GREMLIN Database
PAAA - 1,2-phenylacetyl-CoA epoxidase, subunit A
UniProt: P76077 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13736
Length: 309 (246)
Sequences: 1448 (661)
Seq/√Len: 42.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_A92_D4.0901.00
181_Q185_N4.0721.00
39_A80_Y3.9561.00
37_Q198_N3.5611.00
30_T207_R3.3481.00
124_L184_I3.1151.00
46_M73_A2.9961.00
105_S194_M2.9361.00
61_R161_Q2.8661.00
181_Q239_T2.7971.00
120_V180_L2.7321.00
47_L50_G2.7191.00
208_S214_K2.6811.00
177_K237_G2.6711.00
110_Y190_P2.6161.00
177_K181_Q2.5161.00
171_Q237_G2.4411.00
166_C180_L2.3751.00
77_L90_R2.3621.00
111_P260_D2.3591.00
41_S253_H2.3501.00
116_A183_A2.3201.00
44_V264_F2.2421.00
79_L144_Y2.1751.00
197_P217_T2.1380.99
33_R103_K2.0680.99
127_G159_Q2.0530.99
191_A225_F2.0260.99
123_W166_C1.9700.99
119_G166_C1.9200.99
82_A143_P1.9130.99
79_L133_Q1.9130.99
96_K272_G1.8730.99
230_V240_V1.8540.98
114_S179_M1.8440.98
272_G275_N1.8360.98
170_A180_L1.8330.98
84_E88_C1.7900.98
133_Q155_E1.7650.98
32_I86_L1.7500.98
262_Q266_E1.7500.98
120_V184_I1.7420.98
270_G274_C1.7350.98
82_A141_Y1.7330.98
123_W229_T1.7090.97
110_Y258_E1.7080.97
133_Q161_Q1.6710.97
99_D262_Q1.6320.96
222_R226_V1.5930.96
114_S117_D1.5630.95
188_W241_P1.5550.95
92_D96_K1.5530.95
268_I271_R1.5260.95
197_P219_D1.4870.94
205_S208_S1.4660.94
123_W232_Q1.4620.94
84_E89_A1.4500.93
99_D261_W1.4280.93
175_A178_Q1.4240.93
35_I86_L1.4230.93
126_D129_A1.3960.92
56_A115_W1.3850.92
131_V228_N1.3850.92
181_Q233_V1.3840.92
80_Y93_I1.3840.92
126_D133_Q1.3730.91
206_A210_T1.3710.91
181_Q237_G1.3620.91
108_F125_V1.3600.91
230_V234_E1.3500.90
180_L238_M1.3420.90
217_T220_E1.3260.90
66_L73_A1.3250.90
117_D186_R1.3180.89
130_I152_C1.3160.89
135_A224_R1.3020.89
45_G121_I1.3010.89
152_C156_S1.2910.88
120_V183_A1.2700.88
129_A133_Q1.2660.87
199_D206_A1.2640.87
175_A179_M1.2580.87
178_Q182_D1.2490.87
172_G176_Q1.2430.86
252_G255_R1.2270.86
163_F232_Q1.2260.86
98_L101_R1.1830.84
129_A155_E1.1680.83
105_S125_V1.1630.82
226_V230_V1.1610.82
166_C232_Q1.1490.82
124_L187_F1.1410.81
170_A181_Q1.1400.81
170_A236_L1.1290.81
79_L129_A1.1220.80
159_Q228_N1.1200.80
110_Y260_D1.1200.80
120_V166_C1.1100.79
107_I125_V1.1050.79
170_A177_K1.0980.79
270_G275_N1.0960.78
88_C92_D1.0950.78
261_W265_N1.0940.78
48_P51_N1.0880.78
142_G146_R1.0860.78
72_E126_D1.0840.78
231_P235_M1.0810.78
134_V137_C1.0710.77
192_L222_R1.0680.77
31_L35_I1.0670.77
247_F251_S1.0670.77
41_S105_S1.0620.76
37_Q200_D1.0610.76
223_Q226_V1.0400.75
163_F167_M1.0370.75
50_G69_V1.0320.74
126_D162_G1.0280.74
123_W162_G1.0120.73
72_E155_E1.0100.73
126_D213_I1.0070.72
61_R175_A1.0010.72
138_R210_T1.0000.72
104_Y109_N0.9960.71
