INSQ - ECOLI - GREMLIN Contacts

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INSQ - Putative transposase InsQ for insertion sequence element IS609

UniProt:	P76102	Sequences: MRRFAGACRFVFNRALARQNENHEAGNKYIPYGKMASWLVEWKNATETQWLKDSPSQPLQQSLKDLERAYKNFFRKRAAFPRFKKRGQNDAFRYPQGVKLDQENSRIFLPKLGWMRYRNSRQVTGVVKNVTVSQSCGKWYISIQTESEVSTPVHPSASMVGLDAGVAKLATLSDGTVFEPVNSFQKNQKKLARLQRQLSRKVKFSNNWQKQKRKIQRLHSCIANIRRDYLHKVTTAVSKNHAMIVIEDLKVSNMSKSAAGTVSQPGRNVRAKSGLNRSILDQGWYEMRRQLAYKQLWRGGQVLAVPPAYTSQRCAYCGHTAKENRLSQSKFRCQVCGYTANADVNGARNILAAGHAVLACGEMVQSGRPLKQEPTEMIQATA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13756
Length:	382 (336)
Sequences:	4505 (2824)
Seq/√Len:	154.1

ECOLI - INSQ
HALSA - Q9HSW9 Q9HHJ9 Q9HHG8 Q9HSD4 Q9HM87 Q9HSZ6 Q9HSW7 Q9HHU6 Q9HSY4 Q9HHX8
SULSO - Q97V53 Q97XA4 Q97XQ8 Q97V25 Q97YI2 Q97V47 Q97YW4 Q97XP1 Q97Y44 Q7LXD9 Q97XB6 Q97YI5 Q97Y67 Q97U68 Q97Y48 Q97YU1 Q97XQ0 Q97U51 Q97WY6 Q97X39 Q97UQ8 Q97Z61 Q7LXH2 Q97YW9 Q97WZ3 Q7LXH6 Q97YF7 Q97U09 Q7LX59 Q7LX75 Q97YK6 Y2105 Q7LXH9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
228_D	232_K	5.284	1.00
315_A	345_N	4.205	1.00
250_K	253_N	4.129	1.00
295_Q	302_V	3.462	1.00
169_L	287_M	3.018	1.00
245_V	354_G	2.977	1.00
288_R	304_A	2.944	1.00
246_I	291_L	2.860	1.00
235_T	239_K	2.730	1.00
286_E	290_Q	2.680	1.00
130_V	141_I	2.532	1.00
255_S	280_L	2.439	1.00
188_Q	277_R	2.364	1.00
286_E	289_R	2.352	1.00
238_S	295_Q	2.318	1.00
309_Y	312_Q	2.291	1.00
312_Q	324_N	2.288	1.00
353_A	356_A	2.287	1.00
305_V	350_I	2.272	1.00
287_M	291_L	2.262	1.00
292_A	304_A	2.247	1.00
313_R	320_T	2.238	1.00
325_R	328_Q	2.227	1.00
187_N	225_I	2.123	1.00
194_L	211_Q	2.098	1.00
332_R	339_T	2.089	1.00
128_K	146_E	2.084	1.00
231_H	290_Q	2.076	1.00
244_I	295_Q	2.046	1.00
17_A	21_E	1.970	1.00
32_Y	36_A	1.967	1.00
15_A	63_L	1.965	1.00
20_N	80_F	1.963	1.00
317_C	336_C	1.945	1.00
231_H	293_Y	1.931	1.00
211_Q	215_I	1.910	1.00
234_T	290_Q	1.903	1.00
227_R	286_E	1.873	1.00
33_G	36_A	1.873	1.00
317_C	333_C	1.872	1.00
206_N	209_Q	1.850	1.00
169_L	229_Y	1.847	1.00
312_Q	322_K	1.838	1.00
242_A	300_G	1.836	1.00
310_T	350_I	1.832	1.00
231_H	294_K	1.820	1.00
292_A	296_L	1.819	1.00
