GREMLIN Database
YCJQ - Uncharacterized zinc-type alcohol dehydrogenase-like protein YcjQ
UniProt: P76043 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13914
Length: 350 (300)
Sequences: 52389 (36303)
Seq/√Len: 2095.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_R134_W3.0111.00
327_N330_E2.9151.00
30_R90_I2.9111.00
32_R88_D2.8361.00
7_T15_V2.7121.00
28_K90_I2.6771.00
27_V125_L2.5041.00
133_S136_N2.4531.00
104_S128_M2.4381.00
178_K204_D2.4101.00
100_A103_D2.3881.00
103_D127_K2.3821.00
30_R88_D2.2791.00
19_D114_T2.2721.00
7_T13_A2.2471.00
217_E220_T2.2381.00
160_F183_S2.2211.00
30_R114_T2.1981.00
135_K322_V2.1801.00
161_V177_A2.1531.00
166_L187_G2.1321.00
195_C199_R2.1021.00
5_V15_V2.0731.00
23_L26_E2.0661.00
85_V110_P2.0631.00
156_R159_D2.0511.00
24_A94_S2.0221.00
98_D119_A1.9991.00
306_E310_N1.9981.00
174_I203_A1.9691.00
131_G309_M1.9691.00
24_A95_D1.9681.00
85_V107_G1.9531.00
324_T327_N1.9331.00
196_D200_R1.9131.00
86_V134_W1.9081.00
104_S134_W1.8901.00
143_A172_I1.8871.00
28_K116_I1.8841.00
25_N95_D1.8611.00
90_I114_T1.8481.00
179_R312_Y1.7691.00
195_C206_C1.7361.00
162_V188_V1.7291.00
21_A91_E1.7261.00
162_V227_A1.7241.00
333_M338_Q1.7221.00
228_D248_A1.7161.00
196_D199_R1.6971.00
330_E333_M1.6911.00
252_T278_K1.6911.00
186_I227_A1.6891.00
46_R337_D1.6851.00
323_V331_S1.6741.00
128_M134_W1.6561.00
189_D195_C1.6391.00
197_I200_R1.6341.00
192_A196_D1.6291.00
159_D252_T1.6061.00
164_V243_A1.5971.00
252_T280_V1.5851.00
4_L328_S1.5711.00
205_F221_L1.5651.00
128_M137_A1.5561.00
93_G96_V1.5531.00
192_A208_N1.5331.00
28_K114_T1.5321.00
247_L277_A1.5201.00
92_C101_V1.5191.00
153_A229_V1.5161.00
111_L332_Y1.5151.00
247_L253_I1.5091.00
338_Q341_E1.5051.00
192_A211_G1.5041.00
118_N123_Y1.4881.00
88_D104_S1.4841.00
212_T217_E1.4791.00
22_I116_I1.4741.00
91_E101_V1.4731.00
99_Y127_K1.4731.00
208_N211_G1.4631.00
136_N316_E1.4631.00
31_V85_V1.4601.00
26_E118_N1.4501.00
247_L251_G1.4411.00
183_S205_F1.4381.00
25_N118_N1.4291.00
99_Y103_D1.4281.00
213_D216_K1.4151.00
230_I247_L1.4131.00
329_P333_M1.4061.00
22_I28_K1.3861.00
28_K91_E1.3821.00
45_F332_Y1.3811.00
230_I243_A1.3781.00
26_E116_I1.3741.00
33_F135_K1.3621.00
104_S130_Q1.3521.00
183_S204_D1.3051.00
174_I187_G1.2911.00
27_V99_Y1.2901.00
89_I99_Y1.2891.00
179_R307_L1.2821.00
160_F186_I1.2811.00
306_E309_M1.2801.00
173_A231_I1.2771.00
190_P209_P1.2721.00
88_D134_W1.2641.00
3_K17_Y1.2611.00
