GREMLIN Database
ABGB - p-aminobenzoyl-glutamate hydrolase subunit B
UniProt: P76052 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13351
Length: 481 (362)
Sequences: 2601 (1979)
Seq/√Len: 104.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_F140_F3.6901.00
213_A287_T3.5901.00
198_A207_G3.4221.00
43_L82_Y3.4111.00
25_Q38_W3.1741.00
338_T343_Q2.8501.00
193_F217_M2.7541.00
242_G253_A2.7441.00
68_S139_R2.7381.00
24_D371_N2.7001.00
214_V240_N2.6731.00
93_G97_P2.6631.00
210_A250_Q2.6581.00
113_L172_P2.6581.00
232_A263_E2.6091.00
192_R290_E2.6071.00
113_L369_L2.5531.00
18_R123_I2.5111.00
25_Q42_H2.4331.00
26_I42_H2.3781.00
43_L115_G2.3761.00
48_E56_R2.3341.00
16_R20_T2.3301.00
126_K129_L2.3171.00
75_V137_T2.2991.00
227_H273_R2.2981.00
77_A164_V2.2981.00
46_A49_S2.2741.00
215_T218_T2.2651.00
161_F341_D2.2441.00
11_A127_K2.2411.00
194_K288_T2.2141.00
153_T157_R2.1611.00
77_A167_A2.1411.00
174_A362_L2.1401.00
44_A56_R2.1001.00
221_T274_V2.0551.00
273_R276_K2.0471.00
19_Y120_A2.0371.00
38_W41_E2.0051.00
28_D101_T1.9941.00
275_A279_E1.9821.00
192_R254_E1.9391.00
282_A289_V1.9271.00
37_F63_N1.9031.00
276_K286_E1.8741.00
279_E283_L1.8511.00
239_T256_L1.8371.00
187_I267_V1.8251.00
16_R375_P1.7971.00
167_A341_D1.7891.00
194_K290_E1.7801.00
212_D223_F1.7731.00
190_S292_R1.7691.00
7_F131_Q1.7341.00
274_V291_C1.7211.00
259_I293_F1.7181.00
315_S319_T1.7161.00
89_S103_G1.7031.00
227_H286_E1.6931.00
72_G135_G1.6801.00
208_R287_T1.6651.00
117_A377_A1.6411.00
117_A121_A1.6401.00
139_R163_D1.6261.00
11_A128_W1.6251.00
19_Y116_T1.6121.00
271_Y293_F1.6061.00
82_Y115_G1.6001.00
271_Y275_A1.5961.00
220_G281_A1.5931.00
311_Y315_S1.5831.00
192_R252_Q1.5711.00
41_E45_S1.5681.00
12_I124_A1.5601.00
205_H229_I1.5511.00
190_S254_E1.5501.00
77_A141_Y1.5461.00
18_R46_A1.5381.00
271_Y295_K1.5281.00
10_D14_A1.5281.00
16_R372_E1.5201.00
141_Y167_A1.5091.00
194_K252_Q1.5041.00
32_T86_A1.4951.00
190_S256_L1.4731.00
48_E54_V1.4501.00
92_A97_P1.4491.00
169_T345_S1.4401.00
216_L219_T1.4311.00
268_Q272_D1.4241.00
91_Q366_E1.4221.00
41_E56_R1.4191.00
52_F67_A1.3971.00
278_A289_V1.3971.00
78_L118_A1.3941.00
18_R22_I1.3931.00
44_A54_V1.3851.00
117_A170_W1.3851.00
11_A15_D1.3580.99
46_A50_A1.3520.99
228_I233_R1.3460.99
217_M282_A1.3430.99
170_W348_N1.3390.99
22_I26_I1.3380.99
94_C97_P1.3320.99
360_F364_H1.3240.99
25_Q29_H1.3120.99
22_I42_H1.3110.99
18_R21_D1.3080.99
29_H38_W1.2980.99
17_Q21_D1.2940.99
44_A48_E1.2920.99
264_M339_S1.2880.99
278_A291_C1.2880.99
194_K251_A1.2850.99
52_F126_K1.2840.99
35_E105_N1.2820.99
205_H230_E1.2700.99
215_T219_T1.2600.99
276_K283_L1.2580.99
11_A14_A1.2530.99
92_A96_Q1.2500.99
280_G283_L1.2440.99
38_W42_H1.2410.99
214_V255_V1.2390.99
218_T240_N1.2350.99
272_D276_K1.2230.99
307_E344_N1.2210.99
52_F69_F1.2160.99
168_L306_L1.2110.99
216_L285_T1.2060.99
162_D340_N1.2030.99
