GREMLIN Database
LSRR - Transcriptional regulator LsrR
UniProt: P76141 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13805
Length: 317 (297)
Sequences: 2158 (1681)
Seq/√Len: 97.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
250_D254_D6.8491.00
201_Q272_A4.1691.00
121_A203_A3.4411.00
102_L284_G3.2941.00
118_Q204_D3.0811.00
61_R65_N3.0381.00
82_F293_A2.8481.00
292_I310_T2.8341.00
210_I281_G2.7731.00
251_A290_E2.7301.00
109_M305_V2.7201.00
249_F294_A2.7131.00
82_F296_M2.6881.00
293_A297_K2.6331.00
31_L39_R2.6281.00
106_A282_V2.5431.00
184_A188_K2.5181.00
306_T310_T2.5051.00
281_G301_I2.4961.00
194_K198_L2.2631.00
90_I105_G2.2451.00
209_G281_G2.1551.00
313_A316_R2.1521.00
242_G294_A2.1461.00
119_M199_A2.1451.00
283_A292_I2.1211.00
204_D277_P2.1111.00
278_V303_A2.0851.00
289_A314_I2.0641.00
77_Q80_R2.0141.00
289_A313_A2.0061.00
52_E56_Q1.9961.00
53_K57_S1.9921.00
117_Q143_Q1.9831.00
242_G249_F1.9221.00
106_A131_T1.9151.00
181_A185_R1.8841.00
279_R302_N1.8781.00
293_A314_I1.8681.00
205_V280_V1.8491.00
269_P272_A1.8461.00
88_R105_G1.8421.00
131_T282_V1.8371.00
99_G126_E1.8341.00
289_A310_T1.8231.00
119_M202_A1.8171.00
78_L87_V1.7991.00
200_A203_A1.7711.00
145_R170_N1.7481.00
178_A183_I1.7411.00
119_M203_A1.7151.00
233_L237_R1.7111.00
181_A263_N1.7101.00
86_H303_A1.6921.00
76_T79_R1.6891.00
149_L206_A1.6741.00
109_M303_A1.6671.00
22_I42_L1.6631.00
208_V281_G1.6621.00
208_V279_R1.6521.00
203_A276_I1.6501.00
135_L163_L1.6361.00
22_I36_I1.6271.00
156_Y159_G1.5911.00
91_P308_Q1.5871.00
249_F291_A1.5771.00
179_S191_N1.5511.00
85_Q278_V1.5381.00
79_R87_V1.5291.00
45_L48_S1.5231.00
19_V50_L1.5231.00
120_L205_V1.5201.00
252_K297_K1.5031.00
210_I291_A1.4821.00
285_G307_D1.4811.00
100_G134_R1.4601.00
109_M113_L1.4551.00
251_A294_A1.4331.00
231_E264_E1.4281.00
123_G245_L1.3880.99
22_I40_L1.3860.99
79_R86_H1.3710.99
145_R199_A1.3620.99
120_L146_L1.3380.99
197_L200_A1.3270.99
228_S231_E1.3250.99
130_N133_Q1.3230.99
308_Q312_A1.3190.99
206_A276_I1.3100.99
114_L120_L1.3070.99
234_M238_K1.3070.99
162_Q165_A1.3050.99
292_I306_T1.2990.99
30_G55_H1.2890.99
19_V59_I1.2880.99
31_L35_E1.2850.99
103_G130_N1.2830.99
258_N262_H1.2710.99
170_N199_A1.2530.99
78_L89_V1.2530.99
107_A135_L1.2500.99
250_D256_V1.2500.99
179_S190_E1.2400.99
132_L163_L1.2220.99
27_Y62_V1.2220.99
164_N169_V1.2120.98
121_A124_F1.2110.98
121_A149_L1.2110.98
