GREMLIN Database
PAAK - Phenylacetate-coenzyme A ligase
UniProt: P76085 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13745
Length: 437 (377)
Sequences: 70086 (50921)
Seq/√Len: 2622.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_V104_G4.1931.00
351_F395_Q3.3821.00
309_R323_R3.0851.00
267_Y290_T3.0511.00
286_E303_R2.7891.00
287_L308_T2.7861.00
333_I338_N2.6991.00
131_K157_T2.6891.00
271_V288_L2.6011.00
269_E278_P2.5951.00
426_C429_F2.5741.00
32_H92_A2.5641.00
356_P420_R2.4961.00
311_L323_R2.4861.00
288_L303_R2.4411.00
349_V357_H2.4371.00
330_D427_R2.3971.00
309_R325_S2.3891.00
348_I373_V2.3811.00
372_S413_V2.3781.00
272_N277_T2.2231.00
284_H307_L2.2081.00
350_K399_R2.1451.00
258_G323_R2.1141.00
311_L315_A2.0981.00
177_Q207_S2.0911.00
220_Q224_K2.0891.00
83_P86_Q2.0501.00
269_E288_L2.0391.00
171_Q175_D2.0181.00
355_S378_K1.9741.00
272_N275_D1.9661.00
429_F432_R1.9631.00
343_Q407_S1.8881.00
92_A102_V1.8841.00
284_H325_S1.8821.00
68_K72_R1.8731.00
360_L374_K1.8581.00
375_V414_N1.8361.00
349_V356_P1.8101.00
281_D310_L1.8091.00
345_E359_Q1.8051.00
315_A321_M1.7871.00
363_N369_D1.7871.00
106_T109_D1.7841.00
347_E399_R1.7831.00
307_L328_S1.7491.00
395_Q399_R1.7341.00
130_D179_D1.7301.00
130_D209_R1.7201.00
284_H309_R1.6971.00
247_G289_F1.6791.00
353_H381_S1.6771.00
28_W99_K1.6761.00
294_K297_L1.6761.00
168_K171_Q1.6711.00
359_Q373_V1.6541.00
334_I339_V1.6381.00
374_K430_D1.6381.00
393_C412_I1.6351.00
183_V188_C1.6331.00
376_E418_I1.6321.00
172_L176_F1.6241.00
133_H178_P1.6211.00
159_I178_P1.6161.00
165_Q168_K1.6121.00
174_R203_A1.6051.00
372_S411_M1.6001.00
84_M108_N1.5921.00
377_L414_N1.5911.00
30_L35_E1.5851.00
85_E108_N1.5811.00
298_P301_R1.5781.00
353_H391_Q1.5661.00
421_S426_C1.5561.00
272_N279_L1.5531.00
310_L321_M1.5521.00
248_V268_P1.5501.00
131_K159_I1.5451.00
388_Q391_Q1.5431.00
280_A283_E1.5421.00
270_I308_T1.5331.00
374_K415_C1.5231.00
240_L302_Y1.5211.00
297_L301_R1.5151.00
389_R393_C1.5131.00
122_R264_D1.5111.00
186_S216_E1.5091.00
188_C211_G1.5061.00
361_E369_D1.4861.00
297_L300_I1.4851.00
64_P68_K1.4721.00
397_R408_T1.4701.00
356_P376_E1.4521.00
390_C394_H1.4351.00
362_V372_S1.4331.00
261_I315_A1.4291.00
342_S346_E1.4261.00
82_V86_Q1.4241.00
308_T324_I1.4181.00
375_V412_I1.3991.00
332_L341_P1.3891.00
294_K301_R1.3871.00
180_M210_V1.3861.00
127_S130_D1.3821.00
262_W268_P1.3791.00
58_S61_R1.3781.00
109_D244_M1.3771.00
