GREMLIN Database
YCJX - Uncharacterized protein YcjX
UniProt: P76046 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13921
Length: 465 (447)
Sequences: 452 (297)
Seq/√Len: 14.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_D151_S10.4931.00
80_T83_E5.2751.00
56_S457_E4.5421.00
23_A279_F4.2001.00
55_L460_I4.1241.00
261_N264_C3.8311.00
174_M195_A3.7380.99
260_F264_C3.6910.99
377_L455_A3.5950.99
147_Q155_Q3.5760.99
106_R130_E3.3990.99
193_A197_T3.2860.99
57_A63_L3.1280.98
63_L109_L3.0920.98
179_D182_A2.9120.97
144_M147_Q2.8190.96
333_L375_L2.6960.95
199_Y203_C2.6170.94
222_M227_A2.5820.94
54_L397_A2.4750.92
236_V253_A2.4490.92
36_I131_I2.4030.91
216_F230_F2.3920.91
171_W175_S2.3410.90
288_C382_A2.3170.89
197_T201_H2.3110.89
208_L301_D2.2620.88
332_L367_F2.2420.88
383_T436_F2.2120.87
207_G346_Q2.2000.87
149_Y175_S2.1910.86
40_V105_I2.1080.84
108_A126_T2.0950.84
222_M267_V2.0940.84
386_G399_R2.0720.83
279_F426_W2.0620.83
332_L365_A1.9830.80
160_L172_R1.9760.80
65_G110_R1.9700.80
168_S172_R1.9680.79
113_S125_S1.9560.79
209_H301_D1.9510.79
20_L283_I1.9280.78
23_A370_I1.9130.77
354_L397_A1.8770.76
38_A452_L1.8680.76
248_D251_T1.8380.74
164_R203_C1.8310.74
402_R405_D1.8110.73
201_H211_I1.7650.71
14_R17_D1.7650.71
217_V270_G1.7360.70
108_A128_Y1.7300.70
29_R283_I1.7300.70
351_V376_G1.7280.70
198_D202_H1.7200.69
72_R130_E1.6850.68
12_V15_G1.6840.68
29_R216_F1.6660.67
277_L331_K1.6650.67
102_V221_D1.6590.66
309_L365_A1.6590.66
98_P288_C1.6510.66
209_H337_T1.6490.66
178_L192_I1.6420.66
30_S358_I1.6240.65
105_I217_V1.6210.65
149_Y256_L1.6160.64
222_M226_P1.6160.64
339_A350_M1.6100.64
90_G109_L1.6090.64
403_L437_R1.5900.63
288_C354_L1.5820.63
358_I371_S1.5800.62
42_Q327_P1.5730.62
211_I217_V1.5590.61
149_Y166_E1.5580.61
70_P186_E1.5570.61
167_W199_Y1.5480.61
66_V357_L1.5450.61
275_H283_I1.5440.61
175_S234_P1.5410.60
28_S143_P1.5350.60
189_L196_W1.5340.60
109_L129_L1.5280.60
78_R82_D1.5260.60
425_F429_Q1.5060.59
231_F256_L1.5050.59
318_R330_D1.5000.58
159_L164_R1.4970.58
276_F289_L1.4930.58
257_R269_K1.4930.58
41_N447_L1.4850.58
143_P184_A1.4830.57
384_T399_R1.4820.57
20_L129_L1.4750.57
23_A299_F1.4730.57
170_K174_M1.4690.57
365_A369_G1.4600.56
28_S309_L1.4520.56
69_I126_T1.4440.55
183_P250_H1.4430.55
30_S294_S1.4330.55
293_N433_F1.4150.54
175_S191_D1.4140.54
22_L302_M1.4130.54
292_L353_L1.4060.53
67_K110_R1.3940.53
73_D378_A1.3850.52
160_L223_A1.3750.52
161_N172_R1.3700.51
90_G457_E1.3680.51
343_T416_V1.3600.51
36_I128_Y1.3570.51
144_M448_P1.3560.51
20_L223_A1.3530.50
20_L318_R1.3400.50
359_Q439_Q1.3400.50
293_N386_G1.3310.49
38_A207_G1.3220.49
170_K205_E1.3210.49
397_A418_A1.3190.49
154_R277_L1.3180.49
109_L126_T1.3000.48
114_N367_F1.2870.47
29_R51_R1.2840.47
56_S60_E1.2740.46
102_V172_R1.2690.46
131_I260_F1.2670.46
354_L358_I1.2610.45
