GREMLIN Database
YNEF - Uncharacterized protein YneF
UniProt: P76147 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13814
Length: 315 (288)
Sequences: 12190 (11213)
Seq/√Len: 660.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
213_G216_G3.8501.00
144_L148_F3.7881.00
184_Y302_R3.6091.00
178_M242_A3.4061.00
164_L283_F3.3681.00
176_T271_S3.2671.00
297_S306_S3.1561.00
155_Y159_G3.1411.00
178_M267_I2.9631.00
160_L227_A2.8071.00
154_V205_A2.6211.00
176_T238_G2.6021.00
300_D306_S2.4671.00
182_I204_F2.4541.00
243_E246_R2.4441.00
221_M227_A2.3741.00
160_L219_A2.3441.00
154_V218_V2.3321.00
266_S297_S2.2701.00
199_K202_S2.2391.00
159_G163_A2.2241.00
246_R305_T2.2071.00
135_I139_M2.1701.00
208_I218_V2.1161.00
296_R300_D2.0891.00
183_D266_S2.0711.00
288_V292_T2.0671.00
180_L267_I2.0341.00
300_D304_R2.0271.00
195_E288_V2.0251.00
139_M142_V1.9801.00
143_A147_D1.9361.00
249_V265_V1.9261.00
180_L265_V1.9121.00
200_V263_L1.9021.00
196_C199_K1.8811.00
234_N237_D1.8721.00
188_I200_V1.8681.00
179_L221_M1.8571.00
163_A166_S1.8551.00
297_S304_R1.8481.00
152_T201_L1.8031.00
280_T289_E1.7741.00
212_V218_V1.7531.00
264_T303_N1.7331.00
230_V241_M1.7031.00
211_I248_G1.6771.00
273_R280_T1.6741.00
179_L294_L1.6731.00
282_D285_K1.6651.00
204_F249_V1.6551.00
221_M287_M1.6161.00
296_R306_S1.6111.00
163_A217_L1.6021.00
163_A219_A1.6011.00
147_D162_E1.6001.00
163_A167_P1.5941.00
211_I244_K1.5851.00
178_M230_V1.5851.00
272_G286_L1.5681.00
150_F158_S1.5401.00
175_L286_L1.5311.00
182_I265_V1.5291.00
155_Y217_L1.5261.00
147_D159_G1.4821.00
175_L272_G1.4701.00
203_V207_H1.4691.00
184_Y187_S1.4581.00
186_K190_D1.4501.00
203_V254_F1.4421.00
196_C256_W1.4331.00
157_R198_D1.4311.00
296_R299_K1.4261.00
203_V206_R1.4181.00
281_D289_E1.3951.00
179_L287_M1.3811.00
212_V228_V1.3811.00
128_V131_S1.3801.00
167_P231_P1.3751.00
184_Y224_E1.3621.00
138_L141_Q1.3561.00
241_M244_K1.3541.00
206_R209_Q1.3471.00
243_E247_K1.3461.00
207_H252_Q1.3411.00
273_R279_L1.3311.00
157_R161_Y1.3271.00
132_V135_I1.3001.00
131_S135_I1.2981.00
204_F208_I1.2961.00
136_N139_M1.2961.00
187_S191_N1.2861.00
270_G286_L1.2821.00
205_A218_V1.2821.00
159_G162_E1.2811.00
199_K203_V1.2771.00
189_N197_G1.2741.00
159_G219_A1.2631.00
239_L243_E1.2601.00
246_R267_I1.2501.00
161_Y165_K1.2461.00
161_Y284_N1.2461.00
269_V305_T1.2411.00
224_E264_T1.2411.00
289_E293_C1.2371.00
190_D295_Y1.2271.00
135_I138_L1.2241.00
291_D295_Y1.2211.00
212_V216_G1.2121.00
188_I261_L1.2021.00
269_V307_T1.2011.00
180_L208_I1.1991.00
173_Q232_S1.1951.00
242_A267_I1.1741.00
141_Q145_R1.1711.00
202_S206_R1.1701.00
238_G269_V1.1661.00
159_G217_L1.1551.00
270_G290_A1.1541.00
155_Y219_A1.1501.00
164_L229_A1.1381.00
160_L164_L1.1381.00
145_R158_S1.1291.00
185_F201_L1.1211.00
227_A287_M1.1201.00
160_L229_A1.1191.00
207_H253_P1.1181.00
128_V132_V1.1171.00
239_L305_T1.1141.00
297_S301_G1.1101.00
207_H248_G1.1071.00
180_L228_V1.1041.00
283_F287_M1.1021.00
148_F155_Y1.0901.00
181_D298_K1.0871.00
165_K283_F1.0831.00
202_S205_A1.0821.00
264_T301_G1.0771.00
213_G244_K1.0621.00
270_G289_E1.0621.00
219_A227_A1.0591.00
242_A305_T1.0451.00
