GREMLIN Database
MNAT - L-amino acid N-acyltransferase MnaT
UniProt: P76112 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13770
Length: 172 (158)
Sequences: 12879 (10040)
Seq/√Len: 798.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_R57_E2.8251.00
138_V141_Q2.7231.00
98_R133_S2.7181.00
105_I136_F2.3061.00
66_A104_L2.2941.00
132_Q138_V2.2851.00
98_R134_L2.2041.00
139_T159_Q2.1491.00
118_A131_H2.1361.00
4_R10_D2.1201.00
141_Q156_T1.9321.00
20_H88_H1.9171.00
114_H144_Q1.9081.00
105_I160_L1.9021.00
68_F108_A1.8571.00
138_V156_T1.8571.00
147_T152_W1.8211.00
129_H132_Q1.8151.00
103_R106_D1.8151.00
122_S154_D1.8031.00
105_I116_M1.7991.00
63_T91_H1.7671.00
58_E63_T1.7371.00
102_S134_L1.6911.00
20_H89_P1.6661.00
128_L138_V1.5591.00
81_V113_K1.5291.00
128_L158_M1.5281.00
141_Q154_D1.5091.00
8_K44_E1.4981.00
13_A16_E1.4971.00
12_A36_A1.4951.00
114_H152_W1.4881.00
36_A40_I1.4731.00
6_A14_I1.4651.00
122_S156_T1.4601.00
128_L132_Q1.4411.00
143_P159_Q1.3881.00
98_R102_S1.3851.00
108_A116_M1.3711.00
61_V88_H1.3631.00
55_V62_V1.3541.00
88_H91_H1.3531.00
83_H101_L1.3531.00
101_L134_L1.3511.00
13_A62_V1.3481.00
115_V159_Q1.3461.00
54_L103_R1.3341.00
56_S96_L1.3321.00
138_V158_M1.3211.00
119_G155_L1.3201.00
92_Q126_A1.3151.00
109_R160_L1.3111.00
137_V143_P1.2911.00
8_K40_I1.2841.00
107_E110_D1.2671.00
106_D110_D1.2541.00
66_A100_L1.2481.00
91_H94_K1.2471.00
103_R107_E1.2461.00
127_S131_H1.2441.00
58_E94_K1.2361.00
35_D38_N1.2261.00
87_V96_L1.2161.00
120_I131_H1.2141.00
142_M157_F1.2091.00
57_E60_G1.2021.00
145_V155_L1.1981.00
58_E91_H1.1981.00
99_K103_R1.1881.00
128_L156_T1.1801.00
64_G87_V1.1741.00
107_E111_C1.1581.00
61_V90_D1.1561.00
122_S141_Q1.1501.00
13_A61_V1.1441.00
123_Q153_L1.1411.00
15_A36_A1.1381.00
17_I62_V1.1311.00
144_Q161_Q1.1261.00
115_V161_Q1.1191.00
15_A19_N1.1121.00
115_V139_T1.1031.00
61_V91_H1.0951.00
6_A55_V1.0841.00
85_V131_H1.0821.00
115_V145_V1.0791.00
12_A16_E1.0721.00
125_Q129_H1.0721.00
39_R42_W1.0571.00
87_V97_G1.0381.00
120_I128_L1.0291.00
118_A127_S1.0281.00
80_T117_V1.0201.00
96_L99_K1.0111.00
139_T143_P1.0111.00
11_C43_F1.0061.00
130_L134_L1.0021.00
5_F107_E1.0011.00
68_F104_L0.9981.00
114_H147_T0.9971.00
89_P92_Q0.9851.00
40_I44_E0.9831.00
54_L107_E0.9821.00
20_H24_Y0.9771.00
144_Q154_D0.9731.00
16_E88_H0.9701.00
37_D40_I0.9621.00
41_A45_A0.9561.00
81_V116_M0.8981.00
85_V127_S0.8921.00
56_S100_L0.8921.00
17_I86_Y0.8891.00
19_N23_L0.8821.00
142_M145_V0.8741.00
118_A158_M0.8741.00
125_Q128_L0.8691.00
52_P107_E0.8691.00
65_Y86_Y0.8581.00
24_Y89_P0.8571.00
121_E153_L0.8561.00
57_E62_V0.8521.00
105_I134_L0.8511.00
16_E20_H0.8401.00
93_G126_A0.8201.00
