GREMLIN Database
PAAC - 1,2-phenylacetyl-CoA epoxidase, subunit C
UniProt: P76079 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13737
Length: 248 (227)
Sequences: 1386 (707)
Seq/√Len: 46.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_Q160_N4.2671.00
64_D67_T4.1571.00
12_G53_L4.0701.00
10_R173_D3.4831.00
80_L169_L3.0881.00
179_L185_A2.9551.00
19_S46_L2.9091.00
95_A155_M2.8951.00
34_I136_F2.8481.00
156_Q209_N2.8301.00
99_F159_I2.7901.00
20_Q23_G2.7571.00
152_G207_T2.6261.00
85_Q165_F2.6181.00
17_V232_M2.5741.00
14_N221_K2.5361.00
146_N207_T2.4931.00
152_G156_Q2.4071.00
91_A158_A2.3521.00
86_P228_H2.3491.00
50_R65_E2.2871.00
166_T195_W2.1741.00
141_L155_M2.1561.00
98_Y141_L2.1361.00
52_F119_L2.1111.00
102_A134_L2.0891.00
5_T59_L2.0601.00
200_F210_V1.9820.99
52_F108_F1.9430.99
172_A187_D1.8980.99
55_Y118_Q1.8860.99
85_Q226_T1.8580.99
6_A78_S1.8500.99
145_G155_M1.8080.99
74_E230_G1.7900.99
94_I141_L1.7320.98
53_L68_L1.6560.98
192_R196_E1.6250.97
55_Y116_D1.6090.97
155_M208_L1.5970.97
89_N154_K1.5950.97
108_F130_A1.5900.97
95_A159_I1.5610.97
153_Q157_Q1.5550.97
163_W211_P1.5290.96
108_F136_F1.5250.96
74_E229_L1.4920.96
177_I181_E1.4720.95
67_T71_T1.4030.94
150_V153_Q1.4030.94
8_T59_L1.4020.94
101_D104_H1.4020.94
106_A198_E1.4010.94
127_I131_R1.3960.94
92_D161_K1.3890.94
99_F162_L1.3810.93
21_R24_E1.3810.93
39_A46_L1.3750.93
29_A90_F1.3680.93
98_Y202_G1.3630.93
98_Y199_V1.3260.92
200_F204_N1.3250.92
172_A189_R1.3210.92
187_D190_T1.3100.92
174_E177_I1.2960.91
57_A64_D1.2840.91
229_L233_L1.2800.91
196_E200_F1.2780.91
98_Y137_S1.2760.90
89_N92_D1.2500.90
225_H229_L1.2450.89
105_V127_I1.2340.89
220_G225_H1.2270.89
95_A158_A1.2260.89
110_R194_A1.2260.89
156_Q203_I1.2190.88
201_A205_E1.1950.87
83_V100_I1.1910.87
14_N80_L1.1850.87
145_G152_G1.1820.87
85_Q228_H1.1670.86
104_H130_A1.1640.86
117_P121_A1.1440.85
73_D76_Q1.1440.85
156_Q207_T1.1410.85
18_L96_R1.1100.83
181_E184_I1.1040.83
145_G156_Q1.0960.82
218_T224_L1.0960.82
177_I187_D1.0940.82
141_L202_G1.0890.82
147_G151_S1.0780.81
94_I140_W1.0750.81
167_A192_R1.0720.81
104_H108_F1.0700.81
145_G206_A1.0670.80
52_F104_H1.0630.80
51_N122_I1.0620.80
45_L130_A1.0610.80
102_A106_A1.0550.80
192_R195_W1.0530.80
138_R202_G1.0520.80
79_N84_E1.0320.78
10_R175_I1.0240.78
80_L100_I1.0230.78
95_A141_L1.0210.77
138_R198_E1.0100.77
101_D108_F0.9990.76
193_A196_E0.9980.76
148_T163_W0.9830.75
171_D218_T0.9800.74
170_F192_R0.9720.74
101_D137_S0.9620.73
