GREMLIN Database
PAAH - 3-hydroxyadipyl-CoA dehydrogenase
UniProt: P76083 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13742
Length: 475 (456)
Sequences: 491 (305)
Seq/√Len: 14.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_T125_I10.3381.00
139_A169_L6.5571.00
129_A138_V5.7971.00
405_L415_I4.9621.00
110_C114_T4.4871.00
215_V380_L4.4151.00
141_L169_L3.9211.00
141_L173_T3.8111.00
212_A215_V3.6560.99
410_A415_I3.6010.99
251_N255_Q3.5870.99
243_F254_W3.5390.99
219_A353_T3.2750.99
325_T391_W3.1020.98
446_E459_P2.9170.97
427_Y435_Q2.9170.97
112_P133_K2.8600.97
219_A389_L2.8310.96
273_R280_L2.8080.96
101_A105_Q2.7970.96
351_V380_L2.7390.96
80_H105_Q2.6340.95
420_R431_A2.5590.94
411_S414_D2.5050.93
32_L84_A2.4850.93
103_F128_I2.4770.92
55_R58_R2.4720.92
221_R232_E2.4560.92
398_I433_G2.4260.92
64_E67_E2.4090.91
157_S166_V2.3660.91
209_Q408_G2.3490.90
53_N57_T2.3280.90
103_F116_L2.3140.90
136_E162_A2.2440.88
49_H70_L2.2350.88
203_W234_T2.2080.87
92_A98_V2.1580.86
204_R452_Y2.1240.85
93_S98_V2.0810.84
62_T65_T2.0720.83
205_A210_V2.0610.83
382_I388_M2.0370.82
9_A82_L2.0050.81
185_S400_E1.9990.81
63_A67_E1.9900.81
167_E182_R1.9770.80
107_A132_I1.9680.80
442_L459_P1.9630.80
100_K104_A1.9100.78
53_N70_L1.9000.78
289_R292_V1.8980.77
316_E319_D1.8750.77
220_L393_T1.8470.75
105_Q108_E1.8350.75
358_A383_A1.8100.74
330_A343_V1.7990.73
42_T46_D1.7970.73
328_E336_R1.7950.73
58_R149_V1.7850.73
202_A216_I1.7520.71
36_I39_E1.7490.71
205_A385_Y1.7170.70
442_L446_E1.7100.70
100_K130_A1.7020.69
38_A73_L1.6860.68
257_R455_E1.6830.68
391_W444_L1.6680.68
352_V372_L1.6600.67
266_Q270_I1.6530.67
76_V82_L1.6460.66
244_A269_V1.6350.66
112_P134_N1.6170.65
172_L175_S1.6070.65
405_L410_A1.6020.64
46_D171_E1.5720.63
207_E407_K1.5570.62
234_T239_Q1.5520.62
174_L180_P1.5510.62
52_L69_T1.5470.61
370_Y374_Q1.5390.61
178_K242_N1.5370.61
156_V244_A1.5310.61
231_L351_V1.5300.61
197_P397_I1.5250.60
10_V386_P1.5230.60
197_P400_E1.5200.60
44_A69_T1.5140.60
48_I51_R1.5110.60
9_A83_A1.5090.59
352_V379_V1.5050.59
37_S41_L1.5010.59
237_I265_Q1.4810.58
54_S60_K1.4700.57
132_I138_V1.4640.57
68_R288_E1.4630.57
160_A273_R1.4550.57
324_E344_I1.4530.56
299_S303_S1.4470.56
49_H56_V1.4350.56
200_S237_I1.4350.56
176_W432_W1.4310.55
260_L454_E1.4310.55
77_T81_A1.4270.55
343_V401_A1.4240.55
238_G274_L1.4240.55
54_S156_V1.4080.54
205_A389_L1.4050.54
