GREMLIN Database
PAAF - 2,3-dehydroadipyl-CoA hydratase
UniProt: P76082 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13740
Length: 255 (244)
Sequences: 30188 (19768)
Seq/√Len: 1265.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_R162_S3.1791.00
121_E179_P3.0381.00
176_D186_Y3.0221.00
119_A174_V2.9091.00
97_A114_C2.7951.00
186_Y189_Q2.7791.00
14_L188_L2.6441.00
42_A92_N2.4831.00
39_E87_R2.4661.00
23_R57_R2.2831.00
161_E193_K2.2771.00
122_N180_S2.2761.00
5_I18_N2.2221.00
167_Q170_Q2.1861.00
216_A219_A2.1711.00
164_T167_Q2.1461.00
8_R13_L2.1011.00
155_K161_E2.0851.00
152_L171_A2.0331.00
157_V205_A2.0161.00
14_L53_T2.0051.00
131_T197_H2.0011.00
8_R44_D1.9511.00
11_R48_S1.9081.00
6_V13_L1.8871.00
35_V87_R1.8751.00
98_A187_A1.8681.00
121_E166_Q1.8511.00
29_A33_Q1.8451.00
18_N55_N1.8421.00
239_E248_R1.8321.00
104_L126_G1.8281.00
242_S246_Q1.8171.00
16_T55_N1.8091.00
98_A184_L1.7971.00
23_R58_F1.7951.00
118_V178_F1.7741.00
13_L41_A1.7311.00
182_L185_E1.7301.00
154_S210_R1.7261.00
16_T53_T1.7131.00
155_K175_S1.7081.00
188_L192_S1.7051.00
40_A44_D1.6881.00
50_C91_F1.6631.00
121_E180_S1.6581.00
115_D206_K1.6461.00
167_Q171_A1.6281.00
150_K154_S1.6201.00
13_L47_I1.5901.00
182_L186_Y1.5661.00
32_M80_T1.5651.00
166_Q170_Q1.5561.00
118_V190_L1.5481.00
119_A125_F1.4891.00
155_K176_D1.4861.00
178_F186_Y1.4751.00
120_G180_S1.4641.00
41_A50_C1.4531.00
117_V147_S1.4451.00
117_V151_S1.4451.00
9_Q188_L1.4361.00
42_A87_R1.4341.00
111_A117_V1.4291.00
15_L37_E1.4251.00
10_Q192_S1.4191.00
49_V191_A1.4131.00
154_S209_L1.4051.00
86_A218_Q1.3971.00
99_V111_A1.3931.00
86_A90_A1.3851.00
6_V41_A1.3751.00
169_Q177_V1.3751.00
154_S158_L1.3731.00
100_N120_G1.3451.00
5_I55_N1.3391.00
204_A230_L1.3321.00
9_Q192_S1.3281.00
35_V39_E1.3161.00
99_V103_A1.3141.00
38_L91_F1.3121.00
100_N122_N1.3091.00
108_C127_L1.3071.00
152_L155_K1.3021.00
89_Q143_R1.2971.00
53_T100_N1.2901.00
156_M163_I1.2871.00
57_R100_N1.2861.00
88_L95_L1.2821.00
28_N67_E1.2721.00
183_T187_A1.2661.00
9_Q14_L1.2641.00
161_E167_Q1.2611.00
126_G162_S1.2301.00
184_L188_L1.2141.00
42_A91_F1.1971.00
27_N30_L1.1951.00
207_Q211_Q1.1951.00
14_L184_L1.1941.00
102_Y124_R1.1921.00
35_V83_Q1.1881.00
58_F102_Y1.1861.00
130_I160_G1.1851.00
151_S175_S1.1841.00
53_T184_L1.1771.00
197_H202_L1.1741.00
152_L167_Q1.1691.00
237_R241_I1.1681.00
184_L187_A1.1671.00
33_Q37_E1.1551.00
215_V219_A1.1411.00
17_L30_L1.1351.00
19_R22_A1.1291.00
120_G183_T1.1121.00
7_S16_T1.0951.00
8_R46_S1.0911.00
215_V223_Q1.0861.00
163_I171_A1.0821.00
149_G152_L1.0771.00
165_A177_V1.0721.00
22_A66_N1.0691.00
200_L236_D1.0611.00
8_R40_A1.0551.00
