GREMLIN Database
YNEE - UPF0187 protein YneE
UniProt: P76146 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13813
Length: 304 (277)
Sequences: 1580 (1167)
Seq/√Len: 70.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_L197_G7.4941.00
89_L194_V4.9581.00
77_A84_K4.3821.00
91_I196_A4.2801.00
127_T156_A3.9441.00
122_H125_R3.5531.00
112_E166_W2.9861.00
32_F242_V2.9591.00
81_E200_R2.9191.00
114_A282_L2.9101.00
113_F163_M2.8901.00
88_Q194_V2.7471.00
93_S117_Q2.6921.00
120_F195_L2.5491.00
39_I237_T2.5251.00
263_G268_D2.5231.00
257_E267_N2.5071.00
99_E185_N2.4411.00
265_E268_D2.3511.00
77_A80_V2.2661.00
277_A281_D2.2641.00
190_D193_A2.2391.00
111_R115_R2.2341.00
92_A190_D2.2001.00
123_C159_I2.1891.00
36_I238_P2.1711.00
126_M136_V2.1621.00
126_M131_Q2.1271.00
276_N280_I2.0961.00
90_M274_I2.0501.00
28_L242_V2.0241.00
99_E187_R2.0031.00
89_L124_L1.9781.00
97_L114_A1.9031.00
97_L282_L1.8711.00
142_K145_D1.8631.00
91_I193_A1.8361.00
116_L166_W1.8151.00
40_F44_W1.7861.00
162_I165_E1.7831.00
169_V173_N1.7491.00
65_A69_G1.7461.00
179_I182_I1.7231.00
168_A172_R1.7201.00
160_L192_S1.7111.00
57_F224_M1.6971.00
116_L145_D1.6671.00
100_V110_V1.6330.99
125_R272_D1.6310.99
183_S186_D1.6230.99
123_C155_P1.6090.99
98_R164_G1.5630.99
117_Q163_M1.5500.99
145_D162_I1.5130.99
83_R87_G1.5080.99
89_L191_I1.4670.99
164_G188_L1.4640.99
94_R199_E1.4510.99
14_F18_G1.4410.99
186_D190_D1.4240.98
31_N245_S1.4100.98
93_S278_I1.3980.98
98_R192_S1.3790.98
96_L184_L1.3710.98
83_R204_T1.3620.98
81_E84_K1.3530.98
23_K257_E1.3490.98
116_L163_M1.3410.98
135_E138_A1.3380.98
154_S281_D1.3320.98
203_Y277_A1.3270.97
134_A137_L1.3260.97
119_A141_L1.3220.97
120_F191_I1.3210.97
93_S121_A1.3120.97
177_S180_L1.2980.97
212_L216_R1.2880.97
46_T49_G1.2690.97
39_I43_P1.2530.96
99_E184_L1.2380.96
52_F229_L1.2370.96
29_L33_L1.2340.96
95_S192_S1.2280.96
100_V104_L1.2240.96
33_L40_F1.2210.96
96_L191_I1.2180.96
125_R271_L1.2150.96
87_G91_I1.2110.96
80_V201_I1.2040.96
193_A196_A1.1900.95
124_L195_L1.1780.95
100_V113_F1.1720.95
153_N280_I1.1690.95
170_Q175_Q1.1620.95
109_S166_W1.1590.94
111_R288_E1.1490.94
254_L258_L1.1480.94
71_R259_E1.1390.94
92_A194_V1.1390.94
76_Y80_V1.1370.94
87_G196_A1.1340.94
208_F212_L1.1280.94
139_H142_K1.1260.94
39_I230_V1.1250.94
95_S187_R1.1140.93
138_A150_L1.1140.93
192_S195_L1.1140.93
84_K200_R1.1050.93
69_G248_F1.0940.93
96_L117_Q1.0910.92
115_R283_L1.0890.92
35_S39_I1.0870.92
102_T165_E1.0870.92
36_I39_I1.0860.92
143_T148_R1.0820.92
69_G73_N1.0790.92
101_K104_L1.0780.92
21_L28_L1.0710.92
127_T154_S1.0610.91
146_L150_L1.0580.91
67_F251_L1.0560.91
125_R275_C1.0550.91
23_K38_V1.0500.91
154_S199_E1.0480.91
101_K285_M1.0360.90
71_R75_G1.0320.90
33_L36_I1.0150.89
213_I250_S1.0110.89
105_P172_R1.0090.89
90_M278_I0.9980.89
45_Y50_I0.9930.88
34_F38_V0.9930.88
259_E268_D0.9920.88
96_L113_F0.9840.88
115_R286_N0.9810.88
83_R200_R0.9760.88
109_S170_Q0.9610.87
56_P60_L0.9600.87
167_L181_F0.9540.86
101_K110_V0.9510.86
