PAAE - ECOLI - GREMLIN Contacts

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PAAE - 1,2-phenylacetyl-CoA epoxidase, subunit E

UniProt:	P76081	Sequences: MTTFHSLTVAKVESETRDAVTITFAVPQPLQEAYRFRPGQHLTLKASFDGEELRRCYSICRSYLPGEISVAVKAIEGGRFSRYAREHIRQGMTLEVMVPQGHFGYQPQAERQGRYLAIAAGSGITPMLAIIATTLQTEPESQFTLIYGNRTSQSMMFRQALADLKDKYPQRLQLLCIFSQETLDSDLLHGRIDGEKLQSLGASLINFRLYDEAFICGPAAMMDDAETALKALGMPDKTIHLERFNTPGTRVKRSVNVQSDGQKVTVRQDGRDREIVLNADDESILDAALRQGADLPYACKGGVCATCKCKVLRGKVAMETNYSLEPDELAAGYVLSCQALPLTSDVVVDFDAKGMA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13739
Length:	356 (313)
Sequences:	5395 (3886)
Seq/√Len:	219.6

ECOLI - PAAE YEAX HCR HMP
BACSU - HMP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
282_E	290_R	3.911	1.00
114_R	142_Q	3.312	1.00
15_E	21_T	3.060	1.00
74_A	86_E	2.995	1.00
10_A	25_A	2.956	1.00
7_L	96_V	2.727	1.00
9_V	88_I	2.724	1.00
289_L	300_K	2.651	1.00
278_N	282_E	2.648	1.00
6_S	93_T	2.568	1.00
89_R	92_M	2.516	1.00
22_I	84_A	2.498	1.00
12_V	20_V	2.482	1.00
132_A	160_A	2.444	1.00
275_I	287_A	2.430	1.00
265_T	276_V	2.420	1.00
133_T	137_T	2.404	1.00
309_C	336_S	2.315	1.00
285_L	297_Y	2.296	1.00
21_T	69_S	2.284	1.00
315_K	342_L	2.256	1.00
14_S	20_V	2.225	1.00
265_T	274_E	2.202	1.00
11_K	90_Q	2.199	1.00
313_R	347_V	2.187	1.00
124_I	145_L	2.176	1.00
8_T	93_T	2.168	1.00
149_N	155_M	2.122	1.00
311_V	334_V	2.101	1.00
219_A	223_D	2.092	1.00
8_T	25_A	2.044	1.00
212_E	240_H	2.036	1.00
266_V	284_I	1.966	1.00
278_N	281_D	1.916	1.00
84_A	88_I	1.906	1.00
74_A	82_R	1.900	1.00
313_R	345_D	1.894	1.00
44_L	70_V	1.887	1.00
265_T	345_D	1.862	1.00
119_A	147_Y	1.852	1.00
23_T	67_E	1.851	1.00
215_I	225_A	1.830	1.00
6_S	95_E	1.826	1.00
267_R	345_D	1.818	1.00
118_I	221_M	1.726	1.00
282_E	287_A	1.725	1.00
284_I	334_V	1.718	1.00
152_S	181_E	1.710	1.00
151_T	154_S	1.695	1.00
43_T	56_C	1.676	1.00
267_R	274_E	1.674	1.00
12_V	90_Q	1.627	1.00
114_R	144_T	1.626	1.00
155_M	178_F	1.624	1.00
42_L	96_V	1.621	1.00
82_R	86_E	1.619	1.00
325_E	328_E	1.616	1.00
21_T	157_F	1.593	1.00
11_K	23_T	1.588	1.00
117_A	131_I	1.578	1.00
311_V	316_V	1.572	1.00
23_T	69_S	1.571	1.00
158_R	162_A	1.570	1.00
118_I	225_A	1.568	1.00
286_D	300_K	1.561	1.00
17_R	153_Q	1.550	1.00
120_A	221_M	1.550	1.00
45_K	95_E	1.546	1.00
148_G	221_M	1.534	1.00
284_I	336_S	1.530	1.00
270_G	349_D	1.523	1.00
76_E	79_R	1.523	1.00
119_A	127_M	1.490	1.00
