YCJQ - ECOLI - GREMLIN Contacts

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YCJQ - Uncharacterized zinc-type alcohol dehydrogenase-like protein YcjQ

UniProt:	P76043	Sequences: MKKLVATAPRVAALVEYEDRAILANEVKIRVRFGAPKHGTEVVDFRAASPFIDEDFNGEWQMFTPRPADAPRGIEFGKFQLGNMVVGDIIECGSDVTDYAVGDSVCGYGPLSETVIINAVNNYKLRKMPQGSSWKNAVCYDPAQFAMSGVRDANVRVGDFVVVVGLGAIGQIAIQLAKRAGASVVIGVDPIAHRCDIARRHGADFCLNPIGTDVGKEIKTLTGKQGADVIIETSGYADALQSALRGLAYGGTISYVAFAKPFAEGFNLGREAHFNNAKIVFSRACSEPNPDYPRWSRKRIEETCWELLMNGYLNCEDLIDPVVTFANSPESYMQYVDQHPEQSIKMGVTF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13914
Length:	350 (300)
Sequences:	52389 (36303)
Seq/√Len:	2095.9

ECOLI - YCJQ YBDR YGGP YDJL RSPB GATD YDJJ YPHC YJJN FRMA ADHP QOR1 TDH AHR YAHK IDND ACUI CURA
BACSU - BDHA YJMD DHSO ADHB YOGA TDH ADHA YYCR YFMJ YHFP
HALSA - Q9HQS8 Q9HMB6 Q9HP38 Q9HR85 GLCDH
SULSO - Q97YT7 Q97ZV3 ADH Q97VV5 Q7LXK1 Q97XR4 Q97VW0 Q97WA1 Q97V32 Q97TZ4 GLCD2 GLCD1 GLCD3 Q97YM2 Q97VB8 Q97W06 Q97UW5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
32_R	134_W	3.011	1.00
327_N	330_E	2.915	1.00
30_R	90_I	2.911	1.00
32_R	88_D	2.836	1.00
7_T	15_V	2.712	1.00
28_K	90_I	2.677	1.00
27_V	125_L	2.504	1.00
133_S	136_N	2.453	1.00
104_S	128_M	2.438	1.00
178_K	204_D	2.410	1.00
100_A	103_D	2.388	1.00
103_D	127_K	2.382	1.00
30_R	88_D	2.279	1.00
19_D	114_T	2.272	1.00
7_T	13_A	2.247	1.00
217_E	220_T	2.238	1.00
160_F	183_S	2.221	1.00
30_R	114_T	2.198	1.00
135_K	322_V	2.180	1.00
161_V	177_A	2.153	1.00
166_L	187_G	2.132	1.00
195_C	199_R	2.102	1.00
5_V	15_V	2.073	1.00
23_L	26_E	2.066	1.00
85_V	110_P	2.063	1.00
156_R	159_D	2.051	1.00
24_A	94_S	2.022	1.00
98_D	119_A	1.999	1.00
306_E	310_N	1.998	1.00
174_I	203_A	1.969	1.00
131_G	309_M	1.969	1.00
24_A	95_D	1.968	1.00
85_V	107_G	1.953	1.00
324_T	327_N	1.933	1.00
196_D	200_R	1.913	1.00
86_V	134_W	1.908	1.00
104_S	134_W	1.890	1.00
143_A	172_I	1.887	1.00
28_K	116_I	1.884	1.00
25_N	95_D	1.861	1.00
90_I	114_T	1.848	1.00
179_R	312_Y	1.769	1.00
195_C	206_C	1.736	1.00
162_V	188_V	1.729	1.00
21_A	91_E	1.726	1.00
162_V	227_A	1.724	1.00
333_M	338_Q	1.722	1.00
228_D	248_A	1.716	1.00
196_D	199_R	1.697	1.00
330_E	333_M	1.691	1.00
252_T	278_K	1.691	1.00
186_I	227_A	1.689	1.00
46_R	337_D	1.685	1.00
323_V	331_S	1.674	1.00
128_M	134_W	1.656	1.00
189_D	195_C	1.639	1.00
197_I	200_R	1.634	1.00
192_A	196_D	1.629	1.00
