SAD - ECOLI - GREMLIN Contacts

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SAD - Succinate semialdehyde dehydrogenase [NAD(P)+] Sad

UniProt:	P76149	Sequences: MTITPATHAISINPATGEQLSVLPWAGADDIENALQLAAAGFRDWRETNIDYRAEKLRDIGKALRARSEEMAQMITREMGKPINQARAEVAKSANLCDWYAEHGPAMLKAEPTLVENQQAVIEYRPLGTILAIMPWNFPLWQVMRGAVPIILAGNGYLLKHAPNVMGCAQLIAQVFKDAGIPQGVYGWLNADNDGVSQMIKDSRIAAVTVTGSVRAGAAIGAQAGAALKKCVLELGGSDPFIVLNDADLELAVKAAVAGRYQNTGQVCAAAKRFIIEEGIASAFTERFVAAAAALKMGDPRDEENALGPMARFDLRDELHHQVEKTLAQGARLLLGGEKMAGAGNYYPPTVLANVTPEMTAFREEMFGPVAAITIAKDAEHALELANDSEFGLSATIFTTDETQARQMAARLECGGVFINGYCASDARVAFGGVKKSGFGRELSHFGLHEFCNIQTVWKDRI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13817
Length:	462 (451)
Sequences:	36280 (21737)
Seq/√Len:	1023.5

ECOLI - SAD GABD PUUC FEAB BETB ALDA ABDH ALDB ASTD EUTE PUTA PAAZ PROA ADHE
BACSU - ALDH4 ALDH1 ROCA2 ROCA GABD ALDH5 IOLA BETB ALDY ALDH3 ALDH2 PROA
HALSA - Q9HQZ2 Q9HMJ6 Q9HR91 Q9HRB5
SULSO - Q97XS9 Q97YT9 GAPN Q97XA5 KGSDH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
278_E	377_K	5.508	1.00
222_A	226_A	3.481	1.00
278_E	375_I	3.387	1.00
250_E	287_R	3.353	1.00
356_T	359_M	2.956	1.00
281_A	375_I	2.948	1.00
245_N	277_E	2.907	1.00
338_E	348_P	2.752	1.00
313_F	317_D	2.735	1.00
39_A	204_R	2.719	1.00
285_T	373_I	2.697	1.00
65_R	98_D	2.644	1.00
10_I	22_V	2.566	1.00
254_K	291_A	2.539	1.00
323_V	347_Y	2.531	1.00
324_E	328_A	2.517	1.00
39_A	206_A	2.474	1.00
245_N	279_G	2.459	1.00
171_L	174_Q	2.457	1.00
67_R	70_E	2.454	1.00
325_K	360_T	2.434	1.00
310_M	319_L	2.353	1.00
69_E	87_R	2.261	1.00
27_G	30_D	2.240	1.00
332_R	354_N	2.170	1.00
399_T	405_A	2.168	1.00
60_I	176_F	2.146	1.00
320_H	339_K	2.102	1.00
10_I	19_Q	2.092	1.00
68_S	91_A	2.062	1.00
125_R	455_Q	2.054	1.00
177_K	183_Q	2.051	1.00
320_H	324_E	2.042	1.00
379_A	404_Q	2.032	1.00
275_I	382_A	2.022	1.00
56_K	181_I	1.983	1.00
379_A	407_Q	1.965	1.00
352_L	361_A	1.938	1.00
325_K	329_Q	1.935	1.00
164_N	312_R	1.925	1.00
334_L	353_A	1.907	1.00
327_L	333_L	1.901	1.00
289_V	293_A	1.892	1.00
63_A	178_D	1.890	1.00
407_Q	411_R	1.888	1.00
241_F	256_A	1.887	1.00
246_D	404_Q	1.879	1.00
320_H	347_Y	1.870	1.00
124_Y	452_C	1.868	1.00
283_A	287_R	1.821	1.00
63_A	179_A	1.819	1.00
390_E	436_K	1.816	1.00
63_A	175_V	1.805	1.00
275_I	385_L	1.803	1.00
413_E	435_K	1.801	1.00
124_Y	449_H	1.801	1.00
201_K	223_Q	1.797	1.00
70_E	171_L	1.792	1.00
277_E	376_A	1.781	1.00
36_Q	204_R	1.767	1.00