8_A11_V1.2591.00
216_K220_T1.2441.00
164_V188_V1.2371.00
4_L14_L1.2341.00
151_R300_I1.2191.00
190_P195_C1.1931.00
19_D28_K1.1871.00
32_R104_S1.1851.00
99_Y125_L1.1771.00
192_A195_C1.1761.00
195_C208_N1.1691.00
151_R303_T1.1671.00
200_R317_D1.1571.00
31_V115_V1.1441.00
217_E221_L1.1401.00
160_F228_D1.1391.00
199_R206_C1.1361.00
25_N119_A1.1351.00
155_V182_A1.1201.00
298_K302_E1.1171.00
140_Y308_L1.1111.00
245_R271_E1.0901.00
148_S300_I1.0801.00
159_D228_D1.0751.00
303_T306_E1.0751.00
333_M337_D1.0741.00
22_I26_E1.0691.00
307_L312_Y1.0571.00
117_I125_L1.0541.00
36_P331_S1.0531.00
29_I87_G1.0521.00
215_G245_R1.0471.00
213_D217_E1.0451.00
197_I343_S1.0451.00
4_L325_F1.0381.00
14_L326_A1.0371.00
153_A254_S1.0361.00
199_R205_F1.0321.00
90_I101_V1.0321.00
146_A173_A1.0241.00
152_D278_K1.0221.00
33_F134_W1.0211.00
234_S239_A1.0201.00
45_F337_D1.0101.00
34_G111_L1.0031.00
146_A176_L0.9961.00
38_H84_M0.9941.00
175_Q314_N0.9921.00
5_V17_Y0.9911.00
314_N317_D0.9891.00
166_L189_D0.9881.00
155_V159_D0.9871.00
187_G203_A0.9871.00
328_S348_V0.9861.00
302_E306_E0.9781.00
7_T11_V0.9751.00
29_I105_V0.9741.00
211_G217_E0.9571.00
177_A182_A0.9551.00
242_S245_R0.9501.00
215_G242_S0.9471.00
186_I205_F0.9461.00
32_R86_V0.9441.00
149_G256_V0.9381.00
147_M303_T0.9371.00
111_L328_S0.9371.00
96_V119_A0.9271.00
34_G110_P0.9261.00
232_E235_G0.9231.00
174_I185_V0.9201.00
143_A304_C0.9151.00
241_Q245_R0.9131.00
218_I227_A0.9121.00
191_I194_R0.9091.00
166_L198_A0.9091.00
19_D91_E0.9051.00
5_V80_Q0.8951.00
132_S137_A0.8931.00
215_G219_K0.8921.00
38_H83_N0.8921.00
222_T226_G0.8901.00
190_P210_I0.8851.00
188_V209_P0.8841.00
272_A279_I0.8821.00
163_V173_A0.8811.00
162_V246_G0.8791.00
187_G198_A0.8751.00
33_F347_G0.8731.00
149_G231_I0.8701.00
323_V327_N0.8691.00
3_K80_Q0.8681.00
171_Q197_I0.8661.00
152_D280_V0.8661.00
30_R113_E0.8641.00
85_V115_V0.8631.00
159_D229_V0.8631.00
164_V230_I0.8631.00
163_V177_A0.8621.00
303_T307_L0.8581.00
186_I207_L0.8581.00
166_L174_I0.8561.00
92_C96_V0.8501.00
97_T119_A0.8481.00
106_C305_W0.8481.00
272_A281_F0.8471.00
19_D90_I0.8451.00
111_L348_V0.8441.00
144_Q300_I0.8431.00
4_L12_A0.8411.00
250_G276_N0.8381.00
176_L304_C0.8341.00
35_A84_M0.8311.00
194_R343_S0.8311.00
193_H196_D0.8251.00
160_F227_A0.8191.00
100_A127_K0.8161.00
21_A28_K0.8141.00
9_P77_G0.8121.00
271_E275_N0.8111.00
189_D206_C0.8101.00
92_C100_A0.8091.00
23_L116_I0.8071.00
4_L329_P0.7981.00
