GREMLIN Database
YDCO - Inner membrane protein YdcO
UniProt: P76103 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13758
Length: 391 (376)
Sequences: 972 (613)
Seq/√Len: 31.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_T172_A4.8371.00
355_V374_A4.7651.00
101_N255_L4.6381.00
99_V215_A4.5931.00
91_N205_D4.5291.00
63_L292_A4.4031.00
157_V176_I4.3351.00
356_T371_G4.2251.00
57_S71_T4.1461.00
99_V211_S4.1441.00
235_K240_S4.1201.00
107_C219_F4.1011.00
351_V374_A3.6621.00
123_S345_E3.6231.00
59_L292_A3.6181.00
92_E205_D3.4481.00
351_V378_C3.4301.00
101_N254_A3.0441.00
90_L202_I2.8181.00
137_G354_L2.8071.00
39_T42_Q2.7041.00
135_R139_Q2.6621.00
53_A257_F2.5961.00
286_Q289_L2.5431.00
67_V241_A2.4670.99
207_S210_H2.4310.99
25_S50_L2.4230.99
60_T63_L2.3830.99
59_L295_G2.3240.99
161_T165_A2.3170.99
92_E207_S2.2600.99
63_L291_A2.2200.99
15_F297_F2.2050.99
152_G156_L2.1560.98
151_C322_M2.0990.98
15_F19_L2.0920.98
10_T281_H2.0870.98
358_S367_S2.0140.98
36_A85_L1.9750.97
61_L249_F1.9530.97
332_I350_V1.9500.97
49_A260_F1.9250.97
231_I243_V1.9220.97
237_A276_Q1.8980.97
60_T64_W1.8950.97
211_S215_A1.8770.96
153_S180_I1.8570.96
55_G295_G1.8480.96
38_A263_Y1.8220.96
165_A172_A1.8150.96
77_G218_L1.8000.95
206_F211_S1.7940.95
17_A21_G1.7800.95
220_L288_W1.7710.95
220_L300_L1.7240.94
105_V109_I1.7090.94
21_G50_L1.6500.93
53_A265_V1.6500.93
102_A377_V1.6470.93
180_I184_Q1.6370.92
149_T208_F1.6230.92
10_T289_L1.6150.92
278_P282_P1.6130.92
88_L214_V1.6030.91
17_A275_C1.6020.91
89_T92_E1.6010.91
88_L210_H1.6010.91
51_G263_Y1.5950.91
105_V251_G1.5930.91
141_F355_V1.5820.91
206_F260_F1.5510.90
223_M227_N1.5070.89
235_K241_A1.5040.89
42_Q200_T1.4930.88
105_V255_L1.4920.88
33_A46_W1.4700.87
333_G350_V1.4690.87
100_T104_I1.4640.87
56_V299_L1.4480.87
256_V259_P1.4450.87
147_Q186_D1.4400.86
153_S157_V1.4310.86
75_T270_I1.4210.86
134_L138_L1.4110.85
70_L291_A1.4080.85
134_L357_A1.4050.85
335_S340_L1.4030.85
41_A200_T1.4000.85
25_S54_M1.3810.84
33_A43_I1.3790.84
94_I202_I1.3780.84
70_L294_A1.3740.84
71_T250_T1.3730.84
21_G97_F1.3730.84
148_F152_G1.3710.83
107_C223_M1.3630.83
296_I300_L1.3450.82
57_S253_L1.3350.82
27_A82_V1.3320.82
65_Y242_P1.3310.82
80_L221_V1.3260.81
157_V172_A1.3240.81
21_G25_S1.3050.80
108_G251_G1.3010.80
146_G318_S1.3010.80
137_G332_I1.2810.79
25_S28_I1.2800.79
141_F155_L1.2800.79
26_A47_M1.2450.77