292_A	351_V	1.761	1.00
357_P	385_L	1.728	1.00
249_L	287_R	1.723	1.00
332_R	353_A	1.716	1.00
256_A	284_F	1.713	1.00
42_F	46_R	1.710	1.00
360_T	364_E	1.705	1.00
173_A	188_W	1.695	1.00
219_A	222_A	1.686	1.00
274_F	371_A	1.683	1.00
63_A	66_A	1.679	1.00
156_G	185_V	1.670	1.00
289_V	334_L	1.664	1.00
333_L	352_L	1.663	1.00
62_K	98_D	1.661	1.00
282_S	375_I	1.659	1.00
218_A	436_K	1.642	1.00
380_E	411_R	1.633	1.00
281_A	285_T	1.618	1.00
245_N	404_Q	1.612	1.00
67_R	178_D	1.610	1.00
97_C	148_V	1.601	1.00
286_E	290_A	1.600	1.00
32_E	36_Q	1.599	1.00
381_H	384_E	1.594	1.00
32_E	202_D	1.594	1.00
74_M	171_L	1.584	1.00
362_F	374_T	1.569	1.00
261_Y	292_A	1.568	1.00
62_K	66_A	1.562	1.00
58_R	98_D	1.549	1.00
395_A	414_C	1.512	1.00
198_Q	201_K	1.491	1.00
83_I	87_R	1.489	1.00
76_T	86_A	1.482	1.00
281_A	353_A	1.475	1.00
49_N	52_Y	1.473	1.00
377_K	381_H	1.472	1.00
321_H	360_T	1.454	1.00
17_G	343_A	1.443	1.00
58_R	105_P	1.440	1.00
69_E	73_Q	1.437	1.00
65_R	94_A	1.436	1.00
275_I	376_A	1.429	1.00
52_Y	55_E	1.425	1.00
287_R	290_A	1.421	1.00
378_D	381_H	1.414	1.00
331_A	352_L	1.414	1.00
244_L	376_A	1.409	1.00
256_A	274_F	1.407	1.00
42_F	156_G	1.403	1.00
283_A	286_E	1.403	1.00
174_Q	178_D	1.401	1.00
322_Q	366_M	1.400	1.00
276_I	284_F	1.395	1.00
35_L	202_D	1.395	1.00
103_H	106_A	1.391	1.00
30_D	33_N	1.389	1.00
313_F	345_N	1.388	1.00
255_A	398_F	1.387	1.00
253_V	287_R	1.386	1.00
132_A	157_Y	1.372	1.00
61_G	98_D	1.365	1.00
18_E	343_A	1.362	1.00
244_L	404_Q	1.356	1.00
19_Q	22_V	1.352	1.00
97_C	144_M	1.351	1.00
73_Q	77_R	1.350	1.00
173_A	186_Y	1.332	1.00
291_A	294_A	1.320	1.00
383_L	408_M	1.319	1.00
176_F	186_Y	1.319	1.00
59_D	62_K	1.313	1.00
73_Q	301_R	1.309	1.00
221_G	439_F	1.308	1.00
324_E	327_L	1.307	1.00
326_T	352_L	1.304	1.00
290_A	293_A	1.302	1.00
71_M	171_L	1.299	1.00
13_N	16_T	1.299	1.00
68_S	87_R	1.299	1.00
67_R	171_L	1.281	1.00
295_L	307_L	1.278	1.00
193_N	197_S	1.277	1.00
293_A	335_L	1.274	1.00
316_R	347_Y	1.271	1.00
47_E	411_R	1.263	1.00
316_R	339_K	1.260	1.00
123_E	410_A	1.257	1.00
35_L	204_R	1.249	1.00
319_L	368_G	1.248	1.00
207_A	232_V	1.248	1.00
296_K	304_E	1.244	1.00
381_H	385_L	1.240	1.00
376_A	385_L	1.238	1.00
363_R	388_D	1.238	1.00
285_T	334_L	1.237	1.00
143_V	159_L	1.232	1.00
317_D	321_H	1.220	1.00
12_I	19_Q	1.218	1.00
329_Q	360_T	1.208	1.00
147_A	186_Y	1.205	1.00
184_G	187_G	1.202	1.00
60_I	175_V	1.200	1.00
285_T	289_V	1.198	1.00
282_S	286_E	1.197	1.00
