GREMLIN Database
CURA - NADPH-dependent curcumin reductase
UniProt: P76113 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13772
Length: 345 (300)
Sequences: 52489 (36368)
Seq/√Len: 2099.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
320_N323_Q3.0611.00
46_V122_N2.9521.00
44_R83_V2.8841.00
46_V81_R2.8191.00
42_L83_V2.7241.00
171_K197_D2.6781.00
41_V113_L2.6761.00
152_T176_R2.5901.00
121_Q124_S2.5791.00
95_W116_L2.4741.00
94_D115_K2.4461.00
316_D327_G2.4411.00
210_Q213_K2.3901.00
91_Q94_D2.3561.00
176_R198_V2.3401.00
44_R81_R2.3111.00
33_V105_Y2.2361.00
123_P315_T2.2161.00
44_R105_Y2.2101.00
78_T101_G2.2021.00
89_D110_G2.1551.00
187_C191_T2.1221.00
301_Q305_E2.1101.00
153_L170_G2.1081.00
317_G320_N2.0771.00
148_K151_E2.0321.00
167_G196_F2.0091.00
37_G40_Q2.0081.00
188_R193_V1.9891.00
315_T340_R1.9891.00
314_I327_G1.9851.00
79_V122_N1.9841.00
119_H304_K1.9771.00
78_T98_G1.9291.00
35_T84_E1.9291.00
151_E243_R1.9031.00
326_I330_K1.8941.00
95_W122_N1.8761.00
205_D210_Q1.8421.00
134_G165_T1.8411.00
184_A188_R1.8241.00
18_H29_E1.8191.00
154_V180_V1.8151.00
323_Q326_I1.7991.00
42_L107_I1.7961.00
154_V219_I1.7931.00
83_V105_Y1.7911.00
316_D324_T1.7761.00
59_S329_L1.7741.00
188_R191_T1.7521.00
178_V219_I1.7241.00
220_D239_N1.7191.00
187_C199_C1.7131.00
116_L122_N1.7091.00
238_L244_I1.6831.00
327_G332_K1.6621.00
181_A187_C1.6571.00
323_Q327_G1.6391.00
198_V214_A1.6341.00
172_L307_K1.6141.00
184_A201_D1.6121.00
85_S92_S1.6121.00
156_A234_V1.5921.00
90_Y115_K1.5811.00
36_P107_I1.5801.00
243_R278_R1.5801.00
206_D209_E1.5761.00
189_H193_V1.5761.00
145_G221_I1.5661.00
123_P340_R1.5361.00
40_Q109_S1.5291.00
84_E92_S1.5181.00
167_G179_G1.5111.00
102_W325_F1.4961.00
201_D204_A1.4931.00
238_L277_I1.4851.00
184_A204_A1.4791.00
42_L105_Y1.4741.00
243_R280_Q1.4731.00
45_T78_T1.4701.00
238_L242_A1.4661.00
182_G202_H1.4431.00
90_Y94_D1.4411.00
81_R95_W1.4341.00
36_P42_L1.4271.00
95_W118_D1.4261.00
313_E327_G1.4141.00
39_G109_S1.4071.00
116_L127_L1.4041.00
40_Q107_I1.4011.00
82_V90_Y1.3901.00
222_Y234_V1.3721.00
47_Y123_P1.3561.00
322_P326_I1.3501.00
222_Y238_L1.3461.00
176_R197_D1.3161.00
41_V90_Y1.3001.00
152_T178_V1.2991.00
58_M325_F1.2981.00
159_T179_G1.2951.00
42_L84_E1.2901.00
209_E213_K1.2741.00
81_R122_N1.2611.00
47_Y340_R1.2481.00
21_P25_N1.2451.00
156_A180_V1.2381.00
166_V223_Y1.2301.00
36_P40_Q1.2301.00
143_D298_E1.2291.00
301_Q304_K1.2271.00