182_D185_N0.9900.71
45_G122_G0.9870.71
31_L208_S0.9730.70
119_G165_A0.9720.70
98_L274_C0.9710.70
160_R164_E0.9620.69
225_F229_T0.9590.69
72_E129_A0.9570.68
196_G250_E0.9360.67
163_F228_N0.9280.66
42_E155_E0.9170.65
101_R242_D0.9160.65
222_R225_F0.9140.65
127_G228_N0.9130.65
184_I233_V0.9000.64
68_K161_Q0.8920.63
113_L118_I0.8910.63
77_L146_R0.8910.63
165_A168_A0.8820.62
206_A217_T0.8810.62
167_M236_L0.8800.62
252_G257_G0.8790.62
239_T244_D0.8760.61
130_I156_S0.8730.61
85_T143_P0.8610.60
115_W169_L0.8600.60
126_D161_Q0.8580.60
127_G131_V0.8530.59
129_A161_Q0.8520.59
43_I102_M0.8520.59
32_I35_I0.8460.59
81_S90_R0.8420.58
81_S84_E0.8400.58
257_G261_W0.8390.58
244_D247_F0.8370.58
195_F221_L0.8270.57
84_E90_R0.8250.57
114_S183_A0.8220.57
34_Q215_R0.8190.56
71_D150_K0.8190.56
41_S208_S0.8140.56
40_H97_M0.8120.56
118_I122_G0.8120.56
82_A85_T0.8110.56
35_I82_A0.8070.55
219_D222_R0.8040.55
180_L237_G0.8010.55
208_S213_I0.7970.54
122_G162_G0.7940.54
110_Y117_D0.7930.54
114_S175_A0.7860.53
131_V221_L0.7810.53
41_S129_A0.7800.53
78_Y147_A0.7700.52
110_Y186_R0.7700.52
35_I143_P0.7690.52
79_L126_D0.7680.52
36_G88_C0.7670.51
265_N269_N0.7660.51
105_S108_F0.7660.51
62_K69_V0.7630.51
130_I134_V0.7630.51
174_E207_R0.7620.51
219_D223_Q0.7620.51
71_D126_D0.7560.50
80_Y188_W0.7550.50
161_Q165_A0.7540.50
75_H141_Y0.7490.50
37_Q205_S0.7450.49
128_A132_N0.7440.49
101_R199_D0.7440.49
56_A66_L0.7440.49
79_L161_Q0.7410.49
54_T62_K0.7380.49
159_Q163_F0.7350.48
168_A171_Q0.7300.48
92_D99_D0.7290.48
178_Q227_D0.7280.48
58_T161_Q0.7260.48
109_N258_E0.7210.47
197_P218_N0.7050.46
137_C140_S0.7030.45
132_N155_E0.7020.45
269_N273_I0.7020.45
180_L183_A0.6990.45
170_A238_M0.6980.45
103_K229_T0.6980.45
182_D186_R0.6970.45
124_L191_A0.6950.45
52_W113_L0.6900.44
49_E115_W0.6900.44
42_E75_H0.6890.44
131_V224_R0.6860.44
226_V240_V0.6820.43
263_E267_V0.6820.43
126_D181_Q0.6800.43
138_R182_D0.6770.43
273_I276_Q0.6720.43
192_L196_G0.6710.42
221_L224_R0.6700.42
64_I169_L0.6690.42
68_K144_Y0.6690.42
135_A220_E0.6680.42
50_G66_L0.6600.41
48_P60_R0.6600.41
111_P258_E0.6570.41
106_S251_S0.6550.41
31_L86_L0.6540.41
153_K262_Q0.6540.41
87_G140_S0.6520.41
124_L229_T0.6510.41
33_R200_D0.6510.41
26_A207_R0.6490.40
250_E256_F0.6470.40
200_D214_K0.6470.40
112_T118_I0.6460.40
150_K157_F0.6460.40
69_V73_A0.6460.40
58_T61_R0.6450.40
108_F194_M0.6420.40
134_V227_D0.6380.39
35_I133_Q0.6370.39
33_R37_Q0.6360.39
65_L173_S0.6340.39
128_A156_S0.6340.39
198_N205_S0.6330.39
43_I94_Y0.6310.39
93_I271_R0.6310.39
188_W208_S0.6310.39
60_R91_E0.6280.39
35_I39_A0.6260.38
81_S184_I0.6240.38
143_P146_R0.6220.38
147_A151_I0.6200.38
130_I159_Q0.6170.38
184_I238_M0.6160.37