147_D155_Y1.0401.00
216_G244_K1.0251.00
247_K251_L1.0211.00
200_V224_E1.0201.00
222_G225_E1.0201.00
178_M228_V1.0121.00
212_V245_I0.9991.00
210_K248_G0.9991.00
256_W259_K0.9951.00
204_F265_V0.9951.00
239_L307_T0.9951.00
129_S133_A0.9881.00
285_K288_V0.9861.00
183_D302_R0.9681.00
194_H291_D0.9561.00
248_G252_Q0.9521.00
176_T269_V0.9421.00
150_F161_Y0.9421.00
218_V228_V0.9341.00
146_A156_S0.9341.00
195_E199_K0.9311.00
177_V287_M0.9301.00
270_G293_C0.9291.00
167_P175_L0.9271.00
255_T260_T0.9201.00
139_M143_A0.9191.00
235_P271_S0.9181.00
208_I228_V0.9141.00
162_E166_S0.9101.00
289_E292_T0.9091.00
222_G291_D0.9081.00
223_G295_Y0.9081.00
141_Q144_L0.9051.00
242_A269_V0.9031.00
179_L290_A0.9011.00
222_G295_Y0.8991.00
91_V95_N0.8901.00
233_V237_D0.8891.00
238_G242_A0.8821.00
131_S136_N0.8781.00
151_L201_L0.8781.00
177_V286_L0.8761.00
203_V252_Q0.8761.00
132_V136_N0.8761.00
129_S132_V0.8691.00
182_I264_T0.8661.00
183_D301_G0.8591.00
200_V254_F0.8561.00
249_V263_L0.8551.00
194_H295_Y0.8541.00
189_N223_G0.8501.00
175_L229_A0.8481.00
230_V238_G0.8461.00
212_V241_M0.8441.00
186_K295_Y0.8401.00
206_R210_K0.8361.00
33_K36_Q0.8291.00
188_I256_W0.8281.00
178_M269_V0.8281.00
235_P239_L0.8281.00
177_V227_A0.8261.00
174_H274_A0.8231.00
181_D224_E0.8191.00
246_R303_N0.8071.00
213_G233_V0.8051.00
237_D240_L0.8011.00
133_A136_N0.8001.00
186_K291_D0.7961.00
20_M24_A0.7781.00
36_Q40_A0.7751.00
273_R289_E0.7701.00
209_Q218_V0.7691.00
204_F263_L0.7671.00
253_P262_Y0.7661.00
213_G241_M0.7651.00
140_K143_A0.7611.00
131_S139_M0.7601.00
274_A280_T0.7531.00
195_E284_N0.7511.00
192_Y261_L0.7501.00
216_G241_M0.7481.00
235_P307_T0.7461.00
236_V239_L0.7461.00
285_K289_E0.7461.00
157_R221_M0.7431.00
187_S224_E0.7351.00
113_S116_L0.7251.00
161_Y219_A0.7241.00
267_I305_T0.7221.00
142_V145_R0.7211.00
188_I196_C0.7191.00
186_K189_N0.7131.00
22_T26_P0.7131.00
190_D291_D0.7131.00
225_E291_D0.7131.00
216_G230_V0.7111.00
242_A246_R0.7111.00
131_S134_A0.7101.00
129_S135_I0.7041.00
168_S172_T0.7021.00
181_D194_H0.7011.00
182_I201_L0.7001.00
148_F209_Q0.7001.00
186_K194_H0.7001.00
84_V88_V0.7001.00
170_K215_K0.6991.00
168_S175_L0.6991.00
294_L302_R0.6981.00
80_L83_F0.6961.00
138_L145_R0.6931.00
203_V253_P0.6921.00
245_I265_V0.6911.00
179_L227_A0.6911.00
208_I212_V0.6901.00
82_T86_G0.6901.00
161_Y164_L0.6881.00
181_D189_N0.6851.00
88_V92_L0.6821.00
93_V96_S0.6811.00
241_M245_I0.6791.00
84_V95_N0.6791.00
293_C297_S0.6791.00
142_V146_A0.6781.00
142_V147_D0.6771.00
160_L221_M0.6771.00
190_D225_E0.6761.00
279_L307_T0.6761.00
92_L95_N0.6751.00
207_H254_F0.6751.00
190_D194_H0.6731.00
199_K256_W0.6681.00
182_I185_F0.6651.00
144_L153_Q0.6631.00
23_L27_G0.6581.00
279_L289_E0.6561.00
207_H211_I0.6561.00
136_N140_K0.6551.00
110_Q113_S0.6541.00
34_A38_M0.6541.00
19_C23_L0.6531.00
109_P113_S0.6531.00
238_G271_S0.6501.00
154_V219_A0.6501.00
255_T258_Q0.6481.00
145_R150_F0.6471.00
168_S171_Q0.6471.00
196_C261_L0.6451.00
64_P67_I0.6431.00
38_M41_I0.6401.00
268_G290_A0.6381.00
181_D197_G0.6381.00
86_G89_E0.6381.00
199_K257_Q0.6371.00
208_I245_I0.6361.00
134_A137_S0.6341.00
192_Y196_C0.6341.00
