GREMLIN Database
YDEM - Anaerobic sulfatase-maturating enzyme homolog YdeM
UniProt: P76134 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13795
Length: 385 (326)
Sequences: 6360 (4995)
Seq/√Len: 276.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_Q138_A5.9421.00
14_L96_I3.9981.00
100_N146_R3.5141.00
38_T292_N3.4931.00
104_A150_Y3.3551.00
125_D135_G3.3241.00
274_D290_N3.1701.00
145_E178_I3.1371.00
35_D38_T2.9601.00
137_F174_F2.8741.00
36_D73_K2.8691.00
274_D287_K2.7371.00
13_N94_N2.6741.00
41_E45_Q2.5861.00
295_E298_T2.5651.00
40_K77_Y2.5431.00
100_N149_S2.4981.00
167_Y170_E2.4371.00
120_P123_L2.3831.00
278_C328_C2.3441.00
95_G115_I2.2901.00
72_R105_F2.2481.00
66_A70_F2.2001.00
120_P167_Y2.1731.00
294_S298_T2.1471.00
169_L224_T2.0971.00
146_R149_S2.0711.00
290_N293_K2.0641.00
44_K77_Y2.0441.00
260_Q278_C2.0221.00
118_D128_R2.0041.00
100_N150_Y1.9751.00
11_Q33_W1.9211.00
105_F109_H1.9101.00
123_L167_Y1.9001.00
270_E274_D1.8941.00
121_Q125_D1.8941.00
115_I144_I1.8881.00
104_A108_E1.8721.00
173_H228_Q1.8511.00
173_H177_S1.8401.00
162_N217_A1.8311.00
126_R163_V1.8151.00
79_Q109_H1.7961.00
4_T46_Y1.7911.00
103_C146_R1.7911.00
139_K142_A1.7851.00
145_E149_S1.7801.00
13_N97_L1.7571.00
260_Q263_C1.7461.00
99_N102_W1.7311.00
156_T175_L1.7281.00
38_T41_E1.7271.00
124_H136_T1.7231.00
40_K73_K1.6941.00
36_D40_K1.6711.00
34_M38_T1.6611.00
170_E173_H1.6471.00
58_W89_N1.6131.00
145_E148_K1.6111.00
141_I178_I1.5961.00
275_I299_M1.5851.00
140_V143_A1.5701.00
115_I143_A1.5501.00
107_K150_Y1.5461.00
73_K76_H1.5411.00
39_L74_V1.5341.00
44_K85_K1.5271.00
98_L103_C1.5121.00
121_Q137_F1.5081.00
72_R108_E1.4891.00
142_A146_R1.4841.00
33_W66_A1.4691.00
17_D126_R1.4581.00
113_V147_L1.4581.00
138_A142_A1.4501.00
64_T91_L1.4381.00
142_A145_E1.4311.00
174_F178_I1.4211.00
40_K44_K1.4051.00
270_E276_Y1.3911.00
127_Y161_N1.3851.00
223_S227_M1.3781.00
101_E104_A1.3581.00
45_Q295_E1.3551.00
158_T171_V1.3381.00
260_Q328_C1.3311.00
100_N104_A1.3171.00
64_T97_L1.3121.00
158_T183_M1.3091.00
66_A69_D1.3061.00
73_K77_Y1.3031.00
92_Q114_G1.2851.00
141_I174_F1.2731.00
10_F271_S1.2721.00
34_M39_L1.2691.00
44_K81_Y1.2641.00
148_K179_G1.2641.00
214_P217_A1.2551.00
120_P170_E1.2481.00
220_K224_T1.2341.00
13_N96_I1.2331.00
125_D136_T1.2311.00
172_Y176_K1.2311.00
103_C107_K1.2191.00
103_C150_Y1.2181.00
13_N62_E1.2151.00
102_W106_L1.2101.00
41_E44_K1.2031.00
105_F108_E1.1991.00
124_H135_G1.1951.00
117_I156_T1.1891.00
144_I154_F1.1791.00
32_K272_N1.1781.00
156_T180_S1.1781.00
107_K151_Q1.1631.00
146_R150_Y1.1621.00
36_D70_F1.1601.00
91_L106_L1.1461.00