449_Q459_P1.4040.54
178_K193_R1.3930.53
382_I389_L1.3880.53
352_V375_Q1.3770.52
55_R110_C1.3750.52
8_V97_E1.3680.52
356_A365_T1.3650.52
82_L85_A1.3550.51
53_N66_C1.3510.51
353_T390_I1.3460.51
29_H176_W1.3340.50
203_W282_V1.3300.50
155_V165_V1.3160.49
54_S57_T1.3130.49
256_E260_L1.3110.49
210_V385_Y1.3000.48
26_S69_T1.2950.48
134_N137_R1.2810.47
372_L381_Q1.2810.47
334_A341_V1.2790.47
303_S374_Q1.2750.47
160_A280_L1.2660.46
408_G448_L1.2660.46
179_Q421_L1.2630.46
206_L213_P1.2520.46
222_D351_V1.2500.45
330_A357_A1.2500.45
55_R149_V1.2430.45
446_E464_R1.2430.45
202_A298_V1.2410.45
199_Y242_N1.2410.45
48_I73_L1.2380.45
30_Q74_I1.2350.45
402_L444_L1.2340.45
8_V180_P1.2310.44
436_L441_I1.2310.44
186_T202_A1.2270.44
329_T468_L1.2270.44
89_I244_A1.2260.44
449_Q453_G1.2200.44
300_D303_S1.2180.44
45_I73_L1.2130.43
157_S182_R1.2120.43
198_Y259_F1.2060.43
462_L466_R1.2050.43
323_I341_V1.2030.43
430_L433_G1.1960.42
58_R69_T1.1860.42
76_V81_A1.1760.41
51_R149_V1.1750.41
247_C251_N1.1710.41
325_T340_P1.1680.41
171_E174_L1.1660.41
198_Y220_L1.1620.41
18_A58_R1.1580.40
139_A165_V1.1570.40
104_A131_E1.1530.40
224_A390_I1.1520.40
406_Q462_L1.1500.40
126_T248_S1.1470.40
284_D289_R1.1420.40
74_I274_L1.1410.40
353_T409_V1.1360.39
297_A300_D1.1310.39
216_I388_M1.1210.39
231_L234_T1.1170.38
198_Y267_E1.1140.38
415_I436_L1.1070.38
238_G278_S1.1070.38
97_E174_L1.1050.38
123_I325_T1.1020.38
181_V414_D1.0980.37
242_N246_T1.0960.37
50_A78_D1.0900.37
10_V288_E1.0840.37
8_V156_V1.0810.36
95_R159_L1.0800.36
54_S149_V1.0780.36
206_L216_I1.0720.36
168_Q175_S1.0700.36
268_L273_R1.0600.35
25_A51_R1.0560.35
126_T158_G1.0520.35
11_I98_V1.0460.35
27_H244_A1.0450.35
412_E430_L1.0350.34
115_L165_V1.0320.34
243_F265_Q1.0320.34
68_R72_R1.0290.34
424_N455_E1.0250.34
10_V38_A1.0240.34
67_E372_L1.0220.34
160_A172_L1.0210.33
116_L155_V1.0200.33
193_R242_N1.0090.33
178_K265_Q1.0070.33
193_R265_Q1.0060.33
73_L89_I0.9950.32
42_T77_T0.9950.32
211_A464_R0.9940.32
194_V242_N0.9940.32
274_L278_S0.9910.32
401_A432_W0.9900.32
8_V87_L0.9830.32
24_A265_Q0.9820.32
13_S73_L0.9810.32
44_A114_T0.9810.32
41_L75_P0.9790.31
65_T112_P0.9730.31
394_V432_W0.9670.31
246_T263_L0.9650.31
195_A199_Y0.9650.31
55_R407_K0.9630.31
178_K424_N0.9600.31
22_E54_S0.9600.31
9_A85_A0.9520.30
318_D341_V0.9500.30
183_C410_A0.9420.30
63_A362_D0.9400.30
433_G438_W0.9400.30
136_E171_E0.9370.30