3_R	53_D	1.810	1.00
333_C	336_C	1.793	1.00
258_A	276_N	1.792	1.00
246_I	302_V	1.785	1.00
65_D	93_R	1.762	1.00
314_C	317_C	1.755	1.00
230_L	290_Q	1.732	1.00
107_I	141_I	1.732	1.00
316_Y	338_Y	1.727	1.00
329_S	342_A	1.726	1.00
231_H	234_T	1.719	1.00
32_Y	64_K	1.715	1.00
314_C	333_C	1.704	1.00
314_C	336_C	1.647	1.00
72_N	78_A	1.631	1.00
162_L	170_A	1.616	1.00
198_L	212_K	1.596	1.00
331_F	340_A	1.591	1.00
230_L	286_E	1.577	1.00
209_Q	212_K	1.573	1.00
16_L	66_L	1.562	1.00
201_K	211_Q	1.541	1.00
10_F	50_W	1.523	1.00
246_I	304_A	1.511	1.00
21_E	25_A	1.507	1.00
321_A	331_F	1.481	1.00
246_I	288_R	1.481	1.00
57_Q	96_Q	1.481	1.00
57_Q	95_P	1.467	1.00
330_K	339_T	1.461	1.00
108_F	114_W	1.452	1.00
204_F	208_W	1.447	1.00
257_S	276_N	1.444	1.00
248_D	304_A	1.441	1.00
331_F	338_Y	1.430	1.00
321_A	324_N	1.423	1.00
159_M	351_L	1.421	1.00
319_H	334_Q	1.399	1.00
67_E	71_K	1.394	1.00
171_T	344_V	1.369	1.00
15_A	66_L	1.366	1.00
160_V	172_L	1.353	1.00
234_T	293_Y	1.353	1.00
234_T	294_K	1.344	1.00
70_Y	80_F	1.338	1.00
348_R	352_A	1.337	1.00
135_S	220_S	1.333	1.00
197_Q	201_K	1.332	1.00
172_L	176_T	1.328	1.00
168_K	171_T	1.326	1.00
279_I	284_W	1.315	1.00
292_A	302_V	1.308	1.00
247_E	307_P	1.303	1.00
315_A	348_R	1.297	1.00
220_S	224_N	1.293	1.00
326_L	329_S	1.288	1.00
33_G	37_S	1.275	1.00
234_T	287_M	1.266	1.00
109_L	132_V	1.251	1.00
138_K	220_S	1.246	1.00
238_S	298_R	1.230	1.00
61_Q	95_P	1.230	1.00
20_N	24_E	1.226	1.00
194_L	197_Q	1.222	1.00
187_N	222_I	1.217	1.00
136_C	220_S	1.209	1.00
321_A	334_Q	1.207	1.00
325_R	342_A	1.195	1.00
19_Q	35_M	1.184	1.00
36_A	64_K	1.184	1.00
133_S	142_S	1.177	1.00
162_L	172_L	1.174	1.00
68_R	72_N	1.168	1.00
251_V	285_Y	1.166	1.00
191_L	215_I	1.162	1.00
159_M	243_M	1.157	1.00
310_T	353_A	1.152	1.00
194_L	218_L	1.150	1.00
321_A	325_R	1.147	1.00
161_G	351_L	1.143	1.00
191_L	219_H	1.143	1.00
198_L	211_Q	1.140	1.00
190_K	194_L	1.137	1.00
315_A	340_A	1.137	1.00
61_Q	64_K	1.135	1.00
250_K	307_P	1.133	1.00
71_K	75_R	1.123	1.00
166_V	282_Q	1.118	1.00
324_N	328_Q	1.115	1.00
307_P	310_T	1.104	0.99
39_L	63_L	1.099	0.99
230_L	287_M	1.092	0.99
236_A	240_N	1.091	0.99
227_R	290_Q	1.085	0.99
55_P	58_P	1.080	0.99