124_L376_G1.2450.77
109_I112_L1.2420.77
55_G299_L1.2320.76
51_G54_M1.2070.75
177_G185_G1.2070.75
75_T78_A1.1910.74
111_G137_G1.1880.73
237_A280_A1.1880.73
43_I148_F1.1790.73
224_A232_A1.1760.73
90_L94_I1.1740.73
181_V319_W1.1540.71
158_W347_D1.1490.71
199_P302_G1.1490.71
187_V288_W1.1390.70
33_A136_F1.1390.70
276_Q280_A1.1370.70
222_T266_G1.1360.70
302_G308_I1.1340.70
78_A93_A1.1330.70
100_T219_F1.1240.69
208_F211_S1.1210.69
115_R124_L1.1210.69
159_L255_L1.1150.69
147_Q318_S1.1120.68
210_H215_A1.1020.68
144_L155_L1.0880.67
300_L304_F1.0800.66
75_T250_T1.0800.66
47_M276_Q1.0770.66
379_Y383_N1.0750.66
102_A255_L1.0730.66
297_F300_L1.0710.65
105_V248_V1.0640.65
262_V281_H1.0560.64
196_P376_G1.0560.64
211_S302_G1.0530.64
14_G23_A1.0440.63
48_T199_P1.0430.63
103_L219_F1.0400.63
72_A298_Y1.0370.63
222_T264_S1.0350.63
376_G380_V1.0350.63
167_R241_A1.0320.63
225_S250_T1.0280.62
345_E348_A1.0270.62
24_S50_L1.0210.62
207_S211_S1.0190.62
168_Y257_F1.0150.61
50_L54_M1.0130.61
28_I332_I1.0120.61
246_L371_G1.0100.61
155_L326_L1.0080.61
100_T264_S1.0060.60
141_F354_L1.0020.60
44_S158_W0.9930.59
140_A329_L0.9870.59
159_L351_V0.9820.59
135_R236_A0.9770.58
46_W111_G0.9720.58
144_L152_G0.9710.58
105_V202_I0.9680.57
174_M177_G0.9610.57
234_M241_A0.9600.57
293_V297_F0.9600.57
339_A351_V0.9530.56
292_A295_G0.9520.56
169_A281_H0.9510.56
255_L259_P0.9500.56
110_T192_V0.9490.56
40_T377_V0.9480.56
144_L361_T0.9450.56
32_A46_W0.9420.55
124_L331_T0.9410.55
81_L264_S0.9330.55
106_L341_H0.9300.54
175_I286_Q0.9260.54
98_I102_A0.9220.54
176_I279_E0.9220.54
109_I248_V0.9210.54
154_M177_G0.9200.54
17_A58_T0.9200.54
91_N94_I0.9180.53
106_L115_R0.9170.53
75_T129_L0.9160.53
39_T89_T0.9150.53
183_A300_L0.9130.53
9_P288_W0.9120.53
345_E379_Y0.9120.53
49_A355_V0.9120.53
219_F223_M0.9070.53
55_G296_I0.9050.52
58_T291_A0.9030.52
32_A177_G0.9000.52
222_T227_N0.8940.52
153_S176_I0.8920.51
70_L276_Q0.8910.51
243_V254_A0.8890.51
285_D341_H0.8870.51
56_V60_T0.8850.51
96_V210_H0.8810.50
46_W137_G0.8810.50
360_L367_S0.8790.50
43_I264_S0.8750.50
276_Q291_A0.8710.50
74_S221_V0.8700.50
13_A167_R0.8670.49
55_G59_L0.8660.49
21_G54_M0.8660.49
183_A373_I0.8650.49
64_W233_A0.8640.49
337_Y346_R0.8600.49
80_L128_M0.8600.49
96_V211_S0.8580.49
160_A183_A0.8560.48
250_T339_A0.8550.48
98_I164_V0.8540.48
159_L377_V0.8520.48
241_A245_P0.8500.48
187_V320_I0.8490.48