17_L60_A1.0451.00
185_E189_Q1.0431.00
33_Q36_N1.0421.00
60_A107_G1.0411.00
211_Q223_Q1.0411.00
90_A218_Q1.0391.00
28_N32_M1.0341.00
36_N40_A1.0051.00
7_S14_L0.9971.00
19_R64_D0.9941.00
95_L114_C0.9901.00
116_V190_L0.9901.00
50_C93_K0.9851.00
5_I16_T0.9851.00
81_R138_A0.9681.00
37_E40_A0.9591.00
109_E140_G0.9571.00
148_V152_L0.9561.00
199_P203_Q0.9541.00
147_S151_S0.9441.00
92_N203_Q0.9431.00
51_V187_A0.9351.00
191_A195_A0.9281.00
166_Q169_Q0.9231.00
53_T98_A0.9221.00
108_C125_F0.9201.00
169_Q174_V0.9161.00
50_C95_L0.9091.00
124_R164_T0.9071.00
238_H242_S0.9031.00
179_P182_L0.8961.00
98_A183_T0.8931.00
219_A222_A0.8921.00
207_Q227_L0.8871.00
12_V49_V0.8871.00
130_I205_A0.8801.00
204_A207_Q0.8771.00
75_A79_D0.8761.00
141_T224_E0.8741.00
14_L51_V0.8731.00
47_I93_K0.8711.00
223_Q226_Q0.8661.00
204_A227_L0.8571.00
189_Q193_K0.8531.00
31_L84_L0.8481.00
142_Q220_G0.8471.00
150_K213_Q0.8461.00
56_A100_N0.8391.00
135_M231_L0.8361.00
8_R47_I0.8291.00
99_V125_F0.8291.00
100_N183_T0.8281.00
121_E177_V0.8271.00
35_V80_T0.8261.00
185_E188_L0.8251.00
120_G181_D0.8191.00
45_T93_K0.8161.00
186_Y190_L0.8151.00
188_L191_A0.8151.00
104_L162_S0.8121.00
99_V117_V0.8081.00
169_Q176_D0.7961.00
38_L88_L0.7961.00
39_E43_T0.7911.00
148_V156_M0.7871.00
156_M171_A0.7871.00
204_A231_L0.7861.00
116_V175_S0.7861.00
157_V209_L0.7771.00
23_R61_A0.7761.00
144_L148_V0.7751.00
109_E129_E0.7691.00
66_N245_L0.7641.00
28_N80_T0.7641.00
15_L50_C0.7631.00
208_A227_L0.7611.00
39_E83_Q0.7591.00
42_A93_K0.7581.00
35_V84_L0.7581.00
32_M36_N0.7581.00
176_D190_L0.7521.00
26_L30_L0.7501.00
187_A191_A0.7481.00
52_I114_C0.7451.00
142_Q145_I0.7441.00
41_A47_I0.7431.00
131_T162_S0.7421.00
223_Q227_L0.7361.00
92_N207_Q0.7331.00
91_F95_L0.7271.00
155_K159_S0.7271.00
227_L230_L0.7261.00
235_E238_H0.7261.00
149_G153_A0.7231.00
19_R27_N0.7221.00
58_F100_N0.7221.00
189_Q192_S0.7191.00
27_N67_E0.7171.00
165_A174_V0.7151.00
112_L173_L0.7121.00
217_L221_L0.7081.00
85_W113_L0.7061.00
198_S236_D0.7051.00
168_A173_L0.7021.00
211_Q215_V0.7021.00
79_D225_R0.7001.00
241_I245_L0.6981.00
194_M202_L0.6951.00
105_G128_P0.6921.00
193_K197_H0.6911.00
100_N180_S0.6901.00
72_D76_T0.6891.00
118_V176_D0.6831.00
23_R102_Y0.6811.00
79_D83_Q0.6801.00
129_E137_G0.6761.00
48_S199_P0.6761.00
222_A226_Q0.6761.00
6_V37_E0.6731.00
99_V123_A0.6711.00
192_S196_R0.6661.00
178_F183_T0.6661.00
30_L33_Q0.6651.00
159_S190_L0.6641.00
29_A32_M0.6631.00
6_V40_A0.6591.00
200_L234_T0.6551.00
11_R46_S0.6531.00
150_K210_R0.6501.00
51_V98_A0.6481.00
225_R229_T0.6481.00
44_D47_I0.6471.00
96_I191_A0.6441.00
12_V51_V0.6431.00