67_R	175_V	1.191	1.00
244_L	408_M	1.191	1.00
61_G	65_R	1.182	1.00
277_E	280_I	1.181	1.00
277_E	378_D	1.172	1.00
48_T	52_Y	1.167	1.00
336_G	350_T	1.166	1.00
132_A	209_T	1.166	1.00
288_F	371_A	1.163	1.00
121_V	406_R	1.162	1.00
316_R	320_H	1.162	1.00
60_I	181_I	1.160	1.00
163_P	192_D	1.156	1.00
8_H	22_V	1.153	1.00
59_D	63_A	1.151	1.00
60_I	97_C	1.148	1.00
284_F	288_F	1.137	1.00
71_M	175_V	1.134	1.00
395_A	417_V	1.129	1.00
124_Y	454_I	1.128	1.00
13_N	299_D	1.128	1.00
319_L	370_V	1.127	1.00
357_P	388_D	1.125	1.00
242_I	408_M	1.125	1.00
37_L	187_G	1.125	1.00
363_R	390_E	1.120	1.00
15_A	300_P	1.118	1.00
216_A	219_A	1.118	1.00
405_A	419_I	1.115	1.00
298_G	305_N	1.114	1.00
131_L	199_M	1.112	1.00
66_A	178_D	1.110	1.00
240_P	395_A	1.105	1.00
446_F	449_H	1.104	1.00
329_Q	359_M	1.102	1.00
409_A	457_V	1.100	1.00
76_T	300_P	1.099	1.00
313_F	316_R	1.099	1.00
242_I	382_A	1.094	1.00
358_E	363_R	1.090	1.00
289_V	335_L	1.082	1.00
163_P	193_N	1.081	1.00
296_K	306_A	1.079	1.00
170_Q	188_W	1.075	1.00
110_A	446_F	1.072	1.00
138_F	267_V	1.072	1.00
25_W	192_D	1.070	1.00
48_T	56_K	1.068	1.00
248_D	400_T	1.065	1.00
238_S	272_K	1.062	1.00
282_S	285_T	1.061	1.00
280_I	283_A	1.061	1.00
43_R	47_E	1.059	1.00
73_Q	83_I	1.055	1.00
380_E	407_Q	1.052	1.00
445_H	449_H	1.049	1.00
383_L	411_R	1.048	1.00
36_Q	40_A	1.048	1.00
163_P	194_D	1.043	1.00
21_S	167_G	1.038	1.00
285_T	353_A	1.037	1.00
35_L	205_I	1.029	1.00
340_M	348_P	1.028	1.00
379_A	408_M	1.028	1.00
58_R	102_E	1.024	1.00
129_T	205_I	1.022	1.00
401_D	404_Q	1.021	1.00
181_I	186_Y	1.019	1.00
218_A	228_L	1.019	1.00
123_E	457_V	1.016	1.00
43_R	384_E	1.010	1.00
290_A	294_A	1.010	1.00
336_G	348_P	1.010	1.00
147_A	157_Y	1.008	1.00
293_A	348_P	1.008	1.00
241_F	271_A	1.006	1.00
41_G	156_G	1.005	1.00
110_A	445_H	0.996	1.00
337_G	350_T	0.996	1.00
219_A	223_Q	0.995	1.00
242_I	386_A	0.994	1.00
127_L	207_A	0.993	1.00
299_D	302_D	0.987	1.00
131_L	205_I	0.987	1.00
432_G	441_R	0.986	1.00
221_G	231_C	0.986	1.00
331_A	359_M	0.984	1.00
253_V	288_F	0.983	1.00
13_N	77_R	0.983	1.00
192_D	196_V	0.982	1.00
244_L	379_A	0.981	1.00
316_R	345_N	0.980	1.00
201_K	226_A	0.976	1.00
446_F	454_I	0.976	1.00
215_R	219_A	0.976	1.00
321_H	325_K	0.971	1.00
330_G	359_M	0.971	1.00
213_S	216_A	0.971	1.00
287_R	291_A	0.970	1.00
221_G	225_G	0.967	1.00
382_A	385_L	0.964	1.00
253_V	257_V	0.963	1.00
170_Q	190_N	0.962	1.00
243_V	284_F	0.961	1.00
43_R	413_E	0.959	1.00
206_A	413_E	0.957	1.00