21_G38_A0.8490.48
160_A164_V0.8490.48
106_L109_I0.8480.48
336_L340_L0.8430.47
22_Y51_G0.8420.47
102_A115_R0.8420.47
348_A363_V0.8380.47
101_N105_V0.8370.47
11_L296_I0.8350.47
281_H286_Q0.8260.46
48_T302_G0.8230.46
360_L363_V0.8220.46
16_L310_G0.8210.46
115_R119_I0.8200.45
18_V71_T0.8190.45
254_A326_L0.8180.45
8_P12_L0.8160.45
125_A228_A0.8140.45
129_L270_I0.8120.45
172_A175_I0.8100.45
91_N200_T0.8080.45
210_H289_L0.8080.45
21_G225_S0.8060.44
132_I312_M0.8050.44
65_Y245_P0.8050.44
136_F162_K0.8050.44
51_G276_Q0.8010.44
148_F363_V0.7970.44
140_A306_S0.7960.44
75_T97_F0.7950.43
73_W226_Q0.7950.43
104_I219_F0.7920.43
19_L23_A0.7910.43
122_H341_H0.7880.43
25_S51_G0.7860.43
143_S220_L0.7850.43
128_M158_W0.7850.43
147_Q150_L0.7840.43
136_F140_A0.7840.43
46_W177_G0.7820.42
183_A365_I0.7800.42
124_L216_L0.7790.42
23_A271_T0.7780.42
243_V356_T0.7770.42
138_L377_V0.7770.42
241_A362_L0.7710.42
86_Q89_T0.7700.41
38_A222_T0.7690.41
24_S321_Q0.7690.41
306_S343_E0.7680.41
210_H214_V0.7670.41
257_F305_G0.7650.41
175_I320_I0.7650.41
170_V263_Y0.7650.41
29_I58_T0.7570.40
57_S250_T0.7530.40
203_T240_S0.7520.40
82_V194_F0.7510.40
348_A378_C0.7490.40
66_R247_I0.7440.39
98_I216_L0.7440.39
176_I314_A0.7430.39
90_L308_I0.7400.39
170_V173_A0.7390.39
224_A246_L0.7380.39
342_N345_E0.7350.39
101_N258_S0.7280.38
46_W136_F0.7280.38
23_A281_H0.7270.38
78_A264_S0.7260.38
128_M264_S0.7260.38
289_L293_V0.7220.38
299_L303_L0.7190.38
80_L127_A0.7170.37
296_I361_T0.7140.37
78_A227_N0.7130.37
252_L256_V0.7120.37
209_A360_L0.7090.37
284_K377_V0.7080.37
73_W76_P0.7080.37
331_T340_L0.7080.37
72_A275_C0.7070.37
142_A274_I0.7020.36
58_T70_L0.7020.36
229_P269_A0.7000.36
15_F164_V0.6940.36
237_A281_H0.6920.35
156_L377_V0.6920.35
128_M221_V0.6910.35
163_A382_L0.6900.35
293_V330_S0.6890.35
246_L249_F0.6880.35
35_V329_L0.6870.35
104_I223_M0.6870.35
219_F227_N0.6860.35
157_V178_I0.6860.35
138_L303_L0.6860.35
10_T288_W0.6840.35
221_V272_A0.6830.35
129_L229_P0.6830.35
106_L354_L0.6810.35
182_I216_L0.6810.35
329_L350_V0.6800.35
24_S331_T0.6800.35
89_T205_D0.6780.34
224_A227_N0.6780.34
129_L269_A0.6770.34
17_A336_L0.6750.34
75_T222_T0.6740.34
20_I328_L0.6730.34
376_G379_Y0.6710.34
20_I222_T0.6710.34
14_G305_G0.6680.34
271_T356_T0.6660.34
201_Y259_P0.6660.34
155_L322_M0.6600.33
36_A39_T0.6590.33
60_T372_L0.6580.33
13_A352_A0.6580.33
33_A140_A0.6570.33
