GREMLIN Database
PAAX - Transcriptional repressor PaaX
UniProt: P76086 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13746
Length: 316 (264)
Sequences: 1006 (706)
Seq/√Len: 43.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_P277_A5.7801.00
196_N256_A4.7711.00
199_Y260_A4.5691.00
29_D229_Q4.1021.00
207_R259_T3.0261.00
61_L70_L2.8761.00
37_E73_S2.8111.00
251_L255_W2.7261.00
39_W78_R2.6641.00
110_W146_P2.6631.00
117_G120_K2.6011.00
112_L142_L2.5111.00
39_W42_S2.4041.00
193_T203_I2.3511.00
251_L257_G2.3231.00
199_Y243_D2.3091.00
22_L52_F2.3061.00
41_G78_R2.2991.00
106_W249_E2.2201.00
29_D268_Y2.1901.00
277_A281_E2.1671.00
191_H194_E2.0870.99
234_H237_R2.0750.99
209_L228_I2.0680.99
187_E253_A2.0490.99
23_I57_V2.0200.99
278_F281_E2.0180.99
158_H163_A1.9800.99
109_K172_Q1.9750.99
262_Q266_N1.9530.99
48_E54_E1.9180.99
88_L92_R1.9130.99
123_L127_K1.9110.99
40_L61_L1.9090.99
106_W109_K1.8700.99
114_L142_L1.8380.99
198_M242_K1.8020.98
71_D82_S1.8010.98
226_F278_F1.7770.98
112_L171_A1.7690.98
90_L240_V1.7620.98
111_L168_C1.7550.98
192_L252_P1.7270.98
116_E169_F1.7230.98
24_S64_L1.7090.98
34_R280_S1.6950.97
18_S21_S1.6950.97
227_H231_L1.6640.97
46_L226_F1.6490.97
115_S141_S1.6360.97
62_F271_V1.6230.97
196_N200_E1.5770.96
243_D251_L1.5310.95
18_S27_Y1.5210.95
113_L168_C1.5190.95
167_I188_E1.5190.95
47_L261_R1.4800.94
117_G127_K1.4550.94
44_A133_Q1.4450.94
69_W234_H1.4400.94
135_F153_V1.4370.93
237_R241_L1.3890.92
61_L72_V1.3890.92
40_L77_R1.3750.92
175_L201_T1.3620.92
153_V198_M1.3600.91
172_Q222_P1.3530.91
21_S99_Y1.3490.91
19_G69_W1.3280.90
183_R266_N1.3280.90
233_I241_L1.3260.90
106_W250_L1.3020.90
248_E258_H1.3000.89
48_E284_E1.2940.89
274_A277_A1.2930.89
146_P255_W1.2900.89
65_N189_C1.2700.88
229_Q268_Y1.2590.88
117_G124_A1.2500.88
99_Y237_R1.2380.87
187_E221_T1.2320.87
19_G59_T1.2220.86
171_A175_L1.2190.86
65_N70_L1.2070.86
20_T250_L1.2020.85
258_H262_Q1.1960.85
126_V166_V1.1890.85
49_G223_E1.1860.85
138_L189_C1.1830.84
45_A48_E1.1730.84
223_E227_H1.1730.84
129_Q160_A1.1700.84
29_D79_S1.1690.84
40_L81_Y1.1520.83
51_G223_E1.1270.81
181_A184_A1.1240.81
220_L274_A1.1170.81
49_G278_F1.1120.81
130_L135_F1.1090.80
26_L230_L1.1090.80
233_I264_C1.1070.80
214_K266_N1.1050.80
197_A221_T1.1040.80
272_A275_A1.0890.79
98_I237_R1.0880.79
117_G122_T1.0850.79
130_L202_F1.0830.79
69_W90_L1.0800.79
94_A268_Y1.0770.78
81_Y225_A1.0770.78
94_A234_H1.0680.78
23_I190_W1.0640.78
107_D132_W1.0640.78
210_V214_K1.0640.78
30_S264_C1.0590.77
135_F145_S1.0470.76
98_I238_R1.0450.76
201_T205_S1.0420.76
263_L267_I1.0390.76
194_E198_M1.0360.76
197_A201_T1.0230.75
94_A240_V1.0140.74
48_E222_P1.0140.74
29_D59_T1.0120.74
27_Y36_G1.0090.74
98_I112_L1.0040.73
29_D106_W1.0030.73
21_S38_I1.0030.73
233_I237_R1.0020.73
36_G57_V1.0020.73
85_D249_E0.9940.73
95_E98_I0.9900.72