376_A	382_A	0.955	1.00
397_I	408_M	0.953	1.00
326_T	366_M	0.953	1.00
9_A	25_W	0.952	1.00
441_R	453_N	0.951	1.00
380_E	384_E	0.948	1.00
17_G	345_N	0.945	1.00
374_T	385_L	0.939	1.00
396_T	422_Y	0.939	1.00
355_V	359_M	0.938	1.00
230_K	453_N	0.937	1.00
248_D	251_L	0.935	1.00
327_L	352_L	0.934	1.00
125_R	410_A	0.932	1.00
13_N	18_E	0.930	1.00
127_L	230_K	0.922	1.00
131_L	208_V	0.922	1.00
376_A	381_H	0.922	1.00
322_Q	325_K	0.921	1.00
253_V	291_A	0.921	1.00
127_L	155_N	0.920	1.00
250_E	283_A	0.918	1.00
281_A	354_N	0.917	1.00
281_A	373_I	0.915	1.00
322_Q	360_T	0.915	1.00
260_R	272_K	0.914	1.00
257_V	288_F	0.913	1.00
252_A	256_A	0.909	1.00
46_R	413_E	0.906	1.00
253_V	284_F	0.905	1.00
259_G	271_A	0.905	1.00
208_V	220_I	0.902	1.00
54_A	101_A	0.901	1.00
64_L	94_A	0.898	1.00
434_V	453_N	0.895	1.00
77_R	301_R	0.893	1.00
81_K	89_E	0.892	1.00
357_P	374_T	0.891	1.00
67_R	174_Q	0.887	1.00
64_L	93_S	0.886	1.00
104_G	152_L	0.886	1.00
252_A	284_F	0.884	1.00
93_S	144_M	0.877	1.00
72_A	87_R	0.876	1.00
31_I	131_L	0.876	1.00
384_E	388_D	0.874	1.00
59_D	179_A	0.872	1.00
25_W	195_G	0.872	1.00
61_G	101_A	0.869	1.00
192_D	195_G	0.869	1.00
54_A	105_P	0.864	1.00
317_D	320_H	0.864	1.00
79_M	165_V	0.857	1.00
129_T	156_G	0.857	1.00
395_A	412_L	0.856	1.00
70_E	73_Q	0.855	1.00
120_A	429_V	0.853	1.00
249_L	253_V	0.850	1.00
383_L	387_N	0.847	1.00
41_G	185_V	0.846	1.00
127_L	453_N	0.845	1.00
39_A	43_R	0.844	1.00
241_F	398_F	0.843	1.00
174_Q	177_K	0.843	1.00
319_L	366_M	0.843	1.00
323_V	370_V	0.843	1.00
125_R	434_V	0.840	1.00
239_D	272_K	0.839	1.00
319_L	347_Y	0.839	1.00
159_L	169_A	0.835	1.00
40_A	43_R	0.832	1.00
57_L	152_L	0.831	1.00
130_I	207_A	0.828	1.00
58_R	101_A	0.827	1.00
429_V	456_T	0.824	1.00
200_I	220_I	0.824	1.00
37_L	184_G	0.824	1.00
208_V	224_A	0.822	1.00
244_L	399_T	0.817	1.00
50_I	54_A	0.813	1.00
353_A	375_I	0.807	1.00
251_L	255_A	0.803	1.00
378_D	384_E	0.802	1.00
221_G	224_A	0.799	1.00
217_G	235_L	0.798	1.00
55_E	59_D	0.797	1.00
158_L	187_G	0.796	1.00
143_V	147_A	0.796	1.00
26_A	34_A	0.794	1.00
164_N	314_D	0.790	1.00
221_G	228_L	0.789	1.00
240_P	386_A	0.788	1.00
288_F	351_V	0.788	1.00
26_A	189_L	0.788	1.00
257_V	291_A	0.787	1.00
323_V	352_L	0.787	1.00
325_K	328_A	0.787	1.00
316_R	340_M	0.786	1.00
29_D	32_E	0.785	1.00
402_E	405_A	0.785	1.00
155_N	452_C	0.785	1.00
9_A	192_D	0.785	1.00
93_S	140_L	0.783	1.00
297_M	340_M	0.783	1.00
335_L	351_V	0.782	1.00
87_R	303_E	0.780	1.00