17_D127_Y1.1461.00
8_S58_W1.1451.00
275_I296_L1.1411.00
103_C143_A1.1401.00
55_Y88_F1.1391.00
74_V78_Q1.1341.00
75_I105_F1.1261.00
281_F330_K1.1181.00
276_Y287_K1.1171.00
66_A73_K1.1151.00
175_L180_S1.1141.00
6_K39_L1.1141.00
64_T102_W1.1131.00
20_F59_Q1.1101.00
224_T228_Q1.1051.00
18_Y118_D1.1021.00
119_G137_F1.1011.00
14_L136_T1.1001.00
43_I85_K1.0981.00
119_G123_L1.0981.00
137_F141_I1.0941.00
139_K143_A1.0891.00
312_P338_N1.0861.00
42_F269_V1.0831.00
76_H80_R1.0821.00
217_A220_K1.0811.00
9_S33_W1.0751.00
219_G223_S1.0661.00
78_Q89_N1.0661.00
43_I56_F1.0591.00
64_T143_A1.0541.00
313_A316_Q1.0451.00
115_I147_L1.0431.00
41_E292_N1.0421.00
238_F241_Q1.0371.00
224_T227_M1.0321.00
169_L228_Q1.0231.00
294_S299_M1.0231.00
114_G157_L1.0231.00
228_Q231_K1.0201.00
18_Y127_Y1.0191.00
245_F248_R1.0161.00
119_G128_R1.0161.00
6_K42_F1.0121.00
216_T220_K1.0071.00
45_Q49_A1.0051.00
43_I78_Q1.0001.00
300_N304_L0.9991.00
81_Y84_Q0.9941.00
124_H137_F0.9931.00
315_C318_C0.9861.00
133_G136_T0.9851.00
116_S159_V0.9781.00
267_L296_L0.9781.00
143_A146_R0.9751.00
141_I145_E0.9741.00
124_H140_V0.9741.00
329_P332_R0.9731.00
220_K223_S0.9721.00
315_C324_C0.9701.00
70_F73_K0.9651.00
76_H109_H0.9641.00
147_L152_V0.9641.00
46_Y56_F0.9631.00
44_K48_A0.9621.00
125_D128_R0.9621.00
113_V152_V0.9591.00
173_H176_K0.9521.00
314_K341_V0.9481.00
47_I85_K0.9461.00
75_I111_F0.9451.00
228_Q232_N0.9341.00
13_N65_L0.9331.00
96_I143_A0.9321.00
166_H217_A0.9261.00
91_L113_V0.9201.00
241_Q244_S0.9191.00
66_A74_V0.9161.00
120_P174_F0.9161.00
76_H105_F0.9141.00
171_V175_L0.9091.00
70_F74_V0.9081.00
45_Q48_A0.9011.00
75_I109_H0.9001.00
72_R76_H0.8991.00
72_R102_W0.8961.00
79_Q108_E0.8951.00
168_P224_T0.8941.00
98_L143_A0.8911.00
8_S66_A0.8891.00
226_F230_V0.8881.00
240_R243_E0.8871.00
55_Y90_A0.8851.00
165_V217_A0.8831.00
144_I156_T0.8811.00
314_K342_S0.8801.00
77_Y81_Y0.8741.00
94_N97_L0.8691.00
101_E105_F0.8691.00
7_P59_Q0.8681.00
156_T183_M0.8601.00
301_S304_L0.8531.00
34_M42_F0.8511.00
72_R101_E0.8441.00
56_F89_N0.8421.00
286_Y333_I0.8411.00
313_A317_Q0.8371.00
215_P219_G0.8351.00
98_L106_L0.8301.00
4_T267_L0.8260.99
79_Q89_N0.8230.99
92_Q157_L0.8230.99
102_W105_F0.8220.99
59_Q92_Q0.8210.99
9_S66_A0.8190.99
92_Q279_D0.8160.99
59_Q279_D0.8150.99
39_L42_F0.8140.99
240_R244_S0.8120.99
124_H128_R0.8100.99
56_F78_Q0.8040.99
69_D72_R0.7970.99
158_T175_L0.7950.99
36_D66_A0.7860.99
305_T308_K0.7820.99
289_G294_S0.7810.99
117_I137_F0.7780.99
98_L147_L0.7770.99
138_A141_I0.7740.99
324_C345_C0.7730.99
121_Q135_G0.7690.99
122_E126_R0.7690.99
300_N303_Q0.7660.99
