GREMLIN Database
PAAE - 1,2-phenylacetyl-CoA epoxidase, subunit E
UniProt: P76081 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13739
Length: 356 (313)
Sequences: 5395 (3886)
Seq/√Len: 219.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
282_E290_R3.9111.00
114_R142_Q3.3121.00
15_E21_T3.0601.00
74_A86_E2.9951.00
10_A25_A2.9561.00
7_L96_V2.7271.00
9_V88_I2.7241.00
289_L300_K2.6511.00
278_N282_E2.6481.00
6_S93_T2.5681.00
89_R92_M2.5161.00
22_I84_A2.4981.00
12_V20_V2.4821.00
132_A160_A2.4441.00
275_I287_A2.4301.00
265_T276_V2.4201.00
133_T137_T2.4041.00
309_C336_S2.3151.00
285_L297_Y2.2961.00
21_T69_S2.2841.00
315_K342_L2.2561.00
14_S20_V2.2251.00
265_T274_E2.2021.00
11_K90_Q2.1991.00
313_R347_V2.1871.00
124_I145_L2.1761.00
8_T93_T2.1681.00
149_N155_M2.1221.00
311_V334_V2.1011.00
219_A223_D2.0921.00
8_T25_A2.0441.00
212_E240_H2.0361.00
266_V284_I1.9661.00
278_N281_D1.9161.00
84_A88_I1.9061.00
74_A82_R1.9001.00
313_R345_D1.8941.00
44_L70_V1.8871.00
265_T345_D1.8621.00
119_A147_Y1.8521.00
23_T67_E1.8511.00
215_I225_A1.8301.00
6_S95_E1.8261.00
267_R345_D1.8181.00
118_I221_M1.7261.00
282_E287_A1.7251.00
284_I334_V1.7181.00
152_S181_E1.7101.00
151_T154_S1.6951.00
43_T56_C1.6761.00
267_R274_E1.6741.00
12_V90_Q1.6271.00
114_R144_T1.6261.00
155_M178_F1.6241.00
42_L96_V1.6211.00
82_R86_E1.6191.00
325_E328_E1.6161.00
21_T157_F1.5931.00
11_K23_T1.5881.00
117_A131_I1.5781.00
311_V316_V1.5721.00
23_T69_S1.5711.00
158_R162_A1.5701.00
118_I225_A1.5681.00
286_D300_K1.5611.00
17_R153_Q1.5501.00
120_A221_M1.5501.00
45_K95_E1.5461.00
148_G221_M1.5341.00
284_I336_S1.5301.00
270_G349_D1.5231.00
76_E79_R1.5231.00
119_A127_M1.4901.00
148_G179_S1.4841.00
26_V31_Q1.4691.00
46_A80_F1.4461.00
47_S51_E1.4391.00
116_L213_A1.4331.00
13_E21_T1.4271.00
268_Q288_A1.4201.00
88_I94_L1.4191.00
268_Q271_R1.4091.00
308_K333_Y1.4031.00
114_R211_D1.3991.00
88_I92_M1.3951.00
275_I291_Q1.3951.00
44_L84_A1.3941.00
226_E243_R1.3871.00
18_D154_S1.3731.00
47_S50_G1.3621.00
60_C71_A1.3481.00
226_E241_L1.3461.00
9_V24_F1.3261.00
119_A145_L1.3241.00
33_A68_I1.3201.00
326_P330_A1.2971.00
295_L336_S1.2901.00
152_S158_R1.2851.00
146_I200_L1.2841.00
278_N287_A1.2811.00
324_L328_E1.2791.00
105_Y134_T1.2721.00
72_V84_A1.2631.00
223_D227_T1.2441.00
179_S191_R1.2371.00
289_L297_Y1.2361.00
19_A156_M1.2331.00
148_G192_I1.2171.00
131_I143_F1.2141.00
83_Y87_H1.2131.00
12_V89_R1.1891.00
117_A143_F1.1861.00
317_A342_L1.1841.00
47_S52_E1.1831.00
268_Q275_I1.1791.00
