PUUP - ECOLI - GREMLIN Contacts

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PUUP - Putrescine importer PuuP

UniProt:	P76037	Sequences: MAINSPLNIAAQPGKTRLRKSLKLWQVVMMGLAYLTPMTVFDTFGIVSGISDGHVPASYLLALAGVLFTAISYGKLVRQFPEAGSAYTYAQKSINPHVGFMVGWSSLLDYLFLPMINVLLAKIYLSALFPEVPPWVWVVTFVAILTAANLKSVNLVANFNTLFVLVQISIMVVFIFLVVQGLHKGEGVGTVWSLQPFISENAHLIPIITGATIVCFSFLGFDAVTTLSEETPDAARVIPKAIFLTAVYGGVIFIAASFFMQLFFPDISRFKDPDAALPEIALYVGGKLFQSIFLCTTFVNTLASGLASHASVSRLLYVMGRDNVFPERVFGYVHPKWRTPALNVIMVGIVALSALFFDLVTATALINFGALVAFTFVNLSVFNHFWRRKGMNKSWKDHFHYLLMPLVGALTVGVLWVNLESTSLTLGLVWASLGGAYLWYLIRRYRKVPLYDGDRTPVSET	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13907
Length:	461 (420)
Sequences:	24937 (16376)
Seq/√Len:	799.0

ECOLI - PUUP PLAP ANSP LYSP PROY AROP PHEP CYCA MMUP FRLA ADIC GABP YIFK POTE GADC YBAT YGJI ARCD YCAM CADB YJEM YJEH TNAB
BACSU - YHDG GABP ASPP YDGF ROCC HUTM YFNA YTNA YBXG YBGF YBEC AAPA YVBW STET ROCE YCGH ARCD YECA YDAO GERBB GERAB YNDE GERKB YFKT
HALSA - Q9HHU7 Q9HQB3 Q9HSL5
SULSO - Q97XM0 Q97U05 Q97X49 Q97Z63 Q97VA6 Q97WS3 Q97VA8 Q97U33 Q97VR4 Q7LXI7 Q97ZB5 Q97WD4 Q97Y76 Q97YN3 Q97YX9 Q97U39

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
329_V	342_L	4.389	1.00
146_T	348_G	4.321	1.00
63_L	250_G	3.148	1.00
332_Y	342_L	3.076	1.00
236_R	240_K	2.984	1.00
334_H	337_W	2.926	1.00
23_K	232_P	2.874	1.00
383_N	387_R	2.847	1.00
87_Y	322_D	2.667	1.00
231_T	237_V	2.663	1.00
375_T	409_A	2.643	1.00
233_D	236_R	2.626	1.00
103_G	319_M	2.565	1.00
178_V	259_F	2.557	1.00
329_V	332_Y	2.535	1.00
334_H	341_A	2.478	1.00
28_V	244_L	2.443	1.00
320_G	331_G	2.433	1.00
24_L	244_L	2.379	1.00
176_F	180_Q	2.322	1.00
288_L	292_I	2.239	1.00
91_Q	99_G	2.213	1.00
229_E	321_R	2.213	1.00
75_K	385_F	2.204	1.00
230_E	314_R	2.130	1.00
24_L	237_V	2.113	1.00
345_I	349_I	2.093	1.00
317_Y	321_R	2.088	1.00
279_E	282_L	2.068	1.00
139_V	355_L	2.068	1.00
27_V	231_T	2.065	1.00
147_A	151_K	2.053	1.00
154_N	158_N	2.043	1.00
24_L	28_V	2.029	1.00
150_L	341_A	2.016	1.00
146_T	344_V	2.014	1.00
240_K	244_L	1.979	1.00
406_L	410_L	1.975	1.00
403_L	407_V	1.970	1.00
436_A	440_Y	1.963	1.00
91_Q	96_P	1.958	1.00
323_N	327_E	1.954	1.00
72_S	378_N	1.947	1.00
165_L	169_S	1.913	1.00
107_L	347_V	1.909	1.00
18_L	333_V	1.905	1.00
401_Y	405_P	1.897	1.00
23_K	26_Q	1.886	1.00
47_V	55_V	1.878	1.00
139_V	352_L	1.859	1.00
94_I	383_N	1.847	1.00
378_N	408_G	1.819	1.00
64_A	68_F	1.810	1.00
330_F	346_M	1.807	1.00
130_P	133_P	1.796	1.00
