GREMLIN Database
YNBA - Inner membrane protein YnbA
UniProt: P76090 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13748
Length: 201 (182)
Sequences: 2153 (1504)
Seq/√Len: 111.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_T30_H4.4031.00
22_Y75_L3.6651.00
28_A81_Q3.5131.00
26_V34_A3.1611.00
36_L93_G2.8921.00
96_I184_L2.8151.00
20_W24_H2.6931.00
18_M78_E2.6331.00
85_L195_L2.4601.00
39_S97_S2.4491.00
45_L61_V2.4021.00
31_I75_L2.2261.00
158_W175_L2.1611.00
21_L26_V2.1551.00
122_C184_L2.0241.00
74_M78_E2.0071.00
46_L159_G1.9961.00
106_L116_V1.9701.00
43_G104_P1.8971.00
95_V98_D1.8911.00
119_M180_S1.8801.00
19_F78_E1.7771.00
40_L100_A1.7731.00
69_N90_N1.7711.00
95_V148_K1.7181.00
144_G186_T1.6901.00
18_M75_L1.6591.00
21_L71_L1.6541.00
35_A68_L1.6501.00
22_Y79_C1.6491.00
106_L117_I1.5981.00
157_L161_A1.5871.00
131_L134_Q1.5861.00
46_L104_P1.5671.00
43_G100_A1.5511.00
146_F182_L1.5421.00
49_A55_F1.5401.00
87_A132_L1.5121.00
88_I129_C1.4971.00
96_I122_C1.4821.00
45_L57_L1.4821.00
98_D151_R1.4781.00
91_E132_L1.4661.00
29_N85_L1.4601.00
41_L61_V1.4541.00
99_I121_F1.4541.00
20_W23_K1.4481.00
192_R195_L1.3981.00
95_V128_F1.3961.00
144_G190_R1.3711.00
188_I192_R1.3661.00
126_T186_T1.3531.00
11_Q74_M1.3421.00
146_F154_I1.3371.00
59_P156_G1.3181.00
18_M74_M1.3000.99
39_S65_R1.2980.99
47_M104_P1.2960.99
116_V176_W1.2750.99
44_L48_L1.2720.99
33_L89_L1.2720.99
130_G142_Y1.2700.99
186_T190_R1.2680.99
38_L61_V1.2510.99
88_I194_V1.2460.99
147_G150_D1.2360.99
98_D148_K1.2210.99
71_L74_M1.2110.99
19_F23_K1.1970.99
95_V151_R1.1940.99
91_E130_G1.1610.99
181_I185_W1.1470.99
16_P20_W1.1450.99
192_R196_L1.1340.99
91_E151_R1.1310.98
164_I167_Q1.1200.98
31_I71_L1.1060.98
92_T129_C1.0980.98
185_W188_I1.0960.98
99_I124_I1.0880.98
28_A75_L1.0820.98
144_G150_D1.0630.98
143_A193_S1.0560.98
44_L47_M1.0380.97
99_I125_L1.0370.97
37_A41_L1.0220.97
45_L54_L1.0170.97
154_I175_L1.0060.97
49_A54_L1.0040.97
148_K151_R1.0030.97
48_L54_L1.0030.97
42_T61_V1.0010.97
88_I191_C1.0000.97
134_Q140_R0.9960.97
180_S184_L0.9920.97
28_A82_Q0.9920.97
42_T101_L0.9900.96
129_C191_C0.9830.96
46_L49_A0.9770.96
66_M148_K0.9710.96
65_R148_K0.9610.96
17_T71_L0.9540.96
130_G140_R0.9510.96
127_E130_G0.9500.96
87_A136_I0.9340.95
15_R78_E0.9280.95
179_A183_L0.9250.95
146_F179_A0.9170.95
133_A137_N0.9080.94
41_L107_F0.9020.94
16_P19_F0.8970.94
126_T146_F0.8930.94
65_R90_N0.8830.93
139_V142_Y0.8770.93
128_F134_Q0.8740.93
91_E128_F0.8720.93
41_L44_L0.8650.93
66_M70_A0.8590.92
186_T189_N0.8590.92
161_A165_Y0.8560.92
27_T75_L0.8550.92
40_L48_L0.8550.92
122_C187_A0.8530.92
90_N148_K0.8500.92
128_F132_L0.8500.92
38_L60_I0.8420.92
37_A166_P0.8380.92
9_L12_S0.8380.92
88_I136_I0.8320.91
56_L164_I0.8310.91
96_I187_A0.8290.91
32_T62_L0.8240.91
83_T158_W0.8220.91
14_L74_M0.8210.91
172_N175_L0.8170.91
63_F66_M0.8160.90
12_S16_P0.8150.90
28_A46_L0.8140.90
130_G134_Q0.8070.90
10_F149_S0.8000.90
70_A149_S0.7940.89
65_R69_N0.7910.89
20_W41_L0.7880.89
125_L187_A0.7840.89