171_R180_L0.9510.86
260_D268_D0.9470.86
196_A199_E0.9420.86
34_F223_I0.9370.85
250_S257_E0.9340.85
33_L37_A0.9300.85
128_L198_C0.9270.85
281_D284_Q0.9180.84
235_Y255_A0.9180.84
153_N284_Q0.9160.84
35_S241_S0.9140.84
65_A157_N0.9110.84
81_E85_L0.9060.83
200_R204_T0.9010.83
126_M133_Q0.8970.83
37_A288_E0.8940.83
43_P49_G0.8870.82
279_E283_L0.8850.82
86_W278_I0.8780.81
116_L159_I0.8760.81
21_L274_I0.8670.81
89_L120_F0.8660.81
72_N210_Y0.8640.80
85_L198_C0.8620.80
24_I249_I0.8620.80
174_G178_D0.8590.80
90_M199_E0.8590.80
80_V87_G0.8520.79
91_I278_I0.8490.79
246_Y251_L0.8480.79
112_E145_D0.8460.79
89_L163_M0.8450.79
25_S30_L0.8440.79
32_F35_S0.8420.79
154_S195_L0.8410.79
181_F221_F0.8400.78
276_N279_E0.8390.78
114_A286_N0.8310.78
222_C267_N0.8300.78
28_L35_S0.8300.78
19_S212_L0.8270.77
35_S238_P0.8240.77
45_Y177_S0.8220.77
196_A278_I0.8210.77
109_S175_Q0.8190.77
117_Q191_I0.8160.76
69_G72_N0.8080.76
88_Q190_D0.8080.76
42_L230_V0.8050.75
83_R269_L0.8050.75
92_A191_I0.8050.75
129_R271_L0.8030.75
222_C249_I0.8020.75
49_G231_V0.8000.75
43_P46_T0.8000.75
94_R196_A0.7960.75
87_G200_R0.7940.74
206_I258_L0.7940.74
51_K231_V0.7870.74
92_A187_R0.7870.74
117_Q121_A0.7860.74
126_M132_P0.7840.74
79_Y258_L0.7830.73
118_I280_I0.7830.73
36_I186_D0.7780.73
118_I282_L0.7780.73
42_L231_V0.7750.73
89_L218_V0.7710.72
148_R229_L0.7670.72
67_F252_D0.7660.72
82_A267_N0.7580.71
222_C247_T0.7580.71
118_I279_E0.7570.71
211_T215_H0.7570.71
33_L151_A0.7520.70
217_T247_T0.7520.70
36_I40_F0.7510.70
115_R145_D0.7480.70
196_A252_D0.7460.70
214_L217_T0.7440.70
25_S120_F0.7420.69
125_R129_R0.7420.69
36_I220_L0.7400.69
105_P109_S0.7390.69
87_G179_I0.7370.69
72_N222_C0.7360.69
166_W170_Q0.7350.69
219_Y223_I0.7330.68
260_D265_E0.7310.68
237_T267_N0.7300.68
42_L51_K0.7290.68
108_A138_A0.7220.67
270_P281_D0.7220.67
30_L220_L0.7220.67
24_I62_V0.7210.67
109_S112_E0.7170.67
254_L259_E0.7150.66
246_Y257_E0.7150.66
87_G199_E0.7110.66
252_D259_E0.7090.66
37_A235_Y0.7080.66
250_S269_L0.7080.66
75_G258_L0.7070.66
129_R272_D0.7050.65
86_W271_L0.7030.65
67_F75_G0.7010.65
79_Y82_A0.7000.65
38_V241_S0.7000.65
252_D255_A0.6990.65
178_D182_I0.6980.65
84_K97_L0.6950.64
74_A251_L0.6930.64
70_F210_Y0.6910.64
143_T147_Q0.6900.64
211_T270_P0.6880.64
31_N249_I0.6870.63
112_E116_L0.6860.63
100_V103_T0.6850.63
17_H109_S0.6850.63
87_G277_A0.6840.63
16_W19_S0.6840.63
65_A250_S0.6840.63
24_I247_T0.6830.63
72_N255_A0.6810.63
134_A155_P0.6810.63
148_R151_A0.6800.63
153_N286_N0.6790.62
171_R178_D0.6790.62
149_V162_I0.6780.62
85_L194_V0.6780.62
193_A285_M0.6760.62
128_L201_I0.6750.62
62_V227_F0.6750.62
75_G89_L0.6740.62
71_R258_L0.6710.62
213_I216_R0.6700.61
110_V114_A0.6670.61
30_L137_L0.6620.61
147_Q151_A0.6620.61
61_G67_F0.6600.60
161_L285_M0.6540.60
78_R83_R0.6540.60
75_G181_F0.6530.59
283_L287_D0.6500.59
139_H144_E0.6490.59
81_E87_G0.6480.59
86_W225_L0.6420.58
212_L215_H0.6400.58
263_G269_L0.6400.58
88_Q193_A0.6390.58
123_C137_L0.6380.58