27_P93_T1.1761.00
308_K335_L1.1731.00
230_K236_D1.1701.00
277_L287_A1.1641.00
213_A229_L1.1591.00
161_L174_L1.1571.00
213_A234_M1.1571.00
71_A156_M1.1521.00
284_I346_V1.1511.00
36_F61_R1.1511.00
274_E345_D1.1481.00
12_V22_I1.1441.00
286_D289_L1.1431.00
36_F59_I1.1381.00
8_T27_P1.1371.00
144_T175_L1.1311.00
51_E83_Y1.1051.00
215_I222_M1.0991.00
73_K154_S1.0981.00
15_E157_F1.0971.00
22_I72_V1.0891.00
198_Q232_L1.0871.00
32_E65_P1.0861.00
9_V22_I1.0841.00
222_M241_L1.0841.00
149_N176_C1.0831.00
316_V339_A1.0791.00
179_S220_A1.0661.00
263_K276_V1.0651.00
7_L27_P1.0631.00
28_Q31_Q1.0631.00
21_T71_A1.0621.00
267_R347_V1.0601.00
151_T180_Q1.0591.00
22_I88_I1.0571.00
316_V341_P1.0531.00
226_E239_I1.0501.00
226_E230_K1.0481.00
46_A53_L1.0451.00
7_L33_A1.0421.00
149_N154_S1.0411.00
283_S286_D1.0401.00
172_L176_C1.0391.00
149_N178_F1.0371.00
128_L157_F1.0281.00
115_Y141_S1.0251.00
323_S328_E1.0231.00
319_E340_L1.0211.00
38_P133_T1.0191.00
155_M158_R1.0151.00
267_R272_D0.9981.00
62_S132_A0.9951.00
24_F70_V0.9941.00
81_S85_R0.9921.00
69_S160_A0.9851.00
288_A295_L0.9821.00
287_A291_Q0.9701.00
105_Y130_I0.9691.00
10_A67_E0.9691.00
328_E332_G0.9681.00
13_E23_T0.9621.00
152_S162_A0.9571.00
227_T231_A0.9551.00
18_D73_K0.9511.00
270_G273_R0.9501.00
181_E189_H0.9481.00
59_I68_I0.9411.00
224_D228_A0.9321.00
112_Q115_Y0.9301.00
191_R220_A0.9280.99
310_K333_Y0.9260.99
322_Y335_L0.9240.99
262_Q344_S0.9150.99
127_M145_L0.9130.99
19_A122_S0.9100.99
310_K332_G0.9090.99
172_L177_I0.9000.99
142_Q173_Q0.8980.99
324_L332_G0.8980.99
316_V346_V0.8970.99
10_A23_T0.8930.99
312_L347_V0.8900.99
235_P238_T0.8890.99
297_Y300_K0.8890.99
68_I72_V0.8830.99
193_D199_S0.8830.99
288_A336_S0.8820.99
155_M176_C0.8810.99
20_V85_R0.8780.99
144_T173_Q0.8780.99
53_L79_R0.8770.99
25_A67_E0.8710.99
7_L26_V0.8700.99
70_V74_A0.8690.99
328_E331_A0.8690.99
44_L94_L0.8670.99
36_F129_A0.8660.99
215_I226_E0.8660.99
61_R69_S0.8650.99
131_I145_L0.8620.99
229_L239_I0.8610.99
147_Y156_M0.8600.99
46_A83_Y0.8600.99
135_L143_F0.8580.99
210_Y238_T0.8480.99
278_N290_R0.8470.99
128_L132_A0.8400.99
312_L349_D0.8380.99
215_I239_I0.8380.99
309_C348_V0.8380.99
26_V33_A0.8380.99
317_A340_L0.8380.99
227_T230_K0.8370.99
45_K54_R0.8360.99
37_R104_G0.8350.99
224_D227_T0.8330.99
204_L234_M0.8330.99
222_M243_R0.8330.99
107_P133_T0.8320.99
294_D297_Y0.8310.99
159_Q162_A0.8310.99
162_A176_C0.8280.99
117_A130_I0.8260.99
324_L329_L0.8240.99
152_S180_Q0.8220.99
131_I172_L0.8220.99
204_L211_D0.8210.99