114_L139_A0.9810.72
115_S124_A0.9800.71
200_E259_T0.9790.71
96_S100_R0.9710.71
135_F149_K0.9670.70
68_G201_T0.9600.70
71_D96_S0.9440.69
45_A197_A0.9420.68
201_T204_Q0.9400.68
233_I268_Y0.9350.68
155_T172_Q0.9200.67
64_L237_R0.9200.67
128_K171_A0.9200.67
191_H202_F0.9180.66
41_G44_A0.9140.66
85_D277_A0.9140.66
32_S46_L0.9070.65
273_P277_A0.9050.65
60_A237_R0.9040.65
66_K112_L0.9020.65
119_D122_T0.8930.64
207_R263_L0.8900.64
183_R186_V0.8890.64
197_A273_P0.8840.63
27_Y40_L0.8840.63
69_W241_L0.8830.63
200_E254_H0.8830.63
124_A236_Y0.8770.63
51_G112_L0.8680.62
115_S234_H0.8670.62
266_N270_R0.8650.62
221_T224_R0.8640.62
85_D221_T0.8630.62
46_L279_V0.8570.61
192_L246_L0.8550.61
97_K134_G0.8550.61
249_E262_Q0.8520.61
44_A132_W0.8500.60
146_P243_D0.8470.60
211_P214_K0.8460.60
113_L144_A0.8460.60
24_S27_Y0.8440.60
76_G108_G0.8430.60
82_S142_L0.8430.60
213_L220_L0.8410.60
266_N269_Q0.8400.59
136_G202_F0.8360.59
115_S128_K0.8310.59
192_L231_L0.8310.59
210_V266_N0.8280.58
154_Q163_A0.8260.58
50_L227_H0.8240.58
229_Q276_L0.8240.58
53_G138_L0.8230.58
59_T79_S0.8220.58
200_E256_A0.8190.58
59_T268_Y0.8190.58
39_W268_Y0.8170.57
91_T94_A0.8070.56
219_E281_E0.8030.56
229_Q233_I0.8030.56
91_T143_M0.8030.56
55_R62_F0.7970.55
200_E204_Q0.7970.55
41_G80_F0.7970.55
45_A49_G0.7970.55
241_L264_C0.7960.55
190_W243_D0.7940.55
120_K264_C0.7940.55
208_P263_L0.7930.55
59_T65_N0.7930.55
259_T263_L0.7910.55
38_I69_W0.7900.55
51_G129_Q0.7900.55
144_A276_L0.7870.55
243_D260_A0.7850.54
241_L257_G0.7850.54
21_S257_G0.7840.54
106_W199_Y0.7820.54
229_Q234_H0.7820.54
197_A200_E0.7750.53
155_T193_T0.7710.53
27_Y57_V0.7710.53
43_L76_G0.7700.53
252_P255_W0.7690.53
129_Q220_L0.7670.53
164_D194_E0.7660.53
267_I271_V0.7630.52
85_D151_A0.7620.52
71_D193_T0.7620.52
17_V20_T0.7620.52
77_R226_F0.7570.52
84_S198_M0.7560.52
211_P225_A0.7540.51
52_F141_S0.7440.50
81_Y271_V0.7420.50
157_L253_A0.7410.50
158_H219_E0.7400.50
27_Y167_I0.7400.50
154_Q203_I0.7370.50
164_D201_T0.7370.50
27_Y47_L0.7360.50
32_S95_E0.7330.49
32_S133_Q0.7280.49
208_P225_A0.7280.49
202_F206_F0.7260.49
43_L74_R0.7250.49
73_S262_Q0.7250.49
112_L144_A0.7230.48
192_L195_Q0.7220.48
87_G129_Q0.7200.48
234_H241_L0.7170.48
172_Q197_A0.7160.48
69_W98_I0.7140.48
155_T200_E0.7130.47
42_S45_A0.7100.47
42_S82_S0.7050.47
26_L226_F0.7020.46
55_R59_T0.7010.46
117_G123_L0.6950.46
50_L226_F0.6940.46
118_L221_T0.6890.45
136_G145_S0.6880.45
192_L257_G0.6880.45
262_Q273_P0.6880.45
133_Q250_L0.6860.45
120_K134_G0.6820.45
59_T94_A0.6820.45
53_G128_K0.6810.44
26_L280_S0.6790.44
61_L196_N0.6780.44
202_F260_A0.6760.44
35_G118_L0.6760.44
270_R274_A0.6750.44
143_M202_F0.6740.44
32_S245_L0.6710.43
153_V162_V0.6700.43
187_E193_T0.6660.43
128_K214_K0.6650.43
19_G22_L0.6590.42
85_D88_L0.6590.42
214_K218_D0.6540.42
136_G192_L0.6530.42
82_S283_G0.6510.42
85_D204_Q0.6500.42