159_D	252_T	1.606	1.00
164_V	243_A	1.597	1.00
252_T	280_V	1.585	1.00
4_L	328_S	1.571	1.00
205_F	221_L	1.565	1.00
128_M	137_A	1.556	1.00
93_G	96_V	1.553	1.00
192_A	208_N	1.533	1.00
28_K	114_T	1.532	1.00
247_L	277_A	1.520	1.00
92_C	101_V	1.519	1.00
153_A	229_V	1.516	1.00
111_L	332_Y	1.515	1.00
247_L	253_I	1.509	1.00
338_Q	341_E	1.505	1.00
192_A	211_G	1.504	1.00
118_N	123_Y	1.488	1.00
88_D	104_S	1.484	1.00
212_T	217_E	1.479	1.00
22_I	116_I	1.474	1.00
91_E	101_V	1.473	1.00
99_Y	127_K	1.473	1.00
208_N	211_G	1.463	1.00
136_N	316_E	1.463	1.00
31_V	85_V	1.460	1.00
26_E	118_N	1.450	1.00
247_L	251_G	1.441	1.00
183_S	205_F	1.438	1.00
25_N	118_N	1.429	1.00
99_Y	103_D	1.428	1.00
213_D	216_K	1.415	1.00
230_I	247_L	1.413	1.00
329_P	333_M	1.406	1.00
22_I	28_K	1.386	1.00
28_K	91_E	1.382	1.00
45_F	332_Y	1.381	1.00
230_I	243_A	1.378	1.00
26_E	116_I	1.374	1.00
33_F	135_K	1.362	1.00
104_S	130_Q	1.352	1.00
183_S	204_D	1.305	1.00
174_I	187_G	1.291	1.00
27_V	99_Y	1.290	1.00
89_I	99_Y	1.289	1.00
179_R	307_L	1.282	1.00
160_F	186_I	1.281	1.00
306_E	309_M	1.280	1.00
173_A	231_I	1.277	1.00
190_P	209_P	1.272	1.00
88_D	134_W	1.264	1.00
3_K	17_Y	1.261	1.00
8_A	11_V	1.259	1.00
216_K	220_T	1.244	1.00
164_V	188_V	1.237	1.00
4_L	14_L	1.234	1.00
151_R	300_I	1.219	1.00
190_P	195_C	1.193	1.00
19_D	28_K	1.187	1.00
32_R	104_S	1.185	1.00
99_Y	125_L	1.177	1.00
192_A	195_C	1.176	1.00
195_C	208_N	1.169	1.00
151_R	303_T	1.167	1.00
200_R	317_D	1.157	1.00
31_V	115_V	1.144	1.00
217_E	221_L	1.140	1.00
160_F	228_D	1.139	1.00
199_R	206_C	1.136	1.00
25_N	119_A	1.135	1.00
155_V	182_A	1.120	1.00
298_K	302_E	1.117	1.00
140_Y	308_L	1.111	1.00
245_R	271_E	1.090	1.00
148_S	300_I	1.080	1.00
159_D	228_D	1.075	1.00
303_T	306_E	1.075	1.00
333_M	337_D	1.074	1.00
22_I	26_E	1.069	1.00
307_L	312_Y	1.057	1.00
117_I	125_L	1.054	1.00
36_P	331_S	1.053	1.00
29_I	87_G	1.052	1.00
215_G	245_R	1.047	1.00
213_D	217_E	1.045	1.00
197_I	343_S	1.045	1.00
4_L	325_F	1.038	1.00
14_L	326_A	1.037	1.00
153_A	254_S	1.036	1.00
199_R	205_F	1.032	1.00
90_I	101_V	1.032	1.00
146_A	173_A	1.024	1.00
152_D	278_K	1.022	1.00
33_F	134_W	1.021	1.00
234_S	239_A	1.020	1.00
45_F	337_D	1.010	1.00
34_G	111_L	1.003	1.00
146_A	176_L	0.996	1.00
38_H	84_M	0.994	1.00
175_Q	314_N	0.992	1.00
5_V	17_Y	0.991	1.00
314_N	317_D	0.989	1.00
166_L	189_D	0.988	1.00
155_V	159_D	0.987	1.00
187_G	203_A	0.987	1.00