159_I203_I0.9600.73
140_W143_R0.9520.72
135_R139_G0.9460.72
58_E118_Q0.9450.72
45_L101_D0.9380.71
55_Y58_E0.9370.71
34_I150_V0.9340.71
155_M207_T0.9330.71
157_Q160_N0.9290.70
4_L179_L0.9290.70
15_C130_A0.9190.70
150_V154_K0.9150.69
195_W199_V0.9130.69
103_W107_L0.9120.69
227_E230_G0.9120.69
82_L100_I0.9110.69
54_S57_A0.9070.69
138_R142_E0.9040.68
189_R193_A0.8940.67
105_V109_T0.8930.67
45_L104_H0.8880.67
208_L211_P0.8800.66
157_Q161_K0.8760.66
101_D136_F0.8740.66
93_T97_Q0.8690.65
18_L97_Q0.8660.65
176_D179_L0.8640.65
220_G223_G0.8610.65
109_T112_M0.8570.64
102_A198_E0.8530.64
90_F144_L0.8520.64
110_R190_T0.8510.64
106_A194_A0.8410.63
167_A215_A0.8390.63
85_Q92_D0.8350.62
105_V131_R0.8320.62
21_R33_E0.8270.61
8_T56_A0.8260.61
145_G208_L0.8260.61
8_T12_G0.8220.61
54_S65_E0.8130.60
134_L198_E0.8120.60
35_D39_A0.8090.60
189_R192_R0.8090.60
54_S159_I0.8080.60
167_A217_R0.8010.59
105_V134_L0.7970.59
118_Q121_A0.7970.59
52_F136_F0.7810.57
41_I136_F0.7760.56
27_G35_D0.7760.56
159_I208_L0.7730.56
172_A177_I0.7720.56
57_A65_E0.7710.56
172_A190_T0.7710.56
85_Q161_K0.7700.56
47_G129_E0.7660.56
109_T197_A0.7640.55
42_G46_L0.7620.55
160_N209_N0.7540.54
8_T118_Q0.7480.54
23_G39_A0.7430.53
210_V213_E0.7410.53
179_L184_I0.7410.53
170_F191_L0.7400.53
50_R121_A0.7390.53
67_T74_E0.7360.53
75_R224_L0.7360.53
23_G42_G0.7360.53
89_N158_A0.7350.52
44_D101_D0.7320.52
4_L8_T0.7290.52
97_Q101_D0.7220.51
136_F140_W0.7210.51
159_I201_A0.7190.51
89_N150_V0.7190.51
172_A188_P0.7170.51
104_H136_F0.7160.51
113_E181_E0.7140.50
17_V86_P0.7140.50
99_F166_T0.7140.50
33_E66_D0.7130.50
178_A193_A0.7120.50
4_L187_D0.7120.50
181_E212_Q0.7110.50
149_D153_Q0.7080.50
215_A219_G0.7040.49
90_F116_D0.7000.49
25_W88_G0.6960.49
81_L219_G0.6930.48
93_T122_I0.6900.48
45_L48_Q0.6900.48
76_Q212_Q0.6890.48
203_I210_V0.6860.48
125_K132_Y0.6830.47
113_E204_N0.6780.47
136_F139_G0.6780.47
40_N43_L0.6770.47
10_R176_D0.6770.47
13_D72_R0.6770.47
48_Q116_D0.6760.47
52_F101_D0.6760.47
220_G229_L0.6750.47
106_A191_L0.6750.47
69_A72_R0.6740.46
80_L83_V0.6710.46
8_T55_Y0.6700.46
171_D222_K0.6690.46
6_A175_I0.6690.46
227_E231_P0.6690.46
43_L47_G0.6660.46
29_A39_A0.6650.46
4_L59_L0.6640.45
173_D176_D0.6600.45
78_S199_V0.6580.45
103_W131_R0.6580.45
16_L77_F0.6560.45
13_D21_R0.6560.45
196_E210_V0.6550.45
44_D158_A0.6550.45
29_A36_L0.6540.44
14_N104_H0.6530.44
32_L149_D0.6440.43
143_R146_N0.6410.43
142_E205_E0.6360.43
160_N203_I0.6350.43
116_D126_A0.6330.42
