GREMLIN Database
LSRF - Uncharacterized aldolase LsrF
UniProt: P76143 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13810
Length: 291 (243)
Sequences: 1133 (639)
Seq/√Len: 41.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
240_W244_D4.2661.00
243_I272_V4.2471.00
237_E241_Q4.1651.00
52_V273_V4.0371.00
163_G170_T3.3171.00
242_A247_A3.2091.00
201_I223_V3.1891.00
252_M269_V3.0701.00
174_T194_A2.9291.00
235_A239_C2.8701.00
137_A169_P2.8321.00
160_V170_T2.7611.00
50_K248_S2.6541.00
188_S213_R2.3861.00
207_V210_G2.3591.00
233_R237_E2.3201.00
271_A275_H2.2831.00
231_P234_E2.2781.00
89_R129_D2.1901.00
128_D162_A2.1550.99
83_D274_H2.1480.99
105_V171_M2.1030.99
131_V168_M2.0380.99
250_V269_V2.0280.99
129_D161_D2.0050.99
184_Q188_S1.9920.99
84_V105_V1.9770.99
261_H264_A1.8850.98
195_A219_P1.8590.98
230_L235_A1.8480.98
206_Y211_F1.8480.98
140_A156_I1.8350.98
139_A173_V1.8090.98
53_M223_V1.7980.98
38_S42_R1.7510.98
236_L272_V1.7420.97
187_F207_V1.7370.97
50_K243_I1.7330.97
107_R173_V1.6910.97
256_I269_V1.6880.97
45_N48_T1.6540.96
128_D165_K1.6300.96
126_S161_D1.5990.96
82_A266_M1.5620.95
239_C269_V1.5580.95
138_V159_L1.5570.95
156_I172_A1.5240.94
176_V190_A1.5160.94
107_R139_A1.4830.94
43_I51_T1.4810.94
235_A265_M1.4670.93
207_V211_F1.4620.93
108_A159_L1.4300.92
128_D166_V1.4290.92
70_R73_I1.4250.92
125_L129_D1.4210.92
192_R196_E1.4140.92
154_K158_Q1.4080.92
228_K232_E1.3910.91
146_S152_S1.3760.91
141_Q173_V1.3710.91
59_G196_E1.3600.90
235_A252_M1.3550.90
109_S173_V1.3410.90
43_I84_V1.3400.90
123_V159_L1.3320.89
39_R169_P1.3210.89
121_E173_V1.3130.89
206_Y241_Q1.3080.88
236_L268_A1.3010.88
107_R143_Y1.2990.88
52_V250_V1.2960.88
122_A163_G1.2740.87
107_R175_G1.2740.87
191_T204_T1.2610.86
35_G42_R1.2590.86
229_K255_N1.2290.85
106_L125_L1.2230.85
35_G39_R1.2100.84
107_R141_Q1.1960.83
144_I193_I1.1940.83
60_Y110_G1.1880.83
121_E143_Y1.1850.83
240_W276_N1.1800.82
224_I242_A1.1780.82
42_R136_C1.1690.82
39_R42_R1.1550.81
92_L104_V1.1470.81
36_M200_Q1.1470.81
230_L238_M1.1420.80
36_M164_M1.1420.80
44_F51_T1.1380.80
121_E139_A1.1370.80
123_V156_I1.1360.80
35_G63_G1.1310.80
215_V245_Q1.1190.79
110_G124_A1.1060.78
87_C133_L1.1050.78
213_R216_A1.0930.77
176_V204_T1.0850.77
240_W243_I1.0820.77
209_K212_E1.0750.76
45_N83_D1.0580.75
108_A127_M1.0570.75
47_K275_H1.0550.75
121_E141_Q1.0480.74
107_R121_E1.0390.74
106_L135_S1.0320.73
41_S101_N1.0310.73
162_A165_K1.0270.73
143_Y173_V1.0240.73
61_F107_R1.0150.72
93_R164_M1.0140.72
141_Q175_G1.0090.71
107_R189_L1.0090.71
237_E240_W1.0070.71
109_S139_A1.0060.71
234_E237_E0.9960.70
123_V155_N0.9960.70
122_A150_H0.9960.70
77_P263_V0.9940.70