148_G	179_S	1.484	1.00
26_V	31_Q	1.469	1.00
46_A	80_F	1.446	1.00
47_S	51_E	1.439	1.00
116_L	213_A	1.433	1.00
13_E	21_T	1.427	1.00
268_Q	288_A	1.420	1.00
88_I	94_L	1.419	1.00
268_Q	271_R	1.409	1.00
308_K	333_Y	1.403	1.00
114_R	211_D	1.399	1.00
88_I	92_M	1.395	1.00
275_I	291_Q	1.395	1.00
44_L	84_A	1.394	1.00
226_E	243_R	1.387	1.00
18_D	154_S	1.373	1.00
47_S	50_G	1.362	1.00
60_C	71_A	1.348	1.00
226_E	241_L	1.346	1.00
9_V	24_F	1.326	1.00
119_A	145_L	1.324	1.00
33_A	68_I	1.320	1.00
326_P	330_A	1.297	1.00
295_L	336_S	1.290	1.00
152_S	158_R	1.285	1.00
146_I	200_L	1.284	1.00
278_N	287_A	1.281	1.00
324_L	328_E	1.279	1.00
105_Y	134_T	1.272	1.00
72_V	84_A	1.263	1.00
223_D	227_T	1.244	1.00
179_S	191_R	1.237	1.00
289_L	297_Y	1.236	1.00
19_A	156_M	1.233	1.00
148_G	192_I	1.217	1.00
131_I	143_F	1.214	1.00
83_Y	87_H	1.213	1.00
12_V	89_R	1.189	1.00
117_A	143_F	1.186	1.00
317_A	342_L	1.184	1.00
47_S	52_E	1.183	1.00
268_Q	275_I	1.179	1.00
27_P	93_T	1.176	1.00
308_K	335_L	1.173	1.00
230_K	236_D	1.170	1.00
277_L	287_A	1.164	1.00
213_A	229_L	1.159	1.00
161_L	174_L	1.157	1.00
213_A	234_M	1.157	1.00
71_A	156_M	1.152	1.00
284_I	346_V	1.151	1.00
36_F	61_R	1.151	1.00
274_E	345_D	1.148	1.00
12_V	22_I	1.144	1.00
286_D	289_L	1.143	1.00
36_F	59_I	1.138	1.00
8_T	27_P	1.137	1.00
144_T	175_L	1.131	1.00
51_E	83_Y	1.105	1.00
215_I	222_M	1.099	1.00
73_K	154_S	1.098	1.00
15_E	157_F	1.097	1.00
22_I	72_V	1.089	1.00
198_Q	232_L	1.087	1.00
32_E	65_P	1.086	1.00
9_V	22_I	1.084	1.00
222_M	241_L	1.084	1.00
149_N	176_C	1.083	1.00
316_V	339_A	1.079	1.00
179_S	220_A	1.066	1.00
263_K	276_V	1.065	1.00
7_L	27_P	1.063	1.00
28_Q	31_Q	1.063	1.00
21_T	71_A	1.062	1.00
267_R	347_V	1.060	1.00
151_T	180_Q	1.059	1.00
22_I	88_I	1.057	1.00
316_V	341_P	1.053	1.00
226_E	239_I	1.050	1.00
226_E	230_K	1.048	1.00
46_A	53_L	1.045	1.00
7_L	33_A	1.042	1.00
149_N	154_S	1.041	1.00
283_S	286_D	1.040	1.00
172_L	176_C	1.039	1.00
149_N	178_F	1.037	1.00
128_L	157_F	1.028	1.00
115_Y	141_S	1.025	1.00
323_S	328_E	1.023	1.00
319_E	340_L	1.021	1.00
38_P	133_T	1.019	1.00
155_M	158_R	1.015	1.00
267_R	272_D	0.998	1.00
62_S	132_A	0.995	1.00
24_F	70_V	0.994	1.00
81_S	85_R	0.992	1.00
69_S	160_A	0.985	1.00
288_A	295_L	0.982	1.00
287_A	291_Q	0.970	1.00
105_Y	130_I	0.969	1.00
10_A	67_E	0.969	1.00
328_E	332_G	0.968	1.00
13_E	23_T	0.962	1.00
152_S	162_A	0.957	1.00
227_T	231_A	0.955	1.00
18_D	73_K	0.951	1.00