28_A	32_E	0.777	1.00
26_A	30_D	0.775	1.00
63_A	67_R	0.774	1.00
76_T	83_I	0.773	1.00
72_A	76_T	0.773	1.00
313_F	339_K	0.772	1.00
276_I	280_I	0.772	1.00
33_N	37_L	0.771	1.00
54_A	58_R	0.771	1.00
244_L	277_E	0.770	1.00
217_G	233_L	0.770	1.00
12_I	345_N	0.769	1.00
218_A	222_A	0.768	1.00
15_A	346_Y	0.767	1.00
320_H	323_V	0.767	1.00
210_V	216_A	0.762	1.00
149_P	447_G	0.761	1.00
71_M	140_L	0.760	1.00
321_H	324_E	0.759	1.00
299_D	305_N	0.758	1.00
224_A	231_C	0.752	1.00
29_D	33_N	0.748	1.00
31_I	35_L	0.747	1.00
56_K	179_A	0.744	1.00
72_A	83_I	0.744	1.00
45_W	185_V	0.744	1.00
38_A	187_G	0.743	1.00
132_A	146_G	0.743	1.00
20_L	77_R	0.742	1.00
47_E	410_A	0.741	1.00
295_L	306_A	0.740	1.00
150_I	157_Y	0.739	1.00
200_I	223_Q	0.738	1.00
79_M	311_A	0.736	1.00
286_E	289_V	0.735	1.00
156_G	187_G	0.735	1.00
379_A	383_L	0.734	1.00
414_C	417_V	0.733	1.00
81_K	85_Q	0.730	1.00
289_V	292_A	0.730	1.00
84_N	306_A	0.729	1.00
352_L	355_V	0.729	1.00
406_R	410_A	0.724	1.00
191_A	196_V	0.724	1.00
51_D	105_P	0.723	1.00
246_D	399_T	0.722	1.00
40_A	44_D	0.720	1.00
292_A	335_L	0.719	1.00
173_A	177_K	0.718	1.00
200_I	208_V	0.717	1.00
297_M	307_L	0.712	1.00
24_P	190_N	0.709	1.00
337_G	348_P	0.706	1.00
277_E	379_A	0.706	1.00
161_H	190_N	0.706	1.00
58_R	62_K	0.705	1.00
43_R	46_R	0.705	1.00
181_I	185_V	0.703	1.00
75_I	78_E	0.702	1.00
288_F	373_I	0.701	1.00
144_M	172_I	0.701	1.00
198_Q	219_A	0.699	1.00
170_Q	174_Q	0.698	1.00
322_Q	364_E	0.698	1.00
33_N	36_Q	0.694	1.00
83_I	301_R	0.693	1.00
289_V	351_V	0.691	1.00
250_E	291_A	0.691	1.00
121_V	457_V	0.690	1.00
32_E	204_R	0.690	1.00
153_A	452_C	0.689	1.00
409_A	419_I	0.689	1.00
140_L	168_C	0.685	1.00
302_D	305_N	0.683	1.00
292_A	295_L	0.683	1.00
28_A	195_G	0.681	1.00
214_V	436_K	0.679	1.00
399_T	404_Q	0.678	1.00
275_I	357_P	0.678	1.00
176_F	181_I	0.676	1.00
23_L	166_M	0.676	1.00
44_D	48_T	0.676	1.00
163_P	318_E	0.673	1.00
222_A	225_G	0.670	1.00
28_A	198_Q	0.668	1.00
200_I	227_A	0.667	1.00
12_I	17_G	0.665	1.00
249_L	280_I	0.664	1.00
74_M	167_G	0.664	1.00
275_I	362_F	0.663	1.00
159_L	186_Y	0.662	1.00
218_A	226_A	0.659	1.00
36_Q	39_A	0.659	1.00
146_G	442_E	0.656	1.00
230_K	450_E	0.654	1.00
333_L	350_T	0.654	1.00
357_P	362_F	0.653	1.00
76_T	301_R	0.652	1.00
256_A	288_F	0.652	1.00
13_N	301_R	0.652	1.00
274_F	284_F	0.650	1.00
50_I	104_G	0.648	1.00
143_V	169_A	0.646	1.00
44_D	47_E	0.646	1.00
194_D	198_Q	0.645	1.00
120_A	456_T	0.644	1.00
64_L	71_M	0.642	1.00