105_Q118_T0.9370.30
123_I465_Q0.9360.29
282_V458_R0.9330.29
169_L431_A0.9330.29
50_A65_T0.9320.29
272_G384_D0.9290.29
320_V368_A0.9280.29
102_L445_L0.9260.29
15_T207_E0.9240.29
419_M424_N0.9230.29
332_A451_H0.9190.29
151_K180_P0.9190.29
52_L66_C0.9160.29
322_L372_L0.9160.29
199_Y265_Q0.9150.29
298_V301_S0.9130.28
194_V419_M0.9110.28
280_L284_D0.9090.28
132_I355_A0.9070.28
123_I138_V0.9070.28
139_A430_L0.9060.28
37_S102_L0.9060.28
284_D322_L0.9040.28
202_A417_T0.9010.28
195_A237_I0.8970.28
195_A265_Q0.8940.28
65_T312_D0.8920.28
109_V133_K0.8910.27
242_N265_Q0.8880.27
354_I372_L0.8850.27
243_F266_Q0.8840.27
183_C407_K0.8830.27
68_R289_R0.8830.27
115_L168_Q0.8820.27
242_N419_M0.8810.27
178_K237_I0.8810.27
96_L203_W0.8810.27
442_L463_L0.8800.27
370_Y373_Q0.8780.27
242_N424_N0.8770.27
147_A338_A0.8750.27
9_A401_A0.8750.27
169_L253_F0.8740.27
278_S378_T0.8710.27
9_A87_L0.8700.27
284_D292_V0.8690.27
24_A176_W0.8690.27
123_I185_S0.8680.26
87_L101_A0.8680.26
152_L178_K0.8630.26
264_V411_S0.8590.26
49_H65_T0.8580.26
202_A259_F0.8520.26
193_R419_M0.8460.26
48_I60_K0.8450.26
22_E58_R0.8440.25
253_F274_L0.8440.25
40_A399_N0.8430.25
343_V346_K0.8420.25
340_P343_V0.8410.25
118_T171_E0.8400.25
278_S339_R0.8400.25
32_L81_A0.8380.25
29_H172_L0.8380.25
147_A244_A0.8370.25
200_S397_I0.8370.25
69_T257_R0.8330.25
318_D367_K0.8320.25
156_V255_Q0.8290.25
178_K419_M0.8250.25
113_Q134_N0.8200.24
152_L181_V0.8190.24
9_A76_V0.8190.24
246_T419_M0.8170.24
65_T125_I0.8160.24
92_A156_V0.8150.24
51_R55_R0.8150.24
97_E170_C0.8130.24
198_Y417_T0.8120.24
7_T78_D0.8110.24
55_R109_V0.8100.24
207_E461_S0.8090.24
205_A326_Q0.8080.24
184_H444_L0.8060.24
98_V264_V0.8020.24
268_L400_E0.8010.24
186_T322_L0.8000.24
111_P134_N0.8000.24
110_C387_G0.8000.24
161_T166_V0.7980.24
44_A73_L0.7950.23
206_L258_R0.7940.23
117_T139_A0.7930.23
35_D91_A0.7880.23
155_V440_R0.7860.23
76_V304_P0.7860.23
9_A210_V0.7860.23
385_Y465_Q0.7820.23
26_S403_D0.7790.23
197_P265_Q0.7760.23
115_L412_E0.7720.23
111_P362_D0.7720.23
265_Q393_T0.7720.23
85_A98_V0.7720.23
176_W244_A0.7710.23
230_P234_T0.7710.23
406_Q461_S0.7690.22
155_V169_L0.7680.22
11_I420_R0.7670.22
107_A133_K0.7600.22
92_A118_T0.7580.22
206_L231_L0.7570.22
219_A390_I0.7570.22
183_C467_A0.7550.22
301_S370_Y0.7550.22
82_L420_R0.7540.22
23_V249_V0.7510.22
214_E319_D0.7500.22
185_S267_E0.7490.22
62_T89_I0.7490.22