35_S237_T0.6370.58
205_P267_N0.6370.58
95_S221_F0.6360.57
107_S151_A0.6360.57
204_T260_D0.6360.57
87_G278_I0.6360.57
80_V83_R0.6350.57
64_I258_L0.6340.57
111_R286_N0.6310.57
25_S29_L0.6270.56
226_P241_S0.6270.56
68_L251_L0.6250.56
119_A159_I0.6240.56
62_V221_F0.6220.56
75_G110_V0.6150.55
177_S274_I0.6120.55
120_F124_L0.6090.54
240_I255_A0.6090.54
74_A206_I0.6090.54
127_T281_D0.6070.54
160_L188_L0.6060.54
106_D115_R0.6050.54
201_I274_I0.6010.53
58_S82_A0.6000.53
67_F72_N0.6000.53
96_L100_V0.6000.53
264_T271_L0.5930.52
24_I28_L0.5900.52
51_K73_N0.5900.52
93_S191_I0.5900.52
39_I235_Y0.5880.52
208_F257_E0.5870.52
16_W20_V0.5860.51
202_A260_D0.5850.51
28_L147_Q0.5820.51
45_Y48_L0.5820.51
180_L183_S0.5810.51
122_H272_D0.5810.51
243_L250_S0.5780.50
209_A260_D0.5770.50
68_L254_L0.5740.50
60_L241_S0.5730.50
23_K209_A0.5710.50
55_A241_S0.5690.49
29_L38_V0.5660.49
122_H279_E0.5650.49
33_L189_N0.5650.49
159_I280_I0.5640.49
82_A201_I0.5640.49
67_F256_E0.5600.48
16_W23_K0.5600.48
115_R165_E0.5590.48
138_A175_Q0.5590.48
171_R273_A0.5580.48
45_Y75_G0.5580.48
33_L43_P0.5580.48
66_I212_L0.5550.48
264_T272_D0.5550.48
111_R173_N0.5540.48
39_I238_P0.5540.48
195_L205_P0.5540.48
246_Y254_L0.5520.47
82_A209_A0.5520.47
213_I254_L0.5490.47
69_G251_L0.5480.47
125_R136_V0.5470.47
34_F47_H0.5470.47
213_I222_C0.5440.46
79_Y204_T0.5440.46
167_L171_R0.5440.46
158_R162_I0.5440.46
195_L199_E0.5420.46
208_F267_N0.5410.46
157_N285_M0.5410.46
120_F281_D0.5390.46
66_I211_T0.5380.46
58_S149_V0.5370.46
119_A137_L0.5360.45
97_L101_K0.5350.45
128_L204_T0.5330.45
42_L69_G0.5320.45
217_T243_L0.5310.45
146_L149_V0.5310.45
162_I169_V0.5300.45
119_A123_C0.5290.45
81_E128_L0.5290.45
127_T152_S0.5290.45
16_W21_L0.5290.45
84_K259_E0.5270.44
92_A193_A0.5270.44
134_A140_Y0.5270.44
20_V26_S0.5250.44
143_T146_L0.5240.44
65_A213_I0.5230.44
233_L270_P0.5230.44
53_T232_D0.5200.43
55_A58_S0.5200.43
72_N253_C0.5190.43
102_T105_P0.5180.43
89_L198_C0.5180.43
127_T131_Q0.5180.43
81_E203_Y0.5180.43
42_L49_G0.5150.43
99_E164_G0.5140.43
86_W275_C0.5140.43
30_L223_I0.5100.42
146_L151_A0.5100.42
269_L272_D0.5100.42
63_A241_S0.5090.42
123_C156_A0.5080.42
87_G90_M0.5070.42
88_Q116_L0.5070.42
106_D109_S0.5070.42
57_F160_L0.5070.42
88_Q196_A0.5070.42
273_A276_N0.5060.42
65_A170_Q0.5040.42
107_S110_V0.5040.42
105_P138_A0.5030.41
121_A269_L0.5020.41
167_L283_L0.5020.41
251_L257_E0.5020.41
30_L82_A0.5000.41
171_R181_F0.5000.41
91_I281_D0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wd8A 3 0.8882 100 0.121 Contact Map
4rdqA 5 0.9704 100 0.323 Contact Map
2mi2A 1 0.227 7.9 0.971 Contact Map
2mn6B 2 0.1447 4.4 0.974 Contact Map
4p4hI 3 0.3125 4.3 0.974 Contact Map
4o9lA 1 0.3092 4.1 0.974 Contact Map
2l16A 1 0.1612 3.9 0.975 Contact Map
4xk8I 1 0.0954 3.3 0.976 Contact Map
1lqbD 2 0.0592 3.2 0.976 Contact Map
2azeC 2 0.1447 3.2 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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