GREMLIN Database
LSRB - Autoinducer 2-binding protein LsrB
UniProt: P76142 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13809
Length: 340 (287)
Sequences: 38007 (28792)
Seq/√Len: 1699.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_A176_A3.4871.00
152_K215_D3.3071.00
87_A279_A2.8101.00
171_V175_K2.6691.00
140_L243_V2.6591.00
247_T265_L2.5291.00
152_K241_A2.5161.00
126_Y282_L2.4261.00
138_G180_K2.3561.00
52_A55_E2.2781.00
205_E235_L2.2721.00
201_L234_N2.2401.00
142_D177_K2.2061.00
138_G177_K2.1811.00
138_G176_A2.1771.00
52_A277_Y2.1601.00
205_E231_A2.1331.00
135_Q139_M2.1131.00
274_I277_Y2.0731.00
53_G276_V2.0501.00
134_A172_K2.0291.00
52_A273_K2.0261.00
144_A216_A2.0151.00
136_L245_F2.0001.00
137_G141_V1.9561.00
154_K186_E1.9211.00
48_G272_G1.8971.00
281_A286_G1.8901.00
200_S227_A1.8871.00
156_A214_L1.8281.00
142_D146_R1.8211.00
141_V174_A1.8121.00
31_A85_Y1.8011.00
265_L297_K1.7791.00
137_G218_I1.7771.00
147_Q304_V1.7721.00
209_K235_L1.7641.00
157_F220_P1.7631.00
51_Q269_V1.7591.00
138_G142_D1.7341.00
232_A240_V1.7291.00
219_A228_A1.7271.00
204_A228_A1.7171.00
201_L231_A1.6911.00
267_D270_Q1.6881.00
115_W275_S1.6741.00
231_A235_L1.6651.00
52_A56_L1.6621.00
142_D181_E1.6601.00
135_Q138_G1.6351.00
172_K176_A1.6281.00
127_Y130_Q1.6281.00
48_G269_V1.6241.00
143_M147_Q1.6151.00
145_A181_E1.5991.00
143_M146_R1.5851.00
280_D284_K1.5791.00
139_M296_I1.5761.00
274_I292_D1.5751.00
56_L280_D1.5401.00
145_A177_K1.5271.00
154_K213_D1.5171.00
191_Q206_G1.5061.00
231_A234_N1.4931.00
270_Q274_I1.4921.00
175_K179_A1.4921.00
243_V262_E1.4831.00
194_Y199_K1.4561.00
28_E86_N1.4531.00
201_L230_Q1.4471.00
169_Q172_K1.4411.00
143_M300_G1.4271.00
132_T135_Q1.4111.00
270_Q273_K1.4101.00
154_K215_D1.4101.00
52_A276_V1.4031.00
233_E256_E1.3721.00
236_K239_K1.3691.00
156_A207_I1.3501.00
16_G19_A1.3471.00
137_G173_E1.3331.00
141_V145_A1.3311.00
201_L205_E1.3271.00
136_L296_I1.3251.00
31_A80_F1.3251.00
134_A138_G1.3251.00
211_Y214_L1.3231.00
247_T301_Q1.3191.00
89_I275_S1.3171.00
253_P256_E1.3111.00
177_K180_K1.3061.00
29_R59_D1.3021.00
141_V173_E1.2951.00
53_G60_V1.2891.00
173_E177_K1.2821.00
205_E234_N1.2811.00
277_Y281_A1.2761.00
103_K107_Q1.2761.00
141_V177_K1.2751.00
28_E58_V1.2681.00
204_A232_A1.2601.00
205_E209_K1.2581.00
260_V302_V1.2581.00
78_N104_R1.2561.00
63_D76_L1.2541.00
152_K216_A1.2491.00
139_M142_D1.2471.00
30_I53_G1.2281.00
204_A217_I1.2271.00
186_E189_T1.2241.00
153_A215_D1.2171.00
63_D80_F1.2161.00
49_A276_V1.2141.00
29_R61_T1.2061.00
269_V273_K1.2011.00
32_F49_A1.1841.00
56_L277_Y1.1751.00
227_A231_A1.1671.00
50_Q54_K1.1591.00
174_A178_I1.1521.00
196_D199_K1.1351.00
198_T202_Q1.1281.00
157_F171_V1.1261.00
203_T206_G1.1221.00
134_A173_E1.1201.00
229_A242_I1.1191.00
134_A169_Q1.1171.00
142_D180_K1.1161.00
168_N172_K1.1101.00
206_G210_A1.1081.00
199_K202_Q1.0811.00
274_I278_V1.0751.00
176_A180_K1.0731.00
278_V292_D1.0731.00
49_A89_I1.0691.00
217_I228_A1.0671.00
32_F60_V1.0661.00
8_K11_L1.0651.00
174_A218_I1.0651.00
155_V178_I1.0631.00
46_G50_Q1.0631.00
72_G75_Q1.0541.00
253_P257_R1.0521.00