128_R133_G0.7600.99
58_W78_Q0.7560.99
53_Q88_F0.7500.99
148_K180_S0.7460.99
62_E94_N0.7450.99
7_P271_S0.7430.99
239_I243_E0.7420.99
229_W232_N0.7420.99
237_I242_F0.7420.99
244_S247_S0.7410.99
5_A266_N0.7410.99
40_K81_Y0.7400.99
269_V275_I0.7390.99
21_Y59_Q0.7380.99
103_C113_V0.7380.99
311_I321_K0.7330.99
66_A71_F0.7310.99
62_E93_T0.7310.99
57_T90_A0.7300.99
7_P268_V0.7260.99
161_N164_N0.7260.99
257_C260_Q0.7240.99
166_H220_K0.7240.99
238_F243_E0.7230.99
227_M231_K0.7230.99
284_P287_K0.7190.99
157_L186_I0.7180.99
176_K232_N0.7170.99
12_C19_C0.7170.99
259_F263_C0.7150.99
223_S350_I0.7150.99
289_G299_M0.7150.99
18_Y128_R0.7140.99
327_G342_S0.7140.99
227_M230_V0.7120.99
287_K290_N0.7110.98
226_F229_W0.7100.98
225_I229_W0.7090.98
168_P185_F0.7080.98
71_F75_I0.7070.98
315_C345_C0.7070.98
237_I241_Q0.7070.98
47_I87_I0.7070.98
188_L194_P0.7060.98
12_C16_C0.7060.98
106_L111_F0.7040.98
97_L143_A0.6990.98
16_C19_C0.6990.98
80_R84_Q0.6980.98
5_A57_T0.6970.98
168_P172_Y0.6960.98
125_D133_G0.6960.98
39_L43_I0.6940.98
62_E65_L0.6940.98
38_T42_F0.6920.98
5_A279_D0.6920.98
84_Q87_I0.6910.98
296_L299_M0.6880.98
157_L279_D0.6880.98
114_G155_N0.6840.98
98_L102_W0.6830.98
116_S128_R0.6820.98
239_I242_F0.6810.98
154_F180_S0.6800.98
297_K300_N0.6800.98
57_T92_Q0.6790.98
125_D137_F0.6780.98
148_K181_K0.6780.98
39_L77_Y0.6770.98
144_I178_I0.6760.98
112_L155_N0.6750.98
148_K154_F0.6730.98
244_S248_R0.6720.98
295_E299_M0.6710.98
43_I58_W0.6680.98
136_T140_V0.6680.98
117_I141_I0.6660.98
159_V188_L0.6620.98
174_F177_S0.6620.98
321_K325_N0.6610.98
72_R77_Y0.6600.98
237_I240_R0.6580.98
238_F242_F0.6570.97
37_S41_E0.6560.97
147_L154_F0.6540.97
45_Q297_K0.6530.97
64_T71_F0.6530.97
77_Y84_Q0.6510.97
103_C152_V0.6490.97
218_Y222_M0.6490.97
123_L126_R0.6480.97
235_G239_I0.6480.97
103_C147_L0.6460.97
99_N143_A0.6460.97
119_G167_Y0.6460.97
246_V250_L0.6450.97
100_N103_C0.6440.97
235_G238_F0.6420.97
18_Y159_V0.6400.97
115_I140_V0.6390.97
312_P340_T0.6390.97
40_K80_R0.6380.97
18_Y21_Y0.6370.97
107_K152_V0.6350.97
273_G291_I0.6340.97
128_R136_T0.6340.97
162_N214_P0.6330.97
79_Q110_E0.6320.97
42_F46_Y0.6320.97
269_V291_I0.6290.97
342_S348_Y0.6290.97
117_I140_V0.6280.97
236_E240_R0.6280.97
119_G124_H0.6280.97
23_E193_T0.6280.97
62_E95_G0.6260.97
277_E286_Y0.6250.97
332_R343_Y0.6220.97
48_A297_K0.6220.97
118_D124_H0.6180.96
7_P157_L0.6180.96
319_A349_K0.6170.96
81_Y85_K0.6150.96
153_E181_K0.6150.96
96_I139_K0.6140.96
119_G125_D0.6120.96
259_F262_S0.6110.96
277_E281_F0.6090.96
69_D73_K0.6090.96
7_P21_Y0.6060.96
15_K133_G0.6060.96
324_C328_C0.6030.96
