GREMLIN Database
YCJY - Uncharacterized protein YcjY
UniProt: P76049 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13922
Length: 306 (252)
Sequences: 41566 (34371)
Seq/√Len: 2165.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_G135_A5.5021.00
71_S92_D4.2821.00
251_S277_E3.8771.00
274_H297_V3.4511.00
276_V297_V3.2861.00
61_K299_A3.1081.00
287_G290_Y3.0371.00
251_S275_I2.8441.00
112_G134_K2.7581.00
94_S126_A2.7411.00
126_A130_D2.4621.00
113_A123_T2.3741.00
94_S130_D2.2761.00
127_A136_I2.2731.00
94_S98_D2.2151.00
120_A141_A2.1681.00
258_M275_I2.1501.00
125_N129_Q2.0841.00
140_S253_A2.0821.00
112_G302_F2.0741.00
123_T136_I2.0671.00
110_R134_K2.0631.00
279_A287_G2.0131.00
139_V291_V2.0071.00
138_T141_A1.9501.00
36_A66_I1.8831.00
36_A64_V1.8271.00
246_Q274_H1.8151.00
112_G137_G1.8131.00
236_M240_Y1.8111.00
264_D271_K1.8041.00
41_H73_Q1.8001.00
297_V300_P1.7681.00
40_S70_A1.7351.00
70_A122_Y1.7221.00
35_Q112_G1.7121.00
296_S300_P1.7001.00
93_I126_A1.6981.00
68_Y93_I1.6931.00
137_G298_L1.6571.00
57_K60_E1.6361.00
44_G117_C1.6141.00
276_V279_A1.6061.00
47_K75_E1.6041.00
91_E129_Q1.5911.00
41_H70_A1.5761.00
63_F112_G1.5681.00
126_A133_I1.5581.00
245_T267_S1.5491.00
262_L266_A1.5481.00
40_S93_I1.5371.00
199_L202_A1.5241.00
57_K299_A1.5071.00
272_R297_V1.4821.00
124_A138_T1.4661.00
90_T125_N1.4401.00
85_N88_I1.4191.00
39_L114_M1.4171.00
114_M139_V1.4111.00
137_G246_Q1.3821.00
34_Y64_V1.3781.00
261_D265_R1.3421.00
125_N128_I1.3291.00
57_K61_K1.3271.00
59_A65_T1.3131.00
47_K67_A1.3131.00
35_Q63_F1.3111.00
68_Y96_V1.2961.00
218_G221_T1.2941.00
97_I111_I1.2901.00
55_A67_A1.2851.00
40_S68_Y1.2831.00
267_S271_K1.2801.00
267_S270_D1.2791.00
87_Y129_Q1.2691.00
39_L65_T1.2421.00
261_D264_D1.2421.00
263_Y266_A1.2311.00
35_Q134_K1.2271.00
40_S123_T1.2261.00
162_L166_E1.2211.00
248_V276_V1.2161.00
217_P220_A1.2101.00
249_A275_I1.2071.00
44_G73_Q1.1951.00
97_I105_Y1.1931.00
219_Y223_R1.1861.00
166_E170_N1.1771.00
63_F302_F1.1731.00
66_I100_L1.1681.00
70_A118_A1.1641.00
247_I271_K1.1621.00
31_T34_Y1.1481.00
217_P221_T1.1461.00
128_I236_M1.1461.00
164_Y168_G1.1441.00
262_L265_R1.1431.00
94_S129_Q1.1401.00
92_D95_A1.1371.00
37_I114_M1.1351.00
97_I102_T1.1321.00
196_N199_L1.1311.00
37_I63_F1.1251.00
36_A102_T1.1221.00
249_A258_M1.1061.00
94_S97_I1.1051.00
137_G302_F1.1041.00
223_R226_N1.0971.00
204_E208_T1.0881.00
262_L267_S1.0821.00
204_E207_H1.0781.00
116_I284_L1.0701.00
252_Q278_G1.0701.00
89_R92_D1.0681.00
104_S134_K1.0621.00
251_S278_G1.0581.00
69_D74_G1.0531.00
221_T224_S1.0531.00
249_A273_Y1.0501.00
37_I58_L1.0491.00
205_Y209_P1.0451.00
88_I91_E1.0441.00
53_T56_K1.0441.00
113_A126_A1.0431.00
96_V100_L1.0421.00
66_I96_V1.0411.00
125_N236_M1.0311.00
203_W206_Y1.0251.00