328_S	348_V	0.986	1.00
302_E	306_E	0.978	1.00
7_T	11_V	0.975	1.00
29_I	105_V	0.974	1.00
211_G	217_E	0.957	1.00
177_A	182_A	0.955	1.00
242_S	245_R	0.950	1.00
215_G	242_S	0.947	1.00
186_I	205_F	0.946	1.00
32_R	86_V	0.944	1.00
149_G	256_V	0.938	1.00
147_M	303_T	0.937	1.00
111_L	328_S	0.937	1.00
96_V	119_A	0.927	1.00
34_G	110_P	0.926	1.00
232_E	235_G	0.923	1.00
174_I	185_V	0.920	1.00
143_A	304_C	0.915	1.00
241_Q	245_R	0.913	1.00
218_I	227_A	0.912	1.00
191_I	194_R	0.909	1.00
166_L	198_A	0.909	1.00
19_D	91_E	0.905	1.00
5_V	80_Q	0.895	1.00
132_S	137_A	0.893	1.00
215_G	219_K	0.892	1.00
38_H	83_N	0.892	1.00
222_T	226_G	0.890	1.00
190_P	210_I	0.885	1.00
188_V	209_P	0.884	1.00
272_A	279_I	0.882	1.00
163_V	173_A	0.881	1.00
162_V	246_G	0.879	1.00
187_G	198_A	0.875	1.00
33_F	347_G	0.873	1.00
149_G	231_I	0.870	1.00
323_V	327_N	0.869	1.00
3_K	80_Q	0.868	1.00
171_Q	197_I	0.866	1.00
152_D	280_V	0.866	1.00
30_R	113_E	0.864	1.00
85_V	115_V	0.863	1.00
159_D	229_V	0.863	1.00
164_V	230_I	0.863	1.00
163_V	177_A	0.862	1.00
303_T	307_L	0.858	1.00
186_I	207_L	0.858	1.00
166_L	174_I	0.856	1.00
92_C	96_V	0.850	1.00
97_T	119_A	0.848	1.00
106_C	305_W	0.848	1.00
272_A	281_F	0.847	1.00
19_D	90_I	0.845	1.00
111_L	348_V	0.844	1.00
144_Q	300_I	0.843	1.00
4_L	12_A	0.841	1.00
250_G	276_N	0.838	1.00
176_L	304_C	0.834	1.00
35_A	84_M	0.831	1.00
194_R	343_S	0.831	1.00
193_H	196_D	0.825	1.00
160_F	227_A	0.819	1.00
100_A	127_K	0.816	1.00
21_A	28_K	0.814	1.00
9_P	77_G	0.812	1.00
271_E	275_N	0.811	1.00
189_D	206_C	0.810	1.00
92_C	100_A	0.809	1.00
23_L	116_I	0.807	1.00
4_L	329_P	0.798	1.00
238_D	242_S	0.790	1.00
191_I	208_N	0.790	1.00
176_L	307_L	0.787	1.00
299_R	303_T	0.787	1.00
130_Q	309_M	0.785	1.00
222_T	225_Q	0.783	1.00
198_A	203_A	0.782	1.00
299_R	302_E	0.777	1.00
150_V	177_A	0.777	1.00
38_H	41_E	0.773	1.00
149_G	173_A	0.770	1.00
161_V	182_A	0.770	1.00
146_A	172_I	0.768	1.00
214_V	242_S	0.767	1.00
323_V	346_M	0.766	1.00
190_P	198_A	0.764	1.00
216_K	219_K	0.764	1.00
230_I	253_I	0.764	1.00
25_N	93_G	0.758	1.00
255_Y	279_I	0.758	1.00
40_T	83_N	0.758	1.00
154_N	252_T	0.758	1.00
164_V	239_A	0.755	1.00
27_V	119_A	0.752	1.00
139_C	142_P	0.752	1.00
307_L	310_N	0.752	1.00
233_T	256_V	0.751	1.00
129_P	309_M	0.748	1.00
213_D	242_S	0.748	1.00
215_G	246_G	0.747	1.00
155_V	229_V	0.745	1.00
243_A	253_I	0.743	1.00
110_P	115_V	0.741	1.00
126_R	302_E	0.737	1.00