22_N	26_G	1.077	0.99
32_Y	63_L	1.074	0.99
164_A	284_W	1.074	0.99
5_A	139_W	1.071	0.99
198_L	215_I	1.070	0.99
12_F	62_S	1.067	0.99
99_K	108_F	1.065	0.99
290_Q	293_Y	1.065	0.99
340_A	348_R	1.065	0.99
235_T	298_R	1.062	0.99
31_P	34_K	1.060	0.99
238_S	244_I	1.054	0.99
43_K	59_L	1.050	0.99
18_R	38_W	1.049	0.99
344_V	348_R	1.045	0.99
36_A	63_L	1.043	0.99
313_R	353_A	1.032	0.99
237_V	244_I	1.030	0.99
14_R	18_R	1.029	0.99
294_K	297_W	1.024	0.99
6_G	9_R	1.017	0.99
164_A	288_R	1.012	0.99
177_V	341_N	1.009	0.99
106_R	114_W	1.007	0.99
238_S	300_G	1.002	0.99
257_S	274_G	1.000	0.99
39_L	60_Q	0.999	0.99
305_V	353_A	0.997	0.99
208_W	212_K	0.996	0.99
305_V	354_G	0.994	0.99
234_T	291_L	0.993	0.99
97_G	110_P	0.988	0.99
340_A	344_V	0.986	0.99
168_K	179_E	0.979	0.99
93_R	129_N	0.971	0.99
312_Q	320_T	0.971	0.99
10_F	14_R	0.969	0.99
230_L	234_T	0.968	0.99
239_K	298_R	0.958	0.98
72_N	77_R	0.955	0.98
289_R	292_A	0.954	0.98
57_Q	61_Q	0.952	0.98
230_L	283_G	0.935	0.98
8_C	62_S	0.935	0.98
195_Q	199_S	0.933	0.98
194_L	215_I	0.931	0.98
315_A	338_Y	0.928	0.98
103_E	106_R	0.926	0.98
295_Q	300_G	0.925	0.98
192_A	195_Q	0.922	0.98
248_D	307_P	0.922	0.98
319_H	335_V	0.921	0.98
134_Q	139_W	0.920	0.98
323_E	331_F	0.912	0.98
329_S	341_N	0.909	0.98
191_L	222_I	0.903	0.98
18_R	22_N	0.903	0.98
93_R	131_T	0.902	0.98
159_M	355_H	0.902	0.98
195_Q	215_I	0.901	0.98
223_A	227_R	0.894	0.98
245_V	350_I	0.891	0.98
197_Q	200_R	0.887	0.97
328_Q	331_F	0.884	0.97
60_Q	64_K	0.883	0.97
353_A	357_V	0.880	0.97
37_S	40_V	0.880	0.97
16_L	70_Y	0.878	0.97
160_V	244_I	0.877	0.97
328_Q	342_A	0.872	0.97
235_T	294_K	0.870	0.97
221_C	225_I	0.869	0.97
255_S	258_A	0.866	0.97
73_F	80_F	0.866	0.97
156_S	242_A	0.865	0.97
20_N	70_Y	0.865	0.97
135_S	138_K	0.863	0.97
176_T	236_A	0.863	0.97
315_A	346_G	0.862	0.97
39_L	43_K	0.860	0.97
195_Q	219_H	0.859	0.97
65_D	131_T	0.856	0.97
132_V	141_I	0.852	0.97
323_E	328_Q	0.852	0.97
40_V	44_N	0.850	0.97
285_Y	289_R	0.849	0.97
330_K	340_A	0.848	0.97
275_L	279_I	0.847	0.97
19_Q	67_E	0.847	0.97
173_S	177_V	0.843	0.97
160_V	173_S	0.841	0.97
15_A	35_M	0.840	0.97
17_A	83_F	0.839	0.97
51_L	59_L	0.839	0.97
94_Y	109_L	0.837	0.96
207_N	210_K	0.837	0.96