238_D242_S0.7901.00
191_I208_N0.7901.00
176_L307_L0.7871.00
299_R303_T0.7871.00
130_Q309_M0.7851.00
222_T225_Q0.7831.00
198_A203_A0.7821.00
299_R302_E0.7771.00
150_V177_A0.7771.00
38_H41_E0.7731.00
149_G173_A0.7701.00
161_V182_A0.7701.00
146_A172_I0.7681.00
214_V242_S0.7671.00
323_V346_M0.7661.00
190_P198_A0.7641.00
216_K219_K0.7641.00
230_I253_I0.7641.00
25_N93_G0.7581.00
255_Y279_I0.7581.00
40_T83_N0.7581.00
154_N252_T0.7581.00
164_V239_A0.7551.00
27_V119_A0.7521.00
139_C142_P0.7521.00
307_L310_N0.7521.00
233_T256_V0.7511.00
129_P309_M0.7481.00
213_D242_S0.7481.00
215_G246_G0.7471.00
155_V229_V0.7451.00
243_A253_I0.7431.00
110_P115_V0.7411.00
126_R302_E0.7371.00
186_I218_I0.7351.00
146_A169_I0.7351.00
107_G117_I0.7331.00
177_A185_V0.7321.00
42_V336_V0.7301.00
14_L325_F0.7281.00
132_S308_L0.7271.00
186_I221_L0.7261.00
337_D340_P0.7261.00
183_S186_I0.7251.00
200_R314_N0.7251.00
17_Y80_Q0.7241.00
336_V346_M0.7191.00
22_I91_E0.7171.00
307_L311_G0.7161.00
148_S276_N0.7141.00
154_N278_K0.7131.00
319_I322_V0.7121.00
321_P330_E0.7101.00
182_A229_V0.7091.00
180_A303_T0.7061.00
185_V204_D0.7061.00
106_C128_M0.7051.00
126_R301_E0.7041.00
10_R45_F0.7011.00
262_F265_G0.7001.00
86_V138_V0.7001.00
119_A123_Y0.6991.00
272_A277_A0.6971.00
25_N94_S0.6941.00
200_R316_E0.6931.00
321_P346_M0.6911.00
105_V125_L0.6901.00
323_V348_V0.6891.00
33_F322_V0.6831.00
160_F225_Q0.6801.00
249_Y275_N0.6781.00
147_M307_L0.6761.00
154_N280_V0.6721.00
197_I201_H0.6691.00
223_G226_G0.6681.00
98_D298_K0.6681.00
86_V128_M0.6671.00
240_L253_I0.6661.00
163_V187_G0.6651.00
136_N314_N0.6641.00
147_M304_C0.6641.00
227_A230_I0.6621.00
20_R116_I0.6611.00
83_N142_P0.6601.00
27_V89_I0.6571.00
146_A150_V0.6571.00
229_V254_S0.6571.00
22_I93_G0.6541.00
176_L180_A0.6511.00
36_P111_L0.6501.00
232_E253_I0.6491.00
126_R305_W0.6491.00
305_W309_M0.6451.00
342_Q346_M0.6421.00
36_P336_V0.6421.00
38_H142_P0.6421.00
147_M300_I0.6391.00
262_F267_N0.6371.00
103_D130_Q0.6351.00
25_N123_Y0.6351.00
151_R180_A0.6341.00
225_Q248_A0.6341.00
33_F86_V0.6321.00
218_I246_G0.6321.00
39_G43_V0.6311.00
173_A256_V0.6301.00
153_A252_T0.6301.00
338_Q342_Q0.6291.00
189_D208_N0.6271.00
31_V34_G0.6261.00
40_T44_D0.6261.00
133_S137_A0.6251.00
229_V252_T0.6211.00
205_F217_E0.6171.00
145_F169_I0.6171.00
182_A185_V0.6161.00
174_I201_H0.6151.00
276_N286_S0.6151.00
86_V104_S0.6131.00
227_A246_G0.6131.00
175_Q201_H0.6131.00