274_V278_A1.2030.99
180_N323_N1.1850.99
177_G180_N1.1830.99
26_I115_G1.1790.99
217_M278_A1.1630.98
55_T68_S1.1500.98
189_A237_A1.1480.98
92_A368_V1.1400.98
53_T68_S1.1260.98
32_T105_N1.1260.98
36_E63_N1.1210.98
275_A291_C1.1200.98
214_V253_A1.1190.98
54_V67_A1.1170.98
22_I46_A1.1130.98
122_A140_F1.1050.98
216_L220_G1.1000.98
45_S49_S1.0970.98
352_T356_N1.0950.98
167_A337_L1.0920.98
240_N253_A1.0880.98
150_S297_C1.0860.98
180_N321_E1.0830.97
311_Y324_S1.0820.97
66_I160_V1.0810.97
7_F10_D1.0780.97
233_R270_I1.0760.97
46_A119_F1.0700.97
70_G73_K1.0680.97
167_A343_Q1.0660.97
154_F157_R1.0660.97
113_L374_A1.0640.97
52_F140_F1.0600.97
155_M158_E1.0530.97
68_S137_T1.0490.97
141_Y160_V1.0480.97
191_W291_C1.0460.97
155_M337_L1.0420.97
118_A140_F1.0420.97
34_F145_G1.0410.97
166_A306_L1.0360.97
268_Q295_K1.0330.97
44_A65_F1.0320.97
45_S48_E1.0300.97
352_T358_K1.0280.97
154_F158_E1.0280.97
303_N306_L1.0270.97
76_I168_L1.0270.97
40_A63_N1.0220.96
211_L240_N1.0150.96
229_I326_E1.0100.96
269_H273_R1.0080.96
42_H46_A1.0030.96
350_A373_V1.0010.96
7_F11_A1.0010.96
183_T300_Y0.9950.96
174_A350_A0.9950.96
13_E16_R0.9940.96
191_W278_A0.9860.96
75_V139_R0.9840.96
178_M376_Y0.9790.95
74_P165_D0.9770.95
191_W255_V0.9690.95
94_C368_V0.9660.95
29_H101_T0.9640.95
139_R161_F0.9630.95
96_Q368_V0.9610.95
90_Q96_Q0.9610.95
297_C336_T0.9580.95
210_A249_V0.9500.95
313_A316_H0.9420.94
188_Q246_P0.9390.94
15_D19_Y0.9370.94
185_A261_A0.9360.94
208_R213_A0.9300.94
143_C333_I0.9260.94
352_T370_A0.9180.94
209_S226_E0.9100.93
40_A82_Y0.9100.93
161_F164_V0.9090.93
352_T357_G0.9090.93
139_R164_V0.9080.93
40_A44_A0.9070.93
144_P155_M0.9060.93
304_R308_N0.9050.93
19_Y374_A0.9050.93
328_A347_N0.9040.93
362_L367_T0.9040.93
264_M267_V0.9030.93
221_T237_A0.9020.93
86_A245_S0.8990.93
125_V138_V0.8970.93
275_A289_V0.8950.93
43_L65_F0.8950.93
75_V165_D0.8940.93
300_Y335_A0.8920.93
89_S104_E0.8850.92
185_A299_S0.8810.92
186_N331_K0.8800.92
360_F366_E0.8760.92
329_F333_I0.8730.92
309_A313_A0.8730.92
156_V161_F0.8660.91
78_L121_A0.8650.91
190_S294_D0.8650.91
172_P350_A0.8600.91
15_D124_A0.8570.91
277_I281_A0.8520.91
184_L329_F0.8510.91
229_I232_A0.8500.91
308_N312_Q0.8500.91
128_W131_Q0.8480.91
212_D218_T0.8480.91
200_A238_I0.8480.91
37_F41_E0.8470.91
227_H276_K0.8470.91
189_A257_Y0.8460.90
235_H259_I0.8400.90
183_T347_N0.8360.90
46_A123_I0.8350.90
178_M372_E0.8340.90
55_T158_E0.8290.90
191_W275_A0.8260.89
222_N225_N0.8220.89
212_D215_T0.8200.89
356_N372_E0.8190.89
191_W217_M0.8180.89
12_I375_P0.8160.89
193_F213_A0.8160.89
69_F126_K0.8150.89
15_D127_K0.8140.89
50_A123_I0.8140.89
217_M221_T0.8130.89
310_M346_L0.8130.89
312_Q315_S0.8120.89
310_M344_N0.8100.88
54_V69_F0.8050.88
76_I166_A0.8030.88
224_L277_I0.8020.88
124_A128_W0.8020.88
44_A58_V0.8010.88
298_S336_T0.8000.88
193_F278_A0.7980.88
213_A285_T0.7960.88
367_T371_N0.7960.88
