GREMLIN Database
YDET - Putative uncharacterized protein ydet
UniProt: P76137 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13802
Length: 382 (356)
Sequences: 2425 (1869)
Seq/√Len: 99.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
223_V254_A5.0111.00
185_N200_G4.6891.00
215_G250_I4.0281.00
317_A349_V4.0251.00
187_G198_Y4.0001.00
302_V341_L3.6211.00
45_G70_L3.4891.00
319_V336_V3.3021.00
226_K293_T3.3001.00
48_F69_G3.2681.00
345_G363_Y3.2581.00
72_V79_T3.2251.00
156_Q172_Y3.1741.00
222_M289_I3.1141.00
205_I214_F2.9901.00
207_A212_I2.8971.00
306_L361_V2.8851.00
125_Y137_N2.7621.00
346_Q360_I2.6101.00
361_V379_A2.6071.00
319_V347_L2.6071.00
154_S174_S2.5981.00
213_T244_D2.5001.00
71_N80_S2.4671.00
184_T201_M2.4541.00
208_H213_T2.4071.00
319_V349_V2.3831.00
226_K291_R2.3561.00
224_L248_Y2.3161.00
85_Y96_H2.3161.00
346_Q362_E2.2671.00
260_N284_P2.2261.00
182_G201_M2.2181.00
209_A291_R2.1931.00
204_G215_G2.1801.00
53_R64_Q2.1801.00
223_V262_V2.1491.00
308_Y313_V2.1291.00
347_L361_V2.1261.00
205_I212_I2.1221.00
210_D291_R2.0941.00
227_A230_A2.0711.00
204_G218_L2.0631.00
313_V349_V2.0531.00
352_G357_S2.0411.00
208_H248_Y2.0341.00
306_L336_V2.0261.00
49_F68_F1.9951.00
321_H325_K1.9881.00
32_Q54_Q1.9841.00
82_N99_A1.9311.00
158_G170_S1.9281.00
124_S140_G1.9251.00
218_L222_M1.9201.00
127_M135_M1.8931.00
241_I249_A1.8771.00
317_A351_W1.8731.00
259_E281_T1.8501.00
306_L349_V1.8281.00
233_V243_T1.7871.00
210_D226_K1.7811.00
86_S97_L1.7621.00
300_G343_Q1.7201.00
204_G222_M1.6871.00
220_D286_H1.6771.00
183_N202_S1.6601.00
74_F79_T1.6531.00
175_L186_V1.6471.00
234_K268_S1.6441.00
190_R195_S1.6251.00
276_D295_N1.5861.00
344_S364_K1.5831.00
13_T17_T1.5741.00
159_N169_T1.5741.00
208_H211_G1.5641.00
305_T335_Q1.5621.00
272_N300_G1.5571.00
314_P351_W1.5491.00
151_L177_Y1.5341.00
125_Y139_S1.5241.00
227_A296_A1.4981.00
307_K378_T1.4961.00
145_L153_Y1.4911.00
179_G184_T1.4831.00
80_S101_T1.4711.00
306_L313_V1.4701.00
284_P290_A1.4581.00
155_V173_S1.4481.00
129_N134_G1.4431.00
179_G182_G1.4401.00
235_I251_L1.4141.00
31_G55_S1.4121.00
83_Y98_L1.4021.00
285_T288_A1.3950.99
178_R183_N1.3870.99
151_L175_L1.3830.99
348_Q360_I1.3790.99
81_L100_F1.3760.99
14_N17_T1.3730.99
308_Y311_K1.3720.99
314_P317_A1.3690.99
206_I224_L1.3630.99
44_Y70_L1.3630.99
226_K248_Y1.3470.99
227_A233_V1.3380.99
306_L330_V1.3270.99
349_V361_V1.3260.99
13_T16_Q1.3240.99
304_M361_V1.2920.99
319_V338_L1.2850.99
30_R57_W1.2790.99
305_T378_T1.2790.99
173_S188_Y1.2720.99
130_D134_G1.2650.99
213_T246_R1.2580.99
213_T224_L1.2560.99
206_I289_I1.2460.99
231_D245_W1.2400.99
351_W358_N1.2360.99
77_I102_L1.2270.99
77_I104_V1.2110.99
345_G365_L1.2030.99
206_I222_M1.1960.98
277_E280_V1.1840.98
15_E18_Q1.1840.98
307_K312_S1.1800.98
41_L44_Y1.1700.98
174_S187_G1.1640.98
304_M338_L1.1540.98
