GREMLIN Database
PAAB - 1,2-phenylacetyl-CoA epoxidase, subunit B
UniProt: P76078 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14299
Length: 95 (91)
Sequences: 319 (97)
Seq/√Len: 10.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_K59_E4.6311.00
9_Y32_E3.9960.99
88_I93_E2.4250.82
88_I95_M2.3620.81
21_H51_S2.2930.78
64_Q67_E2.2700.78
91_G95_M2.1650.74
69_G76_E2.1360.73
65_P72_F2.0560.70
74_P83_P1.8380.61
27_L52_I1.7870.59
69_G91_G1.7740.58
5_Y93_E1.7420.57
20_S88_I1.6890.54
16_K86_Y1.6610.53
75_A94_H1.5720.49
74_P77_S1.4520.43
30_A37_E1.4020.41
77_S80_Y1.3950.41
47_S76_E1.3390.38
88_I91_G1.3340.38
64_Q73_D1.3340.38
85_F89_P1.3270.38
44_T48_E1.2660.35
54_V61_V1.2590.35
17_Q64_Q1.2400.34
13_V42_A1.2340.34
64_Q70_E1.2300.34
58_S66_E1.2270.34
17_Q37_E1.2070.33
17_Q22_R1.1980.32
34_M38_N1.1700.31
18_G23_H1.1660.31
73_D76_E1.1010.29
24_V69_G1.0930.28
56_K61_V1.0840.28
17_Q71_F1.0680.27
14_R90_D1.0620.27
28_H62_A1.0460.27
17_Q91_G1.0400.26
73_D94_H1.0320.26
6_W38_N1.0140.25
16_K47_S1.0130.25
13_V52_I1.0100.25
65_P83_P1.0090.25
6_W16_K0.9950.25
73_D77_S0.9850.24
67_E76_E0.9720.24
24_V47_S0.9680.24
84_T94_H0.9660.24
74_P89_P0.9400.23
58_S87_T0.9380.23
87_T93_E0.9380.23
40_R43_Y0.9240.22
17_Q77_S0.9230.22
12_F23_H0.9190.22
79_V85_F0.9140.22
28_H60_I0.9090.22
74_P86_Y0.9010.22
6_W50_C0.8990.22
17_Q69_G0.8980.22
47_S75_A0.8720.21
22_R37_E0.8630.21
24_V59_E0.8580.20
36_L54_V0.8550.20
71_F91_G0.8540.20
14_R19_L0.8520.20
67_E70_E0.8370.20
20_S24_V0.8320.20
10_E26_S0.8190.19
50_C77_S0.8140.19
5_Y17_Q0.8100.19
24_V70_E0.8000.19
47_S93_E0.7880.18
32_E56_K0.7850.18
66_E70_E0.7810.18
43_Y55_V0.7780.18
23_H55_V0.7780.18
5_Y94_H0.7740.18
77_S89_P0.7740.18
12_F53_W0.7660.18
12_F55_V0.7600.18
23_H43_Y0.7470.17
74_P85_F0.7370.17
22_R93_E0.7220.17
17_Q24_V0.7040.16
7_P62_A0.7020.16
30_A76_E0.6950.16
10_E53_W0.6890.16
20_S93_E0.6750.15
8_L48_E0.6680.15
41_D45_R0.6660.15
37_E92_I0.6630.15
17_Q59_E0.6520.15
73_D79_V0.6520.15
73_D84_T0.6460.15
30_A38_N0.6450.15
7_P31_D0.6430.15
57_A68_R0.6430.15
20_S38_N0.6400.15
38_N70_E0.6400.15
72_F75_A0.6370.15
43_Y80_Y0.6360.14
17_Q95_M0.6290.14
9_Y92_I0.6280.14
54_V60_I0.6270.14
19_L22_R0.6220.14
33_R69_G0.6110.14
26_S51_S0.6100.14
6_W30_A0.6100.14
10_E45_R0.6090.14
16_K83_P0.6070.14
69_G93_E0.6070.14
6_W31_D0.6060.14
42_A83_P0.6030.14
82_H89_P0.6010.14
64_Q69_G0.6000.14
14_R44_T0.5950.14
86_Y90_D0.5920.14
42_A85_F0.5900.13
59_E94_H0.5880.13
31_D46_R0.5880.13
64_Q76_E0.5810.13
9_Y24_V0.5800.13
37_E47_S0.5750.13
62_A83_P0.5730.13
9_Y56_K0.5520.13
9_Y72_F0.5440.12
17_Q86_Y0.5420.12
65_P85_F0.5380.12
50_C70_E0.5320.12
7_P28_H0.5230.12
21_H49_G0.5220.12
16_K79_V0.5180.12
8_L26_S0.5060.12
19_L94_H0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4iitB 2 0.6632 100 0.105 Contact Map
3egrA 3 0.6632 100 0.113 Contact Map
2nx9A 2 0.8947 19 0.933 Contact Map
3hblA 4 0.9158 10 0.941 Contact Map
3v8dA 2 0.7895 6.1 0.947 Contact Map
4ynsA 2 0.7158 5.7 0.947 Contact Map
1uf2A 7 0.9263 4.9 0.949 Contact Map
3bg3A 4 0.9579 4.3 0.95 Contact Map
1vpqA 2 0.9263 3.9 0.951 Contact Map
3klkA 1 0.8737 3.8 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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