GREMLIN Database
MCBR - HTH-type transcriptional regulator McbR
UniProt: P76114 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13773
Length: 221 (203)
Sequences: 23628 (17405)
Seq/√Len: 1221.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_Q193_K3.6481.00
98_A201_R3.2791.00
196_D199_G2.9211.00
120_Q186_H2.7051.00
23_Q28_A2.7011.00
30_K33_A2.6061.00
23_Q43_Q2.4031.00
91_E95_M2.3181.00
111_E141_A2.2421.00
37_T48_I2.2071.00
84_E149_P2.0981.00
90_Y209_Q2.0821.00
17_E57_R2.0361.00
65_S75_P2.0341.00
87_R99_L1.9631.00
102_E197_K1.9621.00
21_K61_V1.9531.00
16_V46_M1.9341.00
144_H152_C1.8421.00
66_V72_F1.8221.00
109_L193_K1.7911.00
16_V44_L1.7601.00
191_A199_G1.7481.00
94_L205_A1.7441.00
19_D23_Q1.7421.00
108_D147_N1.7411.00
141_A144_H1.7351.00
105_T108_D1.6811.00
98_A197_K1.6341.00
116_L189_L1.6311.00
184_N210_Q1.6271.00
88_I154_M1.6051.00
127_D130_Q1.6031.00
201_R205_A1.5951.00
94_L201_R1.5891.00
199_G203_C1.5851.00
95_M98_A1.5681.00
22_H26_I1.5381.00
187_L203_C1.5271.00
10_V18_N1.4931.00
118_K134_V1.4901.00
143_Y155_I1.4291.00
120_Q182_I1.4271.00
108_D145_R1.4261.00
139_R185_Y1.4261.00
153_E157_Q1.4231.00
97_V200_C1.4161.00
150_I161_R1.4151.00
90_Y205_A1.4131.00
67_A70_Q1.3901.00
113_Q189_L1.3881.00
140_L156_E1.3861.00
17_E61_V1.3821.00
38_K42_E1.3671.00
115_L134_V1.3651.00
190_A194_A1.3511.00
104_L109_L1.3441.00
90_Y212_I1.3331.00
194_A199_G1.3311.00
197_K201_R1.3011.00
84_E150_I1.3011.00
36_I39_N1.2791.00
186_H190_A1.2631.00
113_Q117_E1.2321.00
39_N43_Q1.2251.00
115_L141_A1.2161.00
114_E118_K1.2091.00
90_Y94_L1.2071.00
118_K137_L1.2051.00
34_R73_T1.1981.00
40_L51_V1.1951.00
116_L186_H1.1891.00
15_Q19_D1.1871.00
67_A73_T1.1691.00
137_L141_A1.1651.00
205_A209_Q1.1641.00
184_N207_I1.1551.00
59_V66_V1.1551.00
202_H206_E1.1491.00
94_L98_A1.1461.00
140_L144_H1.1451.00
19_D22_H1.1411.00
19_D44_L1.1381.00
89_R93_E1.1271.00
115_L137_L1.1151.00
97_V204_L1.1101.00
142_I192_L1.1071.00
23_Q44_L1.1071.00
104_L108_D1.1041.00
104_L195_K1.0951.00
141_A145_R1.0921.00
98_A198_E1.0891.00
199_G202_H1.0871.00
109_L189_L1.0831.00
135_N139_R1.0721.00
96_A143_Y1.0691.00
116_L120_Q1.0691.00
189_L193_K1.0611.00
83_D212_I1.0601.00
97_V101_V1.0591.00
104_L145_R1.0551.00
116_L119_L1.0541.00
84_E148_M1.0541.00
130_Q133_N1.0541.00
113_Q186_H1.0461.00
29_L74_V1.0411.00
134_V137_L1.0371.00
87_R148_M1.0251.00
111_E144_H1.0251.00
65_S73_T1.0241.00
190_A193_K1.0231.00
109_L195_K1.0121.00
10_V15_Q1.0101.00
111_E114_E1.0091.00
78_G81_Q1.0081.00
53_E56_L1.0041.00
154_M157_Q1.0031.00
59_V64_L0.9961.00
99_L103_N0.9791.00
55_L72_F0.9681.00
67_A71_A0.9671.00
23_Q29_L0.9651.00
95_M201_R0.9571.00
191_A196_D0.9551.00
101_V197_K0.9531.00
24_L74_V0.9501.00
138_F189_L0.9491.00
139_R207_I0.9391.00
13_T57_R0.9381.00
117_E120_Q0.9361.00
152_C156_E0.9311.00
93_E139_R0.9261.00
133_N137_L0.9241.00
187_L206_E0.9231.00
185_Y207_I0.9211.00
183_E187_L0.9201.00
111_E115_L0.9161.00
110_A114_E0.9111.00
101_V192_L0.9081.00
57_R60_S0.9071.00
187_L199_G0.9061.00
187_L190_A0.9061.00
37_T52_R0.9061.00
103_N147_N0.8971.00
17_E21_K0.8921.00
64_L72_F0.8881.00
146_S152_C0.8871.00
109_L113_Q0.8871.00
34_R71_A0.8851.00
115_L118_K0.8831.00
198_E202_H0.8691.00
95_M99_L0.8681.00
41_A51_V0.8611.00
70_Q73_T0.8601.00
182_I186_H0.8561.00
21_K63_A0.8551.00
88_I150_I0.8471.00
188_L204_L0.8411.00
47_S50_P0.8371.00
