GREMLIN Database
YNCI - Putative transposase YncI
UniProt: P76119 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14258
Length: 374 (352)
Sequences: 500 (428)
Seq/√Len: 22.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_V206_F5.9871.00
266_S282_R4.6621.00
181_A193_L4.0251.00
152_I177_Q3.8741.00
160_N183_K3.5921.00
18_Q21_K3.5521.00
183_K187_K3.4801.00
149_S154_A2.9801.00
73_T76_R2.9711.00
262_C295_F2.9450.99
238_H262_C2.9420.99
324_I333_I2.6470.99
171_I175_G2.5980.99
155_I175_G2.5640.99
260_K286_S2.4990.98
262_C286_S2.4780.98
32_L64_F2.4480.98
237_L265_L2.4120.98
105_I170_T2.3920.98
197_G203_H2.3920.98
18_Q22_V2.3800.98
155_I180_I2.3460.97
262_C299_I2.3290.97
104_E133_S2.3000.97
33_T74_I2.2880.97
14_P85_A2.2630.97
25_K28_A2.2520.97
194_A282_R2.2480.97
155_I171_I2.1820.96
19_Q22_V2.1390.95
318_N321_A2.1340.95
168_L192_L2.1250.95
190_D287_S2.1070.95
195_V200_G2.0930.95
185_K257_G2.0880.95
175_G180_I2.0750.95
128_M338_K2.0080.94
156_P180_I2.0040.94
33_T336_I1.9980.93
168_L288_K1.9810.93
239_I263_V1.9540.93
55_L59_K1.9540.93
238_H264_A1.9010.92
112_T127_H1.8740.91
32_L55_L1.8580.91
312_V345_R1.8250.90
48_E52_H1.8200.90
49_D355_E1.8170.90
13_T89_M1.8160.90
115_G321_A1.8150.90
322_S333_I1.8020.89
317_M357_K1.8020.89
288_K291_D1.7910.89
238_H296_A1.7780.89
116_S125_A1.7770.88
150_N174_M1.7510.88
165_K188_K1.7460.88
106_I131_A1.7380.87
356_K366_R1.7310.87
38_I340_A1.7250.87
74_I78_V1.7170.87
265_L281_I1.7020.86
64_F67_G1.6790.85
29_I77_V1.6770.85
54_R364_R1.6730.85
139_V338_K1.6710.85
36_A41_A1.6610.85
71_D75_A1.6540.85
24_H76_R1.6450.84
126_I144_K1.6200.83
170_T302_H1.6050.83
53_E363_H1.5980.82
32_L51_G1.5640.81
149_S174_M1.5620.81
13_T30_L1.5580.81
6_L30_L1.5570.81
48_E68_I1.5470.80
10_I89_M1.5370.80
347_C366_R1.5280.79
131_A158_L1.5040.78
176_C282_R1.4920.78
195_V285_I1.4900.78
156_P171_I1.4860.77
75_A324_I1.4860.77
156_P175_G1.4780.77
238_H292_A1.4650.76
113_I334_S1.4620.76
6_L10_I1.4530.76
137_G345_R1.4450.75
33_T78_V1.4300.75
156_P174_M1.3740.72
334_S338_K1.3710.71
203_H207_E1.3700.71
13_T66_N1.3650.71
149_S152_I1.3600.71
130_S305_I1.3550.71
348_K352_G1.3490.70
313_L338_K1.3470.70
111_K319_E1.3410.70
55_L64_F1.3370.69
209_K243_V1.3260.69
171_I174_M1.3230.69
106_I189_A1.3190.68
87_E91_I1.2950.67
224_S237_L1.2920.67
352_G366_R1.2920.67
46_E358_E1.2910.67
146_E149_S1.2880.67
238_H295_F1.2770.66
192_L299_I1.2710.65
46_E354_E1.2710.65
171_I193_L1.2550.64
349_D356_K1.2540.64
130_S338_K1.2500.64
32_L74_I1.2440.64
166_K188_K1.2330.63
182_S186_D1.2300.63
174_M180_I1.2290.63
296_A299_I1.2280.63
139_V309_L1.2270.63
144_K331_E1.2260.63
28_A63_D1.2250.63
351_K366_R1.2200.62
51_G64_F1.2190.62
304_L308_S1.2150.62
171_I180_I1.2070.61
113_I319_E1.2040.61
182_S256_K1.2040.61
184_I189_A1.1950.61
189_A317_M1.1890.60