147_P175_C1.2201.00
172_L302_W1.2171.00
90_Y113_L1.1931.00
143_D295_F1.1911.00
33_V42_L1.1741.00
43_L80_S1.1621.00
159_T181_A1.1611.00
191_T199_C1.1551.00
46_V95_W1.1481.00
187_C201_D1.1431.00
39_G110_G1.1431.00
152_T220_D1.1401.00
179_G196_F1.1321.00
191_T198_V1.1191.00
21_P27_R1.1161.00
83_V92_S1.1091.00
168_Q309_H1.0991.00
210_Q214_A1.0941.00
321_A339_I1.0931.00
45_T106_D1.0931.00
145_G245_P1.0921.00
108_S113_L1.0891.00
124_S309_H1.0861.00
298_E301_Q1.0811.00
18_H27_R1.0791.00
293_H297_R1.0761.00
50_L324_T1.0681.00
184_A187_C1.0661.00
28_L319_E1.0531.00
58_M329_L1.0451.00
151_E220_D1.0441.00
47_Y122_N1.0371.00
22_V25_N1.0361.00
46_V79_V1.0321.00
137_A169_I1.0311.00
183_G201_D1.0281.00
139_M295_F1.0251.00
51_D76_G1.0251.00
302_W307_K1.0241.00
189_H334_F1.0201.00
272_V279_L1.0181.00
206_D210_Q1.0171.00
144_I278_R1.0161.00
51_D77_G1.0161.00
182_G203_H1.0151.00
43_L96_V1.0081.00
226_V230_V1.0041.00
102_W321_A1.0011.00
317_G340_R0.9971.00
236_P271_T0.9901.00
48_L102_W0.9891.00
297_R301_Q0.9811.00
147_P151_E0.9731.00
137_A166_V0.9721.00
140_G247_C0.9651.00
178_V198_V0.9611.00
327_G337_V0.9601.00
48_L101_G0.9531.00
208_A236_P0.9511.00
134_G299_M0.9471.00
33_V84_E0.9451.00
182_G187_C0.9451.00
167_G177_V0.9431.00
204_A210_Q0.9421.00
224_E227_G0.9381.00
47_Y338_V0.9341.00
44_R104_D0.9271.00
215_C218_G0.9221.00
169_I299_M0.9221.00
72_G99_Y0.9181.00
170_G175_C0.9181.00
155_V166_V0.9171.00
55_R328_L0.9061.00
155_V170_G0.9051.00
180_V202_H0.8961.00
102_W339_I0.8941.00
120_P127_L0.8911.00
208_A233_A0.8901.00
193_V309_H0.8901.00
87_H110_G0.8881.00
211_L219_I0.8861.00
130_L303_V0.8861.00
326_I329_L0.8861.00
49_S77_G0.8831.00
35_T42_L0.8831.00
181_A199_C0.8821.00
156_A222_Y0.8821.00
138_Y298_E0.8811.00
91_Q115_K0.8811.00
232_D236_P0.8731.00
33_V83_V0.8721.00
36_P86_N0.8721.00
39_G86_N0.8661.00
164_A189_H0.8641.00
78_T106_D0.8541.00
154_V237_L0.8521.00
152_T219_I0.8471.00
233_A236_P0.8441.00
328_L337_V0.8431.00
179_G190_A0.8371.00
178_V200_L0.8361.00
271_T275_K0.8271.00
185_E188_R0.8261.00
140_G223_Y0.8261.00
241_S276_R0.8241.00
208_A212_A0.8241.00
186_K334_F0.8201.00
28_L318_L0.8151.00
190_A196_F0.8141.00
31_D99_Y0.8111.00
21_P29_E0.8111.00
151_E221_I0.8101.00
124_S311_R0.8071.00
50_L328_L0.8051.00
97_L300_G0.8041.00
169_I302_W0.8041.00
141_L170_G0.8031.00
294_E298_E0.8011.00
178_V211_L0.8001.00
88_P110_G0.7991.00
298_E302_W0.7981.00
