GREMLIN Database
INSH5 - Transposase InsH for insertion sequence element IS5Y
UniProt: P76071 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40008
Length: 326 (297)
Sequences: 2026 (1465)
Seq/√Len: 85.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
235_V241_I4.8021.00
75_G102_R3.7771.00
183_V275_V3.7401.00
80_A84_I3.6721.00
236_D241_I3.5041.00
193_L304_A3.3651.00
63_I81_L3.1311.00
190_T307_F3.0521.00
180_H196_T2.9731.00
192_S212_G2.9281.00
228_Q231_E2.9031.00
46_P50_N2.6921.00
67_Q77_M2.6891.00
58_E62_R2.4161.00
81_L91_A2.3261.00
83_E86_S2.2611.00
74_D109_R2.2361.00
227_P232_L2.2301.00
124_T127_R2.1491.00
193_L307_F2.0751.00
179_A303_L1.9801.00
142_V182_G1.9331.00
228_Q232_L1.9191.00
295_G298_K1.9171.00
232_L241_I1.8721.00
62_R91_A1.8721.00
40_V120_Q1.8591.00
254_N258_N1.8571.00
145_T283_K1.8501.00
226_A232_L1.8281.00
230_E234_E1.8131.00
180_H223_Y1.7891.00
139_G216_F1.7731.00
236_D240_L1.7631.00
255_P258_N1.7491.00
129_L315_V1.7111.00
293_Y298_K1.6991.00
229_R232_L1.6901.00
253_Q256_R1.6691.00
45_Y111_L1.6681.00
282_I306_L1.6661.00
29_E92_R1.6561.00
103_T107_N1.6521.00
181_I279_F1.6491.00
103_T106_M1.6321.00
189_L314_R1.6291.00
194_V300_D1.6241.00
60_M108_F1.6201.00
239_W242_A1.5961.00
238_D241_I1.5801.00
122_F307_F1.5791.00
127_R131_E1.5691.00
16_R26_S1.5691.00
59_T93_L1.5591.00
140_T182_G1.5561.00
144_A178_K1.5551.00
232_L235_V1.5521.00
19_T26_S1.5471.00
78_E102_R1.5361.00
284_R289_V1.5281.00
164_M177_M1.5271.00
119_R123_K1.5221.00
63_I105_I1.5020.99
38_T56_P1.4980.99
291_A299_N1.4760.99
254_N257_K1.4750.99
27_R31_I1.4630.99
184_D187_S1.4530.99
68_H302_Q1.4500.99
196_T205_Q1.4350.99
195_T300_D1.4270.99
37_M41_I1.4070.99
36_N124_T1.4030.99
232_L237_V1.4030.99
78_E101_D1.4010.99
113_E301_N1.3930.99
252_K258_N1.3930.99
38_T58_E1.3900.99
200_E205_Q1.3900.99
244_R247_K1.3840.99
237_V241_I1.3800.99
66_M87_M1.3710.99
252_K256_R1.3700.99
206_L210_L1.3690.99
129_L189_L1.3690.99
167_T178_K1.3660.99
225_G228_Q1.3620.99
140_T191_H1.3590.99
206_L228_Q1.3480.99
148_E290_K1.3480.99
235_V240_L1.3230.99
235_V242_A1.3220.99
288_F306_L1.3210.99
252_K255_P1.3200.99
190_T311_N1.3160.99
141_L185_A1.3140.99
265_E272_R1.3050.99
167_T198_A1.2820.98
183_V278_P1.2750.98
33_P36_N1.2690.98
20_R23_I1.2630.98
181_I278_P1.2580.98
76_A80_A1.2570.98
192_S209_L1.2560.98
291_A302_Q1.2470.98
205_Q209_L1.2420.98
280_R285_Q1.2290.98
148_E174_H1.2090.98