195_V202_L1.1880.60
319_E337_K1.1880.60
55_L63_D1.1870.60
293_K297_H1.1870.60
138_V342_N1.1740.59
229_S281_I1.1600.58
153_T180_I1.1590.58
44_W50_F1.1580.58
338_K341_L1.1570.58
264_A299_I1.1540.58
145_T149_S1.1520.58
157_E286_S1.1510.58
154_A180_I1.1480.57
241_S244_T1.1440.57
106_I164_L1.1410.57
69_P111_K1.1390.57
118_D323_R1.1340.56
130_S231_G1.1250.56
189_A278_G1.1230.56
221_D292_A1.1130.55
10_I13_T1.1110.55
164_L336_I1.1100.55
44_W78_V1.0860.53
222_S239_I1.0850.53
33_T37_V1.0800.53
41_A47_I1.0710.52
81_I288_K1.0690.52
291_D294_E1.0670.52
16_I80_N1.0620.51
28_A59_K1.0610.51
112_T116_S1.0560.51
74_I336_I1.0550.51
86_F90_F1.0370.50
148_K177_Q1.0350.50
48_E71_D1.0350.50
127_H142_Q1.0300.49
361_V367_S1.0170.48
42_D357_K1.0170.48
177_Q180_I1.0150.48
150_N177_Q1.0130.48
24_H28_A1.0130.48
179_D182_S1.0110.48
364_R367_S1.0080.48
149_S153_T1.0010.47
306_E314_D0.9960.47
226_Q233_K0.9910.47
87_E338_K0.9810.46
105_I134_N0.9770.46
169_I293_K0.9720.45
177_Q206_F0.9690.45
31_F65_D0.9570.44
352_G363_H0.9560.44
43_E46_E0.9530.44
310_H314_D0.9530.44
350_I353_E0.9500.44
58_L361_V0.9490.44
348_K351_K0.9460.43
319_E334_S0.9460.43
288_K295_F0.9460.43
51_G68_I0.9440.43
116_S126_I0.9440.43
267_F279_V0.9400.43
24_H62_G0.9380.43
149_S156_P0.9350.43
113_I128_M0.9340.43
108_I131_A0.9330.43
86_F188_K0.9290.42
53_E361_V0.9270.42
83_S331_E0.9260.42
327_G330_A0.9260.42
94_M342_N0.9220.42
148_K280_S0.9160.41
350_I366_R0.9160.41
42_D354_E0.9070.41
127_H174_M0.9060.41
207_E211_P0.8980.40
269_Q277_E0.8980.40
222_S237_L0.8920.40
36_A47_I0.8920.40
147_A225_T0.8860.39
106_I140_L0.8850.39
42_D46_E0.8840.39
106_I183_K0.8830.39
150_N180_I0.8760.39
31_F61_Y0.8730.39
263_V281_I0.8730.39
30_L167_N0.8710.38
347_C356_K0.8690.38
191_Y258_L0.8680.38
31_F64_F0.8630.38
311_W315_V0.8620.38
359_G366_R0.8600.38
113_I338_K0.8520.37
335_G338_K0.8500.37
129_V155_I0.8490.37
180_I184_I0.8470.37
326_R330_A0.8430.37
314_D320_D0.8420.37
236_R300_R0.8370.36
240_V260_K0.8360.36
358_E362_K0.8320.36
197_G363_H0.8290.36
185_K188_K0.8250.35
199_Q231_G0.8170.35
153_T177_Q0.8120.35
199_Q255_W0.8110.35
43_E336_I0.8110.35
32_L62_G0.8100.35
55_L62_G0.8100.35
261_L281_I0.8090.34
334_S337_K0.8080.34
153_T156_P0.8070.34
51_G55_L0.8050.34
24_H31_F0.8010.34
70_V80_N0.7970.34
84_L87_E0.7970.34
64_F74_I0.7920.33
166_K169_I0.7910.33
141_G155_I0.7900.33
306_E320_D0.7870.33
24_H233_K0.7850.33
197_G200_G0.7830.33
308_S345_R0.7830.33
155_I174_M0.7820.33
35_C168_L0.7800.33
112_T125_A0.7790.33
303_W306_E0.7780.33
59_K63_D0.7770.33
225_T286_S0.7700.32
228_I233_K0.7690.32
57_W367_S0.7660.32
268_R278_G0.7650.32
50_F299_I0.7650.32
199_Q285_I0.7640.32
210_F263_V0.7620.32
233_K269_Q0.7610.32
13_T81_I0.7600.31
124_G135_E0.7590.31
160_N187_K0.7590.31
13_T206_F0.7560.31
132_F356_K0.7530.31
