GREMLIN Database
YNCE - Uncharacterized protein YncE
UniProt: P76116 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13775
Length: 353 (291)
Sequences: 3510 (3090)
Seq/√Len: 181.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_T201_T6.3341.00
229_K248_T4.6431.00
189_G202_T4.5801.00
203_N207_E3.9061.00
289_T299_I3.7191.00
248_T258_V3.6391.00
272_P289_T3.0601.00
208_L248_T2.9941.00
201_T211_I2.9881.00
200_Y238_L2.9791.00
255_V289_T2.9531.00
235_N249_D2.9281.00
166_I201_T2.7021.00
247_I279_F2.6491.00
290_H294_G2.4021.00
163_E167_W2.3691.00
256_L268_K2.3681.00
288_V321_L2.3671.00
249_D274_S2.3541.00
276_A290_H2.3181.00
139_R163_E2.2921.00
139_R158_S2.2731.00
209_I221_R2.2671.00
183_T203_N2.2491.00
139_R169_V2.2281.00
190_L201_T2.2021.00
145_E159_G2.1891.00
188_T204_A2.1211.00
160_I163_E2.1091.00
147_V191_A2.0231.00
182_N209_I2.0051.00
290_H316_P1.9851.00
138_V169_V1.9441.00
200_Y236_I1.9381.00
191_A237_S1.9301.00
229_K250_S1.8941.00
237_S278_L1.8641.00
247_I257_V1.7971.00
202_T236_I1.7771.00
202_T233_F1.7741.00
288_V298_V1.7201.00
32_E35_L1.7201.00
157_I199_L1.7161.00
272_P291_R1.6981.00
183_T211_I1.6931.00
183_T209_I1.6931.00
252_A256_L1.6781.00
193_D238_L1.6381.00
200_Y210_T1.6311.00
201_T205_D1.6291.00
247_I286_A1.6221.00
248_T256_L1.5891.00
167_W176_L1.5891.00
157_I160_I1.5821.00
205_D209_I1.5591.00
293_A297_S1.5501.00
44_Y48_Y1.5471.00
167_W179_A1.5441.00
183_T205_D1.5401.00
183_T187_S1.5161.00
190_L199_L1.5111.00
47_A50_Q1.4781.00
318_S331_S1.4651.00
34_M37_K1.4641.00
229_K233_F1.4631.00
212_D215_D1.4541.00
32_E36_R1.4481.00
149_D192_L1.4191.00
259_D262_N1.4101.00
55_L59_T1.4011.00
322_S325_G1.4011.00
201_T209_I1.3951.00
170_D173_N1.3931.00
218_I221_R1.3881.00
33_E36_R1.3871.00
250_S254_E1.3851.00
313_P330_V1.3851.00
39_V43_A1.3851.00
182_N211_I1.3791.00
54_A57_L1.3621.00
43_A47_A1.3571.00
158_S169_V1.3531.00
229_K252_A1.3191.00
296_V330_V1.3181.00
289_T297_S1.3131.00
291_R295_K1.2891.00
72_Y75_D1.2801.00
194_S242_R1.2791.00
157_I192_L1.2771.00
160_I165_V1.2731.00
42_G46_M1.2721.00
166_I190_L1.2681.00
288_V319_L1.2521.00
209_I218_I1.2471.00
93_G107_N1.2461.00
40_G44_Y1.2361.00
48_Y51_Q1.2271.00
247_I277_V1.2121.00
31_A34_M1.2051.00
48_Y52_E1.1951.00
31_A35_L1.1881.00
78_T82_T1.1821.00
38_A41_K1.1741.00
322_S327_T1.1471.00
36_R39_V1.1461.00
46_M49_S1.1391.00
322_S326_K1.1341.00
38_A45_E1.1291.00
157_I168_V1.1281.00
250_S256_L1.1271.00
42_G47_A1.1241.00
54_A58_A1.1211.00
110_N114_T1.1201.00
180_I199_L1.1171.00
194_S238_L1.1011.00
35_L39_V1.0981.00
53_N56_W1.0931.00
272_P299_I1.0861.00
306_V309_T1.0851.00
139_R160_I1.0851.00
40_G45_E1.0681.00
57_L60_S1.0591.00
271_A289_T1.0541.00
63_R67_K1.0471.00
234_I251_K1.0421.00
249_D277_V1.0391.00
150_D196_G1.0321.00
97_N100_T1.0311.00
45_E52_E1.0250.99
280_N283_R1.0170.99
55_L58_A1.0160.99
156_Y159_G1.0160.99
74_L77_V1.0150.99
47_A52_E1.0090.99
97_N101_Q1.0080.99
35_L38_A1.0060.99
33_E37_K1.0000.99
297_S309_T0.9970.99
42_G50_Q0.9920.99
36_R40_G0.9890.99
321_L327_T0.9840.99
92_F95_T0.9800.99
191_A236_I0.9650.99
83_Q87_N0.9620.99