272_V281_G0.7951.00
85_S88_P0.7951.00
137_A162_V0.7951.00
209_E212_A0.7941.00
140_G166_V0.7941.00
135_F295_F0.7941.00
183_G186_K0.7911.00
50_L102_W0.7871.00
36_P39_G0.7831.00
272_V277_I0.7741.00
37_G107_I0.7721.00
147_P221_I0.7721.00
207_F233_A0.7691.00
118_D304_K0.7681.00
36_P84_E0.7681.00
144_I280_Q0.7661.00
51_D54_M0.7631.00
316_D320_N0.7601.00
120_P303_V0.7591.00
159_T190_A0.7581.00
137_A165_T0.7541.00
206_D233_A0.7541.00
302_W305_E0.7531.00
31_D73_V0.7521.00
170_G177_V0.7491.00
85_S91_Q0.7481.00
53_Y76_G0.7481.00
178_V214_A0.7441.00
153_L175_C0.7411.00
17_P25_N0.7401.00
51_D132_M0.7381.00
41_V110_G0.7371.00
77_G132_M0.7361.00
152_T217_K0.7351.00
208_A237_L0.7341.00
314_I323_Q0.7341.00
234_V244_I0.7301.00
139_M276_R0.7281.00
333_N337_V0.7271.00
96_V113_L0.7271.00
98_G108_S0.7241.00
222_Y244_I0.7241.00
327_G330_K0.7231.00
177_V197_D0.7231.00
316_D339_I0.7171.00
302_W306_D0.7161.00
294_E297_R0.7161.00
21_P24_E0.7151.00
114_V297_R0.7131.00
225_N247_C0.7101.00
217_K239_N0.7081.00
155_V179_G0.7041.00
169_I173_K0.7021.00
312_E315_T0.7021.00
221_I245_P0.7011.00
117_G304_K0.6991.00
76_G132_M0.6931.00
219_I222_Y0.6931.00
212_A215_C0.6901.00
173_K298_E0.6891.00
97_L116_L0.6791.00
101_G106_D0.6771.00
316_D337_V0.6751.00
52_P56_G0.6741.00
114_V296_Q0.6721.00
181_A190_A0.6711.00
137_A141_L0.6711.00
314_I337_V0.6681.00
211_L237_L0.6651.00
114_V300_G0.6651.00
231_F244_I0.6641.00
97_L131_G0.6631.00
146_Q280_Q0.6631.00
146_Q243_R0.6631.00
156_A230_V0.6611.00
138_Y299_M0.6611.00
24_E326_I0.6601.00
20_A70_I0.6571.00
212_A218_G0.6571.00
95_W119_H0.6561.00
79_V116_L0.6551.00
187_C190_A0.6551.00
175_C221_I0.6541.00
138_Y302_W0.6521.00
34_A107_I0.6491.00
146_Q278_R0.6451.00
257_E268_L0.6441.00
41_V82_V0.6431.00
136_T162_V0.6431.00
240_T275_K0.6421.00
19_G27_R0.6401.00
79_V95_W0.6401.00
37_G86_N0.6361.00
132_M136_T0.6351.00
47_Y315_T0.6341.00
89_D115_K0.6331.00
43_L98_G0.6331.00
51_D133_P0.6311.00
300_G304_K0.6301.00
133_P161_P0.6301.00
198_V210_Q0.6301.00
171_K177_V0.6291.00
145_G243_R0.6281.00
129_V338_V0.6231.00
167_G194_L0.6221.00
229_K232_D0.6181.00
94_D118_D0.6181.00
219_I237_L0.6181.00
28_L321_A0.6181.00
89_D293_H0.6171.00
39_G111_D0.6151.00
187_C202_H0.6141.00
167_G190_A0.6131.00
47_Y79_V0.6121.00
181_A202_H0.6121.00
189_H311_R0.6111.00
53_Y57_R0.6101.00
246_V279_L0.6101.00
19_G25_N0.6081.00
34_A42_L0.6071.00
116_L128_G0.6061.00
89_D92_S0.6041.00