150_L257_R1.2610.45
168_S190_A1.2570.45
30_S379_S1.2570.45
188_R423_Q1.2550.45
98_P354_L1.2510.45
218_L227_A1.2480.45
339_A347_H1.2480.45
332_L460_I1.2450.45
28_S36_I1.2450.45
148_D297_Q1.2450.45
197_T216_F1.2430.44
296_P300_N1.2370.44
323_R431_F1.2300.44
389_D394_K1.2300.44
68_R82_D1.2290.44
114_N250_H1.2270.44
72_R439_Q1.2260.44
374_C381_Q1.2260.44
92_P421_P1.2260.44
190_A309_L1.2180.43
269_K445_K1.2170.43
29_R337_T1.2070.43
152_W286_V1.2070.43
17_D189_L1.2040.42
389_D393_E1.2010.42
143_P329_I1.1960.42
151_S169_A1.1810.41
167_W203_C1.1760.41
83_E146_A1.1670.40
339_A414_G1.1660.40
71_Q106_R1.1660.40
279_F299_F1.1660.40
334_F345_D1.1660.40
97_T158_G1.1630.40
30_S363_Q1.1580.40
73_D258_E1.1470.39
90_G442_D1.1440.39
71_Q259_R1.1430.39
188_R331_K1.1380.39
333_L455_A1.1350.39
247_A253_A1.1340.39
315_Y327_P1.1290.38
276_F334_F1.1250.38
278_R406_G1.1230.38
203_C374_C1.1220.38
86_A194_A1.1200.38
203_C356_Q1.1180.38
402_R434_E1.1170.38
27_L216_F1.1160.38
179_D251_T1.1080.37
132_V375_L1.0980.37
131_I361_A1.0960.37
174_M177_G1.0950.37
185_D250_H1.0930.37
143_P212_Q1.0890.36
235_D358_I1.0860.36
262_Y266_K1.0850.36
387_I396_P1.0840.36
387_I394_K1.0760.36
110_R260_F1.0680.35
386_G401_N1.0470.34
126_T152_W1.0430.34
20_L236_V1.0430.34
65_G386_G1.0410.34
180_P305_A1.0410.34
253_A366_A1.0400.34
236_V388_I1.0400.34
259_R369_G1.0390.34
192_I195_A1.0260.33
219_P226_P1.0240.33
273_K307_T1.0230.33
24_V33_T1.0150.33
81_Y463_K1.0120.33
288_C358_I1.0110.33
148_D371_S1.0100.33
73_D331_K1.0100.33
129_L300_N1.0080.32
76_I205_E1.0030.32
178_L188_R1.0010.32
90_G205_E0.9950.32
327_P331_K0.9940.32
98_P382_A0.9940.32
62_R112_K0.9910.32
36_I81_Y0.9900.32
104_E130_E0.9850.31
185_D324_L0.9840.31
11_L14_R0.9830.31
64_L110_R0.9820.31
379_S403_L0.9820.31
72_R379_S0.9780.31
152_W334_F0.9770.31
183_P247_A0.9760.31
182_A186_E0.9740.31
277_L365_A0.9670.31
40_V102_V0.9650.30
170_K198_D0.9630.30
203_C208_L0.9600.30
342_V419_R0.9570.30
441_M444_D0.9570.30
181_L248_D0.9570.30
279_F370_I0.9560.30
160_L201_H0.9550.30
292_L334_F0.9540.30
209_H291_P0.9540.30
34_A74_F0.9510.30
388_I457_E0.9490.30
131_I269_K0.9490.30
91_D180_P0.9410.29
111_F433_F0.9410.29
398_L409_L0.9400.29
216_F337_T0.9320.29
276_F323_R0.9310.29
58_V397_A0.9270.29
110_R360_D0.9260.29
373_D457_E0.9240.29
42_Q315_Y0.9230.29
160_L302_M0.9220.28
309_L406_G0.9220.28
450_I461_G0.9190.28
320_L323_R0.9190.28
251_T259_R0.9170.28
138_W282_Q0.9150.28
122_K299_F0.9130.28
131_I277_L0.9110.28
151_S154_R0.9070.28
272_Y343_T0.9060.28
90_G94_A0.9050.28
260_F311_Q0.9040.28
140_L293_N0.9040.28
164_R167_W0.9010.28
33_T413_P0.9010.28
68_R425_F0.9000.28
45_N109_L0.8950.27
145_L413_P0.8920.27
146_A442_D0.8920.27
8_L73_D0.8920.27
107_L320_L0.8880.27
342_V349_N0.8870.27
174_M192_I0.8870.27
102_V274_N0.8870.27
157_T234_P0.8870.27