218_L	222_I	0.837	0.96
131_T	142_S	0.835	0.96
204_F	209_Q	0.833	0.96
168_K	177_V	0.831	0.96
40_V	43_K	0.829	0.96
72_N	75_R	0.828	0.96
160_V	241_H	0.827	0.96
17_A	20_N	0.827	0.96
346_G	349_N	0.827	0.96
183_S	225_I	0.826	0.96
54_S	57_Q	0.825	0.96
23_H	27_N	0.824	0.96
164_A	170_A	0.824	0.96
7_A	50_W	0.822	0.96
4_F	8_C	0.819	0.96
6_G	10_F	0.818	0.96
212_K	216_Q	0.817	0.96
28_K	31_P	0.817	0.96
153_V	156_S	0.815	0.96
255_S	276_N	0.815	0.96
233_V	236_A	0.814	0.96
22_N	30_I	0.812	0.96
158_S	241_H	0.809	0.96
171_T	177_V	0.809	0.96
184_F	188_Q	0.809	0.96
192_A	196_R	0.808	0.96
18_R	21_E	0.807	0.96
171_T	178_F	0.806	0.96
61_Q	93_R	0.806	0.96
229_Y	233_V	0.803	0.96
129_N	144_Q	0.802	0.95
348_R	351_L	0.799	0.95
313_R	349_N	0.798	0.95
180_P	183_S	0.798	0.95
324_N	342_A	0.798	0.95
76_K	79_A	0.797	0.95
159_M	245_V	0.796	0.95
214_K	217_R	0.795	0.95
309_Y	353_A	0.793	0.95
198_L	208_W	0.789	0.95
325_R	329_S	0.788	0.95
170_A	233_V	0.785	0.95
166_V	278_S	0.782	0.95
258_A	274_G	0.782	0.95
315_A	352_A	0.781	0.95
183_S	187_N	0.777	0.95
191_L	199_S	0.765	0.94
184_F	187_N	0.763	0.94
344_V	347_A	0.759	0.94
106_R	116_R	0.759	0.94
90_D	134_Q	0.758	0.94
158_S	174_D	0.757	0.94
36_A	40_V	0.757	0.94
64_K	95_P	0.756	0.94
57_Q	60_Q	0.754	0.94
193_R	197_Q	0.751	0.94
316_Y	348_R	0.750	0.94
15_A	39_L	0.748	0.93
180_P	282_Q	0.747	0.93
248_D	288_R	0.747	0.93
158_S	242_A	0.745	0.93
251_V	284_W	0.743	0.93
178_F	233_V	0.742	0.93
98_V	102_Q	0.738	0.93
326_L	342_A	0.737	0.93
310_T	320_T	0.735	0.93
58_P	92_F	0.733	0.93
7_A	10_F	0.728	0.93
194_L	214_K	0.727	0.92
253_N	307_P	0.724	0.92
163_D	343_D	0.720	0.92
320_T	324_N	0.719	0.92
199_S	215_I	0.719	0.92
70_Y	73_F	0.713	0.92
55_P	94_Y	0.712	0.92
63_L	67_E	0.712	0.92
57_Q	97_G	0.706	0.91
170_A	178_F	0.705	0.91
20_N	23_H	0.705	0.91
244_I	291_L	0.703	0.91
61_Q	65_D	0.701	0.91
12_F	66_L	0.700	0.91
243_M	301_Q	0.698	0.91
157_A	242_A	0.698	0.91
167_A	171_T	0.697	0.91
32_Y	35_M	0.695	0.91
345_N	349_N	0.695	0.91
3_R	7_A	0.694	0.91
7_A	54_S	0.694	0.91
224_N	227_R	0.693	0.91
191_L	195_Q	0.692	0.91
21_E	24_E	0.691	0.90
205_S	208_W	0.689	0.90
26_G	29_Y	0.688	0.90
40_V	56_S	0.686	0.90
331_F	342_A	0.685	0.90
187_N	218_L	0.685	0.90