94_I	379_L	1.793	1.00
233_D	237_V	1.787	1.00
279_E	283_Y	1.777	1.00
243_F	247_V	1.717	1.00
420_E	423_S	1.708	1.00
102_V	376_F	1.698	1.00
193_S	196_P	1.694	1.00
269_R	283_Y	1.692	1.00
26_Q	161_T	1.686	1.00
169_S	173_V	1.686	1.00
90_A	102_V	1.686	1.00
143_A	348_G	1.685	1.00
149_N	306_L	1.638	1.00
337_W	341_A	1.625	1.00
421_S	424_L	1.602	1.00
58_S	210_G	1.589	1.00
334_H	339_T	1.582	1.00
150_L	345_I	1.570	1.00
410_L	414_V	1.565	1.00
95_N	98_V	1.565	1.00
28_V	248_Y	1.562	1.00
54_H	207_I	1.560	1.00
399_F	404_M	1.538	1.00
22_L	26_Q	1.537	1.00
435_G	439_W	1.527	1.00
383_N	386_W	1.524	1.00
138_V	355_L	1.520	1.00
342_L	346_M	1.514	1.00
31_G	245_T	1.506	1.00
104_W	434_G	1.503	1.00
196_P	199_S	1.501	1.00
118_V	305_G	1.500	1.00
193_S	199_S	1.492	1.00
227_L	310_A	1.487	1.00
428_L	432_S	1.473	1.00
247_V	251_V	1.471	1.00
430_W	434_G	1.469	1.00
191_V	194_L	1.464	1.00
190_T	194_L	1.457	1.00
125_L	137_W	1.454	1.00
151_K	337_W	1.431	1.00
133_P	136_V	1.429	1.00
118_V	142_V	1.424	1.00
388_R	391_M	1.417	1.00
282_L	290_Q	1.415	1.00
312_V	347_V	1.409	1.00
121_A	141_F	1.400	1.00
90_A	376_F	1.400	1.00
317_Y	333_V	1.393	1.00
64_A	407_V	1.390	1.00
379_L	383_N	1.389	1.00
70_A	246_A	1.387	1.00
282_L	287_K	1.387	1.00
316_L	343_N	1.386	1.00
62_A	214_V	1.384	1.00
291_S	295_C	1.383	1.00
121_A	298_F	1.381	1.00
327_E	331_G	1.380	1.00
146_T	345_I	1.376	1.00
18_L	317_Y	1.376	1.00
412_V	415_L	1.370	1.00
405_P	409_A	1.368	1.00
26_Q	157_A	1.368	1.00
233_D	240_K	1.363	1.00
265_P	268_S	1.352	1.00
399_F	402_L	1.349	1.00
170_I	296_T	1.349	1.00
179_V	259_F	1.342	1.00
19_R	338_R	1.342	1.00
439_W	443_R	1.338	1.00
168_I	172_V	1.338	1.00
402_L	406_L	1.337	1.00
440_Y	443_R	1.325	1.00
420_E	424_L	1.325	1.00
68_F	407_V	1.325	1.00
332_Y	341_A	1.322	1.00
440_Y	444_R	1.322	1.00
265_P	269_R	1.321	1.00
139_V	143_A	1.321	1.00
24_L	240_K	1.319	1.00
418_N	421_S	1.315	1.00
421_S	425_T	1.313	1.00
94_I	98_V	1.304	1.00
313_S	344_V	1.303	1.00
142_V	348_G	1.299	1.00
419_L	424_L	1.296	1.00
65_G	411_T	1.295	1.00
234_A	239_P	1.294	1.00
194_L	197_F	1.283	1.00
25_W	29_M	1.272	1.00
70_A	242_I	1.272	1.00
175_I	255_A	1.272	1.00
80_F	92_K	1.270	1.00
285_G	289_F	1.267	1.00
83_A	229_E	1.264	1.00
251_V	255_A	1.259	1.00
182_L	262_L	1.250	1.00
190_T	195_Q	1.250	1.00
413_G	417_V	1.249	1.00
69_T	378_N	1.248	1.00
191_V	196_P	1.248	1.00
237_V	240_K	1.244	1.00
22_L	27_V	1.238	1.00
22_L	157_A	1.237	1.00
178_V	263_F	1.233	1.00
145_L	305_G	1.233	1.00