231_P238_M0.9920.70
143_Y257_F0.9860.70
61_F139_A0.9820.69
206_Y247_A0.9750.69
86_M173_V0.9730.69
60_Y152_S0.9730.69
178_K181_V0.9540.67
191_T201_I0.9500.67
139_A175_G0.9490.67
73_I77_P0.9450.66
236_L242_A0.9450.66
136_C169_P0.9400.66
51_T223_V0.9400.66
234_E238_M0.9390.66
40_L51_T0.9360.66
139_A143_Y0.9350.65
151_Q154_K0.9350.65
264_A268_A0.9350.65
121_E189_L0.9320.65
40_L217_G0.9220.64
158_Q267_K0.9160.64
72_D76_A0.9140.64
173_V225_A0.9080.63
53_M84_V0.9070.63
132_R165_K0.9060.63
239_C252_M0.9000.62
68_L192_R0.8940.62
187_F204_T0.8930.62
43_I171_M0.8930.62
125_L161_D0.8900.62
109_S142_V0.8860.61
88_T107_R0.8810.61
138_V200_Q0.8790.61
112_N149_E0.8730.60
52_V266_M0.8690.60
166_V170_T0.8650.59
172_A194_A0.8630.59
61_F173_V0.8620.59
108_A138_V0.8590.59
109_S141_Q0.8580.59
86_M139_A0.8550.58
109_S175_G0.8550.58
52_V270_Q0.8490.58
50_K276_N0.8480.58
59_G192_R0.8480.58
238_M242_A0.8450.58
171_M251_D0.8420.57
75_I87_C0.8410.57
243_I247_A0.8400.57
255_N258_Q0.8370.57
268_A271_A0.8270.56
236_L276_N0.8230.56
207_V214_I0.8200.55
129_D132_R0.8140.55
50_K157_I0.8120.55
176_V251_D0.8010.54
206_Y242_A0.7990.53
53_M105_V0.7980.53
84_V136_C0.7970.53
143_Y189_L0.7950.53
88_T173_V0.7870.52
54_L78_L0.7840.52
260_D264_A0.7830.52
191_T214_I0.7800.52
143_Y175_G0.7790.52
260_D263_V0.7780.51
137_A193_I0.7750.51
263_V272_V0.7750.51
79_F92_L0.7740.51
234_E241_Q0.7730.51
103_P136_C0.7730.51
39_R136_C0.7690.51
92_L106_L0.7670.50
236_L256_I0.7660.50
184_Q213_R0.7660.50
148_Y152_S0.7620.50
230_L234_E0.7590.50
41_S97_P0.7540.49
56_F71_I0.7460.48
51_T83_D0.7440.48
262_P274_H0.7430.48
78_L266_M0.7390.48
173_V189_L0.7360.48
61_F143_Y0.7360.48
232_E238_M0.7270.47
142_V162_A0.7230.46
239_C243_I0.7220.46
39_R137_A0.7180.46
138_V163_G0.7170.46
244_D272_V0.7150.46
146_S177_G0.7140.45
62_Q146_S0.7130.45
267_K272_V0.7120.45
60_Y109_S0.7090.45
61_F121_E0.7090.45
105_V181_V0.7090.45
45_N97_P0.7080.45
71_I75_I0.7060.45
73_I76_A0.7040.45
44_F261_H0.6980.44
110_G114_I0.6960.44
61_F141_Q0.6930.44
143_Y152_S0.6930.44
239_C242_A0.6900.43
144_I174_T0.6880.43
120_N148_Y0.6880.43
117_E146_S0.6870.43
204_T214_I0.6860.43
236_L239_C0.6860.43
67_G192_R0.6830.43
194_A198_G0.6800.42
69_E213_R0.6800.42
53_M239_C0.6790.42
188_S217_G0.6730.42
64_P257_F0.6720.42
141_Q189_L0.6710.42
224_I238_M0.6700.41
137_A244_D0.6670.41
211_F247_A0.6650.41
89_R125_L0.6590.40
55_A111_A0.6590.40
109_S225_A0.6590.40
142_V172_A0.6570.40
76_A272_V0.6560.40
201_I269_V0.6550.40
175_G225_A0.6550.40
199_A221_P0.6520.40
144_I190_A0.6450.39
40_L165_K0.6450.39
177_G225_A0.6440.39
172_A199_A0.6440.39
55_A173_V0.6430.39
206_Y224_I0.6430.39
194_A202_I0.6410.39
147_E180_M0.6400.39