17_T20_I1.1530.98
224_L291_R1.1500.98
6_V11_G1.1490.98
178_R216_Q1.1400.98
304_M377_Q1.1390.98
123_A141_V1.1370.98
50_S67_S1.1290.98
282_V290_A1.1200.98
47_T70_L1.1120.97
129_N135_M1.1010.97
230_A296_A1.0960.97
45_G72_V1.0930.97
318_I326_N1.0930.97
76_D108_H1.0850.97
223_V290_A1.0810.97
176_N183_N1.0800.97
38_S48_F1.0710.97
83_Y96_H1.0630.97
348_Q358_N1.0620.97
208_H224_L1.0570.97
42_G45_G1.0550.97
35_I49_F1.0540.97
84_S97_L1.0510.96
206_I250_I1.0220.96
299_G340_G1.0210.96
276_D297_Q1.0070.95
12_D215_G1.0060.95
216_Q240_G1.0010.95
213_T248_Y0.9940.95
302_V365_L0.9860.95
140_G154_S0.9790.95
157_V171_G0.9760.95
79_T100_F0.9710.95
140_G172_Y0.9700.94
331_A335_Q0.9700.94
54_Q63_D0.9680.94
313_V334_G0.9680.94
234_K265_N0.9650.94
243_T301_K0.9540.94
127_M137_N0.9480.94
273_V298_I0.9460.94
27_Y59_T0.9460.94
270_A273_V0.9450.94
203_G359_C0.9430.94
243_T292_A0.9430.94
6_V12_D0.9370.93
280_V292_A0.9370.93
224_L289_I0.9350.93
304_M336_V0.9330.93
301_K339_T0.9320.93
122_N144_T0.9280.93
126_S138_L0.9200.93
300_G366_P0.9110.92
342_P345_G0.9100.92
327_G347_L0.9070.92
344_S362_E0.9070.92
5_T57_W0.9030.92
123_A139_S0.9000.92
204_G250_I0.8990.92
147_P150_N0.8980.92
317_A330_V0.8900.92
148_D151_L0.8900.92
66_I83_Y0.8880.91
225_V235_I0.8800.91
254_A258_R0.8770.91
309_G312_S0.8750.91
172_Y189_S0.8730.91
181_Y245_W0.8670.90
153_Y157_V0.8670.90
14_N18_Q0.8660.90
320_T350_S0.8650.90
232_N242_H0.8630.90
156_Q236_E0.8580.90
152_N176_N0.8580.90
140_G156_Q0.8550.90
225_V237_N0.8550.90
28_S232_N0.8540.90
228_P296_A0.8540.90
261_R281_T0.8520.90
265_N268_S0.8510.90
182_G216_Q0.8510.90
330_V336_V0.8510.90
105_P287_G0.8490.89
138_L154_S0.8450.89
153_Y186_V0.8400.89
225_V251_L0.8390.89
213_T250_I0.8380.89
11_G169_T0.8380.89
106_F109_W0.8360.89
182_G221_T0.8350.89
3_G224_L0.8330.89
261_R279_V0.8280.88
81_L98_L0.8170.88
171_G190_R0.8160.88
35_I38_S0.8150.87
48_F67_S0.8100.87
34_Q54_Q0.8100.87
313_V317_A0.8060.87
13_T18_Q0.8040.87
204_G207_A0.8040.87
41_L70_L0.8030.87
228_P293_T0.8020.87
244_D248_Y0.7950.86
227_A243_T0.7940.86
234_K242_H0.7930.86
228_P264_L0.7920.86
206_I218_L0.7880.86
303_L335_Q0.7850.85
300_G375_N0.7760.85
16_Q22_Y0.7760.85
230_A275_L0.7740.85
351_W357_S0.7740.85
175_L236_E0.7730.85
231_D243_T0.7700.84
220_D256_E0.7690.84
67_S135_M0.7690.84
150_N179_G0.7690.84
231_D246_R0.7690.84
216_Q241_I0.7680.84
65_Q153_Y0.7670.84
275_L278_T0.7660.84
251_L262_V0.7650.84
22_Y25_L0.7640.84
38_S69_G0.7620.84
223_V251_L0.7600.84
200_G241_I0.7590.84
79_T102_L0.7540.83
208_H244_D0.7530.83
376_Q379_A0.7520.83
149_N152_N0.7520.83
256_E286_H0.7480.83
263_A279_V0.7470.83
297_Q337_Y0.7450.82
153_Y234_K0.7450.82
67_S84_S0.7430.82
139_S142_Y0.7430.82
205_I372_T0.7370.82
341_L345_G0.7370.82
52_S153_Y0.7350.82
188_Y195_S0.7320.81
24_N28_S0.7320.81
160_T349_V0.7300.81
157_V169_T0.7280.81
