GREMLIN Database
PAAD - Putative 1,2-phenylacetyl-CoA epoxidase, subunit D
UniProt: P76080 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13738
Length: 165 (155)
Sequences: 886 (512)
Seq/√Len: 41.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_H154_S4.1901.00
37_M65_L4.1721.00
52_F69_I3.4321.00
137_L140_E3.2031.00
143_S160_D2.9641.00
136_T151_R2.8871.00
134_H153_D2.8761.00
32_I65_L2.8311.00
102_E106_E2.6701.00
34_D103_R2.5851.00
136_T153_D2.5401.00
99_D103_R2.4761.00
102_E105_R2.4011.00
52_F62_T2.3171.00
29_V107_Y2.2901.00
33_T38_V2.2371.00
49_V82_Q2.2031.00
18_L72_A2.0860.99
51_G86_Q2.0420.99
34_D100_A2.0290.99
49_V84_V1.9960.99
27_I107_Y1.9200.99
44_M49_V1.9050.99
40_N51_G1.9000.99
30_L34_D1.8860.98
19_L38_V1.7660.98
70_R74_T1.7440.97
92_T95_W1.7300.97
47_G80_P1.6830.97
97_T100_A1.6370.96
96_M101_R1.6320.96
64_H68_A1.6290.96
19_L33_T1.6010.96
47_G82_Q1.5910.96
30_L96_M1.5860.96
32_I38_V1.5810.95
68_A71_E1.5620.95
105_R126_R1.5600.95
18_L76_N1.5470.95
43_Q48_W1.4860.94
150_Y161_Y1.4690.93
50_I73_M1.4630.93
21_Q72_A1.4370.93
143_S147_K1.4320.92
39_R95_W1.4240.92
147_K162_F1.3660.90
147_K160_D1.3370.89
18_L21_Q1.3370.89
42_T51_G1.3280.89
51_G84_V1.3050.88
30_L37_M1.3040.88
34_D99_D1.2620.87
46_E82_Q1.2060.84
18_L78_F1.1940.83
20_S99_D1.1760.82
140_E165_I1.1580.81
15_I73_M1.1460.81
74_T79_T1.1330.80
125_V135_T1.1230.79
99_D102_E1.1230.79
23_P30_L1.1070.78
38_V62_T1.0720.76
27_I145_A1.0690.76
38_V64_H1.0570.75
105_R131_A1.0460.74
138_I149_L1.0300.73
13_H17_A1.0140.72
66_I70_R1.0120.72
53_T95_W1.0060.71
69_I164_C0.9970.71
67_G71_E0.9730.69
20_S33_T0.9660.68
37_M52_F0.9640.68
14_E17_A0.9610.68
87_L90_A0.9600.68
42_T49_V0.9580.68
113_A116_S0.9570.67
62_T65_L0.9390.66
44_M47_G0.9350.66
31_T34_D0.9250.65
63_E66_I0.9140.64
96_M100_A0.9110.64
143_S162_F0.9020.63
23_P31_T0.8940.62
18_L65_L0.8930.62
103_R106_E0.8920.62
11_Q14_E0.8860.61
72_A76_N0.8790.61
46_E80_P0.8690.60
131_A134_H0.8650.60
89_P157_E0.8550.59
67_G70_R0.8540.59
32_I37_M0.8500.58
109_I145_A0.8490.58
136_T156_R0.8300.56
129_R157_E0.8220.56
96_M162_F0.8220.56
12_V40_N0.8140.55
16_W33_T0.8090.54
27_I143_S0.8060.54
32_I52_F0.7790.52
16_W20_S0.7670.51
14_E76_N0.7620.50
78_F81_V0.7600.50
143_S149_L0.7540.49
19_L164_C0.7450.48
56_Y161_Y0.7400.48
53_T89_P0.7330.47
67_G150_Y0.7300.47
19_L31_T0.7270.47
38_V137_L0.7240.47
53_T157_E0.7210.46
70_R103_R0.7200.46
17_A99_D0.7190.46
48_W81_V0.7160.46
38_V145_A0.7150.46
151_R157_E0.7150.46
27_I78_F0.7140.46
100_A129_R0.7130.46
124_E133_V0.7060.45
12_V41_V0.7050.45
138_I160_D0.7040.45
18_L43_Q0.7010.44
44_M79_T0.7000.44