154_M173_A0.6560.33
142_A341_H0.6540.33
271_T371_G0.6490.32
98_I265_V0.6490.32
66_R286_Q0.6490.32
189_T192_V0.6490.32
213_S368_A0.6480.32
56_V208_F0.6460.32
53_A271_T0.6460.32
210_H307_A0.6450.32
30_W154_M0.6450.32
15_F43_I0.6450.32
309_T335_S0.6450.32
231_I279_E0.6440.32
152_G341_H0.6440.32
51_G331_T0.6420.32
228_A301_A0.6420.32
128_M372_L0.6420.32
44_S169_A0.6400.32
59_L203_T0.6390.32
269_A272_A0.6390.32
157_V207_S0.6380.32
233_A273_A0.6380.32
131_G357_A0.6360.31
21_G51_G0.6350.31
151_C228_A0.6350.31
84_G89_T0.6340.31
124_L268_A0.6340.31
75_T219_F0.6330.31
75_T225_S0.6320.31
97_F227_N0.6320.31
357_A362_L0.6320.31
21_G24_S0.6310.31
340_L360_L0.6300.31
22_Y39_T0.6300.31
115_R149_T0.6300.31
230_G272_A0.6270.31
188_V373_I0.6260.31
277_S281_H0.6260.31
44_S197_V0.6260.31
97_F225_S0.6260.31
213_S361_T0.6250.31
218_L267_I0.6250.31
136_F154_M0.6230.31
60_T365_I0.6230.31
168_Y199_P0.6230.31
17_A50_L0.6220.30
54_M71_T0.6210.30
179_V198_L0.6200.30
192_V195_K0.6200.30
38_A202_I0.6180.30
139_Q142_A0.6180.30
193_V344_R0.6170.30
182_I323_L0.6170.30
50_L60_T0.6160.30
175_I220_L0.6150.30
323_L371_G0.6130.30
85_L116_L0.6120.30
29_I50_L0.6120.30
272_A328_L0.6120.30
353_F366_G0.6120.30
25_S219_F0.6110.30
25_S228_A0.6100.30
107_C113_F0.6100.30
11_L361_T0.6100.30
58_T243_V0.6080.29
89_T278_P0.6070.29
78_A222_T0.6060.29
80_L215_A0.6060.29
123_S344_R0.6050.29
23_A355_V0.6030.29
50_L103_L0.5990.29
20_I225_S0.5990.29
181_V315_L0.5990.29
22_Y128_M0.5970.29
179_V256_V0.5970.29
39_T149_T0.5970.29
116_L123_S0.5970.29
159_L242_P0.5970.29
214_V237_A0.5970.29
209_A296_I0.5960.29
362_L373_I0.5950.29
146_G203_T0.5950.29
284_K362_L0.5940.29
114_A118_R0.5940.29
56_V377_V0.5940.29
31_Q150_L0.5930.28
136_F325_G0.5930.28
195_K362_L0.5890.28
335_S378_C0.5890.28
138_L326_L0.5880.28
86_Q214_V0.5880.28
179_V277_S0.5860.28
207_S345_E0.5830.28
102_A207_S0.5830.28
101_N251_G0.5830.28
26_A315_L0.5820.28
38_A90_L0.5810.28
309_T336_L0.5810.28
46_W140_A0.5800.28
66_R117_M0.5800.28
44_S305_G0.5770.27
32_A43_I0.5770.27
8_P57_S0.5760.27
188_V192_V0.5740.27
124_L372_L0.5720.27
267_I319_W0.5710.27
148_F257_F0.5710.27
292_A340_L0.5710.27
56_V209_A0.5710.27
25_S97_F0.5710.27
263_Y276_Q0.5710.27
46_W92_E0.5710.27
340_L350_V0.5690.27
80_L85_L0.5690.27
43_I146_G0.5680.27
28_I231_I0.5680.27
49_A218_L0.5680.27
263_Y331_T0.5670.27
151_C218_L0.5670.27
63_L66_R0.5660.27
