0.5231.00
8_H24_P0.5221.00
28_A201_K0.5221.00
177_K180_G0.5211.00
416_G425_S0.5171.00
386_A412_L0.5151.00
288_F291_A0.5151.00
20_L167_G0.5151.00
285_T375_I0.5151.00
259_G422_Y0.5131.00
241_F396_T0.5131.00
263_N267_V0.5121.00
318_E321_H0.5121.00
260_R371_A0.5121.00
112_P115_V0.5121.00
100_Y149_P0.5111.00
251_L400_T0.5111.00
26_A31_I0.5111.00
79_M263_N0.5111.00
286_E293_A0.5101.00
36_Q202_D0.5101.00
288_F292_A0.5091.00
214_V218_A0.5071.00
99_W103_H0.5061.00
31_I195_G0.5061.00
418_F421_G0.5031.00
153_A448_L0.5031.00
444_S447_G0.5031.00
23_L167_G0.5021.00
382_A386_A0.5021.00
408_M411_R0.5011.00
175_V178_D0.5011.00
413_E453_N0.5001.00
151_I186_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a4sA 4 1 100 0.031 Contact Map
4o5hA 4 1 100 0.032 Contact Map
4yweA 5 0.9978 100 0.033 Contact Map
4qf6A 4 1 100 0.034 Contact Map
4pxlA 4 1 100 0.035 Contact Map
4pz2A 4 1 100 0.036 Contact Map
3ek1A 5 0.9957 100 0.038 Contact Map
4lihA 5 0.9957 100 0.039 Contact Map
2d4eA 4 0.9978 100 0.039 Contact Map
4wj9A 4 1 100 0.039 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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