GREMLIN Database
SUCP - Putative sucrose phosphorylase
UniProt: P76041 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13910
Length: 559 (453)
Sequences: 8761 (5866)
Seq/√Len: 275.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_H224_E4.7801.00
134_M155_F3.7441.00
410_A555_V3.6171.00
117_Q221_K3.6031.00
79_S474_S3.5671.00
70_N118_Q3.4331.00
208_L254_L3.3331.00
219_L266_T3.2091.00
112_E115_D3.1281.00
409_H473_L3.0661.00
410_A476_L2.9451.00
478_T482_S2.8861.00
73_Y122_C2.7981.00
70_N73_Y2.7851.00
116_I120_G2.7301.00
53_T58_F2.7171.00
317_W321_L2.6771.00
256_R260_D2.6571.00
70_N115_D2.6281.00
413_L477_I2.6051.00
428_G469_V2.5961.00
49_V477_I2.5301.00
134_M200_L2.4331.00
131_C214_V2.4201.00
91_P105_Q2.3981.00
216_L258_I2.3911.00
47_S487_H2.3741.00
77_L81_F2.3361.00
414_S557_W2.1911.00
118_Q122_C2.1861.00
73_Y118_Q2.0821.00
217_C221_K2.0471.00
406_I472_E2.0401.00
53_T72_F2.0211.00
471_H474_S2.0021.00
116_I119_L1.9951.00
298_L415_F1.9931.00
471_H475_R1.9861.00
63_L66_L1.9831.00
72_F119_L1.9631.00
551_R554_Q1.9521.00
84_V123_S1.9511.00
526_H547_E1.9431.00
48_D82_S1.9301.00
68_T71_Q1.9071.00
314_L317_W1.9011.00
209_L213_D1.8931.00
72_F86_L1.8921.00
38_Q222_G1.8801.00
414_S504_I1.8661.00
313_A317_W1.8501.00
423_I450_Y1.8431.00
505_P515_T1.8171.00
503_R517_L1.8051.00
206_E209_L1.7951.00
89_F116_I1.7881.00
143_N147_Q1.7871.00
405_F428_G1.7701.00
48_D83_H1.7661.00
200_L207_V1.7621.00
470_Y474_S1.7451.00
526_H549_T1.7411.00
79_S470_Y1.7381.00
318_A321_L1.7331.00
70_N74_H1.7121.00
56_D60_S1.6961.00
215_L255_L1.6931.00
315_C318_A1.6761.00
281_A284_G1.6741.00
251_I255_L1.6671.00
212_V254_L1.6641.00
314_L318_A1.6601.00
518_F555_V1.6391.00
114_Q117_Q1.6341.00
304_H381_Y1.6251.00
483_H514_L1.6121.00
402_C406_I1.6011.00
334_L408_A1.5941.00
343_N405_F1.5881.00
467_H471_H1.5761.00
219_L259_I1.5711.00
475_R478_T1.5631.00
503_R506_R1.5531.00
202_Y211_M1.5481.00
249_H289_E1.5461.00
104_H210_A1.5441.00
258_I261_N1.5431.00
86_L89_F1.5401.00
536_D539_S1.5381.00
505_P513_C1.5321.00
55_A86_L1.5251.00
524_I549_T1.5221.00
216_L220_A1.5121.00
127_F223_A1.4981.00
409_H421_I1.4821.00
102_D105_Q1.4811.00
404_R553_W1.4801.00
73_Y119_L1.4801.00
313_A321_L1.4661.00
69_F115_D1.4651.00
143_N151_F1.4431.00
83_H126_M1.4401.00
405_F469_V1.4361.00
104_H214_V1.4321.00
126_M225_Y1.4311.00
154_F210_A1.4311.00
201_N204_S1.4251.00
220_A262_V1.4201.00