270_G	273_R	0.950	1.00
181_E	189_H	0.948	1.00
59_I	68_I	0.941	1.00
224_D	228_A	0.932	1.00
112_Q	115_Y	0.930	1.00
191_R	220_A	0.928	0.99
310_K	333_Y	0.926	0.99
322_Y	335_L	0.924	0.99
262_Q	344_S	0.915	0.99
127_M	145_L	0.913	0.99
19_A	122_S	0.910	0.99
310_K	332_G	0.909	0.99
172_L	177_I	0.900	0.99
142_Q	173_Q	0.898	0.99
324_L	332_G	0.898	0.99
316_V	346_V	0.897	0.99
10_A	23_T	0.893	0.99
312_L	347_V	0.890	0.99
235_P	238_T	0.889	0.99
297_Y	300_K	0.889	0.99
68_I	72_V	0.883	0.99
193_D	199_S	0.883	0.99
288_A	336_S	0.882	0.99
155_M	176_C	0.881	0.99
20_V	85_R	0.878	0.99
144_T	173_Q	0.878	0.99
53_L	79_R	0.877	0.99
25_A	67_E	0.871	0.99
7_L	26_V	0.870	0.99
70_V	74_A	0.869	0.99
328_E	331_A	0.869	0.99
44_L	94_L	0.867	0.99
36_F	129_A	0.866	0.99
215_I	226_E	0.866	0.99
61_R	69_S	0.865	0.99
131_I	145_L	0.862	0.99
229_L	239_I	0.861	0.99
147_Y	156_M	0.860	0.99
46_A	83_Y	0.860	0.99
135_L	143_F	0.858	0.99
210_Y	238_T	0.848	0.99
278_N	290_R	0.847	0.99
128_L	132_A	0.840	0.99
312_L	349_D	0.838	0.99
215_I	239_I	0.838	0.99
309_C	348_V	0.838	0.99
26_V	33_A	0.838	0.99
317_A	340_L	0.838	0.99
227_T	230_K	0.837	0.99
45_K	54_R	0.836	0.99
37_R	104_G	0.835	0.99
224_D	227_T	0.833	0.99
204_L	234_M	0.833	0.99
222_M	243_R	0.833	0.99
107_P	133_T	0.832	0.99
294_D	297_Y	0.831	0.99
159_Q	162_A	0.831	0.99
162_A	176_C	0.828	0.99
117_A	130_I	0.826	0.99
324_L	329_L	0.824	0.99
152_S	180_Q	0.822	0.99
131_I	172_L	0.822	0.99
204_L	211_D	0.821	0.99
329_L	332_G	0.819	0.99
285_L	289_L	0.818	0.99
135_L	167_K	0.815	0.99
117_A	127_M	0.814	0.99
201_G	204_L	0.810	0.99
202_A	232_L	0.808	0.99
117_A	134_T	0.803	0.99
107_P	137_T	0.802	0.99
16_T	154_S	0.802	0.99
273_R	291_Q	0.799	0.98
223_D	243_R	0.799	0.98
146_I	177_I	0.797	0.98
105_Y	115_Y	0.791	0.98
289_L	294_D	0.790	0.98
57_Y	81_S	0.786	0.98
43_T	100_Q	0.782	0.98
212_E	238_T	0.773	0.98
159_Q	163_D	0.768	0.98
7_L	94_L	0.767	0.98
62_S	136_Q	0.767	0.98
18_D	74_A	0.765	0.98
178_F	181_E	0.762	0.98
273_R	293_A	0.762	0.98
113_G	212_E	0.760	0.98
268_Q	273_R	0.757	0.98
341_P	344_S	0.757	0.98
34_Y	98_V	0.757	0.98
42_L	59_I	0.756	0.98
26_V	29_P	0.742	0.98
163_D	166_D	0.741	0.98
64_L	67_E	0.741	0.98
40_Q	101_G	0.740	0.98
60_C	69_S	0.738	0.97
269_D	347_V	0.737	0.97
223_D	226_E	0.737	0.97
148_G	177_I	0.736	0.97
258_Q	261_G	0.733	0.97
282_E	286_D	0.730	0.97
12_V	92_M	0.729	0.97
67_E	72_V	0.728	0.97
195_E	198_Q	0.726	0.97