178_A187_L1.2000.98
37_S47_V1.1840.98
73_E77_Q1.1740.98
110_L205_V1.1700.98
19_V53_K1.1640.98
286_E313_A1.1600.98
25_F39_R1.1460.98
24_W28_H1.1410.98
47_V51_L1.1360.98
18_Q50_L1.1310.98
193_V197_L1.1300.98
116_P142_Q1.1290.98
119_M204_D1.1230.98
22_I50_L1.1230.98
198_L202_A1.1210.97
312_A316_R1.1110.97
20_A59_I1.1110.97
131_T207_I1.1010.97
283_A306_T1.0970.97
234_M237_R1.0960.97
206_A273_L1.0930.97
296_M301_I1.0930.97
110_L207_I1.0920.97
152_G243_D1.0890.97
118_Q205_V1.0850.97
76_T80_R1.0770.97
247_Y267_G1.0720.97
133_Q162_Q1.0650.97
233_L236_G1.0640.97
77_Q81_Q1.0520.96
26_Y44_R1.0500.96
86_H112_S1.0490.96
113_L278_V1.0310.96
208_V301_I1.0200.96
85_Q302_N1.0170.96
185_R189_N1.0140.95
32_T35_E1.0110.95
78_L315_L1.0080.95
183_I190_E0.9930.95
81_Q314_I0.9930.95
198_L201_Q0.9840.95
102_L106_A0.9640.94
249_F295_A0.9610.94
81_Q315_L0.9600.94
247_Y262_H0.9600.94
82_F314_I0.9580.94
82_F87_V0.9490.94
270_L300_Y0.9480.94
174_A266_I0.9360.93
210_I292_I0.9300.93
251_A293_A0.9290.93
32_T44_R0.9290.93
187_L266_I0.9270.93
124_F247_Y0.9260.93
16_E67_R0.9230.93
257_T263_N0.9220.93
115_Q118_Q0.9110.92
123_G247_Y0.9110.92
19_V22_I0.9100.92
209_G283_A0.9070.92
268_L276_I0.9070.92
243_D246_G0.9070.92
34_S38_D0.9060.92
145_R168_S0.9040.92
295_A298_G0.9000.92
307_D310_T0.8980.92
78_L314_I0.8940.91
176_L246_G0.8920.91
124_F243_D0.8840.91
45_L66_S0.8820.91
23_A51_L0.8820.91
189_N194_K0.8810.91
289_A293_A0.8800.91
209_G301_I0.8790.91
25_F33_Q0.8730.90
48_S66_S0.8720.90
104_I134_R0.8630.90
103_G284_G0.8620.90
195_D198_L0.8610.90
36_I64_I0.8550.89
25_F36_I0.8550.89
240_A256_V0.8530.89
16_E57_S0.8510.89
251_A297_K0.8460.89
123_G148_T0.8410.89
36_I49_R0.8410.89
84_L304_L0.8380.88
22_I47_V0.8360.88
235_I240_A0.8350.88
110_L131_T0.8330.88
257_T262_H0.8310.88
221_I224_S0.8300.88
294_A297_K0.8260.88
188_K197_L0.8260.88
146_L167_C0.8240.88
109_M280_V0.8240.88
177_R265_L0.8160.87
22_I25_F0.8130.87
148_T173_P0.8090.87
119_M147_V0.8040.86
186_T190_E0.8030.86
18_Q42_L0.8010.86
281_G292_I0.7990.86
88_R109_M0.7970.86
176_L213_V0.7930.86
109_M112_S0.7890.85
18_Q21_R0.7850.85
51_L243_D0.7830.85
209_G265_L0.7820.85
24_W66_S0.7740.84
229_Q233_L0.7710.84
124_F148_T0.7680.84
36_I106_A0.7650.83
115_Q204_D0.7630.83
24_W48_S0.7610.83
163_L291_A0.7600.83
84_L302_N0.7600.83
71_C75_E0.7590.83
209_G292_I0.7580.83
21_R24_W0.7580.83
149_L245_L0.7550.83
177_R264_E0.7500.82