120_I243_V0.5650.27
117_M135_R0.5640.27
52_L253_L0.5610.26
124_L378_C0.5600.26
56_V341_H0.5590.26
171_I330_S0.5590.26
216_L256_V0.5570.26
262_V329_L0.5560.26
101_N212_L0.5550.26
229_P352_A0.5550.26
133_L287_R0.5550.26
150_L180_I0.5540.26
175_I189_T0.5540.26
215_A341_H0.5520.26
46_W110_T0.5520.26
165_A313_A0.5510.26
110_T113_F0.5510.26
258_S267_I0.5510.26
38_A85_L0.5490.26
17_A70_L0.5490.26
25_S38_A0.5480.26
129_L266_G0.5480.26
34_I286_Q0.5480.26
178_I363_V0.5480.26
255_L300_L0.5470.26
157_V174_M0.5460.25
144_L148_F0.5460.25
106_L196_P0.5460.25
163_A378_C0.5450.25
81_L214_V0.5440.25
41_A208_F0.5440.25
365_I369_F0.5420.25
8_P66_R0.5380.25
31_Q113_F0.5380.25
106_L216_L0.5380.25
284_K319_W0.5380.25
174_M356_T0.5370.25
293_V296_I0.5360.25
26_A134_L0.5360.25
151_C371_G0.5360.25
111_G244_S0.5320.25
18_V325_G0.5310.25
255_L377_V0.5310.25
203_T260_F0.5290.24
170_V351_V0.5280.24
197_V302_G0.5270.24
194_F365_I0.5260.24
161_T381_V0.5250.24
178_I329_L0.5250.24
109_I249_F0.5240.24
89_T321_Q0.5240.24
22_Y36_A0.5230.24
174_M318_S0.5230.24
226_Q230_G0.5230.24
369_F378_C0.5230.24
34_I211_S0.5220.24
71_T298_Y0.5210.24
39_T155_L0.5210.24
332_I336_L0.5210.24
54_M57_S0.5200.24
22_Y126_A0.5190.24
338_Q377_V0.5190.24
110_T285_D0.5180.24
340_L349_A0.5170.24
305_G336_L0.5170.24
25_S47_M0.5160.24
254_A263_Y0.5150.24
262_V294_A0.5150.24
223_M339_A0.5150.24
109_I372_L0.5130.23
175_I252_L0.5130.23
151_C376_G0.5130.23
36_A81_L0.5130.23
216_L330_S0.5120.23
257_F274_I0.5120.23
105_V124_L0.5110.23
92_E111_G0.5100.23
299_L348_A0.5080.23
226_Q271_T0.5060.23
132_I382_L0.5060.23
56_V291_A0.5060.23
172_A241_A0.5060.23
376_G381_V0.5060.23
106_L377_V0.5050.23
222_T272_A0.5050.23
22_Y222_T0.5040.23
37_G78_A0.5030.23
142_A145_D0.5020.23
151_C374_A0.5020.23
8_P291_A0.5020.23
78_A263_Y0.5010.23
48_T52_L0.5010.23
73_W258_S0.5000.23
144_L341_H0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.9361 100 0.793 Contact Map
2cfqA 1 0.9028 36.1 0.976 Contact Map
2onkC 2 0.2174 16.1 0.979 Contact Map
4pj0Y 1 0.0742 14 0.98 Contact Map
4humA 1 0.4859 11.5 0.981 Contact Map
2kluA 1 0.1049 11.4 0.981 Contact Map
4gc0A 1 0.2813 8.1 0.982 Contact Map
2yevB 1 0.1355 7.9 0.982 Contact Map
2nq2A 2 0.2992 7.7 0.982 Contact Map
2gsmB 1 0.1483 7 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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