329_L332_G0.8190.99
285_L289_L0.8180.99
135_L167_K0.8150.99
117_A127_M0.8140.99
201_G204_L0.8100.99
202_A232_L0.8080.99
117_A134_T0.8030.99
107_P137_T0.8020.99
16_T154_S0.8020.99
273_R291_Q0.7990.98
223_D243_R0.7990.98
146_I177_I0.7970.98
105_Y115_Y0.7910.98
289_L294_D0.7900.98
57_Y81_S0.7860.98
43_T100_Q0.7820.98
212_E238_T0.7730.98
159_Q163_D0.7680.98
7_L94_L0.7670.98
62_S136_Q0.7670.98
18_D74_A0.7650.98
178_F181_E0.7620.98
273_R293_A0.7620.98
113_G212_E0.7600.98
268_Q273_R0.7570.98
341_P344_S0.7570.98
34_Y98_V0.7570.98
42_L59_I0.7560.98
26_V29_P0.7420.98
163_D166_D0.7410.98
64_L67_E0.7410.98
40_Q101_G0.7400.98
60_C69_S0.7380.97
269_D347_V0.7370.97
223_D226_E0.7370.97
148_G177_I0.7360.97
258_Q261_G0.7330.97
282_E286_D0.7300.97
12_V92_M0.7290.97
67_E72_V0.7280.97
195_E198_Q0.7260.97
68_I96_V0.7260.97
115_Y212_E0.7210.97
267_R313_R0.7210.97
220_A224_D0.7200.97
17_R154_S0.7130.97
24_F94_L0.7130.97
228_A231_A0.7120.97
194_G198_Q0.7110.97
166_D169_P0.7090.97
19_A71_A0.7080.97
51_E79_R0.7070.97
152_S178_F0.7060.97
43_T54_R0.7040.97
135_L168_Y0.7040.97
45_K97_M0.7040.97
120_A148_G0.7030.97
135_L164_L0.7020.97
47_S83_Y0.6990.96
113_G210_Y0.6980.96
131_I135_L0.6960.96
316_V334_V0.6950.96
120_A220_A0.6940.96
165_K168_Y0.6930.96
118_I146_I0.6930.96
124_I147_Y0.6920.96
284_I309_C0.6870.96
7_L42_L0.6860.96
137_T141_S0.6840.96
68_I71_A0.6830.96
298_A306_T0.6800.96
198_Q228_A0.6750.96
69_S132_A0.6740.96
37_R101_G0.6740.96
215_I241_L0.6710.96
283_S340_L0.6700.96
297_Y303_V0.6680.95
45_K52_E0.6670.95
323_S327_D0.6630.95
288_A293_A0.6630.95
76_E82_R0.6620.95
285_L295_L0.6600.95
37_R40_Q0.6580.95
46_A84_A0.6560.95
269_D349_D0.6550.95
247_P321_N0.6530.95
118_I197_L0.6530.95
46_A51_E0.6490.95
198_Q231_A0.6490.95
303_V306_T0.6460.95
103_F130_I0.6460.95
158_R176_C0.6450.95
160_A163_D0.6450.95
42_L70_V0.6430.94
43_T97_M0.6400.94
120_A218_P0.6400.94
108_Q112_Q0.6380.94
73_K156_M0.6350.94
75_I78_G0.6350.94
287_A290_R0.6330.94
327_D330_A0.6320.94
219_A243_R0.6310.94
222_M225_A0.6310.94
134_T141_S0.6300.94
58_S127_M0.6300.94
220_A223_D0.6300.94
346_V349_D0.6300.94
75_I82_R0.6270.94
44_L96_V0.6220.93
225_A228_A0.6220.93
229_L234_M0.6210.93
228_A232_L0.6190.93
335_L338_Q0.6180.93
277_L284_I0.6170.93
7_L24_F0.6160.93
296_P336_S0.6150.93
269_D312_L0.6150.93
223_D241_L0.6120.93
67_E70_V0.6110.93
323_S331_A0.6100.93
345_D349_D0.6090.93
106_Q212_E0.6030.92
55_R130_I0.6020.92
114_R141_S0.6010.92
333_Y336_S0.5970.92
177_I180_Q0.5970.92
213_A225_A0.5960.92