80_G140_F0.7940.87
139_R160_V0.7940.87
241_S254_E0.7920.87
48_E53_T0.7910.87
42_H45_S0.7880.87
280_G284_M0.7880.87
318_G321_E0.7870.87
25_Q28_D0.7870.87
278_A282_A0.7860.87
224_L270_I0.7860.87
74_P134_Q0.7810.87
189_A274_V0.7810.87
332_Q345_S0.7810.87
348_N377_A0.7800.87
33_R36_E0.7750.86
211_L242_G0.7730.86
314_L322_W0.7730.86
96_Q371_N0.7730.86
32_T35_E0.7720.86
193_F282_A0.7710.86
197_A207_G0.7690.86
301_L304_R0.7670.86
352_T355_E0.7650.85
177_G351_A0.7650.85
192_R292_R0.7640.85
22_I116_T0.7610.85
173_E183_T0.7590.85
197_A248_V0.7590.85
54_V65_F0.7590.85
40_A65_F0.7590.85
90_Q106_G0.7570.85
264_M268_Q0.7550.85
80_G118_A0.7520.84
94_C98_T0.7510.84
95_A98_T0.7480.84
160_V163_D0.7470.84
190_S246_P0.7450.84
197_A210_A0.7450.84
345_S349_I0.7450.84
173_E347_N0.7440.84
78_L125_V0.7400.84
13_E375_P0.7350.83
217_M277_I0.7330.83
25_Q33_R0.7230.82
337_L345_S0.7230.82
269_H272_D0.7200.82
261_A270_I0.7200.82
164_V341_D0.7170.82
237_A240_N0.7170.82
306_L309_A0.7140.81
33_R105_N0.7140.81
8_I124_A0.7140.81
102_P105_N0.7120.81
235_H274_V0.7070.81
187_I293_F0.7060.81
228_I270_I0.7030.80
259_I271_Y0.7020.80
172_P362_L0.7010.80
208_R286_E0.7000.80
90_Q368_V0.7000.80
47_L67_A0.7000.80
279_E289_V0.6960.80
21_D25_Q0.6960.80
155_M160_V0.6950.80
258_L331_K0.6950.80
78_L168_L0.6940.79
22_I119_F0.6930.79
11_A124_A0.6930.79
117_A348_N0.6910.79
196_I208_R0.6890.79
203_S206_L0.6860.79
207_G249_V0.6860.79
47_L142_G0.6830.78
8_I12_I0.6800.78
356_N359_V0.6790.78
6_R10_D0.6790.78
188_Q256_L0.6780.78
54_V57_N0.6760.78
156_V164_V0.6740.77
72_G136_G0.6730.77
308_N311_Y0.6730.77
67_A126_K0.6720.77
141_Y337_L0.6690.77
233_R236_Y0.6670.77
113_L117_A0.6670.77
33_R148_G0.6660.77
193_F214_V0.6650.76
350_A369_L0.6620.76
64_A155_M0.6590.76
58_V158_E0.6580.76
221_T235_H0.6570.76
352_T359_V0.6570.76
55_T160_V0.6560.76
14_A17_Q0.6560.76
281_A284_M0.6550.75
235_H277_I0.6550.75
232_A266_D0.6550.75
212_D222_N0.6520.75
71_Q135_G0.6520.75
77_A337_L0.6500.75
212_D219_T0.6480.75
44_A57_N0.6480.75
203_S328_A0.6440.74
235_H238_I0.6410.74
351_A359_V0.6390.74
29_H42_H0.6380.73
276_K279_E0.6330.73
15_D18_R0.6310.73
66_I155_M0.6290.72
353_G359_V0.6280.72
197_A250_Q0.6280.72
200_A236_Y0.6270.72
245_S248_V0.6260.72
185_A331_K0.6260.72
73_K135_G0.6250.72
261_A266_D0.6250.72
212_D225_N0.6200.71
185_A267_V0.6190.71
126_K130_E0.6190.71
90_Q93_G0.6180.71
267_V295_K0.6170.71
261_A267_V0.6170.71
178_M373_V0.6160.71
172_P373_V0.6160.71
62_P154_F0.6150.71
14_A127_K0.6120.70
123_I127_K0.6090.70
333_I336_T0.6080.70
270_I274_V0.6050.70
91_Q98_T0.6030.69
186_N246_P0.6020.69
361_A364_H0.6020.69
268_Q271_Y0.6020.69
90_Q94_C0.6010.69
188_Q294_D0.6010.69
228_I269_H0.6010.69
215_T255_V0.6000.69
236_Y239_T0.5980.69
272_D275_A0.5970.68
173_E362_L0.5950.68
82_Y142_G0.5940.68
66_I139_R0.5930.68
228_I266_D0.5930.68
173_E203_S0.5930.68
279_E288_T0.5920.68