32_Q274_E0.7260.81
327_G338_L0.7250.81
313_V351_W0.7250.81
36_S50_S0.7250.81
15_E19_F0.7250.81
227_A264_L0.7240.81
238_Q241_I0.7230.80
66_I222_M0.7220.80
64_Q87_N0.7220.80
74_F140_G0.7190.80
299_G337_Y0.7190.80
97_L204_G0.7130.80
226_K229_G0.7130.80
16_Q21_D0.7090.79
235_I249_A0.7080.79
304_M379_A0.7080.79
307_K310_N0.7080.79
126_S156_Q0.7060.79
98_L127_M0.7050.79
373_L379_A0.7050.79
359_C381_C0.7050.79
17_T21_D0.7040.79
135_M161_H0.7020.78
102_L343_Q0.7010.78
225_V262_V0.6970.78
321_H327_G0.6960.78
180_A242_H0.6960.78
6_V29_K0.6910.77
251_L294_F0.6900.77
319_V342_P0.6890.77
16_Q19_F0.6870.77
3_G34_Q0.6870.77
129_N133_G0.6860.77
168_G192_G0.6840.77
19_F24_N0.6830.77
15_E20_I0.6830.77
224_L254_A0.6820.76
107_S110_M0.6820.76
300_G365_L0.6820.76
210_D248_Y0.6780.76
343_Q367_E0.6760.76
315_F332_E0.6730.76
170_S195_S0.6720.75
85_Y94_R0.6700.75
247_G359_C0.6670.75
16_Q20_I0.6670.75
68_F91_Q0.6650.75
230_A243_T0.6630.74
3_G270_A0.6630.74
229_G298_I0.6630.74
309_G313_V0.6610.74
19_F23_F0.6600.74
255_T260_N0.6580.74
266_A286_H0.6570.74
254_A262_V0.6550.74
7_K10_T0.6540.73
374_L378_T0.6540.73
39_Q299_G0.6530.73
343_Q347_L0.6520.73
9_P30_R0.6510.73
344_S363_Y0.6500.73
369_S372_T0.6500.73
337_Y374_L0.6500.73
17_T23_F0.6480.73
346_Q366_P0.6480.73
262_V292_A0.6420.72
259_E283_I0.6410.72
160_T168_G0.6390.72
66_I332_E0.6350.71
373_L377_Q0.6340.71
345_G364_K0.6330.71
104_V123_A0.6320.71
288_A299_G0.6320.71
301_K332_E0.6300.71
373_L376_Q0.6290.71
36_S49_F0.6290.71
49_F360_I0.6290.71
207_A224_L0.6290.71
202_S217_P0.6280.70
52_S224_L0.6270.70
240_G249_A0.6260.70
80_S92_N0.6210.70
218_L289_I0.6190.69
221_T240_G0.6190.69
12_D177_Y0.6170.69
206_I282_V0.6160.69
37_I81_L0.6160.69
203_G247_G0.6150.69
141_V155_V0.6140.69
315_F329_I0.6130.69
61_R100_F0.6130.69
219_G256_E0.6120.68
141_V260_N0.6100.68
307_K311_K0.6100.68
42_G133_G0.6090.68
350_S358_N0.6090.68
126_S199_Y0.6070.68
41_L45_G0.6060.68
203_G294_F0.6050.68
8_P12_D0.6050.68
13_T20_I0.6050.68
19_F22_Y0.6040.67
105_P211_G0.6040.67
204_G289_I0.6040.67
93_D184_T0.6040.67
254_A290_A0.6020.67
266_A278_T0.6020.67
328_S336_V0.6010.67
304_M345_G0.6010.67
275_L296_A0.6010.67
233_V296_A0.6000.67
223_V292_A0.6000.67
122_N175_L0.5990.67
44_Y72_V0.5980.67
51_A64_Q0.5970.67
80_S178_R0.5970.67
27_Y58_N0.5960.66
230_A299_G0.5960.66
22_Y26_F0.5950.66
148_D234_K0.5950.66
210_D214_F0.5920.66
313_V330_V0.5910.66
87_N94_R0.5900.66
310_N334_G0.5890.65
269_L275_L0.5890.65
123_A132_K0.5890.65
332_E339_T0.5890.65
241_I252_P0.5880.65
173_S202_S0.5870.65
266_A275_L0.5860.65
140_G145_L0.5860.65
249_A252_P0.5860.65
57_W86_S0.5860.65
30_R34_Q0.5850.65
208_H249_A0.5840.65
48_F71_N0.5840.65
330_V337_Y0.5840.65
221_T256_E0.5830.65
272_N298_I0.5820.65
208_H291_R0.5820.65
30_R55_S0.5820.65
69_G105_P0.5820.65
332_E336_V0.5810.64
274_E339_T0.5790.64