42_D	120_L	1.223	1.00
88_T	92_K	1.218	1.00
117_N	304_S	1.216	1.00
437_Y	440_Y	1.214	1.00
143_A	352_L	1.210	1.00
93_S	380_S	1.204	1.00
192_W	195_Q	1.202	1.00
35_L	249_G	1.198	1.00
56_P	258_F	1.195	1.00
196_P	200_E	1.190	1.00
142_V	351_A	1.190	1.00
71_I	243_F	1.187	1.00
405_P	411_T	1.183	1.00
326_P	329_V	1.166	1.00
180_Q	185_G	1.162	1.00
429_V	433_L	1.161	1.00
342_L	345_I	1.157	1.00
190_T	193_S	1.150	1.00
114_P	351_A	1.144	1.00
107_L	316_L	1.139	1.00
73_Y	86_A	1.134	1.00
426_L	429_V	1.133	1.00
82_E	88_T	1.131	1.00
273_P	279_E	1.129	1.00
32_L	248_Y	1.122	1.00
316_L	325_F	1.121	1.00
327_E	332_Y	1.116	1.00
405_P	412_V	1.110	1.00
190_T	196_P	1.110	1.00
193_S	198_I	1.108	1.00
419_L	423_S	1.096	1.00
79_Q	393_K	1.096	1.00
379_L	409_A	1.095	1.00
97_H	441_L	1.092	1.00
437_Y	441_L	1.089	1.00
27_V	241_A	1.086	1.00
174_F	178_V	1.086	1.00
48_S	55_V	1.085	1.00
232_P	237_V	1.085	1.00
90_A	98_V	1.083	1.00
321_R	331_G	1.081	1.00
77_V	89_Y	1.078	1.00
148_A	159_F	1.077	1.00
72_S	405_P	1.075	1.00
31_G	224_V	1.073	1.00
408_G	411_T	1.072	1.00
125_L	298_F	1.072	1.00
403_L	406_L	1.066	1.00
422_T	425_T	1.065	1.00
179_V	183_H	1.062	1.00
125_L	129_F	1.060	1.00
192_W	196_P	1.059	1.00
419_L	422_T	1.057	1.00
408_G	412_V	1.055	1.00
173_V	177_L	1.048	1.00
172_V	176_F	1.048	1.00
266_D	269_R	1.047	1.00
333_V	338_R	1.047	1.00
197_F	200_E	1.046	1.00
265_P	283_Y	1.045	1.00
21_S	232_P	1.044	1.00
158_N	162_L	1.043	1.00
432_S	436_A	1.037	1.00
30_M	227_L	1.034	1.00
434_G	437_Y	1.033	1.00
180_Q	184_K	1.028	1.00
92_K	388_R	1.023	1.00
140_T	144_I	1.022	1.00
159_F	163_F	1.020	1.00
132_V	136_V	1.018	1.00
79_Q	391_M	1.012	1.00
136_V	140_T	1.008	1.00
402_L	405_P	1.007	1.00
122_K	137_W	1.007	1.00
160_N	306_L	1.005	1.00
82_E	92_K	1.005	1.00
75_K	78_R	1.001	1.00
198_I	201_N	0.998	1.00
143_A	147_A	0.995	1.00
412_V	416_W	0.990	1.00
194_L	199_S	0.989	1.00
32_L	249_G	0.986	1.00
100_F	104_W	0.981	1.00
60_L	254_I	0.981	1.00
191_V	195_Q	0.972	1.00
146_T	150_L	0.971	1.00
389_K	392_N	0.968	1.00
409_A	412_V	0.967	1.00
204_L	207_I	0.959	1.00
104_W	325_F	0.952	1.00
386_W	389_K	0.945	1.00
87_Y	318_V	0.942	1.00
401_Y	404_M	0.940	1.00
219_L	370_A	0.939	1.00
414_V	417_V	0.938	1.00
391_M	394_S	0.937	1.00
150_L	339_T	0.937	1.00
382_F	406_L	0.937	1.00
163_F	303_A	0.933	1.00
29_M	161_T	0.932	1.00
389_K	393_K	0.929	1.00
116_I	363_T	0.922	1.00
258_F	262_L	0.921	1.00
393_K	396_K	0.920	1.00
132_V	135_W	0.919	1.00
418_N	424_L	0.915	1.00
325_F	330_F	0.914	1.00