364_R370_S1.3761.00
189_L222_M1.3721.00
85_E106_T1.3681.00
389_R414_N1.3671.00
347_E350_K1.3661.00
394_H398_H1.3531.00
370_S410_V1.3481.00
161_M172_L1.3461.00
286_E328_S1.3371.00
250_M315_A1.3341.00
224_K228_R1.3341.00
68_K71_L1.3271.00
250_M258_G1.3201.00
233_T251_E1.3171.00
192_I225_E1.3161.00
397_R402_S1.3141.00
330_D342_S1.3141.00
331_M340_F1.3111.00
337_V406_I1.3071.00
226_I230_L1.3041.00
181_I208_L1.3011.00
90_I102_V1.2941.00
393_C397_R1.2931.00
131_K179_D1.2861.00
142_T182_M1.2851.00
268_P289_F1.2831.00
355_S376_E1.2811.00
213_F218_W1.2741.00
335_R367_H1.2731.00
36_N61_R1.2681.00
296_A299_V1.2671.00
395_Q398_H1.2491.00
105_Y109_D1.2421.00
159_I176_F1.2391.00
294_K298_P1.2391.00
131_K178_P1.2361.00
296_A300_I1.2331.00
61_R64_P1.2311.00
167_E194_E1.2291.00
429_F433_N1.2251.00
370_S411_M1.2201.00
130_D180_M1.2171.00
193_E225_E1.2061.00
225_E229_R1.2061.00
219_T222_M1.2051.00
221_A225_E1.1991.00
190_N366_G1.1951.00
64_P67_T1.1951.00
136_Y142_T1.1871.00
28_W32_H1.1791.00
41_R44_F1.1741.00
279_L283_E1.1671.00
415_C433_N1.1651.00
295_E298_P1.1631.00
294_K300_I1.1621.00
62_K66_T1.1551.00
121_L154_L1.1421.00
391_Q394_H1.1421.00
394_H397_R1.1171.00
415_C418_I1.1121.00
391_Q395_Q1.1111.00
362_V411_M1.1101.00
94_S422_E1.1091.00
295_E301_R1.1021.00
418_I425_A1.0961.00
374_K431_L1.0911.00
345_E427_R1.0881.00
72_R75_Y1.0871.00
401_K406_I1.0861.00
311_L314_T1.0811.00
210_V235_L1.0791.00
259_P324_I1.0761.00
428_V432_R1.0711.00
179_D209_R1.0701.00
87_V106_T1.0671.00
332_L371_L1.0611.00
373_V412_I1.0601.00
173_I207_S1.0591.00
93_S103_V1.0581.00
159_I172_L1.0551.00
189_L219_T1.0541.00
274_H328_S1.0541.00
396_L408_T1.0461.00
225_E228_R1.0461.00
358_Y418_I1.0441.00
62_K65_C1.0431.00
276_G288_L1.0341.00
351_F392_V1.0341.00
377_L387_E1.0291.00
218_W223_R1.0151.00
113_W245_G1.0051.00
133_H161_M1.0051.00
67_T70_D1.0041.00
61_R65_C0.9951.00
289_F304_T0.9871.00
112_N265_H0.9831.00
297_L303_R0.9811.00
330_D345_E0.9761.00
105_Y244_M0.9751.00
188_C226_I0.9731.00
269_E290_T0.9731.00
33_A92_A0.9701.00
389_R412_I0.9681.00
151_A156_A0.9591.00
272_N283_E0.9591.00
270_I279_L0.9551.00
174_R204_S0.9541.00
401_K407_S0.9511.00
189_L193_E0.9501.00
243_V247_G0.9411.00
298_P303_R0.9411.00
287_L324_I0.9401.00
296_A301_R0.9241.00
189_L225_E0.9231.00
347_E396_L0.9211.00
31_K99_K0.9051.00
91_H241_S0.9041.00
88_V107_Q0.9031.00
212_V237_I0.9031.00
351_F391_Q0.9031.00
58_S62_K0.9021.00
