GREMLIN Database
INSQ - Putative transposase InsQ for insertion sequence element IS609
UniProt: P76102 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13756
Length: 382 (336)
Sequences: 4505 (2824)
Seq/√Len: 154.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
228_D232_K5.2841.00
315_A345_N4.2051.00
250_K253_N4.1291.00
295_Q302_V3.4621.00
169_L287_M3.0181.00
245_V354_G2.9771.00
288_R304_A2.9441.00
246_I291_L2.8601.00
235_T239_K2.7301.00
286_E290_Q2.6801.00
130_V141_I2.5321.00
255_S280_L2.4391.00
188_Q277_R2.3641.00
286_E289_R2.3521.00
238_S295_Q2.3181.00
309_Y312_Q2.2911.00
312_Q324_N2.2881.00
353_A356_A2.2871.00
305_V350_I2.2721.00
287_M291_L2.2621.00
292_A304_A2.2471.00
313_R320_T2.2381.00
325_R328_Q2.2271.00
187_N225_I2.1231.00
194_L211_Q2.0981.00
332_R339_T2.0891.00
128_K146_E2.0841.00
231_H290_Q2.0761.00
244_I295_Q2.0461.00
17_A21_E1.9701.00
32_Y36_A1.9671.00
15_A63_L1.9651.00
20_N80_F1.9631.00
317_C336_C1.9451.00
231_H293_Y1.9311.00
211_Q215_I1.9101.00
234_T290_Q1.9031.00
227_R286_E1.8731.00
33_G36_A1.8731.00
317_C333_C1.8721.00
206_N209_Q1.8501.00
169_L229_Y1.8471.00
312_Q322_K1.8381.00
242_A300_G1.8361.00
310_T350_I1.8321.00
231_H294_K1.8201.00
292_A296_L1.8191.00
3_R53_D1.8101.00
333_C336_C1.7931.00
258_A276_N1.7921.00
246_I302_V1.7851.00
65_D93_R1.7621.00
314_C317_C1.7551.00
230_L290_Q1.7321.00
107_I141_I1.7321.00
316_Y338_Y1.7271.00
329_S342_A1.7261.00
231_H234_T1.7191.00
32_Y64_K1.7151.00
314_C333_C1.7041.00
314_C336_C1.6471.00
72_N78_A1.6311.00
162_L170_A1.6161.00
198_L212_K1.5961.00
331_F340_A1.5911.00
230_L286_E1.5771.00
209_Q212_K1.5731.00
16_L66_L1.5621.00
201_K211_Q1.5411.00
10_F50_W1.5231.00
246_I304_A1.5111.00
21_E25_A1.5071.00
321_A331_F1.4811.00
246_I288_R1.4811.00
57_Q96_Q1.4811.00
57_Q95_P1.4671.00
330_K339_T1.4611.00
108_F114_W1.4521.00
204_F208_W1.4471.00
257_S276_N1.4441.00
248_D304_A1.4411.00
331_F338_Y1.4301.00
321_A324_N1.4231.00
159_M351_L1.4211.00
319_H334_Q1.3991.00
67_E71_K1.3941.00
171_T344_V1.3691.00
15_A66_L1.3661.00
160_V172_L1.3531.00
234_T293_Y1.3531.00
234_T294_K1.3441.00
70_Y80_F1.3381.00
348_R352_A1.3371.00
135_S220_S1.3331.00
197_Q201_K1.3321.00
172_L176_T1.3281.00
168_K171_T1.3261.00
279_I284_W1.3151.00
292_A302_V1.3081.00
247_E307_P1.3031.00
315_A348_R1.2971.00
220_S224_N1.2931.00
326_L329_S1.2881.00
33_G37_S1.2751.00
234_T287_M1.2661.00
109_L132_V1.2511.00
138_K220_S1.2461.00
238_S298_R1.2301.00
61_Q95_P1.2301.00
20_N24_E1.2261.00
194_L197_Q1.2221.00
187_N222_I1.2171.00
136_C220_S1.2091.00
321_A334_Q1.2071.00
325_R342_A1.1951.00
19_Q35_M1.1841.00
36_A64_K1.1841.00
133_S142_S1.1771.00
162_L172_L1.1741.00
68_R72_N1.1681.00
