INSH5 - ECOLI - GREMLIN Contacts

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INSH5 - Transposase InsH for insertion sequence element IS5Y

UniProt:	P76071	Sequences: MSHQLTFADSEFSTKRRQTRKEIFLSRMEQILPWQNMTAVIEPFYPKAGNGRRPYPLETMLRIHCMQHWYNLSDGAMEDALYEIASMRLFARLSLDSALPDRTTIMNFRHLLEQHQLARQLFKTINRWLAEAGVMMTQGTLVDATIIEAPSSTKNKEQQRDPEMHQTKKGNQWHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHGEEQFVSADAGYQGAPQREELAEVDVDWLIAERPGKVKTLKQNPRKNKTAINIEYMKASIRARVEHPFRIIKRQFGFVKARYKGLLKNDNQLAMLFTLANLFRVDQMIRQWERSQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG40008
Length:	326 (297)
Sequences:	2026 (1465)
Seq/√Len:	85.0

ECOLI - INSH5 INSH1 INSH2 INSH3 INSH4 INSH7 INSH8 INSH9 INH10 INH11 INSH6
HALSA - TH11 Q9HPK7 Q7LYM0 Q9HSX5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
235_V	241_I	4.802	1.00
75_G	102_R	3.777	1.00
183_V	275_V	3.740	1.00
80_A	84_I	3.672	1.00
236_D	241_I	3.504	1.00
193_L	304_A	3.365	1.00
63_I	81_L	3.131	1.00
190_T	307_F	3.052	1.00
180_H	196_T	2.973	1.00
192_S	212_G	2.928	1.00
228_Q	231_E	2.903	1.00
46_P	50_N	2.692	1.00
67_Q	77_M	2.689	1.00
58_E	62_R	2.416	1.00
81_L	91_A	2.326	1.00
83_E	86_S	2.261	1.00
74_D	109_R	2.236	1.00
227_P	232_L	2.230	1.00
124_T	127_R	2.149	1.00
193_L	307_F	2.075	1.00
179_A	303_L	1.980	1.00
142_V	182_G	1.933	1.00
228_Q	232_L	1.919	1.00
295_G	298_K	1.917	1.00
232_L	241_I	1.872	1.00
62_R	91_A	1.872	1.00
40_V	120_Q	1.859	1.00
254_N	258_N	1.857	1.00
145_T	283_K	1.850	1.00
226_A	232_L	1.828	1.00
230_E	234_E	1.813	1.00
180_H	223_Y	1.789	1.00
139_G	216_F	1.773	1.00
236_D	240_L	1.763	1.00
255_P	258_N	1.749	1.00
129_L	315_V	1.711	1.00
293_Y	298_K	1.699	1.00
229_R	232_L	1.690	1.00
253_Q	256_R	1.669	1.00
45_Y	111_L	1.668	1.00
282_I	306_L	1.666	1.00
29_E	92_R	1.656	1.00
103_T	107_N	1.652	1.00
181_I	279_F	1.649	1.00
103_T	106_M	1.632	1.00
189_L	314_R	1.629	1.00
194_V	300_D	1.624	1.00
60_M	108_F	1.620	1.00
239_W	242_A	1.596	1.00
238_D	241_I	1.580	1.00
122_F	307_F	1.579	1.00
127_R	131_E	1.569	1.00
16_R	26_S	1.569	1.00
59_T	93_L	1.559	1.00
140_T	182_G	1.556	1.00
144_A	178_K	1.555	1.00
232_L	235_V	1.552	1.00
19_T	26_S	1.547	1.00
78_E	102_R	1.536	1.00
284_R	289_V	1.528	1.00
164_M	177_M	1.527	1.00
119_R	123_K	1.522	1.00
63_I	105_I	1.502	0.99
38_T	56_P	1.498	0.99
291_A	299_N	1.476	0.99
