GREMLIN Database
PAAI - Acyl-coenzyme A thioesterase PaaI
UniProt: P76084 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13743
Length: 140 (119)
Sequences: 5968 (4101)
Seq/√Len: 375.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_T93_T3.4551.00
27_I37_T3.0821.00
78_S107_T2.6931.00
35_V97_T2.4901.00
28_S35_V2.3221.00
97_T115_V2.3091.00
25_D37_T2.2671.00
28_S33_F2.2081.00
36_V63_A2.1461.00
57_F80_C2.0161.00
30_D33_F1.9511.00
64_F112_I1.9441.00
63_A96_A1.9051.00
113_E121_T1.8741.00
116_N120_K1.8391.00
38_M55_Q1.8301.00
33_F97_T1.7931.00
37_T95_T1.7631.00
35_V95_T1.7611.00
100_V103_Q1.7481.00
33_F99_Q1.7351.00
86_R120_K1.7311.00
68_C108_G1.7031.00
111_D124_L1.6411.00
60_A125_F1.6211.00
39_T93_T1.5891.00
57_F82_I1.5841.00
101_R111_D1.5791.00
73_L133_G1.5411.00
99_Q111_D1.5251.00
99_Q113_E1.4991.00
64_F127_G1.4961.00
60_A112_I1.4221.00
18_C55_Q1.4121.00
27_I35_V1.3711.00
88_G122_V1.3551.00
21_A43_Q1.3541.00
79_A83_D1.3481.00
101_R124_L1.3151.00
18_C58_S1.3111.00
57_F84_F1.3021.00
56_L123_A1.2701.00
113_E124_L1.2621.00
68_C129_S1.2621.00
40_V51_C1.2481.00
102_H107_T1.1801.00
42_A45_L1.1521.00
82_I123_A1.1501.00
41_T44_M1.1351.00
45_L90_A1.1221.00
88_G94_L1.1171.00
60_A114_I1.1141.00
85_L124_L1.1071.00
51_C94_L1.1061.00
96_A112_I1.0861.00
115_V119_Q1.0781.00
108_G131_R1.0721.00
56_L114_I1.0411.00
111_D126_R1.0251.00
115_V121_T1.0191.00
59_L96_A1.0091.00
107_T130_H1.0041.00
61_D77_A0.9971.00
83_D128_K0.9971.00
24_I36_V0.9921.00
38_M59_L0.9921.00
56_L122_V0.9821.00
68_C110_Y0.9781.00
50_S76_V0.9771.00
93_T117_Q0.9581.00
67_A110_Y0.9491.00
106_Q130_H0.9381.00
54_G58_S0.9171.00
25_D93_T0.9101.00
81_T126_R0.8961.00
76_V132_I0.8951.00
51_C88_G0.8921.00
79_A126_R0.8721.00
85_L102_H0.8661.00
67_A98_A0.8601.00
95_T117_Q0.8531.00
42_A90_A0.8531.00
25_D39_T0.8451.00
100_V110_Y0.8351.00
95_T115_V0.8171.00
102_H109_V0.8041.00
97_T113_E0.8011.00
19_A62_T0.7941.00
67_A100_V0.7911.00
94_L114_I0.7801.00
32_G100_V0.7741.00
85_L109_V0.7701.00
85_L121_T0.7641.00
83_D109_V0.7641.00
44_M55_Q0.7631.00
109_V128_K0.7601.00
56_L84_F0.7561.00
70_S73_L0.7541.00
64_F129_S0.7541.00
53_G84_F0.7371.00
26_I36_V0.7361.00
86_R102_H0.7281.00
39_T44_M0.7271.00
79_A128_K0.7271.00
69_N75_A0.7221.00
94_L122_V0.7081.00
27_I93_T0.7060.99
112_I127_G0.7050.99
69_N74_A0.6980.99
80_C84_F0.6940.99
50_S87_P0.6920.99
32_G67_A0.6870.99
61_D65_A0.6810.99
96_A114_I0.6810.99
40_V45_L0.6810.99
47_G65_A0.6810.99
80_C125_F0.6800.99
22_L58_S0.6800.99
52_H62_T0.6710.99
19_A66_Y0.6690.99
17_A20_K0.6590.99
15_N20_K0.6510.99
95_T119_Q0.6490.99
65_A129_S0.6350.99
98_A110_Y0.6240.99
62_T66_Y0.6200.99
77_A80_C0.6170.99
64_F110_Y0.6150.99
71_Q100_V0.6120.99
105_K133_G0.6110.99
88_G116_N0.6100.99
34_A67_A0.6100.99
75_A131_R0.6070.98
64_F125_F0.6030.98
40_V44_M0.6010.98
14_E20_K0.5990.98
23_G43_Q0.5980.98
24_I38_M0.5940.98
121_T124_L0.5930.98
37_T117_Q0.5870.98
63_A98_A0.5840.98
77_A127_G0.5800.98
16_D47_G0.5790.98
60_A82_I0.5780.98
103_Q108_G0.5760.98
74_A132_I0.5750.98
95_T116_N0.5720.98
56_L88_G0.5710.98
20_K43_Q0.5690.98
21_A55_Q0.5690.98
75_A129_S0.5680.98
83_D126_R0.5680.98
109_V124_L0.5660.98
73_L131_R0.5660.98
97_T119_Q0.5640.98
56_L61_D0.5590.97
103_Q131_R0.5580.97
51_C56_L0.5540.97
108_G129_S0.5540.97
98_A112_I0.5530.97
26_I66_Y0.5510.97
27_I36_V0.5410.97
46_N50_S0.5400.97
78_S130_H0.5380.97
48_H69_N0.5340.97
18_C21_A0.5290.96
116_N122_V0.5270.96
77_A129_S0.5230.96
71_Q103_Q0.5200.96
76_V130_H0.5190.96
23_G41_T0.5130.96
48_H76_V0.5110.96
24_I58_S0.5080.96
17_A42_A0.5030.95
40_V94_L0.5020.95
59_L114_I0.5010.95
46_N52_H0.5010.95
82_I125_F0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f1tA 2 0.9286 99.9 0.286 Contact Map
3e29A 3 0.9429 99.9 0.298 Contact Map
3e8pA 3 0.9286 99.9 0.305 Contact Map
4rmmA 2 0.9071 99.9 0.307 Contact Map
3hduA 4 0.9357 99.9 0.312 Contact Map
1yocA 4 0.95 99.9 0.314 Contact Map
3e1eA 3 0.95 99.9 0.317 Contact Map
3lbeA 2 0.8857 99.9 0.318 Contact Map
1t82A 2 0.9286 99.9 0.322 Contact Map
1sh8A 2 0.95 99.9 0.327 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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