251_V285_Y1.1661.00
191_L215_I1.1621.00
159_M243_M1.1571.00
310_T353_A1.1521.00
194_L218_L1.1501.00
321_A325_R1.1471.00
161_G351_L1.1431.00
191_L219_H1.1431.00
198_L211_Q1.1401.00
190_K194_L1.1371.00
315_A340_A1.1371.00
61_Q64_K1.1351.00
250_K307_P1.1331.00
71_K75_R1.1231.00
166_V282_Q1.1181.00
324_N328_Q1.1151.00
307_P310_T1.1040.99
39_L63_L1.0990.99
230_L287_M1.0920.99
236_A240_N1.0910.99
227_R290_Q1.0850.99
55_P58_P1.0800.99
22_N26_G1.0770.99
32_Y63_L1.0740.99
164_A284_W1.0740.99
5_A139_W1.0710.99
198_L215_I1.0700.99
12_F62_S1.0670.99
99_K108_F1.0650.99
290_Q293_Y1.0650.99
340_A348_R1.0650.99
235_T298_R1.0620.99
31_P34_K1.0600.99
238_S244_I1.0540.99
43_K59_L1.0500.99
18_R38_W1.0490.99
344_V348_R1.0450.99
36_A63_L1.0430.99
313_R353_A1.0320.99
237_V244_I1.0300.99
14_R18_R1.0290.99
294_K297_W1.0240.99
6_G9_R1.0170.99
164_A288_R1.0120.99
177_V341_N1.0090.99
106_R114_W1.0070.99
238_S300_G1.0020.99
257_S274_G1.0000.99
39_L60_Q0.9990.99
305_V353_A0.9970.99
208_W212_K0.9960.99
305_V354_G0.9940.99
234_T291_L0.9930.99
97_G110_P0.9880.99
340_A344_V0.9860.99
168_K179_E0.9790.99
93_R129_N0.9710.99
312_Q320_T0.9710.99
10_F14_R0.9690.99
230_L234_T0.9680.99
239_K298_R0.9580.98
72_N77_R0.9550.98
289_R292_A0.9540.98
57_Q61_Q0.9520.98
230_L283_G0.9350.98
8_C62_S0.9350.98
195_Q199_S0.9330.98
194_L215_I0.9310.98
315_A338_Y0.9280.98
103_E106_R0.9260.98
295_Q300_G0.9250.98
192_A195_Q0.9220.98
248_D307_P0.9220.98
319_H335_V0.9210.98
134_Q139_W0.9200.98
323_E331_F0.9120.98
329_S341_N0.9090.98
191_L222_I0.9030.98
18_R22_N0.9030.98
93_R131_T0.9020.98
159_M355_H0.9020.98
195_Q215_I0.9010.98
223_A227_R0.8940.98
245_V350_I0.8910.98
197_Q200_R0.8870.97
328_Q331_F0.8840.97
60_Q64_K0.8830.97
353_A357_V0.8800.97
37_S40_V0.8800.97
16_L70_Y0.8780.97
160_V244_I0.8770.97
328_Q342_A0.8720.97
235_T294_K0.8700.97
221_C225_I0.8690.97
255_S258_A0.8660.97
73_F80_F0.8660.97
156_S242_A0.8650.97
20_N70_Y0.8650.97
135_S138_K0.8630.97
176_T236_A0.8630.97
315_A346_G0.8620.97
39_L43_K0.8600.97
195_Q219_H0.8590.97
65_D131_T0.8560.97
132_V141_I0.8520.97
323_E328_Q0.8520.97
40_V44_N0.8500.97
285_Y289_R0.8490.97
330_K340_A0.8480.97
275_L279_I0.8470.97
19_Q67_E0.8470.97
173_S177_V0.8430.97
160_V173_S0.8410.97
15_A35_M0.8400.97
17_A83_F0.8390.97
51_L59_L0.8390.97
94_Y109_L0.8370.96
207_N210_K0.8370.96
218_L222_I0.8370.96
131_T142_S0.8350.96
204_F209_Q0.8330.96
168_K177_V0.8310.96
40_V43_K0.8290.96
72_N75_R0.8280.96
160_V241_H0.8270.96
17_A20_N0.8270.96
346_G349_N0.8270.96
183_S225_I0.8260.96
54_S57_Q0.8250.96
23_H27_N0.8240.96
164_A170_A0.8240.96
7_A50_W0.8220.96
4_F8_C0.8190.96
6_G10_F0.8180.96
212_K216_Q0.8170.96
28_K31_P0.8170.96
153_V156_S0.8150.96
