TTCA - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

TTCA - tRNA 2-thiocytidine biosynthesis protein TtcA

UniProt:	P76055	Sequences: MQENQQITKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQKQPGFPEHVLPEYLEKLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIQRFADAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIETMFSAMQNVVPSHLCDTNLFDFKGITHGSEVVNGGDLAFDREEIPLQPACWQPEEDENQLDELRLNVVEVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13357
Length:	311 (245)
Sequences:	3136 (2240)
Seq/√Len:	143.1

ECOLI - TTCA TILS
BACSU - TILS
HALSA - Q9HSK1
SULSO - Q7LXT2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
41_R	71_S	3.144	1.00
53_Y	92_Y	3.033	1.00
73_V	101_K	2.804	1.00
73_V	142_A	2.722	1.00
40_D	144_K	2.703	1.00
26_V	58_I	2.649	1.00
54_T	200_A	2.596	1.00
232_D	239_I	2.561	1.00
25_N	195_D	2.413	1.00
46_L	89_L	2.400	1.00
85_P	212_L	2.386	1.00
155_L	242_M	2.289	1.00
41_R	73_V	2.266	1.00
106_N	109_G	2.259	1.00
152_D	239_I	2.217	1.00
193_E	197_Q	2.155	1.00
74_A	98_V	2.136	1.00
87_H	91_E	2.118	1.00
146_A	185_I	2.100	1.00
74_A	93_L	2.079	1.00
40_D	143_T	2.071	1.00
217_P	226_D	2.069	1.00
80_K	104_E	2.064	1.00
87_H	90_P	2.054	1.00
78_D	86_E	1.998	1.00
43_M	142_A	1.993	1.00
75_V	132_I	1.982	1.00
54_T	196_I	1.976	1.00
42_I	146_A	1.928	1.00
35_M	177_S	1.859	1.00
56_L	74_A	1.836	1.00
122_C	213_C	1.823	1.00
44_V	55_M	1.803	1.00
46_L	74_A	1.803	1.00
103_V	135_R	1.795	1.00
92_Y	96_L	1.787	1.00
158_L	246_M	1.779	1.00
137_A	145_I	1.759	1.00
57_E	203_K	1.724	1.00
83_G	86_E	1.709	1.00
91_E	95_K	1.682	1.00
50_K	200_A	1.628	1.00
36_I	185_I	1.628	1.00
57_E	199_F	1.625	1.00
135_R	139_E	1.609	1.00
81_Q	108_Y	1.582	1.00
81_Q	121_T	1.579	1.00
230_D	234_R	1.569	1.00
58_I	62_L	1.568	1.00
90_P	94_E	1.567	1.00
53_Y	205_F	1.548	1.00
223_V	234_R	1.546	1.00
57_E	61_N	1.543	1.00
136_T	140_L	1.539	1.00
101_K	139_E	1.515	1.00
160_L	220_Q	1.515	1.00
23_R	61_N	1.491	1.00
50_K	209_P	1.490	1.00
262_F	266_T	1.477	1.00
27_G	65_S	1.434	1.00
29_A	190_Y	1.431	1.00
91_E	94_E	1.427	1.00
262_F	265_I	1.427	1.00
34_N	37_E	1.426	1.00
43_M	73_V	1.393	1.00
101_K	140_L	1.364	1.00
32_D	190_Y	1.360	1.00
22_L	58_I	1.343	1.00
59_L	146_A	1.336	1.00
44_V	59_L	1.328	1.00
138_T	181_K	1.324	1.00
75_V	136_T	1.314	1.00
43_M	75_V	1.311	1.00
58_I	188_L	1.304	1.00
163_F	231_W	1.285	1.00
255_C	259_L	1.276	1.00
150_H	196_I	1.271	1.00