85_L89_Y0.8860.27
29_R352_S0.8840.27
26_G31_G0.8840.27
26_G32_K0.8840.27
72_R229_Q0.8810.27
378_A439_Q0.8810.27
347_H451_R0.8810.27
34_A226_P0.8790.27
75_G218_L0.8780.27
156_M160_L0.8740.26
344_I385_S0.8720.26
302_M368_E0.8710.26
331_K366_A0.8710.26
253_A257_R0.8680.26
405_D437_R0.8670.26
180_P283_I0.8670.26
60_E274_N0.8620.26
166_E424_A0.8600.26
278_R448_P0.8590.26
319_T377_L0.8590.26
208_L211_I0.8570.26
154_R236_V0.8560.26
88_L338_K0.8560.26
229_Q343_T0.8550.26
20_L119_R0.8550.26
421_P425_F0.8540.26
170_K440_V0.8530.26
273_K278_R0.8510.25
67_K331_K0.8500.25
286_V354_L0.8500.25
58_V117_L0.8480.25
151_S423_Q0.8480.25
146_A158_G0.8480.25
299_F397_A0.8460.25
177_G191_D0.8450.25
72_R267_V0.8440.25
347_H378_A0.8390.25
110_R126_T0.8380.25
173_M202_H0.8380.25
35_F455_A0.8370.25
188_R191_D0.8340.25
58_V110_R0.8330.25
40_V181_L0.8330.25
149_Y178_L0.8310.25
347_H461_G0.8250.24
362_W380_V0.8210.24
23_A231_F0.8180.24
119_R265_E0.8170.24
184_A255_M0.8150.24
346_Q414_G0.8150.24
302_M362_W0.8150.24
306_L329_I0.8140.24
98_P435_A0.8140.24
170_K422_G0.8140.24
346_Q399_R0.8130.24
383_T434_E0.8120.24
158_G404_S0.8110.24
256_L377_L0.8110.24
154_R158_G0.8100.24
149_Y183_P0.8090.24
134_Y138_W0.8070.24
91_D169_A0.8070.24
151_S237_D0.8060.24
34_A225_A0.8050.24
164_R208_L0.8040.24
143_P256_L0.8010.23
174_M178_L0.8000.23
309_L333_L0.8000.23
373_D458_F0.7970.23
151_S194_A0.7960.23
185_D188_R0.7950.23
68_R279_F0.7950.23
224_G350_M0.7940.23
73_D106_R0.7900.23
351_V386_G0.7890.23
30_S183_P0.7880.23
363_Q374_C0.7860.23
268_V328_V0.7810.23
87_Q94_A0.7780.23
86_A90_G0.7770.23
161_N176_E0.7740.22
57_A62_R0.7740.22
23_A436_F0.7710.22
226_P413_P0.7700.22
357_L390_V0.7690.22
237_D331_K0.7690.22
209_H217_V0.7650.22
225_A344_I0.7620.22
307_T375_L0.7610.22
70_P334_F0.7530.22
278_R291_P0.7530.22
323_R327_P0.7510.22
177_G188_R0.7510.22
170_K173_M0.7510.22
68_R229_Q0.7500.22
117_L120_H0.7500.22
333_L458_F0.7490.21
190_A194_A0.7490.21
271_F451_R0.7480.21
29_R383_T0.7480.21
268_V324_L0.7440.21
23_A426_W0.7430.21
91_D181_L0.7410.21
172_R176_E0.7400.21
19_H57_A0.7400.21
30_S101_G0.7390.21
76_I102_V0.7390.21
331_K452_L0.7370.21
268_V451_R0.7340.21
102_V209_H0.7330.21
305_A354_L0.7330.21
119_R376_G0.7330.21
346_Q426_W0.7320.21
313_F335_A0.7310.21
147_Q222_M0.7310.21
236_V457_E0.7300.21
101_G117_L0.7300.21
372_M381_Q0.7290.21
101_G354_L0.7280.21
260_F407_A0.7270.21
436_F455_A0.7270.21
171_W217_V0.7260.21
311_Q330_D0.7250.21
20_L127_L0.7240.21
91_D94_A0.7240.21
354_L382_A0.7230.21
208_L374_C0.7230.21
187_N191_D0.7220.20
42_Q446_P0.7180.20
80_T102_V0.7180.20
343_T414_G0.7170.20
151_S183_P0.7170.20
84_G272_Y0.7160.20
22_L116_S0.7160.20
159_L171_W0.7160.20
93_P212_Q0.7150.20
354_L407_A0.7150.20
260_F269_K0.7140.20
21_R27_L0.7130.20
201_H217_V0.7100.20
14_R30_S0.7100.20
8_L321_F0.7070.20