68_I	96_V	0.726	0.97
115_Y	212_E	0.721	0.97
267_R	313_R	0.721	0.97
220_A	224_D	0.720	0.97
17_R	154_S	0.713	0.97
24_F	94_L	0.713	0.97
228_A	231_A	0.712	0.97
194_G	198_Q	0.711	0.97
166_D	169_P	0.709	0.97
19_A	71_A	0.708	0.97
51_E	79_R	0.707	0.97
152_S	178_F	0.706	0.97
43_T	54_R	0.704	0.97
135_L	168_Y	0.704	0.97
45_K	97_M	0.704	0.97
120_A	148_G	0.703	0.97
135_L	164_L	0.702	0.97
47_S	83_Y	0.699	0.96
113_G	210_Y	0.698	0.96
131_I	135_L	0.696	0.96
316_V	334_V	0.695	0.96
120_A	220_A	0.694	0.96
165_K	168_Y	0.693	0.96
118_I	146_I	0.693	0.96
124_I	147_Y	0.692	0.96
284_I	309_C	0.687	0.96
7_L	42_L	0.686	0.96
137_T	141_S	0.684	0.96
68_I	71_A	0.683	0.96
298_A	306_T	0.680	0.96
198_Q	228_A	0.675	0.96
69_S	132_A	0.674	0.96
37_R	101_G	0.674	0.96
215_I	241_L	0.671	0.96
283_S	340_L	0.670	0.96
297_Y	303_V	0.668	0.95
45_K	52_E	0.667	0.95
323_S	327_D	0.663	0.95
288_A	293_A	0.663	0.95
76_E	82_R	0.662	0.95
285_L	295_L	0.660	0.95
37_R	40_Q	0.658	0.95
46_A	84_A	0.656	0.95
269_D	349_D	0.655	0.95
247_P	321_N	0.653	0.95
118_I	197_L	0.653	0.95
46_A	51_E	0.649	0.95
198_Q	231_A	0.649	0.95
303_V	306_T	0.646	0.95
103_F	130_I	0.646	0.95
158_R	176_C	0.645	0.95
160_A	163_D	0.645	0.95
42_L	70_V	0.643	0.94
43_T	97_M	0.640	0.94
120_A	218_P	0.640	0.94
108_Q	112_Q	0.638	0.94
73_K	156_M	0.635	0.94
75_I	78_G	0.635	0.94
287_A	290_R	0.633	0.94
327_D	330_A	0.632	0.94
219_A	243_R	0.631	0.94
222_M	225_A	0.631	0.94
134_T	141_S	0.630	0.94
58_S	127_M	0.630	0.94
220_A	223_D	0.630	0.94
346_V	349_D	0.630	0.94
75_I	82_R	0.627	0.94
44_L	96_V	0.622	0.93
225_A	228_A	0.622	0.93
229_L	234_M	0.621	0.93
228_A	232_L	0.619	0.93
335_L	338_Q	0.618	0.93
277_L	284_I	0.617	0.93
7_L	24_F	0.616	0.93
296_P	336_S	0.615	0.93
269_D	312_L	0.615	0.93
223_D	241_L	0.612	0.93
67_E	70_V	0.611	0.93
323_S	331_A	0.610	0.93
345_D	349_D	0.609	0.93
106_Q	212_E	0.603	0.92
55_R	130_I	0.602	0.92
114_R	141_S	0.601	0.92
333_Y	336_S	0.597	0.92
177_I	180_Q	0.597	0.92
213_A	225_A	0.596	0.92
27_P	96_V	0.596	0.92
127_M	131_I	0.593	0.92
114_R	210_Y	0.593	0.92
212_E	237_K	0.591	0.92
194_G	197_L	0.590	0.92
309_C	334_V	0.589	0.91
67_E	71_A	0.589	0.91
334_V	339_A	0.587	0.91
37_R	107_P	0.586	0.91
145_L	161_L	0.586	0.91
162_A	166_D	0.585	0.91
53_L	80_F	0.582	0.91
42_L	68_I	0.581	0.91
318_M	322_Y	0.581	0.91
113_G	211_D	0.579	0.91
324_L	327_D	0.579	0.91
264_V	340_L	0.578	0.91
63_Y	66_G	0.578	0.91
116_L	211_D	0.578	0.91