11_Q31_E0.6030.96
277_E280_H0.6020.96
213_V217_A0.6020.96
144_I180_S0.6020.96
59_Q114_G0.6000.96
306_A309_K0.5990.96
220_K350_I0.5990.96
56_F87_I0.5980.96
21_Y279_D0.5980.96
92_Q280_H0.5970.96
253_G256_S0.5970.96
246_V249_F0.5950.96
268_V279_D0.5940.95
312_P341_V0.5900.95
8_S39_L0.5840.95
318_C345_C0.5820.95
18_Y59_Q0.5810.95
175_L183_M0.5800.95
148_K178_I0.5800.95
212_S218_Y0.5780.95
332_R342_S0.5760.95
243_E248_R0.5750.95
242_F246_V0.5750.95
21_Y268_V0.5740.95
70_F77_Y0.5740.95
122_E170_E0.5720.94
185_F225_I0.5720.94
318_C324_C0.5720.94
163_V211_F0.5710.94
93_T115_I0.5700.94
143_A147_L0.5690.94
169_L173_H0.5690.94
40_K76_H0.5690.94
104_A107_K0.5680.94
239_I244_S0.5680.94
159_V186_I0.5670.94
314_K349_K0.5650.94
298_T301_S0.5650.94
231_K234_V0.5640.94
70_F76_H0.5640.94
327_G332_R0.5640.94
242_F245_F0.5600.94
236_E243_E0.5590.94
258_I261_E0.5580.94
42_F291_I0.5560.94
158_T185_F0.5530.93
333_I338_N0.5530.93
292_N295_E0.5530.93
305_T309_K0.5520.93
139_K146_R0.5510.93
276_Y288_I0.5500.93
235_G242_F0.5500.93
43_I87_I0.5480.93
333_I337_N0.5460.93
89_N111_F0.5440.93
8_S71_F0.5400.93
191_T194_P0.5370.92
8_S74_V0.5360.92
121_Q174_F0.5350.92
65_L139_K0.5330.92
168_P221_F0.5320.92
285_Q333_I0.5300.92
241_Q245_F0.5280.92
342_S346_E0.5280.92
236_E239_I0.5270.92
333_I336_V0.5270.92
176_K228_Q0.5260.92
210_D214_P0.5260.92
214_P222_M0.5240.92
39_L66_A0.5240.92
250_L254_H0.5220.91
120_P137_F0.5220.91
165_V220_K0.5210.91
120_P171_V0.5200.91
336_V341_V0.5190.91
208_I211_F0.5160.91
75_I78_Q0.5150.91
11_Q65_L0.5140.91
327_G331_H0.5120.91
288_I304_L0.5120.91
344_F347_G0.5120.91
21_Y159_V0.5120.91
41_E295_E0.5100.90
266_N279_D0.5100.90
232_N236_E0.5100.90
218_Y221_F0.5100.90
59_Q157_L0.5090.90
117_I124_H0.5090.90
213_V221_F0.5080.90
7_P10_F0.5080.90
186_I279_D0.5060.90
7_P279_D0.5060.90
216_T219_G0.5060.90
34_M70_F0.5060.90
183_M187_E0.5060.90
222_M225_I0.5040.90
46_Y53_Q0.5040.90
336_V340_T0.5020.90
20_F186_I0.5020.90
77_Y80_R0.5010.90
172_Y225_I0.5010.90
172_Y232_N0.5000.90
60_G63_P0.5000.90
106_L152_V0.5000.90
106_L110_E0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.9377 100 0.271 Contact Map
1tv8A 2 0.7766 100 0.509 Contact Map
4m7tA 1 0.5948 100 0.544 Contact Map
4rtbA 2 0.8312 100 0.595 Contact Map
4wcxA 1 0.9065 100 0.625 Contact Map
3c8fA 1 0.5662 100 0.631 Contact Map
2yx0A 1 0.6234 99.9 0.657 Contact Map
2z2uA 1 0.5325 99.9 0.668 Contact Map
2qgqA 1 0.6494 99.9 0.674 Contact Map
2a5hA 4 0.7325 99.9 0.679 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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