73_F	81_P	0.676	0.90
239_K	243_M	0.672	0.89
187_N	221_C	0.671	0.89
138_K	224_N	0.670	0.89
4_F	92_F	0.668	0.89
32_Y	40_V	0.668	0.89
196_R	200_R	0.667	0.89
119_N	122_Q	0.666	0.89
201_K	207_N	0.663	0.89
4_F	54_S	0.661	0.88
66_L	70_Y	0.661	0.88
170_A	287_M	0.658	0.88
303_L	354_G	0.658	0.88
23_H	70_Y	0.657	0.88
109_L	115_M	0.655	0.88
10_F	48_T	0.653	0.88
313_R	318_G	0.653	0.88
28_K	34_K	0.653	0.88
70_Y	74_F	0.651	0.88
107_I	130_V	0.650	0.88
201_K	205_S	0.646	0.87
174_D	241_H	0.645	0.87
198_L	201_K	0.645	0.87
185_Q	277_R	0.644	0.87
219_H	226_R	0.643	0.87
340_A	345_N	0.643	0.87
321_A	328_Q	0.642	0.87
35_M	38_W	0.641	0.87
59_L	62_S	0.641	0.87
19_Q	29_Y	0.641	0.87
249_L	307_P	0.640	0.87
290_Q	294_K	0.638	0.87
34_K	37_S	0.638	0.87
243_M	303_L	0.638	0.87
177_V	344_V	0.637	0.87
38_W	42_W	0.637	0.87
149_V	296_L	0.634	0.86
14_R	50_W	0.632	0.86
5_A	8_C	0.631	0.86
99_K	102_Q	0.631	0.86
126_V	146_E	0.630	0.86
197_Q	211_Q	0.630	0.86
241_H	300_G	0.628	0.86
245_V	303_L	0.627	0.86
23_H	26_G	0.624	0.85
350_I	353_A	0.623	0.85
92_F	96_Q	0.623	0.85
11_V	62_S	0.622	0.85
155_P	158_S	0.622	0.85
102_Q	105_S	0.621	0.85
164_A	251_V	0.620	0.85
312_Q	321_A	0.619	0.85
69_A	81_P	0.618	0.85
41_E	44_N	0.615	0.85
98_V	110_P	0.614	0.85
209_Q	213_R	0.614	0.85
178_F	229_Y	0.613	0.84
22_N	27_N	0.612	0.84
293_Y	297_W	0.611	0.84
317_C	321_A	0.609	0.84
309_Y	313_R	0.609	0.84
192_A	199_S	0.606	0.84
91_A	95_P	0.606	0.84
173_S	344_V	0.605	0.84
169_L	282_Q	0.603	0.83
14_R	17_A	0.603	0.83
295_Q	298_R	0.600	0.83
252_S	285_Y	0.600	0.83
308_A	312_Q	0.599	0.83
18_R	35_M	0.598	0.83
309_Y	320_T	0.597	0.83
226_R	281_D	0.594	0.83
117_Y	120_S	0.590	0.82
19_Q	22_N	0.590	0.82
224_N	228_D	0.590	0.82
30_I	35_M	0.587	0.82
22_N	28_K	0.587	0.82
208_W	215_I	0.586	0.82
352_A	357_V	0.584	0.81
313_R	331_F	0.583	0.81
222_I	226_R	0.583	0.81
167_A	341_N	0.583	0.81
197_Q	214_K	0.581	0.81
121_R	124_T	0.581	0.81
165_G	171_T	0.578	0.81
283_G	286_E	0.577	0.81
258_A	280_L	0.576	0.81
254_M	279_I	0.576	0.81
56_S	95_P	0.575	0.80
24_E	27_N	0.575	0.80
63_L	66_L	0.575	0.80
11_V	59_L	0.574	0.80
87_G	90_D	0.574	0.80
19_Q	30_I	0.572	0.80
319_H	323_E	0.569	0.80
94_Y	98_V	0.569	0.80