299_I306_V0.9610.99
80_E87_N0.9600.99
203_N206_G0.9520.99
237_S277_V0.9460.99
183_T207_E0.9450.99
37_K41_K0.9450.99
39_V44_Y0.9430.99
203_N209_I0.9380.99
40_G43_A0.9380.99
239_D279_F0.9320.99
274_S299_I0.9310.99
228_G258_V0.9270.99
75_D78_T0.9220.99
47_A53_N0.9210.99
32_E38_A0.9190.99
284_N300_D0.9140.99
157_I169_V0.9000.99
45_E54_A0.8970.99
46_M50_Q0.8960.99
241_A244_R0.8860.99
48_Y54_A0.8820.98
308_K311_D0.8810.98
42_G45_E0.8800.98
240_T283_R0.8790.98
143_P169_V0.8770.98
32_E37_K0.8770.98
300_D303_S0.8760.98
41_K45_E0.8740.98
95_T147_V0.8720.98
156_Y192_L0.8720.98
278_L288_V0.8680.98
51_Q55_L0.8620.98
31_A37_K0.8550.98
235_N277_V0.8500.98
31_A38_A0.8490.98
38_A43_A0.8470.98
54_A59_T0.8460.98
32_E40_G0.8450.98
36_R41_K0.8400.98
44_Y56_W0.8380.98
284_N302_K0.8360.98
139_R167_W0.8360.98
250_S253_A0.8360.98
308_K313_P0.8340.98
248_T252_A0.8320.98
146_L155_V0.8320.98
34_M39_V0.8270.98
31_A39_V0.8240.98
49_S53_N0.8220.98
104_W107_N0.8210.98
96_I116_I0.8200.98
229_K258_V0.8170.98
35_L40_G0.8170.98
242_R245_A0.8030.97
32_E39_V0.8030.97
44_Y49_S0.8020.97
56_W60_S0.7950.97
38_A54_A0.7950.97
82_T87_N0.7940.97
43_A49_S0.7920.97
80_E88_D0.7880.97
159_G187_S0.7880.97
64_K68_G0.7870.97
66_D72_Y0.7870.97
307_V310_F0.7860.97
177_K181_Q0.7840.97
66_D75_D0.7820.97
148_A238_L0.7740.97
276_A319_L0.7730.97
37_K45_E0.7720.97
65_L68_G0.7700.96
31_A36_R0.7690.96
313_P332_V0.7670.96
52_E56_W0.7670.96
272_P297_S0.7660.96
34_M40_G0.7630.96
50_Q53_N0.7630.96
59_T62_S0.7590.96
125_G128_V0.7590.96
249_D253_A0.7590.96
229_K256_L0.7570.96
35_L41_K0.7570.96
52_E55_L0.7570.96
83_Q88_D0.7540.96
37_K40_G0.7540.96
245_A266_L0.7530.96
285_E288_V0.7520.96
33_E38_A0.7510.96
44_Y47_A0.7500.96
272_P293_A0.7490.96
138_V167_W0.7480.96
84_A87_N0.7450.96
53_N57_L0.7440.96
150_D192_L0.7410.96
193_D200_Y0.7350.95
105_F115_A0.7310.95
31_A41_K0.7310.95
187_S201_T0.7280.95
291_R297_S0.7240.95
50_Q56_W0.7240.95
66_D70_V0.7230.95
320_A329_Y0.7220.95
234_I249_D0.7190.95
185_K203_N0.7140.95
210_T238_L0.7070.94
321_L324_D0.7050.94
204_A232_F0.7040.94
51_Q56_W0.7030.94
40_G47_A0.7000.94
159_G190_L0.6990.94
47_A62_S0.6990.94
265_I269_V0.6990.94
53_N59_T0.6990.94
49_S58_A0.6980.94
312_T330_V0.6970.94
239_D242_R0.6970.94
107_N143_P0.6920.94
85_I88_D0.6910.94
76_P88_D0.6900.94
55_L60_S0.6890.94
233_F248_T0.6880.93
73_R78_T0.6860.93
304_Y308_K0.6850.93
326_K331_S0.6850.93
315_H318_S0.6830.93
297_S306_V0.6820.93
149_D152_T0.6820.93
253_A271_A0.6810.93
95_T146_L0.6800.93
33_E40_G0.6790.93
319_L328_L0.6750.93
166_I187_S0.6750.93
136_E139_R0.6750.93
306_V310_F0.6710.93
327_T332_V0.6710.93
139_R143_P0.6700.93
44_Y52_E0.6700.93
229_K254_E0.6690.93
33_E41_K0.6690.93
40_G46_M0.6660.92
41_K44_Y0.6650.92
78_T81_V0.6650.92
35_L43_A0.6620.92
52_E57_L0.6610.92
65_L72_Y0.6610.92
322_S332_V0.6610.92
182_N201_T0.6610.92
315_H330_V0.6600.92
58_A61_Q0.6590.92
235_N276_A0.6590.92
123_V128_V0.6570.92
35_L56_W0.6550.92
35_L42_G0.6540.92
75_D79_L0.6530.92
277_V289_T0.6530.92
38_A42_G0.6520.92
320_A331_S0.6510.91
239_D244_R0.6490.91
232_F249_D0.6460.91