156_Q	225_A	1.268	1.00
93_L	100_Y	1.265	1.00
110_I	128_L	1.252	1.00
45_C	133_L	1.251	1.00
36_I	42_I	1.249	1.00
66_A	70_F	1.241	1.00
154_I	174_K	1.236	1.00
245_A	249_V	1.236	1.00
60_R	63_Q	1.230	1.00
209_P	215_S	1.227	1.00
227_M	231_W	1.225	1.00
136_T	139_E	1.222	1.00
37_E	40_D	1.210	1.00
123_S	127_R	1.208	1.00
27_G	31_A	1.207	1.00
71_S	99_E	1.185	1.00
54_T	188_L	1.185	1.00
162_M	245_A	1.178	1.00
26_V	191_C	1.176	1.00
57_E	96_L	1.171	1.00
88_V	208_I	1.170	1.00
198_R	202_A	1.166	1.00
110_I	117_E	1.166	1.00
76_N	100_Y	1.157	1.00
50_K	54_T	1.153	0.99
30_I	36_I	1.150	0.99
179_D	182_H	1.138	0.99
46_L	53_Y	1.136	0.99
147_L	184_V	1.133	0.99
158_L	242_M	1.130	0.99
57_E	205_F	1.128	0.99
53_Y	207_I	1.127	0.99
38_E	67_P	1.116	0.99
226_D	230_D	1.108	0.99
50_K	193_E	1.095	0.99
155_L	246_M	1.085	0.99
60_R	96_L	1.082	0.99
220_Q	223_V	1.081	0.99
22_L	191_C	1.077	0.99
155_L	239_I	1.075	0.99
154_I	189_A	1.065	0.99
151_R	192_R	1.062	0.99
107_T	128_L	1.059	0.99
29_A	189_A	1.044	0.99
200_A	205_F	1.043	0.99
194_K	232_D	1.030	0.99
109_G	113_E	1.028	0.99
155_L	243_F	1.025	0.99
44_V	56_L	1.020	0.99
93_L	98_V	1.013	0.99
241_T	244_S	1.010	0.99
230_D	233_K	1.000	0.99
73_V	99_E	0.991	0.98
63_Q	70_F	0.991	0.98
197_Q	201_D	0.985	0.98
160_L	224_I	0.984	0.98
27_G	66_A	0.984	0.98
55_M	59_L	0.980	0.98
30_I	35_M	0.978	0.98
60_R	98_V	0.978	0.98
188_L	191_C	0.975	0.98
151_R	239_I	0.972	0.98
43_M	136_T	0.970	0.98
231_W	238_R	0.969	0.98
78_D	212_L	0.968	0.98
77_L	105_E	0.966	0.98
43_M	101_K	0.964	0.98
101_K	136_T	0.959	0.98
152_D	192_R	0.952	0.98
265_I	268_G	0.948	0.98
89_L	100_Y	0.947	0.98
58_I	191_C	0.945	0.98
163_F	227_M	0.944	0.98
200_A	207_I	0.944	0.98
130_R	147_L	0.942	0.98
129_R	221_R	0.940	0.98
134_Y	137_A	0.939	0.98
29_A	33_F	0.939	0.98
120_T	123_S	0.938	0.98
54_T	199_F	0.934	0.98
45_C	147_L	0.933	0.98
73_V	140_L	0.931	0.98
78_D	104_E	0.930	0.98
158_L	173_P	0.926	0.98
110_I	124_L	0.923	0.98
61_N	203_K	0.920	0.97
28_E	32_D	0.920	0.97
56_L	93_L	0.920	0.97
237_G	241_T	0.908	0.97
159_F	224_I	0.908	0.97
90_P	102_I	0.905	0.97
264_G	268_G	0.900	0.97
169_K	253_H	0.897	0.97
88_V	206_P	0.895	0.97
50_K	207_I	0.892	0.97
88_V	207_I	0.887	0.97
75_V	133_L	0.884	0.97
137_A	182_H	0.881	0.97
211_N	214_G	0.880	0.97
224_I	227_M	0.878	0.97
77_L	132_I	0.875	0.97
121_T	219_L	0.874	0.97
56_L	98_V	0.871	0.96
256_D	260_F	0.861	0.96