166_V	255_S	0.569	0.80
17_A	24_E	0.568	0.80
56_S	96_Q	0.568	0.80
249_L	254_M	0.567	0.80
153_V	300_G	0.567	0.80
3_R	54_S	0.565	0.79
186_K	189_K	0.565	0.79
196_R	199_S	0.564	0.79
62_S	66_L	0.564	0.79
54_S	59_L	0.563	0.79
29_Y	35_M	0.562	0.79
19_Q	23_H	0.558	0.78
57_Q	94_Y	0.557	0.78
14_R	42_W	0.556	0.78
219_H	223_A	0.556	0.78
352_A	355_H	0.550	0.77
187_N	191_L	0.549	0.77
167_A	329_S	0.549	0.77
12_F	69_A	0.548	0.77
306_P	309_Y	0.547	0.77
55_P	97_G	0.547	0.77
184_F	277_R	0.547	0.77
135_S	140_Y	0.546	0.77
4_F	55_P	0.546	0.77
285_Y	288_R	0.545	0.77
125_G	143_I	0.545	0.77
313_R	322_K	0.544	0.77
222_I	281_D	0.544	0.77
310_T	349_N	0.543	0.77
245_V	351_L	0.543	0.77
19_Q	70_Y	0.543	0.77
169_L	234_T	0.543	0.77
332_R	338_Y	0.543	0.77
324_N	329_S	0.542	0.76
112_L	115_M	0.541	0.76
25_A	28_K	0.540	0.76
178_F	181_V	0.539	0.76
193_R	196_R	0.539	0.76
97_G	100_L	0.538	0.76
168_K	341_N	0.536	0.76
128_K	144_Q	0.536	0.76
169_L	230_L	0.534	0.75
291_L	302_V	0.534	0.75
161_G	347_A	0.534	0.75
227_R	231_H	0.534	0.75
23_H	74_F	0.532	0.75
275_L	278_S	0.531	0.75
312_Q	325_R	0.531	0.75
55_P	92_F	0.530	0.75
185_Q	188_Q	0.530	0.75
254_M	257_S	0.530	0.75
91_A	131_T	0.525	0.74
165_G	168_K	0.525	0.74
4_F	7_A	0.525	0.74
7_A	51_L	0.524	0.74
185_Q	189_K	0.523	0.74
316_Y	340_A	0.522	0.74
12_F	70_Y	0.519	0.73
288_R	292_A	0.518	0.73
3_R	6_G	0.518	0.73
233_V	287_M	0.517	0.73
8_C	92_F	0.516	0.73
245_V	355_H	0.516	0.73
276_N	280_L	0.515	0.73
251_V	254_M	0.515	0.73
17_A	22_N	0.514	0.73
351_L	355_H	0.509	0.72
113_G	116_R	0.508	0.72
190_K	193_R	0.507	0.72
185_Q	278_S	0.505	0.71
235_T	290_Q	0.504	0.71
169_L	291_L	0.502	0.71
94_Y	97_G	0.500	0.71

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vhxA	2	0.3586	94.6	0.928	Contact Map
1nu0A	1	0.3403	93.6	0.931	Contact Map
1iv0A	1	0.2539	90.3	0.937	Contact Map
1vq8Z	1	0.1728	88.5	0.939	Contact Map
4aybP	1	0.1126	87.2	0.941	Contact Map
1ffkW	1	0.1754	85.2	0.942	Contact Map
2k4xA	1	0.144	79.8	0.945	Contact Map
3j20Y	1	0.1309	78.2	0.946	Contact Map
1vd4A	1	0.1466	76.8	0.947	Contact Map
1qypA	1	0.1204	75.6	0.948	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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