120_I158_M0.8201.00
82_E119_G0.8091.00
21_A25_T0.8071.00
54_L57_E0.8001.00
11_C15_A0.7931.00
67_S84_S0.7901.00
17_I88_H0.7891.00
95_G98_R0.7851.00
19_N34_V0.7821.00
20_H90_D0.7791.00
143_P154_D0.7681.00
58_E61_V0.7661.00
63_T96_L0.7611.00
83_H116_M0.7591.00
39_R43_F0.7531.00
8_K11_C0.7491.00
119_G142_M0.7391.00
15_A39_R0.7391.00
22_V25_T0.7361.00
26_A153_L0.7241.00
11_C36_A0.7171.00
132_Q158_M0.7161.00
80_T145_V0.7101.00
41_A44_E0.7101.00
53_V67_S0.7081.00
79_H147_T0.7081.00
101_L130_L0.6991.00
119_G157_F0.6941.00
3_I100_L0.6931.00
30_N34_V0.6921.00
125_Q132_Q0.6881.00
34_V39_R0.6861.00
102_S106_D0.6781.00
114_H161_Q0.6701.00
129_H133_S0.6681.00
13_A88_H0.6551.00
85_V101_L0.6551.00
105_I109_R0.6531.00
16_E61_V0.6511.00
28_I31_D0.6481.00
75_D78_R0.6431.00
10_D57_E0.6421.00
18_Y86_Y0.6411.00
81_V108_A0.6401.00
120_I127_S0.6371.00
79_H152_W0.6361.00
23_L26_A0.6351.00
85_V104_L0.6311.00
22_V89_P0.6291.00
22_V26_A0.6271.00
134_L160_L0.6261.00
124_N127_S0.6231.00
3_I99_K0.6221.00
13_A17_I0.6211.00
143_P161_Q0.6181.00
68_F81_V0.6161.00
123_Q151_R0.6151.00
108_A113_K0.6091.00
93_G129_H0.6051.00
148_K151_R0.6051.00
126_A129_H0.5991.00
37_D41_A0.5981.00
136_F160_L0.5951.00
20_H23_L0.5941.00
43_F47_T0.5921.00
82_E117_V0.5901.00
147_T151_R0.5891.00
83_H118_A0.5861.00
101_L131_H0.5861.00
101_L118_A0.5811.00
49_A52_P0.5811.00
11_C40_I0.5801.00
85_V97_G0.5771.00
56_S63_T0.5731.00
122_S153_L0.5711.00
144_Q152_W0.5701.00
42_W46_R0.5691.00
148_K153_L0.5681.00
139_T142_M0.5671.00
97_G130_L0.5651.00
106_D109_R0.5631.00
3_I54_L0.5631.00
26_A149_F0.5581.00
127_S130_L0.5551.00
34_V38_N0.5541.00
11_C14_I0.5461.00
70_D113_K0.5461.00
38_N41_A0.5441.00
137_V159_Q0.5441.00
35_D39_R0.5421.00
80_T115_V0.5411.00
39_R47_T0.5401.00
146_G155_L0.5371.00
53_V56_S0.5351.00
56_S64_G0.5341.00
20_H92_Q0.5331.00
14_I62_V0.5321.00
31_D34_V0.5311.00
36_A39_R0.5301.00
64_G100_L0.5281.00
69_G84_S0.5241.00
30_N42_W0.5211.00
3_I103_R0.5191.00
6_A53_V0.5181.00
40_I43_F0.5171.00
46_R69_G0.5151.00
71_W117_V0.5141.00
65_Y84_S0.5141.00
117_V145_V0.5101.00
99_K102_S0.5101.00
117_V142_M0.5021.00
147_T150_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j8mA 2 0.9826 100 0.221 Contact Map
3dr6A 2 0.9942 100 0.229 Contact Map
4j3gA 2 0.9419 100 0.261 Contact Map
3pzjA 2 0.9535 99.9 0.302 Contact Map
3r9fA 1 0.9244 99.9 0.304 Contact Map
2jlmA 3 0.9942 99.9 0.305 Contact Map
1nslA 3 0.9419 99.9 0.306 Contact Map
1s7kA 2 0.843 99.9 0.307 Contact Map
4mbuA 2 0.9477 99.9 0.308 Contact Map
1vhsA 1 0.9477 99.9 0.308 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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