417_V	455_Q	0.641	1.00
77_R	167_G	0.641	1.00
366_M	370_V	0.639	1.00
46_R	411_R	0.638	1.00
385_L	388_D	0.638	1.00
171_L	175_V	0.637	1.00
315_L	318_E	0.637	1.00
243_V	252_A	0.636	1.00
75_I	89_E	0.636	1.00
65_R	91_A	0.634	1.00
56_K	60_I	0.633	1.00
81_K	138_F	0.632	1.00
39_A	42_F	0.632	1.00
355_V	362_F	0.631	1.00
232_V	450_E	0.631	1.00
64_L	140_L	0.631	1.00
192_D	197_S	0.630	1.00
347_Y	350_T	0.628	1.00
164_N	311_A	0.627	1.00
400_T	403_T	0.625	1.00
119_Q	406_R	0.625	1.00
45_W	56_K	0.623	1.00
339_K	348_P	0.621	1.00
163_P	219_A	0.621	1.00
240_P	414_C	0.621	1.00
37_L	183_Q	0.621	1.00
62_K	65_R	0.620	1.00
146_G	209_T	0.620	1.00
64_L	172_I	0.620	1.00
327_L	338_E	0.620	1.00
131_L	158_L	0.620	1.00
90_V	140_L	0.619	1.00
257_V	295_L	0.618	1.00
46_R	125_R	0.617	1.00
193_N	196_V	0.617	1.00
17_G	313_F	0.615	1.00
312_R	315_L	0.615	1.00
61_G	94_A	0.614	1.00
329_Q	358_E	0.613	1.00
134_M	143_V	0.612	1.00
264_T	307_L	0.611	1.00
397_I	405_A	0.609	1.00
247_A	252_A	0.609	1.00
71_M	90_V	0.606	1.00
355_V	361_A	0.606	1.00
194_D	197_S	0.604	1.00
405_A	409_A	0.604	1.00
132_A	147_A	0.603	1.00
310_M	315_L	0.602	1.00
241_F	274_F	0.601	1.00
143_V	172_I	0.601	1.00
90_V	94_A	0.600	1.00
314_D	317_D	0.599	1.00
314_D	318_E	0.599	1.00
147_A	159_L	0.599	1.00
297_M	306_A	0.599	1.00
38_A	156_G	0.599	1.00
140_L	172_I	0.598	1.00
65_R	68_S	0.597	1.00
331_A	355_V	0.596	1.00
245_N	376_A	0.596	1.00
383_L	412_L	0.596	1.00
127_L	206_A	0.594	1.00
402_E	406_R	0.594	1.00
43_R	411_R	0.592	1.00
280_I	376_A	0.591	1.00
45_W	151_I	0.590	1.00
413_E	434_V	0.588	1.00
69_E	83_I	0.586	1.00
197_S	201_K	0.586	1.00
383_L	407_Q	0.585	1.00
31_I	196_V	0.585	1.00
75_I	86_A	0.585	1.00
60_I	63_A	0.584	1.00
276_I	373_I	0.583	1.00
362_F	385_L	0.580	1.00
46_R	126_P	0.579	1.00
50_I	152_L	0.577	1.00
207_A	450_E	0.575	1.00
267_V	270_A	0.575	1.00
449_H	452_C	0.574	1.00
449_H	454_I	0.572	1.00
310_M	347_Y	0.572	1.00
221_G	233_L	0.572	1.00
249_L	283_A	0.569	1.00
38_A	129_T	0.567	1.00
42_F	185_V	0.567	1.00
172_I	176_F	0.566	1.00
107_M	448_L	0.565	1.00
130_I	155_N	0.563	1.00
198_Q	223_Q	0.563	1.00
253_V	280_I	0.562	1.00
38_A	158_L	0.562	1.00
246_D	400_T	0.561	1.00
278_E	282_S	0.558	1.00
278_E	281_A	0.558	1.00
285_T	351_V	0.558	1.00
130_I	157_Y	0.556	1.00
34_A	189_L	0.556	1.00
403_T	407_Q	0.555	1.00
75_I	168_C	0.555	1.00
158_L	189_L	0.555	1.00
61_G	97_C	0.555	1.00
70_E	174_Q	0.553	1.00
73_Q	76_T	0.552	1.00
163_P	215_R	0.551	1.00