113_L205_V0.7460.82
130_N209_G0.7420.82
71_C89_V0.7370.81
20_A66_S0.7330.81
77_Q312_A0.7320.81
92_G309_D0.7300.81
207_I280_V0.7280.80
45_L64_I0.7270.80
71_C91_P0.7230.80
183_I186_T0.7230.80
47_V273_L0.7210.80
22_I46_K0.7170.79
74_Y89_V0.7170.79
33_Q45_L0.7160.79
33_Q48_S0.7160.79
87_V296_M0.7130.79
294_A298_G0.7100.79
172_I266_I0.7100.79
247_Y265_L0.7070.78
148_T190_E0.7070.78
160_I164_N0.7060.78
60_I64_I0.7060.78
114_L141_S0.7050.78
27_Y51_L0.7030.78
195_D199_A0.7020.78
74_Y312_A0.7010.78
160_I169_V0.7000.78
292_I304_L0.6990.78
102_L306_T0.6990.78
283_A288_K0.6980.78
106_A305_V0.6960.77
299_G302_N0.6940.77
285_G288_K0.6940.77
125_G308_Q0.6920.77
116_P143_Q0.6910.77
260_K289_A0.6870.76
90_I102_L0.6870.76
198_L316_R0.6870.76
50_L169_V0.6830.76
178_A266_I0.6820.76
25_F31_L0.6780.75
219_A222_I0.6780.75
35_E38_D0.6780.75
284_G292_I0.6710.75
262_H265_L0.6700.75
284_G310_T0.6690.74
102_L282_V0.6680.74
113_L303_A0.6660.74
211_G243_D0.6650.74
23_A54_G0.6640.74
106_A209_G0.6630.74
81_Q297_K0.6560.73
54_G66_S0.6510.72
177_R181_A0.6510.72
48_S243_D0.6490.72
273_L276_I0.6430.72
50_L54_G0.6430.72
17_E24_W0.6390.71
197_L266_I0.6390.71
190_E246_G0.6390.71
268_L272_A0.6380.71
83_S299_G0.6370.71
271_S274_K0.6360.71
210_I301_I0.6340.70
121_A128_T0.6330.70
218_D287_N0.6330.70
114_L144_I0.6320.70
247_Y269_P0.6280.70
147_V196_V0.6270.70
21_R79_R0.6270.70
244_I295_A0.6250.69
198_L290_E0.6230.69
229_Q286_E0.6230.69
150_S220_T0.6220.69
280_V302_N0.6210.69
146_L164_N0.6210.69
234_M260_K0.6200.69
49_R173_P0.6190.69
45_L150_S0.6190.69
45_L176_L0.6180.69
178_A193_V0.6170.68
100_G130_N0.6150.68
46_K50_L0.6130.68
76_T309_D0.6110.68
241_V294_A0.6110.68
150_S176_L0.6100.68
120_L252_K0.6100.68
92_G164_N0.6090.67
274_K299_G0.6090.67
51_L55_H0.6090.67
26_Y48_S0.6070.67
34_S44_R0.6070.67
44_R48_S0.6060.67
26_Y33_Q0.6050.67
111_M136_S0.6050.67
24_W148_T0.6040.67
51_L59_I0.6030.67
113_L302_N0.6020.67
95_D309_D0.6010.66
213_V291_A0.6000.66
90_I98_V0.5990.66
109_M277_P0.5980.66
76_T286_E0.5970.66
240_A248_F0.5970.66
71_C308_Q0.5960.66
17_E75_E0.5960.66
42_L47_V0.5950.66
204_D276_I0.5950.66
176_L248_F0.5950.66
18_Q40_L0.5940.66
284_G307_D0.5910.65
45_L248_F0.5910.65
25_F29_D0.5890.65
123_G170_N0.5890.65
178_A273_L0.5890.65
241_V256_V0.5880.65
301_I304_L0.5870.65
77_Q83_S0.5860.64
175_P178_A0.5860.64
146_L247_Y0.5850.64
108_H111_M0.5800.64
128_T169_V0.5750.63