136_I245_T1.0191.00
222_L226_N1.0161.00
91_E94_S1.0061.00
220_A223_R1.0021.00
54_Y57_K0.9951.00
205_Y208_T0.9821.00
200_R204_E0.9801.00
43_G118_A0.9791.00
105_Y111_I0.9731.00
172_R175_D0.9721.00
227_Q230_T0.9641.00
263_Y271_K0.9621.00
59_A62_G0.9571.00
116_I282_M0.9521.00
169_S172_R0.9521.00
115_G123_T0.9501.00
279_A286_D0.9421.00
140_S283_D0.9391.00
114_M298_L0.9371.00
165_V169_S0.9371.00
290_Y297_V0.9351.00
183_I186_L0.9281.00
56_K60_E0.9281.00
113_A133_I0.9271.00
127_A243_Q0.9251.00
162_L165_V0.9181.00
214_P218_G0.9091.00
183_I187_A0.9051.00
47_K69_D0.8971.00
188_P191_E0.8941.00
37_I65_T0.8941.00
55_A65_T0.8891.00
165_V168_G0.8841.00
206_Y209_P0.8831.00
47_K68_Y0.8801.00
55_A59_A0.8731.00
98_D102_T0.8721.00
35_Q110_R0.8711.00
101_T104_S0.8671.00
40_S113_A0.8661.00
102_T105_Y0.8651.00
127_A133_I0.8591.00
263_Y267_S0.8581.00
139_V284_L0.8561.00
161_A165_V0.8531.00
56_K59_A0.8501.00
198_E202_A0.8471.00
96_V99_Y0.8471.00
218_G222_L0.8431.00
185_P188_P0.8401.00
163_P166_E0.8381.00
44_G118_A0.8371.00
220_A224_S0.8361.00
202_A206_Y0.8361.00
114_M137_G0.8351.00
98_D130_D0.8291.00
101_T105_Y0.8271.00
166_E169_S0.8251.00
42_P117_C0.8251.00
160_D164_Y0.8171.00
34_Y63_F0.8151.00
102_T111_I0.8051.00
219_Y222_L0.8051.00
223_R227_Q0.8041.00
184_M188_P0.8011.00
276_V290_Y0.7961.00
238_E266_A0.7861.00
97_I133_I0.7841.00
50_T284_L0.7841.00
140_S250_G0.7831.00
124_A141_A0.7821.00
87_Y91_E0.7811.00
39_L58_L0.7791.00
199_L209_P0.7761.00
185_P189_M0.7751.00
140_S249_A0.7751.00
279_A283_D0.7741.00
38_V113_A0.7731.00
247_I273_Y0.7701.00
201_Q205_Y0.7691.00
246_Q272_R0.7631.00
184_M187_A0.7631.00
111_I133_I0.7601.00
224_S227_Q0.7581.00
121_G142_V0.7571.00
202_A205_Y0.7561.00
222_L225_L0.7431.00
43_G73_Q0.7421.00
169_S173_T0.7391.00
171_A175_D0.7371.00
32_R64_V0.7351.00
139_V283_D0.7341.00
38_V97_I0.7311.00
91_E95_A0.7311.00
45_G50_T0.7271.00
167_A171_A0.7261.00
116_I140_S0.7261.00
214_P217_P0.7221.00
187_A191_E0.7211.00
163_P167_A0.7201.00
52_G56_K0.7201.00
174_S177_S0.7181.00
290_Y296_S0.7161.00
233_A236_M0.7141.00
38_V68_Y0.7101.00
48_E52_G0.7091.00
264_D267_S0.7071.00
227_Q231_Y0.7071.00
135_A301_F0.7061.00
198_E206_Y0.7051.00
35_Q135_A0.7041.00
133_I243_Q0.7031.00
90_T122_Y0.7011.00
195_P199_L0.7011.00
69_D75_E0.7001.00
280_N286_D0.7001.00
224_S228_I0.6991.00
36_A63_F0.6971.00
150_N153_E0.6951.00
261_D275_I0.6941.00
203_W207_H0.6931.00
226_N229_I0.6891.00
95_A98_D0.6861.00
228_I231_Y0.6851.00
95_A99_Y0.6801.00
161_A166_E0.6801.00
116_I139_V0.6771.00
70_A73_Q0.6731.00
186_L190_K0.6711.00
144_I147_I0.6711.00
248_V283_D0.6701.00
196_N200_R0.6671.00
201_Q204_E0.6651.00
242_T269_Q0.6641.00
276_V287_G0.6631.00
63_F299_A0.6621.00
99_Y102_T0.6601.00
249_A256_K0.6491.00