317_W320_N1.4181.00
116_I223_A1.4161.00
69_F106_V1.4161.00
153_D204_S1.4101.00
144_Y157_A1.3981.00
504_I516_G1.3981.00
335_A425_S1.3981.00
413_L421_I1.3961.00
210_A214_V1.3921.00
55_A72_F1.3921.00
53_T84_V1.3811.00
474_S478_T1.3761.00
69_F72_F1.3711.00
427_L450_Y1.3701.00
333_F336_S1.3631.00
59_H74_H1.3551.00
500_S521_S1.3501.00
119_L123_S1.3421.00
313_A316_A1.3341.00
500_S503_R1.3341.00
427_L470_Y1.3321.00
528_N547_E1.3311.00
370_W376_G1.3271.00
65_P68_T1.3251.00
231_V270_T1.3111.00
43_H83_H1.2891.00
477_I481_R1.2891.00
536_D540_E1.2831.00
216_L262_V1.2761.00
427_L455_I1.2721.00
524_I551_R1.2721.00
316_A321_L1.2721.00
451_H454_E1.2701.00
205_P209_L1.2691.00
89_F106_V1.2591.00
409_H476_L1.2591.00
548_I556_M1.2561.00
280_I283_F1.2551.00
440_G447_R1.2551.00
250_L253_K1.2441.00
496_T499_S1.2441.00
479_L537_L1.2431.00
402_C405_F1.2371.00
113_W117_Q1.2361.00
432_D447_R1.2321.00
129_F215_L1.2301.00
454_E466_R1.2231.00
69_F111_G1.2211.00
439_L442_N1.2211.00
120_G125_L1.2201.00
383_I386_T1.2091.00
521_S525_Q1.2041.00
139_E143_N1.2031.00
406_I469_V1.1971.00
390_A393_R1.1971.00
316_A319_Q1.1851.00
116_I127_F1.1821.00
75_Q79_S1.1801.00
407_L518_F1.1791.00
107_A110_A1.1781.00
82_S481_R1.1741.00
386_T389_D1.1701.00
106_V116_I1.1691.00
536_D543_I1.1641.00
58_F76_W1.1341.00
299_P303_L1.1301.00
492_F505_P1.1251.00
507_S513_C1.1171.00
104_H217_C1.1161.00
382_E385_V1.1151.00
153_D206_E1.1141.00
411_I518_F1.1111.00
522_K553_W1.1101.00
93_S101_I1.1101.00
212_V258_I1.1041.00
282_Y285_A1.1021.00
494_I506_R1.0981.00
313_A319_Q1.0941.00
91_P101_I1.0931.00
335_A342_L1.0921.00
444_A448_K1.0921.00
68_T72_F1.0921.00
440_G448_K1.0851.00
154_F206_E1.0851.00
85_H294_Y1.0851.00
113_W217_C1.0841.00
261_N264_P1.0811.00
210_A213_D1.0761.00
384_N389_D1.0731.00
137_K142_K1.0701.00
249_H253_K1.0701.00
53_T423_I1.0701.00
311_V314_L1.0701.00
391_L394_R1.0681.00
524_I552_P1.0661.00
485_E514_L1.0661.00
382_E386_T1.0651.00
384_N388_M1.0641.00
316_A320_N1.0591.00
443_R448_K1.0531.00
455_I470_Y1.0521.00
483_H512_N1.0501.00
302_V411_I1.0491.00
472_E476_L1.0431.00
199_D233_F1.0381.00
114_Q118_Q1.0371.00
55_A69_F1.0361.00
106_V218_Y1.0351.00
45_D48_D1.0351.00
503_R515_T1.0311.00
250_L254_L1.0311.00
281_A285_A1.0301.00
315_C319_Q1.0271.00
445_I449_K1.0151.00
443_R447_R1.0141.00
153_D156_I1.0141.00
464_T471_H1.0111.00
402_C468_A1.0091.00
334_L412_L1.0061.00
362_Q383_I1.0051.00