256_D	259_L	0.860	0.96
77_L	103_V	0.854	0.96
82_P	213_C	0.851	0.96
156_Q	221_R	0.848	0.96
23_R	199_F	0.838	0.96
119_K	124_L	0.830	0.95
78_D	85_P	0.829	0.95
67_P	70_F	0.824	0.95
23_R	27_G	0.821	0.95
57_E	60_R	0.817	0.95
238_R	241_T	0.809	0.95
84_F	212_L	0.808	0.95
157_T	221_R	0.806	0.95
103_V	136_T	0.804	0.95
134_Y	183_I	0.798	0.94
79_Q	129_R	0.798	0.94
262_F	268_G	0.797	0.94
74_A	100_Y	0.793	0.94
35_M	144_K	0.786	0.94
151_R	243_F	0.781	0.94
37_E	144_K	0.778	0.94
122_C	219_L	0.778	0.94
36_I	70_F	0.774	0.93
160_L	221_R	0.774	0.93
45_C	145_I	0.772	0.93
144_K	185_I	0.771	0.93
103_V	132_I	0.771	0.93
167_K	170_G	0.765	0.93
199_F	203_K	0.757	0.93
105_E	128_L	0.754	0.92
90_P	100_Y	0.754	0.92
237_G	240_E	0.752	0.92
131_G	135_R	0.746	0.92
57_E	92_Y	0.741	0.92
109_G	112_K	0.741	0.92
26_V	59_L	0.740	0.92
128_L	131_G	0.738	0.92
44_V	72_L	0.738	0.92
248_N	252_S	0.737	0.92
111_V	124_L	0.736	0.92
41_R	142_A	0.736	0.92
113_E	117_E	0.732	0.91
137_A	142_A	0.728	0.91
30_I	144_K	0.726	0.91
133_L	145_I	0.721	0.91
252_S	256_D	0.721	0.91
158_L	162_M	0.720	0.91
213_C	216_Q	0.716	0.90
24_R	28_E	0.713	0.90
154_I	161_N	0.711	0.90
263_K	267_H	0.708	0.90
74_A	89_L	0.706	0.90
192_R	239_I	0.705	0.90
122_C	125_C	0.704	0.90
163_F	224_I	0.703	0.90
127_R	131_G	0.694	0.89
147_L	150_H	0.693	0.89
42_I	144_K	0.691	0.89
120_T	124_L	0.689	0.89
51_D	149_H	0.687	0.88
51_D	221_R	0.686	0.88
51_D	153_D	0.684	0.88
144_K	183_I	0.682	0.88
155_L	158_L	0.681	0.88
26_V	62_L	0.669	0.87
150_H	193_E	0.667	0.87
63_Q	72_L	0.664	0.87
110_I	119_K	0.664	0.87
166_G	170_G	0.663	0.87
158_L	249_V	0.662	0.87
227_M	238_R	0.660	0.86
133_L	137_A	0.655	0.86
244_S	248_N	0.654	0.86
212_L	215_S	0.654	0.86
36_I	40_D	0.652	0.86
88_V	205_F	0.649	0.85
221_R	225_A	0.647	0.85
36_I	144_K	0.644	0.85
244_S	247_Q	0.643	0.85
46_L	93_L	0.643	0.85
42_I	185_I	0.639	0.85
265_I	269_S	0.637	0.84
35_M	174_K	0.636	0.84
192_R	232_D	0.633	0.84
122_C	216_Q	0.633	0.84
56_L	72_L	0.629	0.84
89_L	208_I	0.629	0.84
105_E	132_I	0.629	0.84
152_D	193_E	0.626	0.83
194_K	198_R	0.624	0.83
91_E	206_P	0.622	0.83
83_G	208_I	0.618	0.83
44_V	74_A	0.618	0.83
253_H	260_F	0.615	0.82
50_K	197_Q	0.613	0.82
94_E	97_G	0.613	0.82
81_Q	122_C	0.611	0.82
228_L	238_R	0.610	0.82
88_V	92_Y	0.609	0.82
80_K	107_T	0.606	0.81
136_T	142_A	0.605	0.81
77_L	133_L	0.605	0.81
167_K	248_N	0.604	0.81
124_L	128_L	0.604	0.81