187_L193_V0.5730.63
48_S52_E0.5720.63
212_A236_G0.5710.62
44_R55_H0.5700.62
88_R303_A0.5700.62
160_I171_I0.5660.62
261_I265_L0.5650.62
169_V190_E0.5650.62
150_S209_G0.5640.62
48_S64_I0.5630.61
91_P105_G0.5630.61
227_I231_E0.5620.61
199_A203_A0.5620.61
201_Q275_T0.5620.61
28_H123_G0.5620.61
19_V54_G0.5610.61
129_M209_G0.5610.61
86_H109_M0.5610.61
261_I282_V0.5590.61
127_A285_G0.5590.61
152_G174_A0.5590.61
288_K307_D0.5590.61
234_M258_N0.5550.60
163_L167_C0.5550.60
247_Y270_L0.5540.60
113_L280_V0.5520.60
16_E59_I0.5520.60
114_L139_I0.5510.60
123_G132_L0.5510.60
154_G221_I0.5500.60
73_E274_K0.5500.60
255_V270_L0.5470.59
122_I223_R0.5470.59
148_T200_A0.5460.59
45_L49_R0.5460.59
84_L303_A0.5460.59
286_E309_D0.5450.59
48_S51_L0.5450.59
183_I187_L0.5430.59
139_I142_Q0.5420.59
198_L234_M0.5420.59
89_V291_A0.5380.58
81_Q97_D0.5380.58
122_I160_I0.5370.58
100_G133_Q0.5360.58
137_G166_A0.5350.58
174_A178_A0.5320.57
164_N167_C0.5320.57
124_F149_L0.5310.57
152_G248_F0.5300.57
146_L163_L0.5300.57
235_I248_F0.5300.57
125_G265_L0.5290.57
200_A268_L0.5280.57
251_A254_D0.5280.57
144_I166_A0.5280.57
81_Q293_A0.5270.56
92_G307_D0.5260.56
163_L295_A0.5240.56
208_V302_N0.5230.56
149_L200_A0.5220.56
303_A306_T0.5210.56
44_R176_L0.5200.55
295_A301_I0.5200.55
206_A267_G0.5190.55
18_Q75_E0.5190.55
154_G193_V0.5170.55
123_G243_D0.5170.55
245_L270_L0.5170.55
144_I168_S0.5150.55
279_R303_A0.5140.55
291_A294_A0.5140.55
150_S154_G0.5140.55
32_T45_L0.5130.54
230_G234_M0.5130.54
246_G267_G0.5130.54
44_R62_V0.5120.54
221_I294_A0.5120.54
46_K49_R0.5100.54
16_E24_W0.5090.54
129_M162_Q0.5070.54
21_R308_Q0.5070.54
95_D98_V0.5070.54
106_A109_M0.5060.53
244_I270_L0.5060.53
124_F150_S0.5050.53
140_S182_D0.5040.53
176_L243_D0.5030.53
304_L310_T0.5030.53
175_P246_G0.5020.53
148_T214_S0.5010.53
272_A275_T0.5000.53
174_A277_P0.5000.53
190_E262_H0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l5jA 4 0.9685 100 0.353 Contact Map
2w48A 3 0.9495 100 0.394 Contact Map
4l4yA 2 0.7539 100 0.436 Contact Map
3efbA 2 0.7539 100 0.484 Contact Map
2o0mA 1 0.7413 100 0.495 Contact Map
2r5fA 1 0.6467 100 0.501 Contact Map
2gnpA 1 0.7823 100 0.504 Contact Map
4r9nA 1 0.7508 100 0.504 Contact Map
3kv1A 2 0.7539 100 0.505 Contact Map
4oqpA 2 0.7697 100 0.507 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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