158_S161_Y0.6321.00
151_L202_S0.6281.00
168_S272_G0.6281.00
69_C72_R0.6271.00
153_Q202_S0.6261.00
71_V74_T0.6251.00
189_N298_K0.6231.00
69_C74_T0.6231.00
17_V21_L0.6221.00
273_R281_D0.6221.00
25_I29_L0.6221.00
160_L287_M0.6201.00
243_E305_T0.6201.00
77_V81_L0.6191.00
147_D158_S0.6191.00
21_L25_I0.6191.00
189_N224_E0.6171.00
167_P170_K0.6161.00
217_L229_A0.6131.00
117_G120_T0.6081.00
242_A265_V0.6071.00
239_L269_V0.6061.00
274_A279_L0.6051.00
225_E295_Y0.6041.00
164_L175_L0.6021.00
78_T81_L0.6001.00
281_D285_K0.6001.00
181_D295_Y0.6001.00
154_V208_I0.5961.00
95_N99_D0.5961.00
169_L272_G0.5951.00
256_W261_L0.5951.00
154_V209_Q0.5951.00
42_A45_V0.5941.00
94_A98_I0.5901.00
284_N288_V0.5891.00
44_I47_V0.5881.00
130_F134_A0.5861.00
185_F224_E0.5861.00
35_E39_P0.5861.00
29_L33_K0.5861.00
61_F64_P0.5851.00
128_V135_I0.5851.00
64_P75_P0.5851.00
37_M41_I0.5841.00
185_F200_V0.5821.00
205_A208_I0.5801.00
158_S162_E0.5801.00
293_C296_R0.5791.00
224_E297_S0.5761.00
174_H271_S0.5731.00
151_L157_R0.5731.00
266_S301_G0.5731.00
164_L219_A0.5711.00
246_R264_T0.5711.00
109_P112_F0.5691.00
163_A229_A0.5671.00
188_I192_Y0.5661.00
138_L142_V0.5651.00
160_L283_F0.5651.00
72_R75_P0.5651.00
253_P260_T0.5651.00
186_K223_G0.5641.00
18_P22_T0.5631.00
161_Y283_F0.5631.00
183_D298_K0.5621.00
116_L120_T0.5621.00
62_P66_L0.5611.00
77_V80_L0.5611.00
148_F153_Q0.5601.00
64_P71_V0.5591.00
195_E221_M0.5581.00
22_T25_I0.5571.00
18_P21_L0.5571.00
228_V245_I0.5571.00
190_D223_G0.5561.00
26_P29_L0.5561.00
128_V133_A0.5551.00
221_M224_E0.5541.00
194_H198_D0.5501.00
148_F154_V0.5491.00
177_V290_A0.5491.00
32_F36_Q0.5481.00
23_L28_V0.5481.00
41_I45_V0.5481.00
224_E298_K0.5461.00
194_H225_E0.5441.00
139_M145_R0.5431.00
63_L67_I0.5421.00
32_F35_E0.5411.00
301_G304_R0.5411.00
240_L244_K0.5401.00
167_P229_A0.5391.00
183_D264_T0.5391.00
253_P256_W0.5391.00
233_V238_G0.5391.00
244_K248_G0.5381.00
171_Q232_S0.5381.00
79_C83_F0.5371.00
63_L66_L0.5371.00
194_H298_K0.5361.00
59_L62_P0.5351.00
185_F189_N0.5351.00
176_T230_V0.5341.00
132_V139_M0.5321.00
25_I28_V0.5311.00
143_A162_E0.5280.99
224_E301_G0.5280.99
85_T89_E0.5270.99
108_I111_M0.5260.99
235_P238_G0.5240.99
184_Y263_L0.5230.99
30_P35_E0.5230.99
81_L84_V0.5230.99
99_D102_V0.5210.99
155_Y163_A0.5190.99
242_A245_I0.5190.99
124_C127_M0.5170.99
205_A209_Q0.5160.99
292_T296_R0.5120.99
76_Q80_L0.5110.99
149_D220_R0.5100.99
61_F71_V0.5090.99
92_L97_V0.5080.99
143_A146_A0.5080.99
194_H224_E0.5070.99
189_N201_L0.5070.99
36_Q39_P0.5070.99
118_I121_M0.5050.99
24_A28_V0.5050.99
133_A137_S0.5050.99
88_V91_V0.5030.99
89_E92_L0.5020.99
64_P73_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w25A 2 0.7016 100 0.376 Contact Map
4j40A 2 0.0032 100 0.384 Contact Map
3pjxA 1 0.5556 100 0.399 Contact Map
4rnhA 2 0.5079 100 0.403 Contact Map
3mtkA 2 0.5143 100 0.41 Contact Map
3tvkA 1 0.5333 100 0.419 Contact Map
3ignA 1 0.5175 100 0.422 Contact Map
3ezuA 2 0.8159 100 0.427 Contact Map
4h54A 2 0.8127 100 0.429 Contact Map
3i5cA 2 0.6095 100 0.433 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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