158_F228_A1.0481.00
147_Q241_A1.0461.00
272_G276_V1.0421.00
172_K175_K1.0421.00
222_A244_G1.0381.00
222_A263_F1.0361.00
197_A230_Q1.0331.00
74_V78_N1.0231.00
241_A304_V1.0201.00
140_L218_I1.0191.00
204_A208_L1.0191.00
273_K277_Y1.0181.00
54_K72_G1.0171.00
219_A224_A1.0131.00
99_C103_K1.0001.00
147_Q300_G0.9951.00
202_Q206_G0.9921.00
256_E260_V0.9911.00
146_R181_E0.9881.00
165_T169_Q0.9871.00
135_Q295_D0.9871.00
58_V280_D0.9861.00
279_A283_L0.9841.00
200_S204_A0.9811.00
78_N82_N0.9751.00
47_N51_Q0.9681.00
69_S72_G0.9671.00
191_Q203_T0.9671.00
140_L264_G0.9621.00
141_V178_I0.9611.00
55_E273_K0.9581.00
143_M304_V0.9571.00
143_M262_E0.9561.00
155_V216_A0.9551.00
16_G22_M0.9551.00
17_I20_I0.9511.00
56_L284_K0.9511.00
126_Y278_V0.9501.00
145_A183_P0.9491.00
162_P192_F0.9461.00
257_R260_V0.9431.00
297_K300_G0.9421.00
219_A225_L0.9411.00
41_F268_V0.9401.00
7_K11_L0.9371.00
267_D297_K0.9271.00
274_I294_L0.9271.00
160_S195_N0.9241.00
177_K181_E0.9101.00
89_I279_A0.8971.00
30_I89_I0.8951.00
49_A272_G0.8841.00
51_Q55_E0.8821.00
265_L299_V0.8791.00
87_A283_L0.8781.00
199_K203_T0.8741.00
29_R83_Q0.8721.00
202_Q205_E0.8691.00
222_A247_T0.8651.00
147_Q152_K0.8611.00
217_I240_V0.8521.00
15_L20_I0.8521.00
131_G267_D0.8491.00
175_K190_T0.8461.00
51_Q273_K0.8441.00
225_L244_G0.8421.00
193_G224_A0.8421.00
132_T293_K0.8411.00
156_A217_I0.8411.00
176_A179_A0.8401.00
208_L231_A0.8351.00
278_V281_A0.8351.00
61_T83_Q0.8351.00
32_F46_G0.8331.00
18_A21_S0.8301.00
232_A242_I0.8271.00
45_G115_W0.8271.00
133_P170_W0.8261.00
33_I76_L0.8191.00
61_T85_Y0.8171.00
189_T210_A0.8171.00
49_A60_V0.8161.00
144_A243_V0.8091.00
276_V280_D0.8091.00
13_S16_G0.8071.00
145_A153_A0.8061.00
131_G266_W0.8051.00
163_T168_N0.8021.00
67_E72_G0.7971.00
46_G62_Y0.7971.00
14_A82_N0.7951.00
75_Q78_N0.7911.00
130_Q293_K0.7891.00
47_N50_Q0.7881.00
127_Y291_G0.7881.00
244_G263_F0.7841.00
178_I183_P0.7821.00
48_G273_K0.7741.00
159_Y171_V0.7731.00
204_A231_A0.7731.00
7_K10_A0.7731.00
154_K189_T0.7701.00
154_K212_S0.7691.00
208_L235_L0.7681.00
153_A183_P0.7681.00
104_R107_Q0.7671.00
131_G296_I0.7661.00
72_G76_L0.7661.00
135_Q296_I0.7631.00
101_A104_R0.7591.00
246_S266_W0.7581.00
157_F218_I0.7531.00
130_Q291_G0.7521.00
35_K42_F0.7521.00
204_A207_I0.7521.00
230_Q233_E0.7521.00
143_M298_G0.7501.00
27_A86_N0.7451.00
118_D291_G0.7451.00
138_G173_E0.7411.00
262_E298_G0.7381.00
19_A22_M0.7361.00
267_D294_L0.7351.00
128_I278_V0.7341.00
158_F219_A0.7301.00
87_A113_L0.7301.00
27_A59_D0.7291.00
89_I115_W0.7281.00
31_A88_I0.7271.00
9_I12_L0.7261.00
169_Q173_E0.7201.00
247_T299_V0.7191.00
171_V190_T0.7191.00
48_G52_A0.7171.00
105_A112_V0.7171.00
106_M125_S0.7151.00
132_T295_D0.7151.00
185_W188_V0.7141.00
175_K185_W0.7121.00
44_S269_V0.7041.00
167_Q195_N0.7001.00
222_A225_L0.7001.00
103_K106_M0.6971.00
145_A182_H0.6951.00
126_Y290_T0.6911.00
74_V101_A0.6901.00
206_G209_K0.6901.00
26_A86_N0.6891.00
39_V223_N0.6881.00
195_N220_P0.6851.00
30_I276_V0.6841.00
197_A250_V0.6831.00
281_A285_K0.6821.00
187_I190_T0.6801.00
152_K184_G0.6801.00
113_L282_L0.6761.00
14_A78_N0.6761.00