331_F337_H0.9971.00
476_L538_I0.9971.00
89_F127_F0.9961.00
118_Q121_E0.9951.00
536_D541_V0.9931.00
506_R509_A0.9911.00
317_W322_T0.9891.00
382_E389_D0.9881.00
113_W221_K0.9861.00
57_Q95_D0.9851.00
67_P71_Q0.9831.00
75_Q78_Q0.9781.00
312_E316_A0.9761.00
253_K289_E0.9721.00
49_V81_F0.9721.00
278_D281_A0.9691.00
49_V481_R0.9671.00
443_R446_N0.9661.00
448_K452_S0.9661.00
451_H455_I0.9641.00
360_A363_Q0.9631.00
443_R449_K0.9631.00
80_I477_I0.9631.00
66_L69_F0.9631.00
390_A394_R0.9621.00
378_R381_Y0.9611.00
409_H469_V0.9591.00
260_D263_A0.9571.00
444_A449_K0.9551.00
497_I500_S0.9501.00
517_L527_V0.9491.00
504_I507_S0.9471.00
115_D118_Q0.9461.00
212_V255_L0.9441.00
231_V252_I0.9421.00
501_V504_I0.9411.00
318_A322_T0.9401.00
411_I520_V0.9381.00
441_Y444_A0.9361.00
501_V506_R0.9361.00
69_F89_F0.9351.00
442_N445_I0.9341.00
280_I285_A0.9321.00
343_N428_G0.9311.00
148_H151_F0.9291.00
550_L556_M0.9271.00
47_S481_R0.9271.00
446_N452_S0.9231.00
498_N525_Q0.9231.00
50_V83_H0.9221.00
47_S488_P0.9211.00
541_V551_R0.9201.00
439_L445_I0.9171.00
192_T233_F0.9131.00
439_L444_A0.9111.00
279_N283_F0.9031.00
442_N446_N0.9031.00
486_F514_L0.9011.00
406_I468_A0.9001.00
539_S543_I0.8981.00
136_A196_D0.8971.00
76_W81_F0.8971.00
158_V191_T0.8941.00
104_H213_D0.8941.00
470_Y473_L0.8931.00
38_Q121_E0.8931.00
507_S510_D0.8911.00
315_C321_L0.8901.00
304_H309_Q0.8901.00
72_F84_V0.8881.00
410_A472_E0.8831.00
517_L550_L0.8821.00
378_R382_E0.8771.00
502_M506_R0.8761.00
340_I344_P0.8751.00
90_Y100_V0.8741.00
494_I515_T0.8731.00
335_A345_L0.8711.00
256_R268_I0.8711.00
421_I473_L0.8711.00
298_L302_V0.8701.00
362_Q365_G0.8641.00
151_F157_A0.8621.00
385_V389_D0.8601.00
539_S542_D0.8581.00
535_R543_I0.8581.00
59_H67_P0.8541.00
65_P74_H0.8521.00
363_Q366_A0.8511.00
152_E157_A0.8501.00
67_P70_N0.8491.00
445_I448_K0.8481.00
121_E222_G0.8441.00
535_R539_S0.8431.00
339_G342_L0.8431.00
413_L419_P0.8431.00
278_D282_Y0.8421.00
229_D271_E0.8411.00
215_L226_V0.8401.00
67_P72_F0.8281.00
495_D498_N0.8281.00
304_H308_K0.8270.99
380_P384_N0.8240.99
445_I451_H0.8230.99
397_S400_E0.8230.99
381_Y386_T0.8210.99
58_F72_F0.8200.99
119_L125_L0.8200.99
335_A339_G0.8190.99
38_Q41_K0.8190.99
442_N448_K0.8160.99
215_L259_I0.8150.99
311_V315_C0.8150.99
312_E318_A0.8120.99
335_A338_D0.8100.99
376_G379_S0.8090.99
150_G153_D0.8070.99
404_R407_L0.8070.99
260_D264_P0.8010.99
541_V554_Q0.7970.99