357_L460_I0.7050.20
75_G129_L0.7050.20
109_L195_A0.7040.20
331_K371_S0.7040.20
224_G339_A0.7030.20
291_P380_V0.7020.20
176_E394_K0.7020.20
307_T360_D0.6980.20
111_F127_L0.6980.20
197_T217_V0.6970.20
227_A264_C0.6960.20
268_V275_H0.6950.20
16_V283_I0.6930.19
21_R104_E0.6920.19
71_Q267_V0.6900.19
144_M222_M0.6890.19
65_G421_P0.6870.19
68_R416_V0.6860.19
221_D376_G0.6860.19
71_Q186_E0.6840.19
30_S66_V0.6830.19
61_E261_N0.6830.19
144_M227_A0.6810.19
208_L290_Q0.6800.19
85_L198_D0.6790.19
169_A202_H0.6770.19
147_Q371_S0.6730.19
149_Y176_E0.6710.19
203_C358_I0.6710.19
35_F219_P0.6690.19
76_I121_F0.6680.19
154_R432_Q0.6680.19
101_G210_F0.6680.19
189_L229_Q0.6670.19
169_A173_M0.6670.19
120_H204_K0.6640.19
117_L334_F0.6630.18
132_V275_H0.6620.18
273_K328_V0.6620.18
371_S379_S0.6600.18
355_Q362_W0.6590.18
190_A391_N0.6590.18
20_L389_D0.6580.18
196_W261_N0.6580.18
235_D305_A0.6570.18
78_R298_A0.6560.18
85_L194_A0.6550.18
317_Q463_K0.6550.18
91_D183_P0.6540.18
347_H455_A0.6530.18
149_Y187_N0.6500.18
102_V227_A0.6500.18
116_S126_T0.6470.18
400_G438_P0.6440.18
148_D176_E0.6430.18
94_A391_N0.6420.18
219_P413_P0.6410.18
233_W328_V0.6410.18
30_S120_H0.6400.18
54_L329_I0.6390.18
303_R346_Q0.6370.18
413_P436_F0.6360.18
294_S437_R0.6350.18
177_G463_K0.6340.18
121_F404_S0.6340.18
171_W204_K0.6330.18
162_G199_Y0.6330.18
227_A266_K0.6330.18
352_S370_I0.6330.18
217_V368_E0.6330.18
82_D342_V0.6320.17
218_L426_W0.6310.17
111_F293_N0.6300.17
169_A393_E0.6280.17
19_H266_K0.6270.17
172_R190_A0.6260.17
396_P403_L0.6200.17
22_L234_P0.6190.17
379_S457_E0.6190.17
102_V217_V0.6180.17
174_M388_I0.6180.17
320_L325_F0.6170.17
61_E77_P0.6140.17
229_Q370_I0.6130.17
151_S188_R0.6130.17
41_N412_Y0.6120.17
320_L331_K0.6120.17
9_N372_M0.6120.17
66_V337_T0.6120.17
119_R125_S0.6110.17
377_L432_Q0.6110.17
132_V333_L0.6110.17
356_Q360_D0.6100.17
30_S211_I0.6090.17
346_Q412_Y0.6090.17
29_R270_G0.6090.17
150_L205_E0.6080.17
317_Q332_L0.6080.17
93_P426_W0.6070.17
41_N312_S0.6070.17
273_K461_G0.6060.17
97_T460_I0.6050.17
64_L247_A0.6040.17
18_R343_T0.6040.17
277_L301_D0.6020.17
162_G297_Q0.6010.17
155_Q382_A0.6000.17
94_A191_D0.5990.16
113_S121_F0.5980.16
85_L176_E0.5970.16
33_T414_G0.5970.16
129_L245_A0.5960.16
109_L258_E0.5950.16
139_L271_F0.5950.16
78_R186_E0.5940.16
424_A463_K0.5940.16
248_D429_Q0.5930.16
194_A440_V0.5930.16
71_Q76_I0.5920.16
63_L441_M0.5920.16
76_I176_E0.5910.16
176_E206_Q0.5910.16
34_A256_L0.5900.16
174_M194_A0.5880.16
182_A185_D0.5880.16
44_L66_V0.5870.16
44_L308_Q0.5870.16
176_E424_A0.5870.16
20_L36_I0.5870.16
28_S209_H0.5840.16
349_N415_E0.5840.16
160_L199_Y0.5830.16
255_M396_P0.5810.16
107_L309_L0.5810.16
247_A407_A0.5780.16
234_P331_K0.5780.16
174_M191_D0.5780.16
357_L392_G0.5750.16
171_W201_H0.5750.16
101_G223_A0.5730.16
64_L112_K0.5730.16