254_N	257_K	1.475	0.99
27_R	31_I	1.463	0.99
184_D	187_S	1.453	0.99
68_H	302_Q	1.450	0.99
196_T	205_Q	1.435	0.99
195_T	300_D	1.427	0.99
37_M	41_I	1.407	0.99
36_N	124_T	1.403	0.99
232_L	237_V	1.403	0.99
78_E	101_D	1.401	0.99
113_E	301_N	1.393	0.99
252_K	258_N	1.393	0.99
38_T	58_E	1.390	0.99
200_E	205_Q	1.390	0.99
244_R	247_K	1.384	0.99
237_V	241_I	1.380	0.99
66_M	87_M	1.371	0.99
252_K	256_R	1.370	0.99
206_L	210_L	1.369	0.99
129_L	189_L	1.369	0.99
167_T	178_K	1.366	0.99
225_G	228_Q	1.362	0.99
140_T	191_H	1.359	0.99
206_L	228_Q	1.348	0.99
148_E	290_K	1.348	0.99
235_V	240_L	1.323	0.99
235_V	242_A	1.322	0.99
288_F	306_L	1.321	0.99
252_K	255_P	1.320	0.99
190_T	311_N	1.316	0.99
141_L	185_A	1.314	0.99
265_E	272_R	1.305	0.99
167_T	198_A	1.282	0.98
183_V	278_P	1.275	0.98
33_P	36_N	1.269	0.98
20_R	23_I	1.263	0.98
181_I	278_P	1.258	0.98
76_A	80_A	1.257	0.98
192_S	209_L	1.256	0.98
291_A	302_Q	1.247	0.98
205_Q	209_L	1.242	0.98
280_R	285_Q	1.229	0.98
148_E	174_H	1.209	0.98
207_G	231_E	1.204	0.98
201_H	204_N	1.203	0.97
286_F	310_A	1.200	0.97
80_A	87_M	1.193	0.97
219_A	222_G	1.191	0.97
165_H	197_A	1.185	0.97
29_E	62_R	1.184	0.97
275_V	278_P	1.179	0.97
93_L	97_S	1.174	0.97
269_A	272_R	1.173	0.97
144_A	202_D	1.172	0.97
55_Y	97_S	1.165	0.97
191_H	213_E	1.159	0.97
118_A	304_A	1.156	0.97
270_S	273_A	1.147	0.97
181_I	190_T	1.141	0.97
182_G	209_L	1.131	0.96
23_I	83_E	1.128	0.96
205_Q	208_N	1.117	0.96
252_K	257_K	1.116	0.96
78_E	99_L	1.115	0.96
33_P	62_R	1.109	0.96
303_L	307_F	1.107	0.96
70_Y	87_M	1.105	0.96
251_L	255_P	1.103	0.96
293_Y	302_Q	1.101	0.96
63_I	100_P	1.101	0.96
253_Q	258_N	1.084	0.95
282_I	310_A	1.076	0.95
208_N	211_H	1.068	0.95
142_V	219_A	1.065	0.95
141_L	274_R	1.064	0.95
241_I	244_R	1.063	0.95
60_M	104_T	1.063	0.95
163_E	296_L	1.061	0.95
242_A	245_P	1.060	0.95
194_V	205_Q	1.057	0.95
170_G	174_H	1.051	0.95
63_I	77_M	1.048	0.94
226_A	233_A	1.047	0.94
250_T	253_Q	1.046	0.94
72_L	104_T	1.039	0.94
180_H	202_D	1.039	0.94
235_V	238_D	1.036	0.94
251_L	254_N	1.033	0.94
251_L	257_K	1.027	0.94
171_N	298_K	1.014	0.93
35_Q	38_T	1.012	0.93
145_T	179_A	1.012	0.93
55_Y	59_T	1.009	0.93
216_F	240_L	1.002	0.93
182_G	213_E	0.996	0.93
78_E	105_I	0.995	0.93
189_L	315_V	0.991	0.93
168_K	173_W	0.984	0.92
114_Q	297_L	0.983	0.92
24_F	28_M	0.983	0.92
182_G	192_S	0.975	0.92