500_S506_R0.7970.99
105_Q113_W0.7960.99
94_S196_D0.7910.99
209_L254_L0.7880.99
379_S383_I0.7870.99
382_E387_Y0.7860.99
142_K145_L0.7860.99
304_H307_Q0.7860.99
120_G223_A0.7860.99
337_H344_P0.7860.99
343_N360_A0.7850.99
516_G557_W0.7850.99
256_R291_H0.7830.99
279_N282_Y0.7830.99
305_A520_V0.7830.99
77_L84_V0.7820.99
131_C211_M0.7820.99
306_V407_L0.7800.99
441_Y445_I0.7760.99
66_L72_F0.7760.99
311_V317_W0.7760.99
341_G344_P0.7750.99
429_S448_K0.7730.99
296_F299_P0.7730.99
444_A447_R0.7730.99
314_L320_N0.7720.99
446_N449_K0.7710.99
101_I135_S0.7710.99
151_F154_F0.7710.99
407_L520_V0.7710.99
492_F507_S0.7700.99
363_Q378_R0.7640.99
479_L483_H0.7630.99
43_H46_E0.7620.99
400_E404_R0.7620.99
336_S339_G0.7610.99
258_I262_V0.7600.99
214_V217_C0.7600.99
140_W143_N0.7570.99
414_S516_G0.7540.99
402_C469_V0.7520.99
431_N440_G0.7520.99
535_R541_V0.7500.99
378_R383_I0.7500.99
156_I159_D0.7490.99
117_Q222_G0.7480.99
387_Y393_R0.7460.99
369_N376_G0.7450.99
50_V331_F0.7440.99
366_A369_N0.7440.99
312_E315_C0.7430.99
254_L257_S0.7420.99
103_Y210_A0.7420.99
149_P152_E0.7420.99
48_D267_V0.7410.99
382_E388_M0.7410.99
331_F419_P0.7400.99
396_S400_E0.7400.99
100_V103_Y0.7390.99
550_L554_Q0.7370.99
314_L321_L0.7370.99
300_P303_L0.7360.99
291_H295_Q0.7360.99
65_P70_N0.7340.99
410_A518_F0.7340.99
139_E142_K0.7330.99
257_S260_D0.7330.99
76_W470_Y0.7320.99
377_T381_Y0.7320.99
364_E369_N0.7320.99
147_Q151_F0.7310.99
86_L123_S0.7310.99
442_N449_K0.7260.99
364_E378_R0.7260.99
319_Q322_T0.7250.99
338_D342_L0.7250.99
429_S450_Y0.7240.99
439_L443_R0.7240.99
52_I87_L0.7230.99
536_D556_M0.7220.99
517_L556_M0.7220.99
306_V411_I0.7200.99
443_R451_H0.7190.99
97_G110_A0.7180.99
58_F77_L0.7170.99
315_C322_T0.7170.99
303_L307_Q0.7140.99
410_A414_S0.7130.99
280_I284_G0.7130.99
54_Y87_L0.7110.98
86_L125_L0.7100.98
133_H229_D0.7080.98
70_N112_E0.7060.98
379_S382_E0.7050.98
208_L212_V0.7040.98
339_G344_P0.7030.98
401_R404_R0.7010.98
450_Y455_I0.7010.98
342_L345_L0.6980.98
428_G466_R0.6980.98
64_K68_T0.6940.98
295_Q332_N0.6940.98
440_G443_R0.6910.98
361_L366_A0.6900.98
158_V161_Q0.6870.98
399_E403_A0.6870.98
379_S385_V0.6860.98
147_Q150_G0.6850.98
361_L367_L0.6840.98
209_L258_I0.6830.98
445_I452_S0.6810.98
439_L446_N0.6800.98
439_L448_K0.6790.98
447_R450_Y0.6790.98
446_N450_Y0.6770.98
509_A512_N0.6750.98
367_L370_W0.6720.98
380_P383_I0.6710.98
125_L224_E0.6690.98
