GREMLIN Database
YNEG - Uncharacterized protein YneG
UniProt: P76148 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13815
Length: 119 (112)
Sequences: 301 (195)
Seq/√Len: 18.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_V100_Q5.6771.00
21_R115_Q5.1081.00
78_T108_I3.7591.00
84_L104_I3.7031.00
7_L107_V3.4371.00
50_L84_L3.1150.99
23_G26_E2.8450.98
103_Y107_V2.5010.97
85_A92_Q2.3120.95
15_K19_R2.0140.89
88_H103_Y1.8960.86
109_Y112_L1.8850.86
39_E109_Y1.8730.85
50_L104_I1.7530.81
30_C35_A1.6880.79
47_A101_Q1.6410.77
42_A69_V1.6410.77
35_A113_V1.6400.77
26_E71_I1.6190.76
110_H114_V1.6020.75
84_L90_I1.4440.67
45_F86_K1.4330.66
30_C39_E1.4170.65
5_D110_H1.3840.63
30_C38_I1.3820.63
41_H45_F1.3650.62
14_S86_K1.3380.61
39_E112_L1.3070.59
28_Q31_L1.2950.58
77_A107_V1.2900.58
43_A102_R1.2830.57
9_A97_S1.2710.57
41_H66_G1.2370.54
53_A93_G1.2090.53
27_R30_C1.1920.52
14_S29_Y1.1860.51
59_G62_T1.1850.51
46_V51_A1.1750.51
15_K18_S1.1730.50
10_R19_R1.1600.50
8_F107_V1.1470.49
30_C109_Y1.1450.49
30_C112_L1.1310.48
39_E105_V1.1280.48
11_L14_S1.1180.47
31_L116_M1.0790.45
23_G71_I1.0290.42
43_A101_Q1.0260.41
30_C116_M1.0160.41
24_M28_Q0.9920.39
43_A95_S0.9910.39
57_N64_M0.9870.39
47_A98_E0.9850.39
46_V108_I0.9850.39
11_L33_K0.9520.37
46_V105_V0.9460.37
11_L87_W0.9350.36
42_A105_V0.9200.35
24_M98_E0.9190.35
18_S109_Y0.9040.34
77_A106_A0.8700.32
48_K55_P0.8570.32
54_L93_G0.8540.32
44_D48_K0.8480.31
97_S101_Q0.8470.31
39_E106_A0.8370.31
54_L97_S0.8350.31
45_F101_Q0.8310.30
41_H67_H0.8290.30
90_I100_Q0.8280.30
47_A97_S0.8280.30
25_K33_K0.8120.29
25_K42_A0.7820.28
73_Q82_G0.7750.27
40_Q44_D0.7660.27
91_P94_V0.7610.27
60_K66_G0.7520.26
76_T108_I0.7500.26
67_H111_W0.7490.26
15_K43_A0.7380.26
92_Q106_A0.7360.26
45_F67_H0.7330.25
19_R26_E0.7320.25
28_Q32_E0.7280.25
29_Y33_K0.7280.25
54_L99_E0.7280.25
76_T88_H0.7260.25
76_T107_V0.7220.25
16_F49_R0.7190.25
11_L86_K0.7110.24
90_I104_I0.7070.24
18_S38_I0.7050.24
70_F111_W0.7020.24
27_R35_A0.7000.24
37_V95_S0.6990.24
32_E102_R0.6950.24
30_C45_F0.6950.24
6_P32_E0.6940.24
57_N86_K0.6930.24
67_H70_F0.6840.23
96_L104_I0.6810.23
10_R53_A0.6700.23
22_L111_W0.6690.23
7_L88_H0.6640.22
6_P94_V0.6610.22
27_R31_L0.6610.22
14_S45_F0.6580.22
110_H115_Q0.6580.22
52_P55_P0.6580.22
37_V102_R0.6560.22
31_L97_S0.6560.22
13_R35_A0.6540.22
6_P60_K0.6520.22
29_Y86_K0.6490.22
50_L90_I0.6420.21
9_A24_M0.6410.21
36_P99_E0.6390.21
5_D66_G0.6360.21
77_A110_H0.6310.21
10_R40_Q0.6290.21
16_F111_W0.6220.21
31_L52_P0.6220.21
8_F101_Q0.6210.20
46_V104_I0.6200.20
92_Q114_V0.6170.20
15_K32_E0.6150.20
42_A77_A0.6130.20
71_I108_I0.6110.20
68_P111_W0.6080.20
16_F67_H0.6050.20
53_A101_Q0.6000.20
24_M54_L0.5980.20
20_F75_A0.5950.19
55_P95_S0.5910.19
64_M71_I0.5890.19
8_F48_K0.5890.19
13_R105_V0.5860.19
78_T91_P0.5860.19
37_V88_H0.5790.19
19_R23_G0.5740.19
100_Q113_V0.5630.18
49_R65_R0.5560.18
98_E116_M0.5540.18
48_K56_A0.5420.17
77_A87_W0.5420.17
49_R67_H0.5420.17
42_A46_V0.5380.17
9_A82_G0.5370.17
88_H104_I0.5370.17
76_T116_M0.5360.17
13_R113_V0.5330.17
59_G75_A0.5320.17
37_V40_Q0.5290.17
22_L70_F0.5280.17
60_K64_M0.5280.17
105_V108_I0.5280.17
62_T79_C0.5280.17
22_L67_H0.5220.17
6_P85_A0.5190.17
9_A12_S0.5140.16
61_Q83_C0.5080.16
62_T75_A0.5070.16
46_V116_M0.5060.16
27_R115_Q0.5050.16
71_I115_Q0.5030.16
42_A67_H0.5020.16
29_Y68_P0.5020.16
28_Q95_S0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vsy4 1 0.916 35.5 0.946 Contact Map
3m62A 1 0.9664 34.6 0.946 Contact Map
1e8eA 1 0.7983 28 0.949 Contact Map
4wz3B 1 0.8403 15 0.955 Contact Map
2yy9A 2 0.3613 10.9 0.958 Contact Map
1vw4Q 1 0.4622 10.5 0.958 Contact Map
1b9hA 2 0.8571 10.5 0.958 Contact Map
2i3dA 2 0.4874 10.4 0.958 Contact Map
3bb8A 2 0.8992 9.9 0.958 Contact Map
1z68A 2 0.4286 8.7 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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