207_G231_E1.2040.98
201_H204_N1.2030.97
286_F310_A1.2000.97
80_A87_M1.1930.97
219_A222_G1.1910.97
165_H197_A1.1850.97
29_E62_R1.1840.97
275_V278_P1.1790.97
93_L97_S1.1740.97
269_A272_R1.1730.97
144_A202_D1.1720.97
55_Y97_S1.1650.97
191_H213_E1.1590.97
118_A304_A1.1560.97
270_S273_A1.1470.97
181_I190_T1.1410.97
182_G209_L1.1310.96
23_I83_E1.1280.96
205_Q208_N1.1170.96
252_K257_K1.1160.96
78_E99_L1.1150.96
33_P62_R1.1090.96
303_L307_F1.1070.96
70_Y87_M1.1050.96
251_L255_P1.1030.96
293_Y302_Q1.1010.96
63_I100_P1.1010.96
253_Q258_N1.0840.95
282_I310_A1.0760.95
208_N211_H1.0680.95
142_V219_A1.0650.95
141_L274_R1.0640.95
241_I244_R1.0630.95
60_M104_T1.0630.95
163_E296_L1.0610.95
242_A245_P1.0600.95
194_V205_Q1.0570.95
170_G174_H1.0510.95
63_I77_M1.0480.94
226_A233_A1.0470.94
250_T253_Q1.0460.94
72_L104_T1.0390.94
180_H202_D1.0390.94
235_V238_D1.0360.94
251_L254_N1.0330.94
251_L257_K1.0270.94
171_N298_K1.0140.93
35_Q38_T1.0120.93
145_T179_A1.0120.93
55_Y59_T1.0090.93
216_F240_L1.0020.93
182_G213_E0.9960.93
78_E105_I0.9950.93
189_L315_V0.9910.93
168_K173_W0.9840.92
114_Q297_L0.9830.92
24_F28_M0.9830.92
182_G192_S0.9750.92
206_L219_A0.9680.92
273_A277_H0.9670.92
150_P294_K0.9650.92
102_R106_M0.9640.92
170_G222_G0.9530.91
125_I129_L0.9510.91
146_I167_T0.9500.91
93_L99_L0.9490.91
222_G225_G0.9480.91
144_A167_T0.9460.91
248_V252_K0.9450.91
250_T254_N0.9400.91
138_Q215_Q0.9390.90
78_E82_Y0.9360.90
311_N314_R0.9280.90
314_R318_M0.9270.90
281_I286_F0.9270.90
139_G218_S0.9230.90
161_D177_M0.9210.90
40_V124_T0.9210.90
47_K50_N0.9190.90
125_I308_T0.9170.89
180_H209_L0.9140.89
250_T256_R0.9110.89
211_H214_E0.9090.89
309_L313_F0.9090.89
281_I313_F0.9070.89
77_M105_I0.9040.89
282_I288_F0.9040.89
35_Q90_F0.9010.89
121_L308_T0.8900.88
142_V206_L0.8900.88
226_A230_E0.8900.88
32_L62_R0.8900.88
66_M70_Y0.8880.88
65_C69_W0.8850.88
300_D304_A0.8840.88
281_I310_A0.8750.87
296_L300_D0.8570.86
236_D239_W0.8550.86
88_R99_L0.8530.86
188_G281_I0.8520.86
232_L240_L0.8490.85
50_N53_R0.8450.85
46_P49_G0.8410.85
90_F175_F0.8330.84
242_A247_K0.8320.84
62_R90_F0.8300.84
280_R284_R0.8260.84
245_P248_V0.8250.84
122_F304_A0.8220.84
145_T279_F0.8220.84
244_R248_V0.8210.83
63_I91_A0.8190.83
178_K202_D0.8150.83
238_D243_E0.8120.83
302_Q306_L0.8120.83
84_I87_M0.8110.83
251_L258_N0.8070.82
245_P249_K0.8060.82
292_R302_Q0.8020.82
265_E268_K0.8000.82
182_G217_V0.7990.82