125_F174_V0.6431.00
119_A123_A0.6421.00
129_E136_P0.6401.00
208_A223_Q0.6391.00
118_V187_A0.6391.00
22_A25_A0.6371.00
69_A242_S0.6351.00
41_A93_K0.6331.00
190_L193_K0.6301.00
152_L169_Q0.6291.00
226_Q230_L0.6281.00
19_R25_A0.6281.00
91_F94_P0.6271.00
104_L128_P0.6271.00
39_E42_A0.6241.00
174_V177_V0.6211.00
52_I95_L0.6211.00
218_Q222_A0.6201.00
135_M208_A0.6161.00
97_A117_V0.6141.00
51_V188_L0.6131.00
37_E41_A0.6131.00
126_G160_G0.6101.00
136_P205_A0.6061.00
8_R11_R0.6061.00
63_A68_M0.6041.00
75_A229_T0.6031.00
150_K209_L0.5991.00
36_N39_E0.5981.00
118_V186_Y0.5971.00
44_D93_K0.5961.00
34_L84_L0.5941.00
129_E228_F0.5931.00
118_V183_T0.5931.00
158_L202_L0.5911.00
166_Q177_V0.5901.00
122_N165_A0.5901.00
235_E239_E0.5891.00
49_V195_A0.5891.00
12_V188_L0.5871.00
12_V191_A0.5851.00
49_V96_I0.5851.00
6_V15_L0.5841.00
75_A226_Q0.5841.00
109_E137_G0.5831.00
147_S175_S0.5821.00
22_A64_D0.5811.00
148_V153_A0.5781.00
163_I168_A0.5751.00
155_K167_Q0.5741.00
83_Q86_A0.5731.00
240_G243_A0.5721.00
102_Y162_S0.5691.00
134_I237_R0.5661.00
48_S195_A0.5651.00
239_E242_S0.5641.00
205_A208_A0.5621.00
38_L87_R0.5621.00
242_S245_L0.5601.00
239_E243_A0.5601.00
182_L189_Q0.5581.00
236_D240_G0.5571.00
200_L231_L0.5571.00
142_Q146_R0.5521.00
127_L157_V0.5491.00
15_L38_L0.5491.00
141_T220_G0.5471.00
76_T80_T0.5471.00
159_S194_M0.5471.00
83_Q87_R0.5431.00
164_T170_Q0.5431.00
154_S206_K0.5421.00
111_A114_C0.5411.00
161_E176_D0.5411.00
148_V171_A0.5391.00
239_E246_Q0.5371.00
72_D75_A0.5311.00
165_A169_Q0.5301.00
105_G127_L0.5291.00
38_L95_L0.5271.00
108_C173_L0.5271.00
113_L143_R0.5271.00
116_V194_M0.5261.00
127_L140_G0.5251.00
159_S193_K0.5231.00
152_L170_Q0.5221.00
109_E127_L0.5211.00
120_G123_A0.5201.00
29_A67_E0.5191.00
15_L52_I0.5191.00
63_A106_A0.5171.00
69_A245_L0.5151.00
130_I197_H0.5131.00
65_L132_L0.5121.00
109_E139_G0.5111.00
135_M205_A0.5111.00
127_L144_L0.5101.00
31_L35_V0.5071.00
106_A138_A0.5061.00
222_A225_R0.5061.00
26_L106_A0.5051.00
130_I202_L0.5041.00
145_I212_S0.5031.00
16_T184_L0.5021.00
100_N123_A0.5021.00
168_A174_V0.5011.00
73_L76_T0.5001.00
40_A43_T0.5001.00
69_A241_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lk5A 3 0.9725 100 0.075 Contact Map
3tlfA 5 0.9961 100 0.078 Contact Map
4mi2A 3 0.9961 100 0.079 Contact Map
3kqfA 3 1 100 0.08 Contact Map
3g64A 6 1 100 0.08 Contact Map
2fbmA 3 0.9529 100 0.083 Contact Map
1nzyA 4 1 100 0.083 Contact Map
3sllA 6 0.9843 100 0.085 Contact Map
3qreA 3 0.7686 100 0.085 Contact Map
2pbpA 5 1 100 0.085 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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