27_P96_V0.5960.92
127_M131_I0.5930.92
114_R210_Y0.5930.92
212_E237_K0.5910.92
194_G197_L0.5900.92
309_C334_V0.5890.91
67_E71_A0.5890.91
334_V339_A0.5870.91
37_R107_P0.5860.91
145_L161_L0.5860.91
162_A166_D0.5850.91
53_L80_F0.5820.91
42_L68_I0.5810.91
318_M322_Y0.5810.91
113_G211_D0.5790.91
324_L327_D0.5790.91
264_V340_L0.5780.91
63_Y66_G0.5780.91
116_L211_D0.5780.91
16_T156_M0.5770.91
142_Q211_D0.5760.91
266_V275_I0.5730.90
41_H318_M0.5670.90
130_I214_F0.5670.90
63_Y67_E0.5660.90
276_V291_Q0.5650.90
316_V331_A0.5650.90
56_C100_Q0.5640.90
65_P68_I0.5630.90
234_M238_T0.5620.89
107_P141_S0.5590.89
60_C157_F0.5580.89
276_V280_D0.5580.89
72_V81_S0.5580.89
32_E66_G0.5580.89
105_Y214_F0.5570.89
286_D290_R0.5550.89
194_G231_A0.5530.89
201_G229_L0.5530.89
74_A85_R0.5520.89
319_E339_A0.5510.89
34_Y68_I0.5500.88
317_A339_A0.5500.88
221_M224_D0.5500.88
164_L167_K0.5470.88
177_I189_H0.5450.88
284_I288_A0.5440.88
119_A149_N0.5410.88
20_V84_A0.5410.88
301_G321_N0.5400.88
15_E71_A0.5390.87
273_R288_A0.5380.87
122_S156_M0.5330.87
318_M329_L0.5320.87
71_A74_A0.5310.87
283_S338_Q0.5310.87
115_Y214_F0.5300.87
327_D331_A0.5300.87
38_P105_Y0.5290.86
150_R179_S0.5280.86
81_S157_F0.5270.86
168_Y172_L0.5270.86
191_R224_D0.5260.86
87_H92_M0.5260.86
145_L172_L0.5260.86
320_T323_S0.5260.86
16_T218_P0.5260.86
9_V94_L0.5250.86
63_Y136_Q0.5250.86
308_K328_E0.5240.86
118_I213_A0.5240.86
303_V321_N0.5220.86
16_T19_A0.5220.86
180_Q191_R0.5220.86
275_I341_P0.5210.86
10_A90_Q0.5210.86
328_E333_Y0.5200.86
82_R87_H0.5190.85
35_R65_P0.5190.85
104_G107_P0.5180.85
197_L225_A0.5180.85
120_A224_D0.5160.85
106_Q240_H0.5160.85
37_R106_Q0.5140.85
246_T303_V0.5140.85
181_E190_G0.5130.85
129_A132_A0.5130.85
115_Y134_T0.5130.85
165_K169_P0.5120.85
116_L146_I0.5120.85
275_I288_A0.5110.85
14_S18_D0.5110.85
131_I164_L0.5090.84
61_R64_L0.5080.84
146_I175_L0.5070.84
308_K322_Y0.5070.84
318_M339_A0.5030.84
16_T20_V0.5020.83
191_R194_G0.5010.83
303_V322_Y0.5000.83
147_Y155_M0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2piaA 1 0.882 100 0.322 Contact Map
1gvhA 3 0.677 100 0.48 Contact Map
1cqxA 2 0.677 100 0.487 Contact Map
4g1vA 3 0.6629 100 0.512 Contact Map
1tvcA 1 0.6713 100 0.525 Contact Map
1krhA 1 0.6573 100 0.526 Contact Map
4eh1A 2 0.6489 100 0.528 Contact Map
4p6vF 1 0.6657 100 0.532 Contact Map
2eixA 2 0.6573 100 0.535 Contact Map
2cndA 1 0.6629 100 0.537 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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