39_A42_E0.7980.82
118_A301_N0.7970.82
314_R317_Q0.7920.81
291_A303_L0.7910.81
34_W90_F0.7900.81
169_K174_H0.7890.81
195_T303_L0.7850.81
278_P310_A0.7800.80
78_E106_M0.7800.80
167_T176_G0.7800.80
166_Q173_W0.7780.80
151_S160_R0.7780.80
195_T299_N0.7770.80
146_I198_A0.7730.80
274_R277_H0.7720.80
146_I202_D0.7700.79
238_D248_V0.7690.79
181_I275_V0.7690.79
194_V208_N0.7640.79
201_H225_G0.7640.79
164_M175_F0.7600.78
180_H205_Q0.7580.78
144_A180_H0.7570.78
310_A314_R0.7560.78
170_G173_W0.7540.78
74_D106_M0.7480.77
271_I274_R0.7410.77
161_D164_M0.7410.77
246_G249_K0.7410.77
192_S213_E0.7370.76
239_W244_R0.7340.76
156_K175_F0.7340.76
153_T175_F0.7320.76
203_L222_G0.7230.75
34_W37_M0.7210.75
155_N166_Q0.7210.75
138_Q186_K0.7180.74
253_Q257_K0.7160.74
72_L80_A0.7150.74
188_G310_A0.7140.74
237_V242_A0.7130.74
27_R30_Q0.7110.74
177_M296_L0.7110.74
138_Q216_F0.7100.74
26_S89_L0.7050.73
40_V43_P0.7050.73
193_L303_L0.7050.73
293_Y299_N0.7040.73
106_M110_H0.7000.73
190_T310_A0.6990.72
264_I267_M0.6990.72
126_N129_L0.6970.72
203_L225_G0.6940.72
151_S175_F0.6930.72
282_I307_F0.6910.72
129_L161_D0.6910.72
218_S271_I0.6830.71
147_I179_A0.6810.70
268_K272_R0.6790.70
267_M272_R0.6790.70
281_I314_R0.6780.70
70_Y83_E0.6770.70
125_I312_L0.6730.70
55_Y108_F0.6710.69
166_Q175_F0.6640.69
188_G278_P0.6540.67
81_L99_L0.6520.67
177_M299_N0.6510.67
226_A229_R0.6500.67
55_Y63_I0.6500.67
128_W132_A0.6500.67
119_R212_G0.6480.67
23_I86_S0.6450.66
23_I149_A0.6450.66
235_V239_W0.6450.66
74_D108_F0.6440.66
69_W309_L0.6420.66
246_G251_L0.6410.66
161_D165_H0.6410.66
110_H298_K0.6390.66
65_C90_F0.6360.65
122_F193_L0.6360.65
167_T174_H0.6320.65
247_K251_L0.6320.65
25_L70_Y0.6320.65
180_H200_E0.6290.64
130_A135_M0.6290.64
45_Y54_P0.6270.64
38_T42_E0.6250.64
309_L316_D0.6250.64
179_A307_F0.6240.64
283_K288_F0.6230.64
242_A251_L0.6230.64
203_L226_A0.6210.63
152_S160_R0.6190.63
25_L34_W0.6190.63
101_D106_M0.6180.63
96_D100_P0.6170.63
304_A307_F0.6170.63
227_P234_E0.6170.63
64_H77_M0.6160.63
301_N305_M0.6150.63
188_G274_R0.6140.63
57_L151_S0.6090.62
147_I291_A0.6070.62
107_N110_H0.6050.61
219_A224_Q0.6050.61
312_L316_D0.6040.61
25_L66_M0.6030.61
315_V318_M0.6020.61
25_L90_F0.6010.61
39_A43_P0.5990.61
236_D245_P0.5990.61
279_F283_K0.5990.61
227_P231_E0.5960.60
57_L60_M0.5960.60
168_K174_H0.5960.60
144_A223_Y0.5950.60
107_N121_L0.5930.60
23_I89_L0.5910.60
59_T92_R0.5890.59