13_L16_P0.7830.89
131_L135_T0.7830.89
56_L60_I0.7760.88
178_I182_L0.7760.88
101_L152_A0.7670.88
127_E151_R0.7660.87
118_L180_S0.7610.87
65_R97_S0.7560.87
38_L68_L0.7530.87
132_L135_T0.7460.86
30_H38_L0.7450.86
41_L45_L0.7430.86
176_W179_A0.7430.86
133_A140_R0.7300.85
85_L88_I0.7280.85
180_S183_L0.7220.84
66_M156_G0.7200.84
185_W189_N0.7200.84
21_L24_H0.7200.84
85_L194_V0.7180.84
54_L57_L0.7150.84
42_T62_L0.7140.84
26_V30_H0.7110.83
32_T150_D0.7020.82
84_R157_L0.7010.82
41_L60_I0.7000.82
126_T187_A0.6950.82
46_L58_L0.6940.82
33_L37_A0.6930.82
154_I158_W0.6910.81
142_Y147_G0.6890.81
33_L192_R0.6890.81
158_W172_N0.6880.81
32_T93_G0.6870.81
11_Q18_M0.6850.81
125_L128_F0.6840.81
66_M95_V0.6840.81
157_L196_L0.6820.81
63_F156_G0.6820.81
128_F135_T0.6790.80
10_F59_P0.6780.80
30_H34_A0.6780.80
115_L177_S0.6700.79
115_L176_W0.6660.79
153_L157_L0.6600.78
69_N91_E0.6600.78
95_V102_Y0.6580.78
29_N192_R0.6580.78
69_N148_K0.6570.78
29_N81_Q0.6560.78
34_A38_L0.6530.78
46_L101_L0.6460.77
56_L160_L0.6420.77
128_F151_R0.6400.76
115_L158_W0.6380.76
57_L61_V0.6370.76
168_W173_N0.6340.76
118_L121_F0.6280.75
90_N145_P0.6280.75
23_K111_S0.6190.74
154_I179_A0.6180.74
70_A150_D0.6150.73
92_T191_C0.6150.73
21_L27_T0.6120.73
91_E95_V0.6110.73
119_M183_L0.5990.71
63_F67_A0.5980.71
89_L93_G0.5940.71
19_F160_L0.5920.71
47_M107_F0.5910.70
58_L105_F0.5890.70
88_I91_E0.5850.70
105_F116_V0.5830.69
58_L159_G0.5790.69
111_S173_N0.5790.69
61_V193_S0.5790.69
177_S181_I0.5770.69
11_Q15_R0.5760.69
122_C180_S0.5720.68
106_L178_I0.5720.68
193_S196_L0.5710.68
82_Q85_L0.5690.68
46_L54_L0.5680.67
13_L71_L0.5670.67
35_A91_E0.5610.67
110_E113_A0.5600.66
109_P112_N0.5590.66
131_L140_R0.5540.66
29_N195_L0.5540.66
91_E98_D0.5520.65
122_C129_C0.5510.65
114_S118_L0.5510.65
163_A166_P0.5460.64
133_A138_G0.5460.64
96_I183_L0.5440.64
39_S42_T0.5440.64
42_T46_L0.5410.64
10_F14_L0.5410.64
34_A54_L0.5390.63
148_K152_A0.5390.63
77_R90_N0.5380.63
35_A97_S0.5370.63
21_L31_I0.5350.63
91_E131_L0.5320.62
55_F104_P0.5270.62
144_G149_S0.5270.62
112_N115_L0.5270.62
95_V127_E0.5250.61
67_A147_G0.5250.61
59_P159_G0.5240.61
11_Q14_L0.5200.61
162_V165_Y0.5170.60
137_N140_R0.5160.60
38_L65_R0.5160.60
47_M168_W0.5140.60
92_T96_I0.5120.60
62_L88_I0.5110.59
58_L104_P0.5110.59
130_G137_N0.5090.59
69_N77_R0.5090.59
88_I133_A0.5080.59
65_R91_E0.5070.59
30_H84_R0.5050.59
140_R194_V0.5050.59
15_R19_F0.5030.58
91_E148_K0.5030.58
13_L17_T0.5030.58
19_F84_R0.5020.58
24_H79_C0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o6mA 2 0.9353 100 0.337 Contact Map
4mndA 2 0.9303 100 0.43 Contact Map
4od4A 1 0.9254 1.9 0.961 Contact Map
2dlwA 1 0.3682 1.8 0.962 Contact Map
3tx3A 2 0.9254 1.7 0.962 Contact Map
2i15A 3 0.2239 1.6 0.963 Contact Map
4tq3A 1 0.9254 1.5 0.963 Contact Map
4uf1A 2 0.1891 1.3 0.965 Contact Map
2ww9A 1 0.4229 1.3 0.965 Contact Map
3j1rA 5 0.1294 1.3 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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