156_S159_Q0.6160.37
170_A237_G0.6140.37
139_T224_R0.6140.37
118_I235_M0.6100.37
115_W141_Y0.6070.37
185_N239_T0.6050.37
134_V138_R0.6050.37
251_S255_R0.6040.36
145_A149_V0.6040.36
185_N233_V0.6030.36
77_L81_S0.6020.36
111_P190_P0.6020.36
42_E72_E0.5990.36
34_Q47_L0.5980.36
122_G126_D0.5960.36
92_D277_E0.5950.36
107_I233_V0.5940.36
152_C155_E0.5920.35
192_L248_D0.5920.35
247_F256_F0.5900.35
37_Q225_F0.5900.35
66_L69_V0.5890.35
35_I58_T0.5880.35
106_S122_G0.5860.35
127_G171_Q0.5860.35
197_P220_E0.5840.35
136_L145_A0.5840.35
233_V237_G0.5820.35
132_N221_L0.5800.34
157_F276_Q0.5780.34
71_D183_A0.5780.34
56_A72_E0.5770.34
53_I274_C0.5760.34
104_Y261_W0.5750.34
174_E178_Q0.5740.34
74_G154_E0.5730.34
259_I262_Q0.5720.34
262_Q275_N0.5710.34
56_A62_K0.5700.34
58_T115_W0.5660.33
93_I261_W0.5660.33
67_A172_G0.5650.33
243_P264_F0.5650.33
31_L82_A0.5640.33
59_L140_S0.5630.33
197_P206_A0.5630.33
238_M241_P0.5620.33
228_N231_P0.5610.33
191_A247_F0.5600.33
184_I231_P0.5600.33
173_S188_W0.5580.33
130_I228_N0.5580.33
89_A95_Q0.5570.32
240_V244_D0.5550.32
200_D207_R0.5550.32
196_G254_Y0.5550.32
62_K66_L0.5510.32
118_I147_A0.5500.32
85_T108_F0.5490.32
136_L221_L0.5490.32
56_A63_A0.5480.32
59_L174_E0.5460.32
167_M235_M0.5450.31
41_S114_S0.5450.31
117_D183_A0.5450.31
108_F112_T0.5440.31
161_Q164_E0.5430.31
29_K223_Q0.5420.31
72_E75_H0.5410.31
167_M252_G0.5410.31
128_A133_Q0.5400.31
65_L233_V0.5380.31
223_Q230_V0.5370.31
46_M125_V0.5360.31
224_R234_E0.5360.31
247_F250_E0.5350.31
35_I83_A0.5350.31
138_R207_R0.5320.30
171_Q238_M0.5300.30
50_G118_I0.5300.30
112_T117_D0.5300.30
129_A162_G0.5290.30
44_V111_P0.5290.30
258_E271_R0.5270.30
82_A122_G0.5240.30
186_R189_W0.5210.30
42_E58_T0.5200.29
89_A219_D0.5200.29
169_L180_L0.5200.29
53_I78_Y0.5190.29
211_W242_D0.5180.29
76_G120_V0.5180.29
56_A101_R0.5160.29
53_I272_G0.5160.29
219_D231_P0.5150.29
218_N223_Q0.5140.29
68_K126_D0.5130.29
193_M255_R0.5130.29
39_A42_E0.5120.29
31_L200_D0.5120.29
58_T73_A0.5110.29
45_G108_F0.5110.29
49_E69_V0.5100.29
137_C152_C0.5090.29
220_E223_Q0.5070.28
207_R210_T0.5030.28
79_L123_W0.5020.28
154_E157_F0.5020.28
81_S146_R0.5000.28
116_A177_K0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1otkA 2 0.7832 100 0.247 Contact Map
3pvtA 1 0.9741 100 0.255 Contact Map
3pf7A 1 0.9676 100 0.329 Contact Map
4mudA 2 0.7087 100 0.456 Contact Map
1mtyB 2 0.7994 97.9 0.914 Contact Map
3ge3A 2 0.9515 97.7 0.917 Contact Map
2incA 2 0.9515 97.6 0.919 Contact Map
1mtyD 2 0.9547 97.6 0.92 Contact Map
1mhyB 2 0.7994 97.3 0.924 Contact Map
3ez0A 2 0.6731 97.2 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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