39_A131_E0.5880.59
243_E247_K0.5870.59
152_S202_D0.5870.59
299_N303_L0.5860.59
237_V244_R0.5860.59
169_K223_Y0.5850.59
101_D107_N0.5840.59
226_A234_E0.5840.59
194_V212_G0.5820.58
244_R250_T0.5800.58
47_K53_R0.5770.58
188_G277_H0.5770.58
60_M105_I0.5770.58
73_S109_R0.5770.58
188_G314_R0.5760.58
104_T107_N0.5750.58
236_D243_E0.5750.58
119_R300_D0.5740.57
274_R280_R0.5740.57
309_L314_R0.5740.57
194_V209_L0.5740.57
171_N174_H0.5720.57
238_D242_A0.5720.57
175_F283_K0.5720.57
237_V240_L0.5710.57
122_F313_F0.5690.57
63_I107_N0.5690.57
243_E248_V0.5670.56
106_M109_R0.5670.56
72_L126_N0.5650.56
228_Q233_A0.5640.56
109_R311_N0.5610.56
286_F313_F0.5610.56
149_A152_S0.5610.56
239_W246_G0.5600.56
135_M187_S0.5600.56
156_K221_A0.5580.55
154_K170_G0.5580.55
216_F238_D0.5560.55
218_S240_L0.5560.55
293_Y303_L0.5540.55
188_G193_L0.5520.55
270_S274_R0.5520.55
154_K166_Q0.5510.54
144_A279_F0.5500.54
85_A88_R0.5490.54
79_D83_E0.5480.54
16_R55_Y0.5480.54
28_M33_P0.5460.54
73_S219_A0.5450.54
207_G211_H0.5440.53
90_F279_F0.5440.53
233_A258_N0.5440.53
151_S294_K0.5430.53
265_E269_A0.5430.53
67_Q74_D0.5420.53
284_R290_K0.5400.53
154_K188_G0.5380.53
64_H305_M0.5370.53
17_R21_K0.5370.53
33_P58_E0.5340.52
306_L309_L0.5340.52
196_T200_E0.5330.52
169_K172_Q0.5330.52
299_N308_T0.5320.52
281_I285_Q0.5320.52
141_L183_V0.5300.52
25_L30_Q0.5290.51
66_M77_M0.5260.51
35_Q40_V0.5250.51
268_K271_I0.5240.51
112_L221_A0.5230.51
73_S78_E0.5230.51
27_R316_D0.5210.50
201_H222_G0.5170.50
263_N266_Y0.5170.50
54_P57_L0.5160.50
209_L212_G0.5150.50
286_F291_A0.5120.49
42_E47_K0.5100.49
125_I128_W0.5090.49
39_A215_Q0.5080.49
154_K175_F0.5080.49
206_L217_V0.5080.49
78_E81_L0.5070.48
154_K272_R0.5070.48
147_I299_N0.5070.48
236_D247_K0.5070.48
193_L308_T0.5060.48
24_F36_N0.5060.48
155_N165_H0.5050.48
76_A79_D0.5020.48
20_R24_F0.5010.48
74_D178_K0.5010.48
75_G106_M0.5000.48
149_A177_M0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8037 98.4 0.88 Contact Map
4u7bA 2 0.8497 90.2 0.936 Contact Map
4dyqA 5 0.362 46.4 0.956 Contact Map
3kksA 2 0.411 46.1 0.956 Contact Map
4mq3A 1 0.3742 43.5 0.957 Contact Map
1c6vA 4 0.3896 42.3 0.957 Contact Map
3l3uA 2 0.4141 38 0.958 Contact Map
4fcyA 4 0.816 37.8 0.958 Contact Map
1bcoA 1 0.4877 32.5 0.96 Contact Map
1ex4A 5 0.411 32 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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