220_L226_F0.7460.22
76_V206_L0.7460.22
115_L436_L0.7450.22
152_L191_V0.7440.22
152_L180_P0.7420.21
267_E400_E0.7410.21
414_D436_L0.7410.21
443_R447_N0.7400.21
171_E216_I0.7390.21
223_G400_E0.7370.21
48_I54_S0.7370.21
391_W462_L0.7360.21
342_V368_A0.7340.21
125_I341_V0.7330.21
32_L76_V0.7330.21
115_L220_L0.7300.21
42_T270_I0.7300.21
286_R339_R0.7300.21
402_L434_A0.7300.21
114_T435_Q0.7290.21
293_V366_R0.7290.21
341_V346_K0.7280.21
166_V182_R0.7270.21
56_V110_C0.7260.21
178_K194_V0.7240.21
258_R458_R0.7220.21
320_V371_Y0.7190.21
48_I127_A0.7190.21
147_A263_L0.7180.21
404_A409_V0.7170.21
71_K76_V0.7150.20
126_T159_L0.7150.20
210_V342_V0.7140.20
241_V379_V0.7110.20
224_A436_L0.7100.20
194_V404_A0.7090.20
337_L341_V0.7080.20
223_G278_S0.7070.20
200_S239_Q0.7070.20
118_T129_A0.7060.20
193_R199_Y0.7060.20
446_E453_G0.7050.20
38_A165_V0.7050.20
243_F247_C0.7050.20
100_K175_S0.7040.20
15_T432_W0.7020.20
197_P396_M0.7010.20
222_D380_L0.7010.20
160_A202_A0.7000.20
206_L267_E0.7000.20
57_T60_K0.6970.20
152_L237_I0.6970.20
343_V355_A0.6960.20
48_I70_L0.6960.20
61_L98_V0.6940.20
286_R295_L0.6920.20
104_A108_E0.6910.20
78_D363_S0.6910.20
210_V383_A0.6880.20
81_A105_Q0.6870.19
60_K136_E0.6870.19
128_I442_L0.6870.19
26_S61_L0.6860.19
23_V218_A0.6820.19
35_D429_P0.6810.19
421_L466_R0.6800.19
60_K113_Q0.6770.19
114_T320_V0.6760.19
354_I388_M0.6740.19
15_T219_A0.6740.19
323_I333_L0.6740.19
82_L147_A0.6730.19
164_E349_G0.6730.19
48_I52_L0.6720.19
55_R181_V0.6710.19
76_V79_I0.6710.19
293_V296_E0.6690.19
286_R289_R0.6680.19
276_K285_W0.6680.19
152_L193_R0.6660.19
371_Y375_Q0.6660.19
193_R197_P0.6640.19
134_N361_P0.6610.19
162_A401_A0.6590.19
30_Q68_R0.6580.19
343_V400_E0.6580.19
108_E133_K0.6580.19
219_A257_R0.6570.18
340_P344_I0.6540.18
259_F403_D0.6540.18
259_F409_V0.6540.18
195_A419_M0.6530.18
9_A81_A0.6530.18
49_H53_N0.6530.18
290_E294_G0.6510.18
7_T54_S0.6500.18
152_L419_M0.6500.18
42_T378_T0.6480.18
257_R436_L0.6470.18
202_A382_I0.6470.18
7_T32_L0.6460.18
183_C219_A0.6460.18
286_R292_V0.6450.18
197_P200_S0.6450.18
250_F253_F0.6450.18
322_L368_A0.6440.18
33_L379_V0.6440.18
195_A200_S0.6440.18
103_F106_L0.6440.18
151_K249_V0.6430.18
130_A197_P0.6420.18
103_F132_I0.6410.18
46_D60_K0.6410.18
167_E171_E0.6400.18
103_F255_Q0.6400.18
393_T432_W0.6390.18
152_L386_P0.6380.18
444_L460_C0.6350.18
8_V77_T0.6350.18
297_A302_F0.6350.18