158_G183_S0.6111.00
189_D198_A0.6081.00
267_N271_E0.6081.00
43_V48_A0.6071.00
189_D209_P0.6041.00
219_K222_T0.6041.00
241_Q265_G0.6021.00
236_Y239_A0.6001.00
75_E79_F0.6001.00
98_D101_V0.5981.00
178_K185_V0.5961.00
141_D145_F0.5951.00
29_I107_G0.5931.00
140_Y304_C0.5911.00
38_H345_K0.5901.00
145_F256_V0.5881.00
98_D127_K0.5881.00
104_S131_G0.5881.00
34_G348_V0.5871.00
20_R114_T0.5851.00
239_A243_A0.5841.00
188_V207_L0.5831.00
323_V330_E0.5821.00
241_Q271_E0.5821.00
195_C198_A0.5791.00
230_I246_G0.5781.00
107_G125_L0.5761.00
162_V230_I0.5761.00
126_R298_K0.5711.00
161_V229_V0.5711.00
198_A206_C0.5701.00
76_F79_F0.5681.00
39_G167_G0.5681.00
97_T100_A0.5651.00
8_A13_A0.5641.00
92_C103_D0.5641.00
254_S282_S0.5641.00
160_F222_T0.5631.00
134_W137_A0.5621.00
40_T43_V0.5601.00
44_D49_S0.5601.00
106_C141_D0.5601.00
238_D241_Q0.5591.00
214_V218_I0.5591.00
12_A332_Y0.5571.00
19_D116_I0.5531.00
219_K226_G0.5531.00
157_V180_A0.5521.00
151_R299_R0.5511.00
321_P343_S0.5481.00
29_I125_L0.5451.00
195_C209_P0.5451.00
271_E277_A0.5431.00
150_V176_L0.5431.00
9_P47_A0.5421.00
82_G111_L0.5421.00
174_I198_A0.5411.00
42_V46_R0.5411.00
20_R26_E0.5401.00
207_L221_L0.5381.00
207_L217_E0.5371.00
282_S285_C0.5351.00
172_I176_L0.5351.00
142_P145_F0.5341.00
18_E21_A0.5331.00
118_N124_K0.5321.00
99_Y119_A0.5311.00
320_D344_I0.5301.00
271_E274_F0.5281.00
31_V107_G0.5271.00
149_G282_S0.5261.00
189_D194_R0.5251.00
164_V214_V0.5241.00
19_D22_I0.5231.00
20_R28_K0.5231.00
119_A125_L0.5211.00
147_M180_A0.5191.00
166_L170_G0.5191.00
86_V137_A0.5181.00
241_Q267_N0.5181.00
35_A138_V0.5171.00
22_I95_D0.5171.00
84_M345_K0.5161.00
321_P327_N0.5151.00
42_V337_D0.5141.00
172_I313_L0.5141.00
171_Q201_H0.5121.00
80_Q109_G0.5101.00
157_V181_G0.5101.00
220_T223_G0.5091.00
172_I175_Q0.5091.00
133_S322_V0.5071.00
14_L328_S0.5061.00
148_S152_D0.5051.00
165_G233_T0.5051.00
178_K203_A0.5041.00
222_T227_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1f8fA 4 0.88 100 0.199 Contact Map
4ej6A 1 0.8714 100 0.2 Contact Map
3ukoA 4 0.8829 100 0.201 Contact Map
1cdoA 2 0.8829 100 0.202 Contact Map
4ilkA 2 0.8686 100 0.203 Contact Map
2dq4A 4 0.8829 100 0.205 Contact Map
1e3iA 2 0.8771 100 0.206 Contact Map
3fpcA 4 0.8914 100 0.208 Contact Map
2jhfA 2 0.8829 100 0.208 Contact Map
3uogA 4 0.8714 100 0.21 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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