16_T	156_M	0.577	0.91
142_Q	211_D	0.576	0.91
266_V	275_I	0.573	0.90
41_H	318_M	0.567	0.90
130_I	214_F	0.567	0.90
63_Y	67_E	0.566	0.90
276_V	291_Q	0.565	0.90
316_V	331_A	0.565	0.90
56_C	100_Q	0.564	0.90
65_P	68_I	0.563	0.90
234_M	238_T	0.562	0.89
107_P	141_S	0.559	0.89
60_C	157_F	0.558	0.89
276_V	280_D	0.558	0.89
72_V	81_S	0.558	0.89
32_E	66_G	0.558	0.89
105_Y	214_F	0.557	0.89
286_D	290_R	0.555	0.89
194_G	231_A	0.553	0.89
201_G	229_L	0.553	0.89
74_A	85_R	0.552	0.89
319_E	339_A	0.551	0.89
34_Y	68_I	0.550	0.88
317_A	339_A	0.550	0.88
221_M	224_D	0.550	0.88
164_L	167_K	0.547	0.88
177_I	189_H	0.545	0.88
284_I	288_A	0.544	0.88
119_A	149_N	0.541	0.88
20_V	84_A	0.541	0.88
301_G	321_N	0.540	0.88
15_E	71_A	0.539	0.87
273_R	288_A	0.538	0.87
122_S	156_M	0.533	0.87
318_M	329_L	0.532	0.87
71_A	74_A	0.531	0.87
283_S	338_Q	0.531	0.87
115_Y	214_F	0.530	0.87
327_D	331_A	0.530	0.87
38_P	105_Y	0.529	0.86
150_R	179_S	0.528	0.86
81_S	157_F	0.527	0.86
168_Y	172_L	0.527	0.86
191_R	224_D	0.526	0.86
87_H	92_M	0.526	0.86
145_L	172_L	0.526	0.86
320_T	323_S	0.526	0.86
16_T	218_P	0.526	0.86
9_V	94_L	0.525	0.86
63_Y	136_Q	0.525	0.86
308_K	328_E	0.524	0.86
118_I	213_A	0.524	0.86
303_V	321_N	0.522	0.86
16_T	19_A	0.522	0.86
180_Q	191_R	0.522	0.86
275_I	341_P	0.521	0.86
10_A	90_Q	0.521	0.86
328_E	333_Y	0.520	0.86
82_R	87_H	0.519	0.85
35_R	65_P	0.519	0.85
104_G	107_P	0.518	0.85
197_L	225_A	0.518	0.85
120_A	224_D	0.516	0.85
106_Q	240_H	0.516	0.85
37_R	106_Q	0.514	0.85
246_T	303_V	0.514	0.85
181_E	190_G	0.513	0.85
129_A	132_A	0.513	0.85
115_Y	134_T	0.513	0.85
165_K	169_P	0.512	0.85
116_L	146_I	0.512	0.85
275_I	288_A	0.511	0.85
14_S	18_D	0.511	0.85
131_I	164_L	0.509	0.84
61_R	64_L	0.508	0.84
146_I	175_L	0.507	0.84
308_K	322_Y	0.507	0.84
318_M	339_A	0.503	0.84
16_T	20_V	0.502	0.83
191_R	194_G	0.501	0.83
303_V	322_Y	0.500	0.83
147_Y	155_M	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2piaA	1	0.882	100	0.322	Contact Map
1gvhA	3	0.677	100	0.48	Contact Map
1cqxA	2	0.677	100	0.487	Contact Map
4g1vA	3	0.6629	100	0.512	Contact Map
1tvcA	1	0.6713	100	0.525	Contact Map
1krhA	1	0.6573	100	0.526	Contact Map
4eh1A	2	0.6489	100	0.528	Contact Map
4p6vF	1	0.6657	100	0.532	Contact Map
2eixA	2	0.6573	100	0.535	Contact Map
2cndA	1	0.6629	100	0.537	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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