132_F304_L0.7520.31
333_I339_M0.7520.31
130_S280_S0.7510.31
194_A284_Y0.7510.31
33_T36_A0.7490.31
164_L169_I0.7490.31
52_H56_E0.7460.31
59_K367_S0.7400.30
72_D300_R0.7390.30
7_L11_S0.7380.30
227_E305_I0.7380.30
10_I256_K0.7340.30
227_E344_L0.7320.30
9_Y92_E0.7300.30
224_S278_G0.7270.30
153_T197_G0.7270.30
239_I265_L0.7270.30
310_H320_D0.7250.29
89_M200_G0.7180.29
26_L77_V0.7180.29
353_E366_R0.7170.29
24_H66_N0.7170.29
16_I183_K0.7140.29
231_G270_K0.7140.29
189_A199_Q0.7140.29
127_H181_A0.7100.29
177_Q255_W0.7050.28
137_G359_G0.7030.28
139_V342_N0.6990.28
41_A46_E0.6990.28
184_I304_L0.6970.28
67_G159_L0.6940.28
295_F299_I0.6940.28
90_F232_R0.6930.28
74_I301_A0.6910.28
48_E51_G0.6900.27
128_M142_Q0.6880.27
343_L346_D0.6870.27
223_F293_K0.6860.27
284_Y299_I0.6860.27
39_A205_A0.6840.27
251_F256_K0.6840.27
111_K302_H0.6840.27
271_K335_G0.6820.27
178_K254_E0.6820.27
223_F296_A0.6810.27
54_R362_K0.6790.27
150_N156_P0.6770.27
7_L10_I0.6770.27
105_I298_A0.6740.27
209_K241_S0.6730.27
322_S357_K0.6730.27
128_M334_S0.6720.26
35_C102_D0.6710.26
94_M97_C0.6700.26
256_K291_D0.6700.26
38_I361_V0.6690.26
168_L298_A0.6690.26
103_G128_M0.6640.26
44_W75_A0.6630.26
211_P252_E0.6620.26
328_N332_I0.6620.26
46_E50_F0.6610.26
97_C141_G0.6610.26
45_Q71_D0.6600.26
191_Y283_Y0.6600.26
139_V312_V0.6580.26
348_K353_E0.6530.25
90_F342_N0.6510.25
194_A299_I0.6510.25
176_C193_L0.6490.25
162_L342_N0.6470.25
348_K366_R0.6470.25
24_H83_S0.6470.25
66_N304_L0.6460.25
211_P241_S0.6420.25
205_A208_E0.6420.25
205_A241_S0.6410.25
58_L61_Y0.6410.25
66_N285_I0.6410.25
127_H150_N0.6390.25
192_L286_S0.6390.25
357_K362_K0.6380.25
9_Y43_E0.6380.25
208_E244_T0.6370.25
316_K351_K0.6310.24
144_K149_S0.6310.24
111_K115_G0.6300.24
42_D81_I0.6300.24
142_Q191_Y0.6290.24
114_R318_N0.6290.24
87_E238_H0.6280.24
127_H159_L0.6280.24
45_Q75_A0.6270.24
153_T158_L0.6270.24
132_F284_Y0.6260.24
153_T175_G0.6240.24
114_R183_K0.6230.24
345_R348_K0.6230.24
322_S362_K0.6230.24
38_I58_L0.6220.24
234_E300_R0.6220.24
201_K299_I0.6210.24
272_E315_V0.6210.24
305_I308_S0.6210.24
354_E358_E0.6200.24
106_I353_E0.6190.24
44_W51_G0.6170.24
210_F257_G0.6170.24
225_T299_I0.6160.24
13_T18_Q0.6150.24
138_V311_W0.6150.24
152_I174_M0.6140.23
38_I344_L0.6120.23
78_V167_N0.6120.23
109_D172_D0.6110.23
265_L305_I0.6100.23
222_S355_E0.6090.23
23_K27_S0.6080.23
58_L292_A0.6070.23
78_V210_F0.6070.23
301_A333_I0.6060.23
134_N258_L0.6050.23
6_L352_G0.6050.23
43_E117_F0.6040.23
170_T192_L0.6030.23
166_K287_S0.6030.23
57_W347_C0.6010.23
29_I32_L0.5990.23
90_F130_S0.5990.23
44_W93_W0.5980.23
38_I181_A0.5980.23
19_Q50_F0.5970.23
240_V367_S0.5950.23
64_F70_V0.5930.22
164_L236_R0.5930.22
75_A79_S0.5910.22
262_C284_Y0.5910.22
18_Q74_I0.5880.22
235_T269_Q0.5870.22
28_A67_G0.5870.22