255_S276_N0.8150.96
233_V236_A0.8140.96
22_N30_I0.8120.96
158_S241_H0.8090.96
171_T177_V0.8090.96
184_F188_Q0.8090.96
192_A196_R0.8080.96
18_R21_E0.8070.96
171_T178_F0.8060.96
61_Q93_R0.8060.96
229_Y233_V0.8030.96
129_N144_Q0.8020.95
348_R351_L0.7990.95
313_R349_N0.7980.95
180_P183_S0.7980.95
324_N342_A0.7980.95
76_K79_A0.7970.95
159_M245_V0.7960.95
214_K217_R0.7950.95
309_Y353_A0.7930.95
198_L208_W0.7890.95
325_R329_S0.7880.95
170_A233_V0.7850.95
166_V278_S0.7820.95
258_A274_G0.7820.95
315_A352_A0.7810.95
183_S187_N0.7770.95
191_L199_S0.7650.94
184_F187_N0.7630.94
344_V347_A0.7590.94
106_R116_R0.7590.94
90_D134_Q0.7580.94
158_S174_D0.7570.94
36_A40_V0.7570.94
64_K95_P0.7560.94
57_Q60_Q0.7540.94
193_R197_Q0.7510.94
316_Y348_R0.7500.94
15_A39_L0.7480.93
180_P282_Q0.7470.93
248_D288_R0.7470.93
158_S242_A0.7450.93
251_V284_W0.7430.93
178_F233_V0.7420.93
98_V102_Q0.7380.93
326_L342_A0.7370.93
310_T320_T0.7350.93
58_P92_F0.7330.93
7_A10_F0.7280.93
194_L214_K0.7270.92
253_N307_P0.7240.92
163_D343_D0.7200.92
320_T324_N0.7190.92
199_S215_I0.7190.92
70_Y73_F0.7130.92
55_P94_Y0.7120.92
63_L67_E0.7120.92
57_Q97_G0.7060.91
170_A178_F0.7050.91
20_N23_H0.7050.91
244_I291_L0.7030.91
61_Q65_D0.7010.91
12_F66_L0.7000.91
243_M301_Q0.6980.91
157_A242_A0.6980.91
167_A171_T0.6970.91
32_Y35_M0.6950.91
345_N349_N0.6950.91
3_R7_A0.6940.91
7_A54_S0.6940.91
224_N227_R0.6930.91
191_L195_Q0.6920.91
21_E24_E0.6910.90
205_S208_W0.6890.90
26_G29_Y0.6880.90
40_V56_S0.6860.90
331_F342_A0.6850.90
187_N218_L0.6850.90
73_F81_P0.6760.90
239_K243_M0.6720.89
187_N221_C0.6710.89
138_K224_N0.6700.89
4_F92_F0.6680.89
32_Y40_V0.6680.89
196_R200_R0.6670.89
119_N122_Q0.6660.89
201_K207_N0.6630.89
4_F54_S0.6610.88
66_L70_Y0.6610.88
170_A287_M0.6580.88
303_L354_G0.6580.88
23_H70_Y0.6570.88
109_L115_M0.6550.88
10_F48_T0.6530.88
313_R318_G0.6530.88
28_K34_K0.6530.88
70_Y74_F0.6510.88
107_I130_V0.6500.88
201_K205_S0.6460.87
174_D241_H0.6450.87
198_L201_K0.6450.87
185_Q277_R0.6440.87
219_H226_R0.6430.87
340_A345_N0.6430.87
321_A328_Q0.6420.87
35_M38_W0.6410.87
59_L62_S0.6410.87
19_Q29_Y0.6410.87
249_L307_P0.6400.87
290_Q294_K0.6380.87
34_K37_S0.6380.87
243_M303_L0.6380.87
177_V344_V0.6370.87
38_W42_W0.6370.87
149_V296_L0.6340.86
14_R50_W0.6320.86
5_A8_C0.6310.86
99_K102_Q0.6310.86
126_V146_E0.6300.86
197_Q211_Q0.6300.86
241_H300_G0.6280.86
245_V303_L0.6270.86
23_H26_G0.6240.85
350_I353_A0.6230.85
92_F96_Q0.6230.85
11_V62_S0.6220.85
155_P158_S0.6220.85
102_Q105_S0.6210.85
164_A251_V0.6200.85
312_Q321_A0.6190.85
69_A81_P0.6180.85
41_E44_N0.6150.85
98_V110_P0.6140.85
209_Q213_R0.6140.85
178_F229_Y0.6130.84
22_N27_N0.6120.84
293_Y297_W0.6110.84