118_H122_P0.6980.44
100_A138_I0.6950.44
82_Q153_D0.6930.44
30_L97_T0.6900.43
17_A21_Q0.6870.43
134_H150_Y0.6780.42
52_F85_L0.6750.42
65_L118_H0.6730.42
12_V16_W0.6710.42
74_T81_V0.6690.41
65_L100_A0.6690.41
121_L124_E0.6650.41
22_I72_A0.6650.41
56_Y138_I0.6640.41
148_A161_Y0.6620.41
27_I162_F0.6590.41
56_Y139_S0.6570.40
22_I32_I0.6560.40
126_R131_A0.6560.40
15_I23_P0.6530.40
140_E160_D0.6520.40
41_V48_W0.6500.40
27_I109_I0.6490.40
113_A164_C0.6470.40
89_P94_D0.6450.39
16_W31_T0.6400.39
151_R165_I0.6370.39
126_R133_V0.6360.39
101_R111_P0.6320.38
33_T105_R0.6320.38
21_Q99_D0.6320.38
56_Y143_S0.6300.38
118_H123_P0.6240.37
39_R53_T0.6240.37
138_I157_E0.6240.37
114_G117_C0.6200.37
37_M62_T0.6180.37
15_I18_L0.6160.37
69_I85_L0.6150.37
119_A156_R0.6100.36
22_I136_T0.6050.36
28_P93_T0.6030.36
19_L69_I0.6000.35
151_R156_R0.5980.35
98_P102_E0.5940.35
14_E18_L0.5940.35
86_Q165_I0.5900.35
57_S147_K0.5880.34
41_V101_R0.5860.34
28_P57_S0.5760.33
92_T107_Y0.5750.33
139_S151_R0.5750.33
32_I164_C0.5750.33
47_G81_V0.5730.33
68_A164_C0.5720.33
147_K157_E0.5710.33
30_L106_E0.5690.33
68_A148_A0.5680.33
90_A132_S0.5680.33
102_E114_G0.5670.33
12_V48_W0.5660.33
15_I76_N0.5640.32
134_H138_I0.5640.32
57_S86_Q0.5630.32
94_D135_T0.5620.32
66_I85_L0.5610.32
121_L126_R0.5610.32
57_S122_P0.5600.32
21_Q40_N0.5580.32
27_I161_Y0.5570.32
116_S119_A0.5570.32
29_V53_T0.5550.32
101_R136_T0.5540.32
97_T103_R0.5510.31
147_K150_Y0.5490.31
93_T101_R0.5470.31
71_E131_A0.5440.31
33_T97_T0.5430.31
18_L73_M0.5390.30
56_Y95_W0.5370.30
104_L111_P0.5360.30
13_H43_Q0.5330.30
57_S87_L0.5300.30
14_E43_Q0.5290.30
20_S34_D0.5270.29
15_I48_W0.5260.29
39_R89_P0.5250.29
145_A164_C0.5250.29
44_M51_G0.5230.29
113_A126_R0.5220.29
157_E160_D0.5180.29
123_P150_Y0.5180.29
18_L69_I0.5170.29
137_L150_Y0.5160.29
140_E147_K0.5150.29
17_A79_T0.5150.29
140_E164_C0.5150.29
65_L164_C0.5140.28
63_E83_V0.5110.28
96_M145_A0.5100.28
78_F153_D0.5080.28
15_I142_G0.5060.28
101_R131_A0.5050.28
39_R57_S0.5050.28
113_A161_Y0.5050.28
119_A122_P0.5030.28
47_G75_T0.5010.28
27_I142_G0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lnoA 1 0.6182 99.9 0.667 Contact Map
3cq1A 2 0.5939 99.9 0.67 Contact Map
1uwdA 1 0.6061 99.9 0.672 Contact Map
3ux2A 2 0.6909 99.9 0.706 Contact Map
4esjA 1 0.4061 87.2 0.933 Contact Map
1k81A 1 0.2182 73.1 0.943 Contact Map
1wiiA 1 0.3697 70.4 0.944 Contact Map
1vd4A 1 0.3212 65.2 0.946 Contact Map
3cc2Z 1 0.297 63.4 0.946 Contact Map
3j20Y 1 0.303 63.3 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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