139_M264_G0.6751.00
81_V108_R0.6741.00
106_M123_C0.6741.00
50_Q60_V0.6731.00
221_D246_S0.6721.00
191_Q210_A0.6701.00
175_K187_I0.6681.00
193_G199_K0.6671.00
230_Q234_N0.6641.00
200_S203_T0.6581.00
114_T119_T0.6581.00
247_T251_M0.6551.00
77_I88_I0.6541.00
116_D166_D0.6531.00
191_Q207_I0.6501.00
232_A235_L0.6441.00
70_V74_V0.6411.00
14_A18_A0.6411.00
157_F174_A0.6401.00
122_E125_S0.6401.00
226_P250_V0.6391.00
218_I243_V0.6351.00
210_A214_L0.6351.00
87_A275_S0.6351.00
81_V110_V0.6341.00
71_S75_Q0.6301.00
145_A178_I0.6301.00
20_I24_V0.6271.00
79_N83_Q0.6261.00
26_A284_K0.6251.00
221_D224_A0.6241.00
50_Q65_P0.6221.00
30_I87_A0.6211.00
53_G58_V0.6211.00
44_S268_V0.6181.00
114_T127_Y0.6171.00
230_Q256_E0.6161.00
251_M263_F0.6151.00
12_L15_L0.6141.00
300_G304_V0.6141.00
254_Y257_R0.6101.00
116_D133_P0.6101.00
144_A218_I0.6041.00
229_A233_E0.6041.00
229_A236_K0.6011.00
218_I245_F0.5961.00
106_M112_V0.5961.00
262_E304_V0.5961.00
160_S167_Q0.5921.00
42_F91_S0.5911.00
30_I283_L0.5881.00
76_L79_N0.5871.00
198_T201_L0.5851.00
251_M260_V0.5851.00
29_R86_N0.5831.00
230_Q260_V0.5791.00
143_M243_V0.5791.00
88_I110_V0.5781.00
204_A227_A0.5781.00
45_G268_V0.5761.00
47_N269_V0.5751.00
63_D79_N0.5741.00
100_P103_K0.5741.00
30_I58_V0.5721.00
48_G268_V0.5711.00
222_A248_P0.5711.00
185_W190_T0.5711.00
154_K214_L0.5691.00
113_L128_I0.5691.00
133_P166_D0.5681.00
75_Q79_N0.5671.00
154_K211_Y0.5651.00
113_L279_A0.5651.00
118_D127_Y0.5621.00
215_D241_A0.5601.00
155_V215_D0.5601.00
167_Q220_P0.5591.00
104_R108_R0.5581.00
170_W266_W0.5581.00
58_V86_N0.5571.00
278_V282_L0.5561.00
21_S24_V0.5551.00
133_P169_Q0.5541.00
293_K296_I0.5531.00
269_V272_G0.5531.00
216_A241_A0.5511.00
156_A189_T0.5511.00
245_F266_W0.5501.00
79_N82_N0.5501.00
282_L285_K0.5501.00
197_A227_A0.5491.00
41_F45_G0.5491.00
140_L216_A0.5481.00
195_N224_A0.5481.00
188_V191_Q0.5451.00
229_A255_V0.5451.00
214_L217_I0.5441.00
203_T207_I0.5441.00
180_K183_P0.5411.00
207_I211_Y0.5411.00
113_L278_V0.5411.00
130_Q133_P0.5391.00
74_V104_R0.5381.00
228_A232_A0.5331.00
58_V283_L0.5321.00
53_G280_D0.5321.00
100_P104_R0.5321.00
29_R85_Y0.5311.00
139_M143_M0.5271.00
28_E283_L0.5271.00
193_G200_S0.5261.00
116_D271_Q0.5251.00
210_A213_D0.5251.00
80_F85_Y0.5231.00
201_L204_A0.5231.00
138_G141_V0.5211.00
28_E284_K0.5171.00
271_Q294_L0.5151.00
219_A244_G0.5131.00
40_G223_N0.5121.00
113_L275_S0.5121.00
111_R283_L0.5101.00
300_G303_E0.5091.00
138_G181_E0.5091.00
183_P187_I0.5081.00
188_V211_Y0.5071.00
178_I185_W0.5061.00
226_P248_P0.5021.00
208_L232_A0.5001.00
164_V167_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hsgA 1 0.8559 100 0.268 Contact Map
2iksA 2 0.7971 100 0.272 Contact Map
3dbiA 2 0.8059 100 0.273 Contact Map
1qpzA 2 0.8912 100 0.274 Contact Map
3bilA 2 0.7471 100 0.275 Contact Map
3brqA 2 0.8 100 0.279 Contact Map
3kjxA 2 0.8676 100 0.28 Contact Map
3huuA 2 0.7706 100 0.281 Contact Map
4o5aA 2 0.7824 100 0.283 Contact Map
3e3mA 2 0.7794 100 0.284 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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