44_W47_S0.6690.98
72_F123_S0.6690.98
494_I500_S0.6680.98
515_T518_F0.6670.98
65_P69_F0.6660.98
383_I387_Y0.6660.98
384_N387_Y0.6650.98
365_G368_V0.6650.98
404_R408_A0.6650.98
143_N146_Q0.6650.98
58_F452_S0.6640.98
131_C228_L0.6590.98
363_Q367_L0.6560.97
137_K196_D0.6530.97
361_L364_E0.6530.97
385_V404_R0.6520.97
523_N552_P0.6520.97
251_I257_S0.6510.97
60_S63_L0.6500.97
236_K250_L0.6490.97
194_S197_Q0.6480.97
278_D283_F0.6470.97
143_N149_P0.6460.97
259_I264_P0.6460.97
446_N451_H0.6450.97
391_L398_D0.6450.97
61_N446_N0.6440.97
337_H341_G0.6440.97
359_E363_Q0.6430.97
381_Y385_V0.6430.97
54_Y110_A0.6430.97
228_L290_A0.6420.97
94_S99_S0.6400.97
444_A450_Y0.6400.97
254_L258_I0.6390.97
501_V527_V0.6350.97
449_K452_S0.6350.97
294_Y420_A0.6340.97
263_A266_T0.6330.97
126_M267_V0.6330.97
46_E489_D0.6330.97
230_A233_F0.6320.97
311_V321_L0.6290.97
273_N339_G0.6290.97
439_L449_K0.6290.97
335_A340_I0.6280.97
100_V135_S0.6280.97
40_R222_G0.6280.97
230_A273_N0.6260.97
538_I543_I0.6240.97
55_A89_F0.6230.97
252_I255_L0.6230.97
294_Y299_P0.6210.96
295_Q299_P0.6170.96
361_L365_G0.6170.96
380_P386_T0.6150.96
318_A324_P0.6150.96
255_L260_D0.6150.96
370_W378_R0.6140.96
251_I256_R0.6130.96
403_A406_I0.6130.96
76_W426_I0.6120.96
337_H342_L0.6120.96
45_D267_V0.6100.96
486_F506_R0.6090.96
465_L471_H0.6090.96
270_T290_A0.6070.96
292_M418_V0.6070.96
144_Y147_Q0.6060.96
64_K67_P0.6060.96
219_L226_V0.6060.96
253_K257_S0.6050.96
331_F339_G0.6040.96
65_P71_Q0.6040.96
90_Y127_F0.6030.96
51_L423_I0.6030.96
340_I343_N0.6010.96
117_Q121_E0.6010.96
394_R397_S0.6010.96
544_L547_E0.6010.96
380_P385_V0.6010.96
505_P508_N0.6000.96
138_S141_F0.5990.96
248_T251_I0.5990.96
126_M269_I0.5980.96
298_L303_L0.5960.96
215_L228_L0.5950.95
44_W48_D0.5940.95
387_Y390_A0.5940.95
296_F304_H0.5940.95
313_A322_T0.5930.95
69_F119_L0.5910.95
504_I509_A0.5900.95
385_V388_M0.5890.95
43_H47_S0.5890.95
362_Q378_R0.5880.95
494_I503_R0.5870.95
84_V119_L0.5870.95
269_I420_A0.5860.95
311_V318_A0.5850.95
270_T293_V0.5840.95
143_N150_G0.5840.95
55_A110_A0.5830.95
121_E124_H0.5820.95
402_C465_L0.5820.95
150_G155_F0.5810.95
398_D402_C0.5800.95
412_L419_P0.5800.95
69_F73_Y0.5800.95
443_R450_Y0.5780.95
202_Y248_T0.5780.95
362_Q368_V0.5770.95
147_Q152_E0.5760.95
379_S386_T0.5750.95
49_V82_S0.5750.95
66_L71_Q0.5740.95
535_R542_D0.5740.95
155_F160_P0.5690.94
55_A87_L0.5680.94
302_V408_A0.5680.94