131_K177_Q0.9001.00
82_V107_Q0.8981.00
282_G312_P0.8951.00
276_G303_R0.8941.00
57_L60_L0.8921.00
235_L251_E0.8911.00
210_V233_T0.8911.00
141_F245_G0.8911.00
358_Y430_D0.8911.00
334_I410_V0.8881.00
376_E417_S0.8871.00
307_L326_G0.8751.00
248_V321_M0.8731.00
362_V370_S0.8691.00
393_C408_T0.8661.00
342_S345_E0.8651.00
28_W31_K0.8631.00
28_W92_A0.8631.00
346_E350_K0.8631.00
167_E171_Q0.8621.00
184_T187_Y0.8621.00
387_E391_Q0.8611.00
227_E233_T0.8601.00
188_C213_F0.8601.00
411_M414_N0.8591.00
68_K75_Y0.8581.00
173_I178_P0.8581.00
127_S209_R0.8521.00
89_R105_Y0.8521.00
258_G315_A0.8511.00
164_G187_Y0.8501.00
141_F240_L0.8501.00
171_Q174_R0.8491.00
350_K395_Q0.8441.00
358_Y425_A0.8441.00
140_L337_V0.8411.00
271_V278_P0.8411.00
334_I361_E0.8401.00
268_P287_L0.8401.00
60_L63_F0.8361.00
334_I371_L0.8351.00
377_L381_S0.8331.00
182_M246_P0.8311.00
130_D156_A0.8281.00
363_N366_G0.8271.00
390_C393_C0.8271.00
274_H286_E0.8251.00
88_V110_I0.8221.00
250_M253_L0.8221.00
243_V289_F0.8221.00
40_Y44_F0.8221.00
269_E301_R0.8201.00
59_D62_K0.8181.00
189_L221_A0.8151.00
168_K172_L0.8131.00
295_E300_I0.8131.00
119_R123_A0.8121.00
392_V412_I0.8111.00
268_P321_M0.8111.00
77_F80_F0.8081.00
118_A121_L0.8081.00
196_E225_E0.8021.00
315_A323_R0.8001.00
172_L175_D0.7981.00
65_C68_K0.7981.00
363_N368_L0.7941.00
396_L400_I0.7921.00
303_R328_S0.7921.00
389_R411_M0.7891.00
266_F293_T0.7871.00
240_L243_V0.7861.00
281_D312_P0.7861.00
203_A206_C0.7851.00
270_I321_M0.7831.00
360_L431_L0.7811.00
208_L211_G0.7791.00
132_I180_M0.7791.00
295_E299_V0.7791.00
135_A187_Y0.7771.00
133_H173_I0.7761.00
89_R144_G0.7731.00
402_S408_T0.7731.00
69_Q72_R0.7701.00
157_T176_F0.7681.00
133_H172_L0.7671.00
190_N193_E0.7671.00
151_A158_V0.7671.00
222_M225_E0.7641.00
240_L304_T0.7611.00
218_W234_A0.7551.00
268_P308_T0.7551.00
59_D63_F0.7541.00
221_A224_K0.7531.00
126_G180_M0.7521.00
139_G337_V0.7501.00
237_I246_P0.7491.00
142_T214_G0.7471.00
358_Y427_R0.7441.00
66_T71_L0.7431.00
40_Y45_D0.7421.00
173_I181_I0.7411.00
236_D257_D0.7391.00
171_Q203_A0.7391.00
119_R122_R0.7371.00
251_E254_E0.7341.00
278_P288_L0.7311.00
334_I367_H0.7301.00
134_V158_V0.7291.00
145_L182_M0.7291.00
196_E229_R0.7281.00
410_V414_N0.7281.00
86_Q107_Q0.7271.00
174_R206_C0.7251.00
347_E395_Q0.7241.00
346_E349_V0.7211.00
296_A302_Y0.7211.00
89_R110_I0.7211.00
161_M169_Q0.7211.00
387_E392_V0.7211.00
284_H328_S0.7181.00
129_K179_D0.7181.00