102_E204_Q0.6470.41
207_R210_V0.6430.41
90_L129_Q0.6420.41
25_S234_H0.6410.41
172_Q277_A0.6390.40
236_Y268_Y0.6380.40
184_A200_E0.6370.40
70_L157_L0.6340.40
73_S82_S0.6330.40
123_L126_V0.6300.40
113_L166_V0.6300.40
163_A269_Q0.6270.39
195_Q239_V0.6240.39
71_D269_Q0.6240.39
276_L280_S0.6200.39
39_W206_F0.6180.39
229_Q236_Y0.6150.38
218_D281_E0.6120.38
158_H253_A0.6120.38
60_A261_R0.6120.38
129_Q156_L0.6110.38
59_T119_D0.6110.38
120_K239_V0.6090.38
102_E245_L0.6080.38
201_T259_T0.6070.38
27_Y43_L0.6060.37
211_P221_T0.6060.37
237_R264_C0.6060.37
152_D156_L0.6040.37
25_S268_Y0.6040.37
21_S185_R0.6020.37
25_S237_R0.6010.37
33_H276_L0.6000.37
56_F97_K0.5980.37
37_E44_A0.5970.37
52_F57_V0.5960.37
20_T24_S0.5930.36
84_S89_R0.5930.36
259_T277_A0.5900.36
56_F143_M0.5880.36
89_R96_S0.5860.36
243_D255_W0.5840.36
111_L135_F0.5810.35
20_T241_L0.5800.35
151_A204_Q0.5790.35
20_T56_F0.5750.35
99_Y257_G0.5740.35
40_L57_V0.5740.35
29_D233_I0.5730.35
75_I128_K0.5680.34
113_L137_A0.5670.34
230_L234_H0.5660.34
207_R211_P0.5660.34
22_L69_W0.5650.34
54_E76_G0.5640.34
52_F68_G0.5640.34
37_E80_F0.5640.34
59_T229_Q0.5640.34
158_H197_A0.5640.34
276_L283_G0.5620.34
39_W230_L0.5590.33
151_A155_T0.5590.33
43_L58_R0.5590.33
85_D207_R0.5580.33
193_T257_G0.5570.33
28_G98_I0.5560.33
81_Y162_V0.5550.33
87_G279_V0.5530.33
66_K175_L0.5520.33
61_L129_Q0.5510.33
203_I263_L0.5500.33
50_L239_V0.5480.32
136_G206_F0.5470.32
40_L55_R0.5450.32
146_P190_W0.5450.32
42_S236_Y0.5450.32
73_S164_D0.5450.32
44_A65_N0.5440.32
222_P232_L0.5430.32
60_A70_L0.5430.32
42_S171_A0.5420.32
200_E203_I0.5390.32
21_S25_S0.5390.32
144_A264_C0.5380.32
110_W182_L0.5370.32
27_Y238_R0.5350.31
84_S113_L0.5340.31
98_I126_V0.5320.31
203_I259_T0.5320.31
214_K270_R0.5300.31
164_D228_I0.5260.31
61_L83_L0.5250.31
171_A265_I0.5240.30
19_G27_Y0.5240.30
188_E209_L0.5230.30
79_S241_L0.5220.30
25_S252_P0.5210.30
67_E264_C0.5190.30
151_A197_A0.5180.30
111_L150_L0.5180.30
252_P260_A0.5150.30
134_G199_Y0.5140.30
84_S87_G0.5140.30
134_G190_W0.5130.30
77_R80_F0.5120.30
44_A50_L0.5110.29
74_R77_R0.5100.29
31_L38_I0.5100.29
78_R195_Q0.5090.29
16_P187_E0.5090.29
133_Q156_L0.5060.29
171_A193_T0.5050.29
61_L73_S0.5040.29
82_S194_E0.5030.29
115_S127_K0.5030.29
84_S213_L0.5030.29
197_A253_A0.5010.29
69_W135_F0.5000.29
154_Q158_H0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kfwX 4 0.731 100 0.367 Contact Map
3l09A 4 0.7848 100 0.396 Contact Map
3cuoA 2 0.2911 97.7 0.903 Contact Map
2e1nA 2 0.2943 97.6 0.905 Contact Map
4k2eA 2 0.2816 97.6 0.906 Contact Map
3pqkA 2 0.307 97.5 0.907 Contact Map
2fbkA 2 0.3766 97.5 0.908 Contact Map
2co5A 2 0.2911 97.4 0.908 Contact Map
3f6vA 2 0.3038 97.4 0.908 Contact Map
4l9nA 2 0.3892 97.4 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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