189_H194_L0.6041.00
164_A311_R0.6031.00
325_F329_L0.6021.00
224_E244_I0.6011.00
138_Y295_F0.6001.00
46_V340_R0.5991.00
45_T48_L0.5961.00
56_G61_E0.5951.00
168_Q194_L0.5951.00
69_D72_G0.5901.00
200_L205_D0.5901.00
222_Y237_L0.5891.00
253_Y268_L0.5891.00
271_T277_I0.5881.00
180_V200_L0.5881.00
207_F211_L0.5861.00
34_A105_Y0.5861.00
221_I243_R0.5841.00
38_E86_N0.5831.00
200_L214_A0.5831.00
181_A201_D0.5811.00
85_S94_D0.5791.00
230_V234_V0.5771.00
88_P91_Q0.5771.00
159_T167_G0.5761.00
303_V310_Y0.5741.00
51_D336_K0.5711.00
166_V247_C0.5701.00
224_E248_G0.5691.00
55_R329_L0.5681.00
133_P165_T0.5671.00
165_T169_I0.5661.00
327_G333_N0.5661.00
98_G113_L0.5661.00
149_E173_K0.5641.00
153_L221_I0.5641.00
193_V311_R0.5641.00
141_L169_I0.5631.00
45_T101_G0.5621.00
33_V107_I0.5591.00
79_V128_G0.5581.00
143_D173_K0.5571.00
178_V215_C0.5551.00
110_G113_L0.5531.00
271_T274_K0.5531.00
43_L113_L0.5521.00
114_V293_H0.5521.00
190_A199_C0.5511.00
39_G85_S0.5501.00
140_G282_F0.5501.00
52_P160_G0.5501.00
33_V36_P0.5501.00
171_K196_F0.5501.00
136_T247_C0.5491.00
154_V222_Y0.5491.00
273_L281_G0.5491.00
303_V308_I0.5481.00
53_Y56_G0.5481.00
68_V72_G0.5461.00
181_A186_K0.5461.00
85_S90_Y0.5451.00
268_L271_T0.5381.00
17_P21_P0.5371.00
26_F325_F0.5351.00
152_T215_C0.5341.00
75_V102_W0.5331.00
159_T186_K0.5301.00
73_V100_S0.5301.00
245_P282_F0.5301.00
48_L339_I0.5291.00
270_A273_L0.5291.00
23_P326_I0.5291.00
17_P20_A0.5281.00
32_D35_T0.5271.00
45_T98_G0.5251.00
90_Y110_G0.5241.00
143_D294_E0.5241.00
306_D309_H0.5221.00
156_A207_F0.5211.00
138_Y173_K0.5201.00
17_P72_G0.5191.00
98_G106_D0.5181.00
129_V310_Y0.5181.00
131_G296_Q0.5171.00
87_H90_Y0.5161.00
43_L78_T0.5151.00
55_R59_S0.5131.00
150_G175_C0.5121.00
116_L120_P0.5101.00
316_D323_Q0.5091.00
165_T168_Q0.5091.00
200_L207_F0.5081.00
324_T339_I0.5031.00
182_G201_D0.5011.00
200_L210_Q0.5011.00
90_Y96_V0.5011.00
282_F286_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gi2A 2 0.9449 100 0.235 Contact Map
3nx4A 2 0.9043 100 0.236 Contact Map
3uogA 4 0.8986 100 0.236 Contact Map
4j6fA 2 0.9275 100 0.239 Contact Map
1yb5A 3 0.913 100 0.239 Contact Map
4a27A 2 0.8783 100 0.242 Contact Map
4dupA 2 0.9304 100 0.242 Contact Map
3ukoA 4 0.9188 100 0.244 Contact Map
4jxkA 2 0.913 100 0.251 Contact Map
1tt7A 5 0.9188 100 0.253 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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