68_K74_N0.7161.00
118_A122_R0.7151.00
353_H377_L0.7131.00
393_C396_L0.7131.00
369_D431_L0.7121.00
211_G232_I0.7111.00
113_W246_P0.7101.00
213_F234_A0.7091.00
147_A151_A0.7071.00
90_I104_G0.7061.00
402_S406_I0.7061.00
413_V433_N0.7051.00
227_E254_E0.7051.00
238_Y247_G0.7041.00
419_P430_D0.7041.00
282_G309_R0.7021.00
263_E266_F0.7021.00
290_T301_R0.7011.00
363_N367_H0.7011.00
409_D412_I0.7001.00
341_P427_R0.6971.00
348_I357_H0.6961.00
32_H99_K0.6951.00
60_L64_P0.6951.00
355_S377_L0.6951.00
353_H395_Q0.6931.00
170_A174_R0.6931.00
211_G226_I0.6911.00
174_R205_G0.6891.00
131_K134_V0.6881.00
132_I151_A0.6881.00
59_D64_P0.6871.00
174_R207_S0.6871.00
382_L388_Q0.6861.00
194_E197_R0.6851.00
58_S64_P0.6851.00
134_V160_P0.6851.00
201_G229_R0.6841.00
387_E390_C0.6811.00
355_S379_E0.6811.00
223_R236_D0.6811.00
120_S123_A0.6801.00
107_Q111_D0.6801.00
71_L74_N0.6791.00
113_W244_M0.6781.00
353_H378_K0.6771.00
145_L245_G0.6761.00
182_M237_I0.6751.00
271_V276_G0.6751.00
224_K227_E0.6721.00
278_P310_L0.6721.00
382_L387_E0.6711.00
374_K413_V0.6681.00
161_M168_K0.6621.00
154_L157_T0.6561.00
134_V143_G0.6561.00
196_E202_D0.6551.00
113_W145_L0.6551.00
408_T412_I0.6531.00
243_V302_Y0.6521.00
223_R227_E0.6521.00
133_H169_Q0.6511.00
63_F66_T0.6501.00
332_L361_E0.6501.00
136_Y182_M0.6491.00
170_A191_L0.6491.00
143_G147_A0.6451.00
135_A184_T0.6441.00
146_G182_M0.6431.00
246_P249_A0.6421.00
308_T325_S0.6381.00
46_A49_V0.6381.00
71_L75_Y0.6351.00
364_R368_L0.6341.00
428_V431_L0.6341.00
169_Q173_I0.6331.00
91_H141_F0.6331.00
347_E400_I0.6331.00
70_D73_D0.6321.00
364_R367_H0.6321.00
356_P418_I0.6321.00
123_A251_E0.6311.00
329_D369_D0.6311.00
374_K433_N0.6301.00
164_G169_Q0.6291.00
294_K299_V0.6291.00
224_K256_T0.6271.00
308_T321_M0.6271.00
67_T72_R0.6241.00
348_I396_L0.6241.00
351_F354_L0.6241.00
217_P324_I0.6221.00
181_I211_G0.6211.00
334_I369_D0.6201.00
218_W236_D0.6191.00
267_Y301_R0.6171.00
270_I285_G0.6151.00
272_N276_G0.6141.00
98_G340_F0.6121.00
57_L63_F0.6121.00
226_I234_A0.6121.00
377_L382_L0.6101.00
170_A195_L0.6071.00
166_T194_E0.6061.00
345_E349_V0.6051.00
417_S420_R0.6031.00
379_E382_L0.6031.00
345_E373_V0.6021.00
331_M338_N0.6001.00
362_V374_K0.6001.00
378_K381_S0.5981.00
135_A183_V0.5981.00
114_A149_Y0.5971.00
195_L229_R0.5951.00
134_V147_A0.5941.00
288_L301_R0.5931.00
354_L375_V0.5911.00
179_D207_S0.5911.00
305_R329_D0.5901.00
67_T71_L0.5901.00
334_I370_S0.5901.00