10_I195_V0.5860.22
151_E172_D0.5850.22
260_K288_K0.5820.22
116_S123_K0.5820.22
31_F57_W0.5810.22
216_S276_A0.5790.22
135_E160_N0.5780.22
45_Q355_E0.5780.22
112_T194_A0.5770.22
160_N182_S0.5770.22
332_I344_L0.5760.22
302_H310_H0.5750.22
114_R280_S0.5750.22
50_F284_Y0.5740.22
145_T205_A0.5730.21
172_D196_K0.5730.21
306_E310_H0.5710.21
23_K34_V0.5710.21
178_K199_Q0.5710.21
230_H299_I0.5700.21
192_L290_M0.5680.21
129_V149_S0.5670.21
102_D126_I0.5660.21
330_A341_L0.5660.21
25_K64_F0.5650.21
172_D306_E0.5650.21
290_M295_F0.5640.21
166_K190_D0.5640.21
165_K328_N0.5640.21
314_D319_E0.5630.21
47_I112_T0.5630.21
190_D311_W0.5630.21
294_E297_H0.5620.21
140_L287_S0.5610.21
163_Y253_F0.5610.21
148_K285_I0.5610.21
88_K182_S0.5600.21
115_G124_G0.5600.21
9_Y12_V0.5590.21
325_R330_A0.5590.21
124_G215_F0.5590.21
154_A174_M0.5590.21
39_A60_K0.5570.21
62_G159_L0.5570.21
6_L11_S0.5570.21
108_I117_F0.5560.21
84_L145_T0.5550.21
316_K339_M0.5550.21
141_G158_L0.5530.21
206_F255_W0.5520.21
249_C252_E0.5490.20
178_K252_E0.5440.20
270_K277_E0.5440.20
338_K342_N0.5430.20
244_T252_E0.5420.20
115_G125_A0.5390.20
96_E367_S0.5390.20
324_I337_K0.5380.20
282_R357_K0.5370.20
6_L327_G0.5370.20
36_A209_K0.5370.20
129_V199_Q0.5360.20
249_C253_F0.5350.20
24_H33_T0.5350.20
269_Q272_E0.5350.20
85_A137_G0.5330.20
54_R68_I0.5320.20
13_T86_F0.5310.20
16_I159_L0.5310.20
225_T233_K0.5290.20
24_H32_L0.5290.20
106_I141_G0.5280.19
53_E362_K0.5260.19
152_I206_F0.5260.19
132_F285_I0.5240.19
237_L281_I0.5230.19
194_A295_F0.5230.19
184_I187_K0.5230.19
91_I272_E0.5220.19
83_S311_W0.5210.19
149_S175_G0.5210.19
9_Y89_M0.5210.19
169_I299_I0.5200.19
43_E324_I0.5180.19
142_Q159_L0.5170.19
49_D359_G0.5170.19
11_S305_I0.5170.19
79_S328_N0.5170.19
69_P319_E0.5170.19
156_P177_Q0.5160.19
86_F336_I0.5150.19
24_H96_E0.5150.19
188_K197_G0.5140.19
128_M162_L0.5130.19
138_V258_L0.5100.19
203_H299_I0.5100.19
159_L183_K0.5100.19
240_V290_M0.5090.19
299_I343_L0.5090.19
90_F144_K0.5090.19
50_F71_D0.5090.19
261_L312_V0.5080.19
22_V39_A0.5080.19
363_H366_R0.5070.19
229_S267_F0.5060.19
236_R258_L0.5060.19
127_H148_K0.5060.19
112_T298_A0.5050.18
25_K63_D0.5050.18
30_L168_L0.5050.18
182_S334_S0.5040.18
81_I185_K0.5040.18
46_E100_I0.5030.18
50_F195_V0.5010.18
49_D286_S0.5000.18
238_H299_I0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8663 98 0.932 Contact Map
2abkA 1 0.361 33 0.975 Contact Map
1ornA 1 0.3636 17.2 0.978 Contact Map
4unfA 1 0.377 15.4 0.978 Contact Map
1tq8A 4 0.3396 12.5 0.979 Contact Map
1nafA 1 0.1497 12.4 0.979 Contact Map
2omzB 1 0.262 12.1 0.979 Contact Map
2d74B 1 0.3316 11.8 0.979 Contact Map
1neeA 1 0.3369 10.4 0.98 Contact Map
4r3uC 1 0.3396 10.4 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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