186_I	218_I	0.735	1.00
146_A	169_I	0.735	1.00
107_G	117_I	0.733	1.00
177_A	185_V	0.732	1.00
42_V	336_V	0.730	1.00
14_L	325_F	0.728	1.00
132_S	308_L	0.727	1.00
186_I	221_L	0.726	1.00
337_D	340_P	0.726	1.00
183_S	186_I	0.725	1.00
200_R	314_N	0.725	1.00
17_Y	80_Q	0.724	1.00
336_V	346_M	0.719	1.00
22_I	91_E	0.717	1.00
307_L	311_G	0.716	1.00
148_S	276_N	0.714	1.00
154_N	278_K	0.713	1.00
319_I	322_V	0.712	1.00
321_P	330_E	0.710	1.00
182_A	229_V	0.709	1.00
180_A	303_T	0.706	1.00
185_V	204_D	0.706	1.00
106_C	128_M	0.705	1.00
126_R	301_E	0.704	1.00
10_R	45_F	0.701	1.00
262_F	265_G	0.700	1.00
86_V	138_V	0.700	1.00
119_A	123_Y	0.699	1.00
272_A	277_A	0.697	1.00
25_N	94_S	0.694	1.00
200_R	316_E	0.693	1.00
321_P	346_M	0.691	1.00
105_V	125_L	0.690	1.00
323_V	348_V	0.689	1.00
33_F	322_V	0.683	1.00
160_F	225_Q	0.680	1.00
249_Y	275_N	0.678	1.00
147_M	307_L	0.676	1.00
154_N	280_V	0.672	1.00
197_I	201_H	0.669	1.00
223_G	226_G	0.668	1.00
98_D	298_K	0.668	1.00
86_V	128_M	0.667	1.00
240_L	253_I	0.666	1.00
163_V	187_G	0.665	1.00
136_N	314_N	0.664	1.00
147_M	304_C	0.664	1.00
227_A	230_I	0.662	1.00
20_R	116_I	0.661	1.00
83_N	142_P	0.660	1.00
27_V	89_I	0.657	1.00
146_A	150_V	0.657	1.00
229_V	254_S	0.657	1.00
22_I	93_G	0.654	1.00
176_L	180_A	0.651	1.00
36_P	111_L	0.650	1.00
232_E	253_I	0.649	1.00
126_R	305_W	0.649	1.00
305_W	309_M	0.645	1.00
342_Q	346_M	0.642	1.00
36_P	336_V	0.642	1.00
38_H	142_P	0.642	1.00
147_M	300_I	0.639	1.00
262_F	267_N	0.637	1.00
103_D	130_Q	0.635	1.00
25_N	123_Y	0.635	1.00
151_R	180_A	0.634	1.00
225_Q	248_A	0.634	1.00
33_F	86_V	0.632	1.00
218_I	246_G	0.632	1.00
39_G	43_V	0.631	1.00
173_A	256_V	0.630	1.00
153_A	252_T	0.630	1.00
338_Q	342_Q	0.629	1.00
189_D	208_N	0.627	1.00
31_V	34_G	0.626	1.00
40_T	44_D	0.626	1.00
133_S	137_A	0.625	1.00
229_V	252_T	0.621	1.00
205_F	217_E	0.617	1.00
145_F	169_I	0.617	1.00
182_A	185_V	0.616	1.00
174_I	201_H	0.615	1.00
276_N	286_S	0.615	1.00
86_V	104_S	0.613	1.00
227_A	246_G	0.613	1.00
175_Q	201_H	0.613	1.00
158_G	183_S	0.611	1.00
189_D	198_A	0.608	1.00
267_N	271_E	0.608	1.00
43_V	48_A	0.607	1.00
189_D	209_P	0.604	1.00
219_K	222_T	0.604	1.00
241_Q	265_G	0.602	1.00
236_Y	239_A	0.600	1.00
75_E	79_F	0.600	1.00
98_D	101_V	0.598	1.00
178_K	185_V	0.596	1.00
141_D	145_F	0.595	1.00
29_I	107_G	0.593	1.00
140_Y	304_C	0.591	1.00
38_H	345_K	0.590	1.00
145_F	256_V	0.588	1.00