171_W411_V0.5720.16
166_E194_A0.5710.16
23_A69_I0.5710.16
355_Q374_C0.5710.16
185_D419_R0.5700.16
207_G414_G0.5700.16
168_S350_M0.5700.16
23_A256_L0.5700.16
134_Y282_Q0.5670.16
182_A194_A0.5670.16
116_S442_D0.5660.16
90_G174_M0.5660.16
22_L105_I0.5660.16
412_Y415_E0.5630.15
29_R414_G0.5630.15
217_V291_P0.5630.15
91_D440_V0.5620.15
72_R270_G0.5620.15
191_D194_A0.5600.15
11_L354_L0.5600.15
402_R412_Y0.5590.15
55_L361_A0.5590.15
222_M321_F0.5570.15
183_P248_D0.5570.15
91_D422_G0.5560.15
140_L414_G0.5550.15
292_L327_P0.5550.15
105_I171_W0.5550.15
42_Q312_S0.5550.15
111_F318_R0.5530.15
283_I391_N0.5530.15
114_N148_D0.5530.15
199_Y382_A0.5510.15
38_A367_F0.5500.15
68_R370_I0.5500.15
144_M199_Y0.5490.15
256_L306_L0.5480.15
283_I339_A0.5480.15
78_R378_A0.5480.15
73_D78_R0.5460.15
218_L323_R0.5460.15
196_W266_K0.5450.15
178_L236_V0.5450.15
451_R461_G0.5440.15
201_H388_I0.5440.15
209_H294_S0.5440.15
294_S443_V0.5430.15
41_N446_P0.5430.15
183_P253_A0.5430.15
176_E248_D0.5430.15
116_S457_E0.5430.15
117_L121_F0.5420.15
231_F359_Q0.5420.15
169_A246_Q0.5410.15
300_N303_R0.5410.15
147_Q151_S0.5410.15
37_T379_S0.5400.15
61_E459_L0.5400.15
16_V195_A0.5390.15
33_T400_G0.5390.15
127_L396_P0.5390.15
28_S112_K0.5380.15
379_S411_V0.5370.15
17_D325_F0.5350.15
71_Q104_E0.5350.15
359_Q363_Q0.5340.15
60_E190_A0.5330.15
85_L119_R0.5310.15
36_I332_L0.5310.15
14_R143_P0.5310.15
65_G377_L0.5300.15
375_L455_A0.5280.14
112_K324_L0.5270.14
77_P164_R0.5270.14
178_L189_L0.5260.14
40_V382_A0.5250.14
17_D93_P0.5240.14
376_G445_K0.5240.14
129_L171_W0.5230.14
186_E341_H0.5220.14
283_I450_I0.5220.14
400_G449_H0.5220.14
264_C339_A0.5210.14
12_V367_F0.5200.14
101_G332_L0.5190.14
144_M257_R0.5180.14
55_L196_W0.5170.14
375_L396_P0.5160.14
190_A386_G0.5160.14
117_L274_N0.5160.14
187_N190_A0.5150.14
129_L204_K0.5150.14
88_L149_Y0.5150.14
153_S233_W0.5140.14
156_M253_A0.5140.14
317_Q361_A0.5140.14
451_R459_L0.5130.14
347_H450_I0.5130.14
212_Q416_V0.5120.14
169_A266_K0.5110.14
212_Q231_F0.5110.14
14_R52_L0.5100.14
215_R263_Y0.5090.14
294_S447_L0.5080.14
295_G450_I0.5080.14
407_A418_A0.5060.14
62_R461_G0.5050.14
343_T398_L0.5050.14
55_L380_V0.5050.14
77_P455_A0.5040.14
57_A411_V0.5030.14
265_E378_A0.5010.14
20_L247_A0.5010.14
21_R171_W0.5010.14
143_P156_M0.5000.14
131_I314_H0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ileA 1 0.3785 97.8 0.954 Contact Map
1zd9A 1 0.357 97.8 0.954 Contact Map
1g16A 3 0.3462 97.8 0.954 Contact Map
1zj6A 2 0.372 97.8 0.954 Contact Map
3l0iB 1 0.3742 97.8 0.954 Contact Map
1z2aA 1 0.3527 97.8 0.954 Contact Map
2gedA 2 0.3161 97.8 0.954 Contact Map
2x77A 2 0.3892 97.7 0.955 Contact Map
1kshA 1 0.3548 97.7 0.955 Contact Map
3r7wA 1 0.4667 97.7 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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