274_H290_Y0.6471.00
186_L189_M0.6461.00
225_L228_I0.6451.00
220_A225_L0.6431.00
161_A168_G0.6431.00
202_A207_H0.6411.00
215_T218_G0.6391.00
69_D76_S0.6371.00
96_V101_T0.6371.00
167_A172_R0.6361.00
248_V297_V0.6361.00
127_A241_L0.6361.00
274_H300_P0.6361.00
168_G172_R0.6351.00
177_S180_E0.6311.00
128_I240_Y0.6291.00
170_N174_S0.6271.00
120_A140_S0.6261.00
248_V274_H0.6251.00
138_T247_I0.6241.00
99_Y103_L0.6211.00
173_T176_I0.6181.00
161_A164_Y0.6171.00
180_E184_M0.6151.00
198_E201_Q0.6091.00
52_G67_A0.6051.00
115_G120_A0.6051.00
170_N173_T0.6031.00
160_D163_P0.6031.00
171_A174_S0.6021.00
39_L67_A0.6011.00
54_Y291_V0.6001.00
45_G285_Y0.5991.00
89_R93_I0.5931.00
143_N146_S0.5921.00
181_Y184_M0.5911.00
218_G225_L0.5881.00
50_T116_I0.5871.00
89_R118_A0.5861.00
89_R122_Y0.5851.00
250_G283_D0.5851.00
90_T129_Q0.5831.00
38_V93_I0.5831.00
162_L171_A0.5831.00
87_Y125_N0.5821.00
118_A122_Y0.5811.00
54_Y58_L0.5791.00
226_N230_T0.5781.00
83_L88_I0.5771.00
120_A124_A0.5761.00
251_S258_M0.5751.00
151_G154_N0.5731.00
246_Q301_F0.5731.00
149_R153_E0.5731.00
90_T94_S0.5721.00
174_S178_S0.5721.00
164_Y169_S0.5701.00
183_I191_E0.5691.00
135_A244_P0.5671.00
195_P198_E0.5651.00
40_S122_Y0.5641.00
162_L168_G0.5641.00
181_Y185_P0.5641.00
97_I126_A0.5621.00
162_L167_A0.5581.00
37_I112_G0.5561.00
282_M285_Y0.5561.00
147_I150_N0.5561.00
232_D235_H0.5551.00
258_M261_D0.5551.00
117_C282_M0.5541.00
129_Q236_M0.5491.00
182_A186_L0.5491.00
160_D168_G0.5491.00
296_S299_A0.5461.00
197_E201_Q0.5451.00
175_D178_S0.5451.00
167_A170_N0.5431.00
218_G223_R0.5431.00
221_T225_L0.5401.00
291_V298_L0.5401.00
165_V171_A0.5371.00
187_A190_K0.5361.00
182_A185_P0.5351.00
217_P223_R0.5341.00
60_E299_A0.5321.00
41_H68_Y0.5321.00
199_L203_W0.5291.00
198_E203_W0.5281.00
216_A221_T0.5281.00
184_M190_K0.5241.00
92_D96_V0.5231.00
289_A296_S0.5211.00
200_R203_W0.5201.00
278_G287_G0.5181.00
189_M192_S0.5171.00
184_M191_E0.5161.00
177_S181_Y0.5161.00
183_I188_P0.5141.00
162_L169_S0.5141.00
33_Q64_V0.5141.00
57_K289_A0.5111.00
120_A138_T0.5081.00
161_A167_A0.5071.00
187_A192_S0.5071.00
136_I243_Q0.5071.00
252_Q277_E0.5051.00
36_A111_I0.5051.00
135_A302_F0.5041.00
38_V111_I0.5031.00
42_P116_I0.5031.00
235_H238_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hdwA 2 0.9739 100 0.287 Contact Map
3pe6A 1 0.8987 100 0.308 Contact Map
1zoiA 3 0.8758 100 0.321 Contact Map
1a8sA 4 0.8693 100 0.336 Contact Map
3fobA 3 0.8922 100 0.338 Contact Map
1mtzA 1 0.915 100 0.34 Contact Map
3nwoA 1 0.9248 100 0.341 Contact Map
3hjuA 2 0.902 100 0.341 Contact Map
1ehyA 1 0.8627 100 0.341 Contact Map
2wtmA 2 0.8039 100 0.344 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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