292_V297_A0.6350.18
52_L432_W0.6340.18
71_K112_P0.6340.18
46_D213_P0.6340.18
79_I105_Q0.6340.18
141_L152_L0.6330.18
320_V340_P0.6330.18
250_F329_T0.6320.18
129_A220_L0.6320.18
383_A415_I0.6310.18
303_S367_K0.6300.18
245_V425_Y0.6300.18
23_V223_G0.6290.18
244_A247_C0.6280.18
169_L391_W0.6280.18
15_T210_V0.6270.18
365_T381_Q0.6260.17
133_K136_E0.6240.17
302_F443_R0.6240.17
58_R123_I0.6220.17
368_A381_Q0.6210.17
193_R404_A0.6190.17
379_V430_L0.6190.17
170_C182_R0.6180.17
110_C147_A0.6170.17
73_L241_V0.6160.17
98_V210_V0.6160.17
265_Q424_N0.6150.17
8_V56_V0.6130.17
64_E68_R0.6130.17
63_A332_A0.6100.17
185_S343_V0.6090.17
439_Q467_A0.6080.17
43_R57_T0.6080.17
391_W455_E0.6070.17
452_Y461_S0.6070.17
123_I410_A0.6070.17
42_T450_H0.6060.17
186_T198_Y0.6060.17
10_V369_I0.6060.17
176_W265_Q0.6060.17
296_E362_D0.6050.17
168_Q244_A0.6050.17
325_T388_M0.6050.17
253_F407_K0.6020.17
298_V443_R0.6020.17
190_I259_F0.6010.17
211_A231_L0.5970.17
158_G248_S0.5970.17
205_A386_P0.5960.17
252_A267_E0.5950.17
298_V304_P0.5950.17
71_K155_V0.5940.16
96_L128_I0.5940.16
460_C465_Q0.5940.16
241_V253_F0.5940.16
342_V430_L0.5930.16
178_K200_S0.5920.16
216_I408_G0.5910.16
193_R237_I0.5900.16
11_I151_K0.5900.16
65_T362_D0.5900.16
218_A342_V0.5890.16
253_F271_G0.5880.16
42_T83_A0.5850.16
132_I405_L0.5850.16
268_L424_N0.5850.16
136_E167_E0.5850.16
178_K199_Y0.5850.16
228_M238_G0.5810.16
257_R403_D0.5800.16
252_A419_M0.5800.16
304_P367_K0.5790.16
30_Q84_A0.5790.16
370_Y454_E0.5790.16
71_K109_V0.5780.16
77_T459_P0.5780.16
199_Y267_E0.5780.16
178_K195_A0.5770.16
323_I337_L0.5770.16
68_R74_I0.5770.16
118_T136_E0.5750.16
100_K227_P0.5730.16
259_F262_S0.5730.16
43_R270_I0.5720.16
55_R72_R0.5710.16
195_A423_V0.5690.16
40_A458_R0.5670.16
76_V161_T0.5660.16
18_A346_K0.5640.16
118_T250_F0.5640.16
191_V418_A0.5630.16
8_V85_A0.5610.16
325_T444_L0.5600.15
157_S173_T0.5590.15
332_A468_L0.5590.15
193_R246_T0.5570.15
215_V394_V0.5570.15
67_E355_A0.5540.15
115_L156_V0.5530.15
330_A334_A0.5530.15
56_V62_T0.5520.15
100_K408_G0.5520.15
81_A413_Q0.5520.15
147_A207_E0.5510.15
54_S322_L0.5510.15
267_E270_I0.5510.15
194_V237_I0.5510.15
315_T455_E0.5500.15
195_A242_N0.5500.15
155_V368_A0.5490.15
119_N192_N0.5490.15
78_D81_A0.5480.15
71_K75_P0.5480.15
203_W462_L0.5470.15
325_T330_A0.5470.15
216_I231_L0.5450.15
333_L337_L0.5450.15
320_V352_V0.5450.15
388_M400_E0.5450.15