171_G301_A0.6460.91
65_L69_G0.6400.91
293_A299_I0.6400.91
38_A51_Q0.6400.91
31_A45_E0.6390.91
62_S66_D0.6370.91
91_P94_A0.6330.90
62_S67_K0.6320.90
314_T332_V0.6310.90
124_K128_V0.6300.90
154_T168_V0.6280.90
316_P330_V0.6280.90
50_Q54_A0.6250.90
80_E83_Q0.6250.90
46_M56_W0.6240.90
77_V88_D0.6240.90
40_G52_E0.6240.90
280_N284_N0.6220.90
168_V213_T0.6210.89
81_V84_A0.6200.89
51_Q57_L0.6200.89
290_H297_S0.6200.89
63_R69_G0.6190.89
64_K67_K0.6190.89
81_V85_I0.6180.89
91_P116_I0.6130.89
77_V80_E0.6080.88
274_S293_A0.6050.88
156_Y199_L0.6040.88
203_N233_F0.6030.88
258_V279_F0.6000.88
73_R83_Q0.6000.88
237_S279_F0.5990.88
40_G48_Y0.5990.88
298_V310_F0.5980.88
324_D328_L0.5960.87
66_D69_G0.5950.87
208_L233_F0.5930.87
63_R66_D0.5920.87
54_A62_S0.5910.87
37_K43_A0.5900.87
169_V176_L0.5900.87
75_D88_D0.5900.87
200_Y245_A0.5900.87
47_A54_A0.5880.87
50_Q55_L0.5870.87
192_L199_L0.5870.87
82_T86_H0.5850.86
316_P319_L0.5840.86
76_P86_H0.5840.86
208_L236_I0.5800.86
76_P80_E0.5800.86
124_K127_L0.5790.86
176_L179_A0.5790.86
198_R210_T0.5750.86
37_K53_N0.5750.86
265_I268_K0.5750.86
36_R46_M0.5750.86
326_K330_V0.5740.85
139_R157_I0.5730.85
65_L77_V0.5720.85
147_V190_L0.5700.85
38_A46_M0.5680.85
157_I190_L0.5670.85
40_G59_T0.5660.85
189_G235_N0.5650.85
122_E125_G0.5650.85
105_F146_L0.5640.84
117_D121_G0.5630.84
45_E50_Q0.5610.84
74_L80_E0.5600.84
49_S57_L0.5590.84
253_A256_L0.5560.84
44_Y51_Q0.5560.84
257_V269_V0.5530.83
96_I102_T0.5530.83
170_D212_D0.5510.83
259_D264_N0.5510.83
105_F155_V0.5490.83
91_P97_N0.5480.83
275_L292_Q0.5470.83
282_A285_E0.5460.83
35_L48_Y0.5460.83
46_M53_N0.5450.82
170_D177_K0.5430.82
31_A43_A0.5420.82
187_S205_D0.5420.82
76_P82_T0.5420.82
113_V158_S0.5400.82
326_K332_V0.5400.82
74_L79_L0.5390.82
180_I201_T0.5380.82
317_N332_V0.5380.82
92_F96_I0.5330.81
52_E58_A0.5320.81
44_Y54_A0.5320.81
39_V47_A0.5270.80
95_T98_N0.5270.80
238_L260_T0.5260.80
47_A51_Q0.5240.80
255_V271_A0.5240.80
164_S206_G0.5230.80
329_Y332_V0.5230.80
303_S306_V0.5220.80
49_S55_L0.5220.80
72_Y77_V0.5200.79
45_E61_Q0.5200.79
160_I167_W0.5190.79
46_M52_E0.5180.79
56_W61_Q0.5180.79
34_M47_A0.5170.79
48_Y53_N0.5150.79
289_T293_A0.5140.79
210_T260_T0.5130.79
277_V286_A0.5130.79
45_E51_Q0.5120.78
328_L331_S0.5100.78
212_D261_R0.5100.78
278_L320_A0.5080.78
39_V53_N0.5070.78
321_L328_L0.5070.78
271_A291_R0.5070.78
78_T88_D0.5060.78
325_G329_Y0.5050.77
70_V75_D0.5040.77
305_K308_K0.5040.77
40_G53_N0.5040.77
216_N219_L0.5010.77
41_K48_Y0.5010.77
58_A67_K0.5010.77
317_N330_V0.5000.77
324_D327_T0.5000.77
36_R49_S0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vyhC 1 0.7479 100 0.297 Contact Map
4j73A 1 0.7394 100 0.326 Contact Map
3j60g 1 0.898 100 0.331 Contact Map
1gotB 1 0.8499 100 0.334 Contact Map
4j87A 1 0.7309 100 0.337 Contact Map
4u1eI 1 0.7309 100 0.344 Contact Map
5a1uD 1 0.7422 100 0.346 Contact Map
3zey7 1 0.7677 100 0.346 Contact Map
3mkqA 2 0.7365 100 0.346 Contact Map
3j38g 1 0.7649 100 0.347 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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