320_H	327_L	0.551	1.00
11_S	78_E	0.550	1.00
11_S	21_S	0.549	1.00
11_S	166_M	0.548	1.00
234_E	393_L	0.548	1.00
120_A	458_W	0.548	1.00
296_K	302_D	0.547	1.00
52_Y	56_K	0.546	1.00
89_E	138_F	0.545	1.00
354_N	375_I	0.545	1.00
277_E	377_K	0.545	1.00
141_W	145_R	0.544	1.00
412_L	417_V	0.544	1.00
333_L	336_G	0.544	1.00
274_F	373_I	0.541	1.00
123_E	455_Q	0.540	1.00
246_D	401_D	0.540	1.00
92_K	141_W	0.540	1.00
261_Y	295_L	0.539	1.00
64_L	97_C	0.537	1.00
102_E	105_P	0.537	1.00
39_A	129_T	0.537	1.00
130_I	209_T	0.536	1.00
32_E	35_L	0.536	1.00
68_S	94_A	0.535	1.00
131_L	200_I	0.534	1.00
403_T	406_R	0.534	1.00
41_G	44_D	0.534	1.00
91_A	94_A	0.534	1.00
131_L	196_V	0.533	1.00
111_E	122_I	0.533	1.00
223_Q	226_A	0.533	1.00
72_A	86_A	0.533	1.00
107_M	452_C	0.532	1.00
81_K	86_A	0.531	1.00
177_K	184_G	0.531	1.00
215_R	314_D	0.530	1.00
37_L	41_G	0.530	1.00
250_E	253_V	0.529	1.00
214_V	391_F	0.528	1.00
329_Q	356_T	0.528	1.00
251_L	254_K	0.528	1.00
323_V	350_T	0.527	1.00
269_A	426_D	0.527	1.00
129_T	206_A	0.527	1.00
271_A	396_T	0.526	1.00
239_D	394_S	0.526	1.00
68_S	72_A	0.526	1.00
326_T	360_T	0.526	1.00
394_S	418_F	0.525	1.00
32_E	198_Q	0.524	1.00
225_G	228_L	0.523	1.00
8_H	24_P	0.522	1.00
28_A	201_K	0.522	1.00
177_K	180_G	0.521	1.00
416_G	425_S	0.517	1.00
386_A	412_L	0.515	1.00
288_F	291_A	0.515	1.00
20_L	167_G	0.515	1.00
285_T	375_I	0.515	1.00
259_G	422_Y	0.513	1.00
241_F	396_T	0.513	1.00
263_N	267_V	0.512	1.00
318_E	321_H	0.512	1.00
260_R	371_A	0.512	1.00
112_P	115_V	0.512	1.00
100_Y	149_P	0.511	1.00
251_L	400_T	0.511	1.00
26_A	31_I	0.511	1.00
79_M	263_N	0.511	1.00
286_E	293_A	0.510	1.00
36_Q	202_D	0.510	1.00
288_F	292_A	0.509	1.00
214_V	218_A	0.507	1.00
99_W	103_H	0.506	1.00
31_I	195_G	0.506	1.00
418_F	421_G	0.503	1.00
153_A	448_L	0.503	1.00
444_S	447_G	0.503	1.00
23_L	167_G	0.502	1.00
382_A	386_A	0.502	1.00
408_M	411_R	0.501	1.00
175_V	178_D	0.501	1.00
413_E	453_N	0.500	1.00
151_I	186_Y	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a4sA	4	1	100	0.031	Contact Map
4o5hA	4	1	100	0.032	Contact Map
4yweA	5	0.9978	100	0.033	Contact Map
4qf6A	4	1	100	0.034	Contact Map
4pxlA	4	1	100	0.035	Contact Map
4pz2A	4	1	100	0.036	Contact Map
3ek1A	5	0.9957	100	0.038	Contact Map
4lihA	5	0.9957	100	0.039	Contact Map
2d4eA	4	0.9978	100	0.039	Contact Map
4wj9A	4	1	100	0.039	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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