100_K111_P0.5430.15
152_L265_Q0.5430.15
13_S266_Q0.5430.15
234_T256_E0.5430.15
126_T394_V0.5430.15
390_I404_A0.5430.15
159_L401_A0.5420.15
127_A422_G0.5420.15
104_A113_Q0.5410.15
30_Q50_A0.5380.15
263_L270_I0.5370.15
239_Q419_M0.5370.15
237_I242_N0.5370.15
152_L242_N0.5360.15
86_D89_I0.5360.15
333_L391_W0.5350.15
262_S404_A0.5340.15
168_Q284_D0.5340.15
60_K111_P0.5340.15
57_T64_E0.5340.15
272_G358_A0.5330.15
210_V452_Y0.5330.15
151_K421_L0.5330.15
195_A397_I0.5320.15
252_A259_F0.5320.15
72_R173_T0.5320.15
443_R446_E0.5310.15
156_V183_C0.5310.15
193_R424_N0.5310.15
109_V134_N0.5300.15
193_R200_S0.5300.15
344_I372_L0.5300.15
448_L452_Y0.5290.15
11_I63_A0.5280.15
42_T81_A0.5280.15
88_V370_Y0.5280.15
46_D98_V0.5270.15
178_K197_P0.5270.15
32_L446_E0.5260.15
239_Q265_Q0.5260.15
123_I360_N0.5240.14
29_H432_W0.5230.14
249_V416_D0.5220.14
108_E450_H0.5220.14
31_V218_A0.5220.14
224_A394_V0.5220.14
107_A203_W0.5220.14
197_P268_L0.5210.14
265_Q432_W0.5200.14
37_S65_T0.5190.14
333_L341_V0.5190.14
29_H175_S0.5180.14
105_Q109_V0.5170.14
34_Y80_H0.5160.14
361_P364_A0.5160.14
237_I393_T0.5150.14
68_R278_S0.5140.14
126_T186_T0.5140.14
34_Y59_G0.5130.14
25_A69_T0.5130.14
184_H282_V0.5130.14
61_L166_V0.5130.14
340_P346_K0.5130.14
178_K268_L0.5120.14
195_A391_W0.5120.14
171_E411_S0.5120.14
7_T111_P0.5120.14
44_A313_G0.5110.14
26_S52_L0.5110.14
350_K362_D0.5110.14
126_T262_S0.5100.14
73_L344_I0.5100.14
44_A165_V0.5100.14
53_N84_A0.5090.14
256_E400_E0.5080.14
238_G269_V0.5070.14
129_A447_N0.5070.14
369_I375_Q0.5070.14
82_L322_L0.5060.14
147_A234_T0.5060.14
39_E356_A0.5060.14
9_A468_L0.5050.14
133_K438_W0.5050.14
63_A287_A0.5040.14
202_A222_D0.5040.14
320_V375_Q0.5040.14
149_V285_W0.5040.14
147_A423_V0.5030.14
156_V320_V0.5030.14
185_S317_I0.5020.14
9_A226_F0.5020.14
198_Y224_A0.5020.14
50_A335_I0.5010.14
430_L462_L0.5000.14
282_V407_K0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mogA 3 0.9937 100 0.478 Contact Map
1wdkA 2 0.8337 100 0.514 Contact Map
2wtbA 1 0.8 100 0.519 Contact Map
3zwcA 1 0.8484 100 0.523 Contact Map
4b3hA 1 0.8126 100 0.526 Contact Map
3k6jA 1 0.8063 100 0.527 Contact Map
1zcjA 1 0.8484 100 0.527 Contact Map
4j0eA 2 0.6 100 0.639 Contact Map
1f0yA 2 0.6 100 0.653 Contact Map
4r1nA 2 0.5937 100 0.658 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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