192_I222_M0.5881.00
42_R45_D0.5871.00
270_I310_L0.5871.00
76_P79_T0.5871.00
170_A205_G0.5821.00
354_L357_H0.5801.00
237_I249_A0.5791.00
142_T212_V0.5791.00
283_E309_R0.5771.00
295_E302_Y0.5761.00
271_V303_R0.5761.00
37_V62_K0.5741.00
145_L246_P0.5721.00
162_S168_K0.5701.00
202_D206_C0.5691.00
126_G130_D0.5681.00
365_R368_L0.5681.00
108_N112_N0.5671.00
185_P216_E0.5651.00
259_P308_T0.5641.00
397_R409_D0.5641.00
142_T237_I0.5641.00
213_F236_D0.5631.00
137_G140_L0.5631.00
103_V241_S0.5621.00
330_D341_P0.5591.00
357_H396_L0.5581.00
214_G237_I0.5581.00
375_V392_V0.5581.00
182_M214_G0.5571.00
341_P359_Q0.5561.00
119_R264_D0.5551.00
270_I287_L0.5551.00
204_S207_S0.5541.00
326_G341_P0.5541.00
132_I156_A0.5531.00
258_G311_L0.5521.00
362_V432_R0.5521.00
251_E261_I0.5511.00
167_E203_A0.5501.00
344_L371_L0.5491.00
123_A264_D0.5491.00
375_V389_R0.5481.00
182_M212_V0.5471.00
248_V259_P0.5461.00
69_Q73_D0.5451.00
124_A212_V0.5441.00
158_V161_M0.5431.00
240_L247_G0.5381.00
112_N292_L0.5381.00
296_A303_R0.5371.00
397_R401_K0.5351.00
247_G266_F0.5351.00
63_F68_K0.5341.00
126_G156_A0.5331.00
118_A153_R0.5331.00
114_A152_E0.5321.00
79_T82_V0.5321.00
121_L153_R0.5321.00
94_S421_S0.5311.00
157_T160_P0.5291.00
142_T246_P0.5281.00
78_D82_V0.5281.00
68_K73_D0.5281.00
186_S190_N0.5261.00
214_G246_P0.5261.00
121_L126_G0.5241.00
407_S414_N0.5221.00
326_G342_S0.5211.00
183_V187_Y0.5191.00
250_M255_T0.5191.00
381_S388_Q0.5181.00
220_Q257_D0.5181.00
29_T102_V0.5171.00
288_L297_L0.5141.00
213_F226_I0.5141.00
419_P433_N0.5141.00
108_N292_L0.5131.00
96_T426_C0.5121.00
114_A153_R0.5111.00
66_T72_R0.5111.00
247_G268_P0.5101.00
290_T300_I0.5091.00
31_K59_D0.5081.00
150_G153_R0.5081.00
290_T299_V0.5081.00
177_Q206_C0.5081.00
250_M254_E0.5071.00
164_G190_N0.5061.00
70_D74_N0.5051.00
144_G148_H0.5051.00
190_N194_E0.5031.00
135_A161_M0.5021.00
149_Y152_E0.5001.00
34_Y59_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tsyA 2 0.7277 100 0.229 Contact Map
3etcA 2 0.9153 100 0.233 Contact Map
3ni2A 1 0.9474 100 0.242 Contact Map
2d1sA 1 0.9565 100 0.243 Contact Map
1mdbA 1 0.9497 100 0.244 Contact Map
3c5eA 1 0.9542 100 0.245 Contact Map
1pg4A 1 0.9611 100 0.246 Contact Map
4lgcA 1 0.6773 100 0.246 Contact Map
2y27A 2 0.9634 100 0.248 Contact Map
3g7sA 2 0.8673 100 0.249 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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