206_L	219_A	0.968	0.92
273_A	277_H	0.967	0.92
150_P	294_K	0.965	0.92
102_R	106_M	0.964	0.92
170_G	222_G	0.953	0.91
125_I	129_L	0.951	0.91
146_I	167_T	0.950	0.91
93_L	99_L	0.949	0.91
222_G	225_G	0.948	0.91
144_A	167_T	0.946	0.91
248_V	252_K	0.945	0.91
250_T	254_N	0.940	0.91
138_Q	215_Q	0.939	0.90
78_E	82_Y	0.936	0.90
311_N	314_R	0.928	0.90
314_R	318_M	0.927	0.90
281_I	286_F	0.927	0.90
139_G	218_S	0.923	0.90
161_D	177_M	0.921	0.90
40_V	124_T	0.921	0.90
47_K	50_N	0.919	0.90
125_I	308_T	0.917	0.89
180_H	209_L	0.914	0.89
250_T	256_R	0.911	0.89
211_H	214_E	0.909	0.89
309_L	313_F	0.909	0.89
281_I	313_F	0.907	0.89
77_M	105_I	0.904	0.89
282_I	288_F	0.904	0.89
35_Q	90_F	0.901	0.89
121_L	308_T	0.890	0.88
142_V	206_L	0.890	0.88
226_A	230_E	0.890	0.88
32_L	62_R	0.890	0.88
66_M	70_Y	0.888	0.88
65_C	69_W	0.885	0.88
300_D	304_A	0.884	0.88
281_I	310_A	0.875	0.87
296_L	300_D	0.857	0.86
236_D	239_W	0.855	0.86
88_R	99_L	0.853	0.86
188_G	281_I	0.852	0.86
232_L	240_L	0.849	0.85
50_N	53_R	0.845	0.85
46_P	49_G	0.841	0.85
90_F	175_F	0.833	0.84
242_A	247_K	0.832	0.84
62_R	90_F	0.830	0.84
280_R	284_R	0.826	0.84
245_P	248_V	0.825	0.84
122_F	304_A	0.822	0.84
145_T	279_F	0.822	0.84
244_R	248_V	0.821	0.83
63_I	91_A	0.819	0.83
178_K	202_D	0.815	0.83
238_D	243_E	0.812	0.83
302_Q	306_L	0.812	0.83
84_I	87_M	0.811	0.83
251_L	258_N	0.807	0.82
245_P	249_K	0.806	0.82
292_R	302_Q	0.802	0.82
265_E	268_K	0.800	0.82
182_G	217_V	0.799	0.82
39_A	42_E	0.798	0.82
118_A	301_N	0.797	0.82
314_R	317_Q	0.792	0.81
291_A	303_L	0.791	0.81
34_W	90_F	0.790	0.81
169_K	174_H	0.789	0.81
195_T	303_L	0.785	0.81
278_P	310_A	0.780	0.80
78_E	106_M	0.780	0.80
167_T	176_G	0.780	0.80
166_Q	173_W	0.778	0.80
151_S	160_R	0.778	0.80
195_T	299_N	0.777	0.80
146_I	198_A	0.773	0.80
274_R	277_H	0.772	0.80
146_I	202_D	0.770	0.79
238_D	248_V	0.769	0.79
181_I	275_V	0.769	0.79
194_V	208_N	0.764	0.79
201_H	225_G	0.764	0.79
164_M	175_F	0.760	0.78
180_H	205_Q	0.758	0.78
144_A	180_H	0.757	0.78
310_A	314_R	0.756	0.78
170_G	173_W	0.754	0.78
74_D	106_M	0.748	0.77
271_I	274_R	0.741	0.77
161_D	164_M	0.741	0.77
246_G	249_K	0.741	0.77
192_S	213_E	0.737	0.76
239_W	244_R	0.734	0.76
156_K	175_F	0.734	0.76
153_T	175_F	0.732	0.76
203_L	222_G	0.723	0.75
34_W	37_M	0.721	0.75
155_N	166_Q	0.721	0.75
138_Q	186_K	0.718	0.74