9_P28_S0.5790.64
63_D178_R0.5780.64
18_Q21_D0.5770.64
203_G214_F0.5770.64
352_G356_N0.5770.64
101_T154_S0.5760.64
186_V200_G0.5750.64
250_I325_K0.5750.64
230_A273_V0.5740.64
191_S194_S0.5730.63
11_G150_N0.5730.63
36_S80_S0.5730.63
157_V338_L0.5720.63
173_S186_V0.5710.63
46_T71_N0.5700.63
43_N127_M0.5670.63
66_I92_N0.5670.63
350_S353_K0.5660.62
328_S339_T0.5650.62
304_M363_Y0.5650.62
154_S172_Y0.5650.62
40_Q44_Y0.5640.62
33_E296_A0.5630.62
264_L269_L0.5600.62
141_V188_Y0.5590.61
302_V361_V0.5590.61
341_L347_L0.5580.61
13_T19_F0.5560.61
181_Y201_M0.5550.61
254_A284_P0.5540.61
59_T100_F0.5540.61
199_Y251_L0.5530.61
7_K57_W0.5520.61
74_F77_I0.5520.61
235_I263_A0.5500.60
70_L79_T0.5500.60
272_N301_K0.5500.60
136_T158_G0.5490.60
208_H227_A0.5480.60
264_L275_L0.5480.60
106_F352_G0.5470.60
104_V109_W0.5460.60
34_Q52_S0.5460.60
39_Q51_A0.5450.60
69_G128_S0.5450.60
196_Q216_Q0.5440.59
338_L341_L0.5440.59
124_S141_V0.5420.59
36_S350_S0.5420.59
91_Q338_L0.5410.59
209_A224_L0.5400.59
237_N315_F0.5390.59
307_K360_I0.5370.58
277_E295_N0.5360.58
102_L162_G0.5360.58
77_I322_G0.5360.58
107_S173_S0.5340.58
302_V363_Y0.5330.58
94_R231_D0.5310.58
57_W60_S0.5310.58
302_V340_G0.5310.58
243_T246_R0.5300.57
336_V361_V0.5280.57
20_I23_F0.5280.57
11_G31_G0.5270.57
336_V339_T0.5260.57
306_L379_A0.5260.57
257_Y285_T0.5260.57
36_S375_N0.5250.57
48_F51_A0.5240.57
181_Y277_E0.5240.57
180_A244_D0.5230.56
68_F376_Q0.5220.56
6_V222_M0.5210.56
320_T348_Q0.5210.56
312_S334_G0.5200.56
243_T247_G0.5200.56
377_Q380_I0.5190.56
228_P243_T0.5190.56
331_A336_V0.5190.56
218_L221_T0.5190.56
56_Y63_D0.5190.56
104_V125_Y0.5180.56
201_M204_G0.5180.56
264_L278_T0.5180.56
61_R89_I0.5170.56
70_L339_T0.5170.56
134_G162_G0.5170.56
154_S157_V0.5170.56
216_Q341_L0.5170.56
176_N185_N0.5160.55
71_N367_E0.5150.55
303_L328_S0.5150.55
221_T287_G0.5140.55
299_G351_W0.5130.55
41_L47_T0.5130.55
243_T248_Y0.5120.55
21_D162_G0.5120.55
100_F127_M0.5110.55
25_L28_S0.5110.55
216_Q220_D0.5090.54
233_V276_D0.5090.54
70_L207_A0.5080.54
28_S31_G0.5080.54
5_T9_P0.5060.54
186_V199_Y0.5060.54
169_T258_R0.5060.54
222_M266_A0.5060.54
202_S331_A0.5050.54
16_Q35_I0.5040.54
208_H252_P0.5040.54
286_H301_K0.5020.53
52_S65_Q0.5020.53
237_N337_Y0.5020.53
17_T22_Y0.5020.53
123_A140_G0.5010.53
334_G380_I0.5010.53
48_F54_Q0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rfzB 2 0.9791 100 0.162 Contact Map
3fipA 1 0.4424 100 0.678 Contact Map
2xetA 1 0.2199 99.6 0.793 Contact Map
3l48A 1 0.2199 99.5 0.811 Contact Map
4oq1A 1 0.4581 71.5 0.949 Contact Map
2ynkA 1 0.2801 68.9 0.95 Contact Map
2fgqX 3 0.3246 53.3 0.954 Contact Map
3kvnX 1 0.2749 44.6 0.956 Contact Map
1phoA 3 0.3377 40.5 0.958 Contact Map
4u3sB 1 0.2173 39.6 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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