243_I273_V0.6380.39
83_D102_R0.6340.38
161_D164_M0.6310.38
141_Q152_S0.6280.38
140_A160_V0.6270.38
236_L255_N0.6250.37
204_T211_F0.6240.37
121_E257_F0.6240.37
80_E263_V0.6220.37
147_E179_D0.6200.37
54_L82_A0.6190.37
127_M138_V0.6180.37
44_F201_I0.6160.37
94_S219_P0.6150.37
38_S54_L0.6130.36
223_V248_S0.6100.36
227_G254_R0.6090.36
122_A154_K0.6070.36
41_S46_P0.6070.36
149_E153_I0.6060.36
104_V135_S0.6030.36
108_A126_S0.6030.36
107_R225_A0.6020.36
145_G178_K0.6010.35
236_L243_I0.5970.35
127_M159_L0.5970.35
43_I105_V0.5950.35
67_G196_E0.5910.35
226_G254_R0.5900.34
205_Y225_A0.5880.34
88_T139_A0.5870.34
75_I133_L0.5840.34
75_I162_A0.5840.34
100_T202_I0.5830.34
75_I95_V0.5810.34
79_F91_I0.5810.34
88_T175_G0.5810.34
230_L255_N0.5800.34
221_P274_H0.5750.33
133_L138_V0.5740.33
156_I171_M0.5740.33
215_V252_M0.5720.33
203_K254_R0.5710.33
74_N164_M0.5700.33
146_S204_T0.5690.33
128_D157_I0.5690.33
146_S251_D0.5670.33
79_F150_H0.5640.32
152_S177_G0.5640.32
111_A257_F0.5640.32
173_V177_G0.5610.32
35_G131_V0.5600.32
223_V251_D0.5550.32
127_M131_V0.5550.32
141_Q199_A0.5540.32
62_Q143_Y0.5530.31
232_E235_A0.5510.31
68_L211_F0.5500.31
106_L146_S0.5500.31
64_P104_V0.5490.31
236_L265_M0.5480.31
36_M39_R0.5480.31
161_D165_K0.5480.31
231_P240_W0.5450.31
239_C272_V0.5440.31
217_G223_V0.5440.31
38_S136_C0.5430.31
35_G198_G0.5390.30
35_G38_S0.5380.30
93_R198_G0.5370.30
211_F224_I0.5360.30
111_A121_E0.5360.30
109_S121_E0.5360.30
51_T248_S0.5350.30
201_I213_R0.5350.30
151_Q165_K0.5330.30
121_E177_G0.5310.30
179_D228_K0.5290.30
169_P257_F0.5280.29
93_R250_V0.5260.29
220_V248_S0.5250.29
55_A107_R0.5220.29
120_N154_K0.5220.29
270_Q275_H0.5210.29
141_Q257_F0.5210.29
127_M168_M0.5200.29
221_P248_S0.5180.29
234_E260_D0.5180.29
36_M43_I0.5170.29
191_T217_G0.5160.29
265_M269_V0.5160.29
87_C92_L0.5150.28
159_L165_K0.5150.28
35_G195_A0.5150.28
59_G257_F0.5120.28
62_Q186_Y0.5120.28
71_I233_R0.5100.28
174_T252_M0.5090.28
89_R157_I0.5080.28
190_A205_Y0.5070.28
168_M213_R0.5070.28
61_F175_G0.5040.28
175_G189_L0.5030.28
68_L196_E0.5020.28
101_N104_V0.5020.28
264_A276_N0.5000.27
58_H221_P0.5000.27
64_P174_T0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fokA 3 0.8832 100 0.42 Contact Map
3glcA 6 0.945 100 0.434 Contact Map
4mozA 5 0.9485 100 0.479 Contact Map
3iv3A 2 0.8729 100 0.488 Contact Map
1to3A 2 0.8522 100 0.524 Contact Map
1w8sA 4 0.8213 100 0.596 Contact Map
2qjgA 6 0.9072 100 0.618 Contact Map
3oa3A 2 0.7766 100 0.705 Contact Map
3r12A 2 0.8007 100 0.706 Contact Map
3ndoA 2 0.7148 100 0.716 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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