253_Q	257_K	0.716	0.74
72_L	80_A	0.715	0.74
188_G	310_A	0.714	0.74
237_V	242_A	0.713	0.74
27_R	30_Q	0.711	0.74
177_M	296_L	0.711	0.74
138_Q	216_F	0.710	0.74
26_S	89_L	0.705	0.73
40_V	43_P	0.705	0.73
193_L	303_L	0.705	0.73
293_Y	299_N	0.704	0.73
106_M	110_H	0.700	0.73
190_T	310_A	0.699	0.72
264_I	267_M	0.699	0.72
126_N	129_L	0.697	0.72
203_L	225_G	0.694	0.72
151_S	175_F	0.693	0.72
282_I	307_F	0.691	0.72
129_L	161_D	0.691	0.72
218_S	271_I	0.683	0.71
147_I	179_A	0.681	0.70
268_K	272_R	0.679	0.70
267_M	272_R	0.679	0.70
281_I	314_R	0.678	0.70
70_Y	83_E	0.677	0.70
125_I	312_L	0.673	0.70
55_Y	108_F	0.671	0.69
166_Q	175_F	0.664	0.69
188_G	278_P	0.654	0.67
81_L	99_L	0.652	0.67
177_M	299_N	0.651	0.67
226_A	229_R	0.650	0.67
55_Y	63_I	0.650	0.67
128_W	132_A	0.650	0.67
119_R	212_G	0.648	0.67
23_I	86_S	0.645	0.66
23_I	149_A	0.645	0.66
235_V	239_W	0.645	0.66
74_D	108_F	0.644	0.66
69_W	309_L	0.642	0.66
246_G	251_L	0.641	0.66
161_D	165_H	0.641	0.66
110_H	298_K	0.639	0.66
65_C	90_F	0.636	0.65
122_F	193_L	0.636	0.65
167_T	174_H	0.632	0.65
247_K	251_L	0.632	0.65
25_L	70_Y	0.632	0.65
180_H	200_E	0.629	0.64
130_A	135_M	0.629	0.64
45_Y	54_P	0.627	0.64
38_T	42_E	0.625	0.64
309_L	316_D	0.625	0.64
179_A	307_F	0.624	0.64
283_K	288_F	0.623	0.64
242_A	251_L	0.623	0.64
203_L	226_A	0.621	0.63
152_S	160_R	0.619	0.63
25_L	34_W	0.619	0.63
101_D	106_M	0.618	0.63
96_D	100_P	0.617	0.63
304_A	307_F	0.617	0.63
227_P	234_E	0.617	0.63
64_H	77_M	0.616	0.63
301_N	305_M	0.615	0.63
188_G	274_R	0.614	0.63
57_L	151_S	0.609	0.62
147_I	291_A	0.607	0.62
107_N	110_H	0.605	0.61
219_A	224_Q	0.605	0.61
312_L	316_D	0.604	0.61
25_L	66_M	0.603	0.61
315_V	318_M	0.602	0.61
25_L	90_F	0.601	0.61
39_A	43_P	0.599	0.61
236_D	245_P	0.599	0.61
279_F	283_K	0.599	0.61
227_P	231_E	0.596	0.60
57_L	60_M	0.596	0.60
168_K	174_H	0.596	0.60
144_A	223_Y	0.595	0.60
107_N	121_L	0.593	0.60
23_I	89_L	0.591	0.60
59_T	92_R	0.589	0.59
39_A	131_E	0.588	0.59
243_E	247_K	0.587	0.59
152_S	202_D	0.587	0.59
299_N	303_L	0.586	0.59
237_V	244_R	0.586	0.59
169_K	223_Y	0.585	0.59
101_D	107_N	0.584	0.59
226_A	234_E	0.584	0.59
194_V	212_G	0.582	0.58
244_R	250_T	0.580	0.58
47_K	53_R	0.577	0.58
188_G	277_H	0.577	0.58
60_M	105_I	0.577	0.58
73_S	109_R	0.577	0.58
188_G	314_R	0.576	0.58
104_T	107_N	0.575	0.58
236_D	243_E	0.575	0.58