53_Y	200_A	0.603	0.81
217_P	222_Q	0.603	0.81
59_L	72_L	0.602	0.81
257_T	261_D	0.602	0.81
171_M	245_A	0.601	0.81
264_G	267_H	0.599	0.81
157_T	161_N	0.599	0.81
149_H	153_D	0.598	0.81
25_N	191_C	0.595	0.80
47_S	51_D	0.594	0.80
163_F	238_R	0.594	0.80
232_D	237_G	0.592	0.80
29_A	176_M	0.588	0.79
63_Q	71_S	0.587	0.79
192_R	195_D	0.585	0.79
55_M	188_L	0.585	0.79
200_A	209_P	0.578	0.78
154_I	173_P	0.576	0.78
53_Y	88_V	0.575	0.78
86_E	208_I	0.570	0.77
42_I	70_F	0.568	0.77
61_N	65_S	0.568	0.77
55_M	146_A	0.568	0.77
76_N	93_L	0.567	0.77
82_P	214_G	0.566	0.77
138_T	267_H	0.566	0.77
110_I	113_E	0.560	0.76
171_M	241_T	0.559	0.76
213_C	219_L	0.558	0.76
151_R	240_E	0.557	0.76
211_N	222_Q	0.557	0.76
149_H	157_T	0.556	0.76
162_M	242_M	0.555	0.75
53_Y	89_L	0.555	0.75
164_Y	220_Q	0.555	0.75
33_F	190_Y	0.553	0.75
122_C	126_S	0.553	0.75
30_I	40_D	0.551	0.75
159_F	227_M	0.549	0.75
235_Y	238_R	0.549	0.75
147_L	186_R	0.546	0.74
162_M	171_M	0.544	0.74
62_L	70_F	0.543	0.74
85_P	213_C	0.541	0.74
75_V	103_V	0.541	0.74
253_H	257_T	0.541	0.74
197_Q	209_P	0.540	0.73
199_F	205_F	0.539	0.73
239_I	243_F	0.539	0.73
50_K	122_C	0.538	0.73
212_L	216_Q	0.537	0.73
243_F	246_M	0.532	0.72
126_S	214_G	0.531	0.72
79_Q	126_S	0.530	0.72
41_R	140_L	0.530	0.72
59_L	70_F	0.529	0.72
222_Q	225_A	0.529	0.72
137_A	183_I	0.529	0.72
46_L	92_Y	0.528	0.72
134_Y	182_H	0.528	0.72
216_Q	219_L	0.525	0.71
60_R	64_Q	0.524	0.71
50_K	196_I	0.523	0.71
63_Q	66_A	0.523	0.71
35_M	189_A	0.522	0.71
177_S	183_I	0.522	0.71
39_G	97_G	0.519	0.71
159_F	238_R	0.518	0.70
26_V	29_A	0.517	0.70
108_Y	111_V	0.517	0.70
193_E	225_A	0.514	0.70
47_S	52_S	0.514	0.70
39_G	144_K	0.514	0.70
59_L	185_I	0.513	0.70
153_D	221_R	0.512	0.69
168_M	252_S	0.507	0.69
79_Q	107_T	0.506	0.69
163_F	235_Y	0.506	0.69
121_T	125_C	0.505	0.68
26_V	188_L	0.504	0.68
126_S	130_R	0.502	0.68
253_H	256_D	0.501	0.68
35_M	176_M	0.500	0.68

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3a2kA	1	0.9068	100	0.338	Contact Map
1wy5A	4	0.8971	100	0.376	Contact Map
3vrhA	2	0.9068	100	0.386	Contact Map
1ni5A	2	0.8746	100	0.389	Contact Map
2derA	1	0.8071	100	0.642	Contact Map
1surA	2	0.6463	100	0.65	Contact Map
3k32A	2	0.6174	100	0.657	Contact Map
2hmaA	2	0.8392	100	0.659	Contact Map
1zunA	1	0.5852	100	0.661	Contact Map
2vxoA	2	0.9807	100	0.662	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.