21_K25_S0.8291.00
113_Q190_A0.8241.00
56_L59_V0.8231.00
12_L15_Q0.8231.00
187_L191_A0.8221.00
81_Q150_I0.8171.00
101_V195_K0.8161.00
198_E201_R0.8121.00
100_A145_R0.8091.00
118_K121_Q0.8091.00
150_I154_M0.8041.00
122_A130_Q0.8041.00
108_D111_E0.8031.00
39_N42_E0.7991.00
135_N185_Y0.7981.00
191_A203_C0.7951.00
89_R208_M0.7941.00
150_I153_E0.7941.00
55_L64_L0.7931.00
106_P110_A0.7931.00
56_L66_V0.7891.00
12_L50_P0.7851.00
104_L192_L0.7841.00
101_V200_C0.7821.00
188_L203_C0.7751.00
112_L141_A0.7721.00
106_P195_K0.7691.00
14_L57_R0.7691.00
11_S14_L0.7681.00
99_L102_E0.7651.00
117_E121_Q0.7591.00
87_R212_I0.7581.00
98_A102_E0.7551.00
80_R147_N0.7501.00
99_L148_M0.7501.00
203_C206_E0.7451.00
140_L159_W0.7451.00
40_L55_L0.7401.00
46_M51_V0.7341.00
117_E186_H0.7331.00
179_R183_E0.7331.00
87_R103_N0.7321.00
88_I151_L0.7291.00
136_R159_W0.7211.00
86_N211_N0.7201.00
80_R84_E0.7201.00
13_T17_E0.7191.00
119_L131_I0.7181.00
209_Q213_A0.7171.00
110_A193_K0.7121.00
136_R163_G0.7071.00
112_L189_L0.7041.00
130_Q134_V0.6991.00
110_A113_Q0.6991.00
202_H205_A0.6981.00
206_E210_Q0.6961.00
188_L200_C0.6931.00
140_L152_C0.6921.00
122_A134_V0.6911.00
111_E137_L0.6901.00
108_D141_A0.6871.00
209_Q212_I0.6821.00
88_I96_A0.6821.00
10_V14_L0.6801.00
118_K122_A0.6801.00
114_E117_E0.6731.00
118_K130_Q0.6731.00
29_L33_A0.6701.00
120_Q124_E0.6671.00
184_N187_L0.6671.00
87_R95_M0.6661.00
28_A43_Q0.6651.00
91_E151_L0.6641.00
109_L192_L0.6641.00
57_R61_V0.6631.00
116_L182_I0.6601.00
137_L140_L0.6581.00
188_L207_I0.6501.00
50_P54_A0.6471.00
108_D144_H0.6431.00
13_T53_E0.6391.00
122_A127_D0.6371.00
69_A72_F0.6281.00
100_A104_L0.6261.00
100_A146_S0.6261.00
97_V197_K0.6251.00
32_G76_E0.6191.00
210_Q214_I0.6161.00
96_A151_L0.6151.00
23_Q27_G0.6041.00
88_I92_L0.6011.00
94_L204_L0.5911.00
90_Y208_M0.5881.00
119_L182_I0.5851.00
96_A146_S0.5851.00
91_E94_L0.5781.00
44_L51_V0.5741.00
31_P76_E0.5721.00
98_A205_A0.5701.00
153_E161_R0.5681.00
35_L64_L0.5631.00
93_E185_Y0.5601.00
107_Q111_E0.5591.00
131_I181_H0.5561.00
94_L197_K0.5561.00
149_P152_C0.5551.00
88_I91_E0.5551.00
38_K41_A0.5541.00
23_Q26_I0.5531.00
112_L145_R0.5521.00
136_R140_L0.5501.00
56_L60_S0.5471.00
20_L40_L0.5471.00
80_R149_P0.5431.00
14_L18_N0.5431.00
106_P193_K0.5421.00
210_Q213_A0.5371.00
92_L155_I0.5361.00
100_A142_I0.5361.00
164_P168_Y0.5361.00
97_V142_I0.5331.00
112_L116_L0.5301.00
81_Q149_P0.5291.00
25_S63_A0.5281.00
73_T76_E0.5271.00
42_E45_G0.5261.00
112_L115_L0.5241.00
29_L35_L0.5221.00
188_L191_A0.5211.00
153_E156_E0.5161.00
184_N206_E0.5161.00
87_R91_E0.5131.00
192_L200_C0.5131.00
183_E186_H0.5111.00
99_L146_S0.5101.00
81_Q161_R0.5081.00
75_P164_P0.5081.00
87_R90_Y0.5071.00
177_E180_E0.5061.00
204_L208_M0.5061.00
123_Q126_G0.5051.00
206_E209_Q0.5051.00
177_E214_I0.5041.00
36_I69_A0.5031.00
38_K48_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hs5A 1 0.9367 100 0.114 Contact Map
3sxyA 2 0.905 100 0.118 Contact Map
3c7jA 4 0.9774 100 0.118 Contact Map
3ihuA 1 0.9231 100 0.124 Contact Map
4p9fA 1 0.9548 100 0.125 Contact Map
4p96A 2 0.9683 100 0.153 Contact Map
2di3A 2 0.9457 100 0.173 Contact Map
1hw1A 2 0.9276 100 0.195 Contact Map
3ic7A 2 0.4977 99.8 0.522 Contact Map
3by6A 2 0.5566 99.8 0.529 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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