105_V198_E0.6320.42
22_L42_G0.6310.42
142_E206_A0.6280.42
115_R191_L0.6270.42
134_L138_R0.6260.42
219_G223_G0.6240.42
136_F195_W0.6240.42
186_V194_A0.6220.41
152_G208_L0.6200.41
99_F199_V0.6200.41
34_I158_A0.6200.41
53_L163_W0.6170.41
153_Q214_Q0.6150.41
15_C45_L0.6120.40
188_P193_A0.6120.40
37_A144_L0.6110.40
193_A212_Q0.6090.40
50_R54_S0.6060.40
221_K231_P0.6050.40
175_I178_A0.6040.40
44_D132_Y0.5970.39
79_N229_L0.5950.39
15_C104_H0.5940.39
15_C48_Q0.5880.38
213_E232_M0.5860.38
97_Q137_S0.5850.38
84_E226_T0.5840.38
31_E90_F0.5830.38
23_G93_T0.5810.37
22_L90_F0.5800.37
217_R222_K0.5800.37
163_W210_V0.5790.37
217_R224_L0.5760.37
144_L155_M0.5760.37
87_N93_T0.5750.37
41_I119_L0.5750.37
11_L41_I0.5730.37
14_N89_N0.5720.37
107_L130_A0.5700.36
17_V20_Q0.5700.36
217_R220_G0.5700.36
120_A191_L0.5690.36
26_C42_G0.5680.36
175_I185_A0.5650.36
153_Q197_A0.5640.36
31_E136_F0.5610.36
75_R212_Q0.5590.35
69_A123_S0.5580.35
149_D178_A0.5540.35
197_A200_F0.5530.35
203_I207_T0.5530.35
19_S103_W0.5530.35
146_N152_G0.5530.35
125_K158_A0.5500.35
14_N179_L0.5480.34
178_A181_E0.5470.34
180_S191_L0.5470.34
4_L48_Q0.5470.34
193_A233_L0.5460.34
122_I126_A0.5450.34
216_Y221_K0.5450.34
79_N225_H0.5440.34
109_T194_A0.5430.34
48_Q130_A0.5420.34
19_S100_I0.5410.34
201_A232_M0.5400.34
190_T193_A0.5400.34
47_G132_Y0.5390.34
224_L231_P0.5380.34
101_D184_I0.5370.33
82_L203_I0.5370.33
47_G125_K0.5370.33
5_T8_T0.5360.33
64_D70_F0.5360.33
91_A144_L0.5340.33
167_A171_D0.5330.33
59_L71_T0.5320.33
80_L221_K0.5310.33
168_E223_G0.5310.33
114_S183_G0.5300.33
153_Q200_F0.5260.32
191_L194_A0.5260.32
180_S187_D0.5250.32
107_L191_L0.5230.32
210_V214_Q0.5220.32
182_E185_A0.5210.32
174_E204_N0.5210.32
22_L46_L0.5200.32
31_E34_I0.5200.32
87_N92_D0.5190.32
17_V117_P0.5120.31
92_D158_A0.5120.31
29_A45_L0.5120.31
109_T190_T0.5110.31
193_A200_F0.5080.31
18_L100_I0.5040.31
157_Q209_N0.5040.31
74_E227_E0.5030.31
59_L182_E0.5030.31
109_T196_E0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1otkA 2 0.9798 100 0.052 Contact Map
3pf7A 1 0.9798 100 0.246 Contact Map
3pvtA 1 0.9879 100 0.32 Contact Map
4mudA 2 0.8226 100 0.406 Contact Map
3ge3A 2 0.9637 98.3 0.878 Contact Map
2incA 2 0.9677 98.3 0.881 Contact Map
1mtyD 2 0.9798 98.2 0.881 Contact Map
3u52A 2 0.9677 98 0.89 Contact Map
1mtyB 2 0.8669 97.6 0.897 Contact Map
3u52C 2 0.8145 97.5 0.9 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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