119_R	300_D	0.574	0.57
274_R	280_R	0.574	0.57
309_L	314_R	0.574	0.57
194_V	209_L	0.574	0.57
171_N	174_H	0.572	0.57
238_D	242_A	0.572	0.57
175_F	283_K	0.572	0.57
237_V	240_L	0.571	0.57
122_F	313_F	0.569	0.57
63_I	107_N	0.569	0.57
243_E	248_V	0.567	0.56
106_M	109_R	0.567	0.56
72_L	126_N	0.565	0.56
228_Q	233_A	0.564	0.56
109_R	311_N	0.561	0.56
286_F	313_F	0.561	0.56
149_A	152_S	0.561	0.56
239_W	246_G	0.560	0.56
135_M	187_S	0.560	0.56
156_K	221_A	0.558	0.55
154_K	170_G	0.558	0.55
216_F	238_D	0.556	0.55
218_S	240_L	0.556	0.55
293_Y	303_L	0.554	0.55
188_G	193_L	0.552	0.55
270_S	274_R	0.552	0.55
154_K	166_Q	0.551	0.54
144_A	279_F	0.550	0.54
85_A	88_R	0.549	0.54
79_D	83_E	0.548	0.54
16_R	55_Y	0.548	0.54
28_M	33_P	0.546	0.54
73_S	219_A	0.545	0.54
207_G	211_H	0.544	0.53
90_F	279_F	0.544	0.53
233_A	258_N	0.544	0.53
151_S	294_K	0.543	0.53
265_E	269_A	0.543	0.53
67_Q	74_D	0.542	0.53
284_R	290_K	0.540	0.53
154_K	188_G	0.538	0.53
64_H	305_M	0.537	0.53
17_R	21_K	0.537	0.53
33_P	58_E	0.534	0.52
306_L	309_L	0.534	0.52
196_T	200_E	0.533	0.52
169_K	172_Q	0.533	0.52
299_N	308_T	0.532	0.52
281_I	285_Q	0.532	0.52
141_L	183_V	0.530	0.52
25_L	30_Q	0.529	0.51
66_M	77_M	0.526	0.51
35_Q	40_V	0.525	0.51
268_K	271_I	0.524	0.51
112_L	221_A	0.523	0.51
73_S	78_E	0.523	0.51
27_R	316_D	0.521	0.50
201_H	222_G	0.517	0.50
263_N	266_Y	0.517	0.50
54_P	57_L	0.516	0.50
209_L	212_G	0.515	0.50
286_F	291_A	0.512	0.49
42_E	47_K	0.510	0.49
125_I	128_W	0.509	0.49
39_A	215_Q	0.508	0.49
154_K	175_F	0.508	0.49
206_L	217_V	0.508	0.49
78_E	81_L	0.507	0.48
154_K	272_R	0.507	0.48
147_I	299_N	0.507	0.48
236_D	247_K	0.507	0.48
193_L	308_T	0.506	0.48
24_F	36_N	0.506	0.48
155_N	165_H	0.505	0.48
76_A	79_D	0.502	0.48
20_R	24_F	0.501	0.48
74_D	178_K	0.501	0.48
75_G	106_M	0.500	0.48
149_A	177_M	0.500	0.48

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.8037	98.4	0.88	Contact Map
4u7bA	2	0.8497	90.2	0.936	Contact Map
4dyqA	5	0.362	46.4	0.956	Contact Map
3kksA	2	0.411	46.1	0.956	Contact Map
4mq3A	1	0.3742	43.5	0.957	Contact Map
1c6vA	4	0.3896	42.3	0.957	Contact Map
3l3uA	2	0.4141	38	0.958	Contact Map
4fcyA	4	0.816	37.8	0.958	Contact Map
1bcoA	1	0.4877	32.5	0.96	Contact Map
1ex4A	5	0.411	32	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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