98_D	127_K	0.588	1.00
104_S	131_G	0.588	1.00
34_G	348_V	0.587	1.00
20_R	114_T	0.585	1.00
239_A	243_A	0.584	1.00
188_V	207_L	0.583	1.00
323_V	330_E	0.582	1.00
241_Q	271_E	0.582	1.00
195_C	198_A	0.579	1.00
230_I	246_G	0.578	1.00
107_G	125_L	0.576	1.00
162_V	230_I	0.576	1.00
126_R	298_K	0.571	1.00
161_V	229_V	0.571	1.00
198_A	206_C	0.570	1.00
76_F	79_F	0.568	1.00
39_G	167_G	0.568	1.00
97_T	100_A	0.565	1.00
8_A	13_A	0.564	1.00
92_C	103_D	0.564	1.00
254_S	282_S	0.564	1.00
160_F	222_T	0.563	1.00
134_W	137_A	0.562	1.00
40_T	43_V	0.560	1.00
44_D	49_S	0.560	1.00
106_C	141_D	0.560	1.00
238_D	241_Q	0.559	1.00
214_V	218_I	0.559	1.00
12_A	332_Y	0.557	1.00
19_D	116_I	0.553	1.00
219_K	226_G	0.553	1.00
157_V	180_A	0.552	1.00
151_R	299_R	0.551	1.00
321_P	343_S	0.548	1.00
29_I	125_L	0.545	1.00
195_C	209_P	0.545	1.00
271_E	277_A	0.543	1.00
150_V	176_L	0.543	1.00
9_P	47_A	0.542	1.00
82_G	111_L	0.542	1.00
174_I	198_A	0.541	1.00
42_V	46_R	0.541	1.00
20_R	26_E	0.540	1.00
207_L	221_L	0.538	1.00
207_L	217_E	0.537	1.00
282_S	285_C	0.535	1.00
172_I	176_L	0.535	1.00
142_P	145_F	0.534	1.00
18_E	21_A	0.533	1.00
118_N	124_K	0.532	1.00
99_Y	119_A	0.531	1.00
320_D	344_I	0.530	1.00
271_E	274_F	0.528	1.00
31_V	107_G	0.527	1.00
149_G	282_S	0.526	1.00
189_D	194_R	0.525	1.00
164_V	214_V	0.524	1.00
19_D	22_I	0.523	1.00
20_R	28_K	0.523	1.00
119_A	125_L	0.521	1.00
147_M	180_A	0.519	1.00
166_L	170_G	0.519	1.00
86_V	137_A	0.518	1.00
241_Q	267_N	0.518	1.00
35_A	138_V	0.517	1.00
22_I	95_D	0.517	1.00
84_M	345_K	0.516	1.00
321_P	327_N	0.515	1.00
42_V	337_D	0.514	1.00
172_I	313_L	0.514	1.00
171_Q	201_H	0.512	1.00
80_Q	109_G	0.510	1.00
157_V	181_G	0.510	1.00
220_T	223_G	0.509	1.00
172_I	175_Q	0.509	1.00
133_S	322_V	0.507	1.00
14_L	328_S	0.506	1.00
148_S	152_D	0.505	1.00
165_G	233_T	0.505	1.00
178_K	203_A	0.504	1.00
222_T	227_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1f8fA	4	0.88	100	0.199	Contact Map
4ej6A	1	0.8714	100	0.2	Contact Map
3ukoA	4	0.8829	100	0.201	Contact Map
1cdoA	2	0.8829	100	0.202	Contact Map
4ilkA	2	0.8686	100	0.203	Contact Map
2dq4A	4	0.8829	100	0.205	Contact Map
1e3iA	2	0.8771	100	0.206	Contact Map
3fpcA	4	0.8914	100	0.208	Contact Map
2jhfA	2	0.8829	100	0.208	Contact Map
3uogA	4	0.8714	100	0.21	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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