494_I504_I0.5670.94
253_K288_D0.5670.94
313_A318_A0.5660.94
99_S135_S0.5650.94
427_L454_E0.5630.94
129_F226_V0.5610.94
136_A141_F0.5600.94
429_S451_H0.5600.94
381_Y384_N0.5590.94
51_L426_I0.5590.94
143_N148_H0.5580.94
499_S503_R0.5570.94
312_E317_W0.5570.94
363_Q368_V0.5550.94
321_L324_P0.5540.93
383_I388_M0.5540.93
376_G382_E0.5520.93
434_A443_R0.5500.93
425_S473_L0.5490.93
306_V408_A0.5480.93
93_S137_K0.5480.93
498_N506_R0.5480.93
317_W324_P0.5460.93
316_A322_T0.5460.93
413_L480_R0.5450.93
229_D338_D0.5440.93
500_S520_V0.5410.93
142_K146_Q0.5410.93
493_T496_T0.5410.93
278_D284_G0.5400.93
153_D201_N0.5390.93
259_I266_T0.5390.93
385_V400_E0.5380.92
365_G369_N0.5350.92
94_S194_S0.5350.92
496_T500_S0.5340.92
148_H153_D0.5330.92
364_E368_V0.5320.92
387_Y391_L0.5310.92
227_R271_E0.5310.92
333_F345_L0.5300.92
274_V278_D0.5290.92
514_L537_L0.5290.92
146_Q210_A0.5280.92
503_R508_N0.5280.92
249_H252_I0.5270.92
534_G539_S0.5260.92
466_R469_V0.5250.92
411_I415_F0.5240.91
440_G445_I0.5230.91
343_N390_A0.5230.91
359_E362_Q0.5220.91
535_R538_I0.5220.91
431_N448_K0.5220.91
360_A366_A0.5220.91
362_Q366_A0.5210.91
80_I474_S0.5200.91
52_I56_D0.5180.91
403_A472_E0.5180.91
200_L211_M0.5180.91
339_G343_N0.5180.91
313_A320_N0.5180.91
140_W154_F0.5180.91
299_P304_H0.5170.91
500_S507_S0.5170.91
98_F271_E0.5170.91
292_M296_F0.5160.91
494_I507_S0.5160.91
149_P155_F0.5160.91
333_F337_H0.5150.91
234_M252_I0.5150.91
414_S476_L0.5130.91
493_T500_S0.5120.91
259_I268_I0.5110.90
219_L263_A0.5090.90
67_P115_D0.5090.90
67_P74_H0.5080.90
338_D344_P0.5080.90
448_K451_H0.5070.90
130_V229_D0.5070.90
310_N499_S0.5070.90
130_V271_E0.5070.90
208_L250_L0.5060.90
90_Y135_S0.5060.90
76_W427_L0.5060.90
267_V418_V0.5050.90
503_R507_S0.5040.90
202_Y251_I0.5040.90
60_S68_T0.5020.90
288_D291_H0.5020.90
469_V473_L0.5010.90
474_S477_I0.5000.89
400_E403_A0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zo9A 4 0.9034 100 0.284 Contact Map
4wf7A 2 0.8784 100 0.29 Contact Map
3ucqA 2 0.9803 100 0.304 Contact Map
3czgA 1 0.9356 100 0.309 Contact Map
4mb1A 1 0.8354 100 0.312 Contact Map
2ze0A 2 0.8336 100 0.312 Contact Map
1g5aA 1 0.9589 100 0.314 Contact Map
1uokA 1 0.839 100 0.315 Contact Map
3wy2A 1 0.8229 100 0.318 Contact Map
3aj7A 1 0.8551 100 0.319 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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