317_C321_A0.6090.84
309_Y313_R0.6090.84
192_A199_S0.6060.84
91_A95_P0.6060.84
173_S344_V0.6050.84
169_L282_Q0.6030.83
14_R17_A0.6030.83
295_Q298_R0.6000.83
252_S285_Y0.6000.83
308_A312_Q0.5990.83
18_R35_M0.5980.83
309_Y320_T0.5970.83
226_R281_D0.5940.83
117_Y120_S0.5900.82
19_Q22_N0.5900.82
224_N228_D0.5900.82
30_I35_M0.5870.82
22_N28_K0.5870.82
208_W215_I0.5860.82
352_A357_V0.5840.81
313_R331_F0.5830.81
222_I226_R0.5830.81
167_A341_N0.5830.81
197_Q214_K0.5810.81
121_R124_T0.5810.81
165_G171_T0.5780.81
283_G286_E0.5770.81
258_A280_L0.5760.81
254_M279_I0.5760.81
56_S95_P0.5750.80
24_E27_N0.5750.80
63_L66_L0.5750.80
11_V59_L0.5740.80
87_G90_D0.5740.80
19_Q30_I0.5720.80
319_H323_E0.5690.80
94_Y98_V0.5690.80
166_V255_S0.5690.80
17_A24_E0.5680.80
56_S96_Q0.5680.80
249_L254_M0.5670.80
153_V300_G0.5670.80
3_R54_S0.5650.79
186_K189_K0.5650.79
196_R199_S0.5640.79
62_S66_L0.5640.79
54_S59_L0.5630.79
29_Y35_M0.5620.79
19_Q23_H0.5580.78
57_Q94_Y0.5570.78
14_R42_W0.5560.78
219_H223_A0.5560.78
352_A355_H0.5500.77
187_N191_L0.5490.77
167_A329_S0.5490.77
12_F69_A0.5480.77
306_P309_Y0.5470.77
55_P97_G0.5470.77
184_F277_R0.5470.77
135_S140_Y0.5460.77
4_F55_P0.5460.77
285_Y288_R0.5450.77
125_G143_I0.5450.77
313_R322_K0.5440.77
222_I281_D0.5440.77
310_T349_N0.5430.77
245_V351_L0.5430.77
19_Q70_Y0.5430.77
169_L234_T0.5430.77
332_R338_Y0.5430.77
324_N329_S0.5420.76
112_L115_M0.5410.76
25_A28_K0.5400.76
178_F181_V0.5390.76
193_R196_R0.5390.76
97_G100_L0.5380.76
168_K341_N0.5360.76
128_K144_Q0.5360.76
169_L230_L0.5340.75
291_L302_V0.5340.75
161_G347_A0.5340.75
227_R231_H0.5340.75
23_H74_F0.5320.75
275_L278_S0.5310.75
312_Q325_R0.5310.75
55_P92_F0.5300.75
185_Q188_Q0.5300.75
254_M257_S0.5300.75
91_A131_T0.5250.74
165_G168_K0.5250.74
4_F7_A0.5250.74
7_A51_L0.5240.74
185_Q189_K0.5230.74
316_Y340_A0.5220.74
12_F70_Y0.5190.73
288_R292_A0.5180.73
3_R6_G0.5180.73
233_V287_M0.5170.73
8_C92_F0.5160.73
245_V355_H0.5160.73
276_N280_L0.5150.73
251_V254_M0.5150.73
17_A22_N0.5140.73
351_L355_H0.5090.72
113_G116_R0.5080.72
190_K193_R0.5070.72
185_Q278_S0.5050.71
235_T290_Q0.5040.71
169_L291_L0.5020.71
94_Y97_G0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhxA 2 0.3586 94.6 0.928 Contact Map
1nu0A 1 0.3403 93.6 0.931 Contact Map
1iv0A 1 0.2539 90.3 0.937 Contact Map
1vq8Z 1 0.1728 88.5 0.939 Contact Map
4aybP 1 0.1126 87.2 0.941 Contact Map
1ffkW 1 0.1754 85.2 0.942 Contact Map
2k4xA 1 0.144 79.8 0.945 Contact Map
3j20Y 1 0.1309 78.2 0.946 Contact Map
1vd4A 1 0.1466 76.8 0.947 Contact Map
1qypA 1 0.1204 75.6 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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