55_T58_V0.5910.68
262_P299_S0.5900.68
67_A140_F0.5890.67
150_S154_F0.5870.67
172_P369_L0.5870.67
262_P327_L0.5860.67
181_T376_Y0.5860.67
170_W346_L0.5860.67
58_V155_M0.5850.67
72_G137_T0.5820.67
176_A179_F0.5800.66
306_L338_T0.5780.66
54_V126_K0.5760.66
9_D12_I0.5740.65
185_A266_D0.5730.65
15_D120_A0.5730.65
227_H269_H0.5730.65
203_S330_A0.5720.65
328_A331_K0.5710.65
336_T339_S0.5690.65
70_G136_G0.5690.65
63_N144_P0.5680.65
156_V160_V0.5680.65
251_A365_R0.5670.65
306_L344_N0.5670.65
17_Q49_S0.5640.64
22_I120_A0.5630.64
10_D13_E0.5620.64
12_I120_A0.5610.64
273_R286_E0.5600.64
46_A120_A0.5590.63
42_H67_A0.5590.63
91_Q94_C0.5580.63
113_L350_A0.5580.63
84_A115_G0.5580.63
34_F150_S0.5580.63
309_A312_Q0.5550.63
212_D216_L0.5550.63
189_A291_C0.5540.63
82_Y155_M0.5520.62
201_A329_F0.5520.62
15_D123_I0.5510.62
55_T139_R0.5500.62
213_A216_L0.5490.62
31_E39_S0.5480.62
40_A58_V0.5460.62
119_F123_I0.5450.62
282_A287_T0.5440.61
332_Q335_A0.5430.61
50_A126_K0.5420.61
111_H171_H0.5420.61
91_Q252_Q0.5410.61
48_E65_F0.5410.61
197_A365_R0.5400.61
22_I25_Q0.5400.61
168_L343_Q0.5390.61
216_L281_A0.5370.60
23_A112_N0.5370.60
26_I46_A0.5360.60
85_L88_L0.5360.60
184_L330_A0.5350.60
214_V218_T0.5350.60
69_F129_L0.5340.60
76_I138_V0.5340.60
211_L218_T0.5340.60
169_T337_L0.5330.60
68_S163_D0.5330.60
229_I262_P0.5320.60
173_E330_A0.5310.60
213_A282_A0.5310.60
181_T314_L0.5300.59
92_A366_E0.5300.59
33_R149_G0.5290.59
187_I261_A0.5290.59
9_D13_E0.5280.59
355_E359_V0.5280.59
139_R158_E0.5270.59
20_T24_D0.5270.59
74_P135_G0.5260.59
79_L143_C0.5240.59
214_V219_T0.5230.58
369_L373_V0.5230.58
74_P136_G0.5220.58
235_H239_T0.5210.58
29_H102_P0.5210.58
8_I11_A0.5210.58
241_S256_L0.5210.58
49_S67_A0.5190.58
277_I280_G0.5190.58
199_H247_N0.5190.58
12_I15_D0.5190.58
43_L118_A0.5190.58
109_C112_N0.5160.57
240_N255_V0.5160.57
58_V62_P0.5160.57
74_P137_T0.5150.57
337_L340_N0.5150.57
222_N236_Y0.5120.57
201_A346_L0.5120.57
191_W214_V0.5120.57
184_L262_P0.5110.57
263_E266_D0.5110.57
236_Y240_N0.5110.57
298_S339_S0.5090.56
88_L364_H0.5080.56
48_E52_F0.5060.56
31_E111_H0.5050.56
71_Q131_Q0.5050.56
80_G115_G0.5050.56
215_T240_N0.5050.56
276_K280_G0.5040.56
259_I270_I0.5040.56
266_D269_H0.5030.55
207_G210_A0.5020.55
305_T308_N0.5020.55
72_G130_E0.5020.55
33_R63_N0.5020.55
193_F210_A0.5010.55
352_T360_F0.5010.55
88_L108_G0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ramA 4 0.8004 100 0.579 Contact Map
1xmbA 1 0.7464 100 0.613 Contact Map
3io1A 4 0.7235 100 0.614 Contact Map
4ewtA 4 0.7755 100 0.624 Contact Map
1ysjA 2 0.7297 100 0.632 Contact Map
3pfoA 2 0.7838 100 0.649 Contact Map
3rzaA 2 0.736 100 0.663 Contact Map
3gb0A 2 0.736 100 0.665 Contact Map
3dljA 2 0.7859 100 0.666 Contact Map
1cg2A 4 0.7755 100 0.671 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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