135_W	139_V	0.914	1.00
153_V	310_A	0.914	1.00
228_S	238_I	0.913	1.00
54_H	198_I	0.908	1.00
427_G	431_A	0.907	1.00
122_K	138_V	0.907	1.00
422_T	426_L	0.902	1.00
174_F	281_A	0.900	1.00
175_I	259_F	0.895	1.00
97_H	435_G	0.895	1.00
222_D	226_T	0.893	1.00
275_A	279_E	0.890	1.00
97_H	101_M	0.889	1.00
441_L	444_R	0.889	1.00
244_L	248_Y	0.888	1.00
144_I	302_L	0.886	1.00
425_T	429_V	0.884	1.00
21_S	154_N	0.883	1.00
145_L	306_L	0.880	1.00
375_T	413_G	0.879	1.00
396_K	399_F	0.876	1.00
250_G	254_I	0.874	1.00
56_P	261_Q	0.873	1.00
429_V	432_S	0.872	1.00
368_F	427_G	0.872	1.00
63_L	218_F	0.871	1.00
26_Q	158_N	0.871	1.00
381_V	405_P	0.868	1.00
433_L	437_Y	0.864	1.00
168_I	252_I	0.864	1.00
167_Q	300_N	0.862	1.00
404_M	408_G	0.861	1.00
150_L	334_H	0.859	1.00
330_F	342_L	0.857	1.00
341_A	345_I	0.852	1.00
411_T	415_L	0.851	1.00
405_P	416_W	0.850	1.00
84_G	88_T	0.845	1.00
196_P	201_N	0.844	1.00
375_T	379_L	0.843	1.00
121_A	302_L	0.842	1.00
91_Q	322_D	0.839	1.00
309_H	348_G	0.838	1.00
25_W	161_T	0.833	1.00
273_P	276_A	0.832	1.00
18_L	230_E	0.831	1.00
18_L	314_R	0.830	1.00
395_W	398_H	0.828	1.00
398_H	403_L	0.827	1.00
121_A	301_T	0.823	1.00
116_I	216_F	0.820	1.00
204_L	208_I	0.819	1.00
390_G	393_K	0.817	1.00
405_P	408_G	0.817	1.00
409_A	413_G	0.810	1.00
349_I	353_S	0.809	1.00
399_F	405_P	0.806	1.00
84_G	87_Y	0.804	1.00
263_F	280_I	0.803	1.00
57_A	207_I	0.802	1.00
424_L	427_G	0.798	1.00
78_R	394_S	0.798	1.00
365_L	369_G	0.798	1.00
175_I	179_V	0.797	1.00
410_L	413_G	0.795	1.00
223_A	311_S	0.794	1.00
24_L	241_A	0.790	1.00
194_L	198_I	0.789	1.00
182_L	185_G	0.788	1.00
398_H	401_Y	0.787	1.00
158_N	161_T	0.784	1.00
179_V	255_A	0.781	1.00
131_E	134_P	0.777	1.00
209_T	213_I	0.776	1.00
180_Q	183_H	0.775	1.00
137_W	140_T	0.774	1.00
239_P	242_I	0.770	1.00
98_V	376_F	0.770	1.00
394_S	398_H	0.770	1.00
411_T	416_W	0.770	1.00
405_P	417_V	0.766	1.00
151_K	155_L	0.766	1.00
67_L	71_I	0.766	1.00
428_L	431_A	0.759	1.00
145_L	309_H	0.757	1.00
385_F	389_K	0.755	1.00
424_L	428_L	0.754	1.00
28_V	241_A	0.753	1.00
79_Q	394_S	0.751	1.00
147_A	150_L	0.750	1.00
401_Y	409_A	0.750	1.00
352_L	355_L	0.749	1.00
60_L	64_A	0.749	1.00
399_F	403_L	0.748	1.00
387_R	390_G	0.746	1.00
67_L	243_F	0.746	1.00
381_V	385_F	0.746	1.00
21_S	153_V	0.742	1.00
420_E	425_T	0.740	1.00
76_L	381_V	0.738	1.00
352_L	356_F	0.735	1.00
406_L	409_A	0.732	1.00
191_V	197_F	0.732	1.00
382_F	405_P	0.731	1.00
111_L	350_V	0.728	1.00
286_G	289_F	0.727	1.00
35_L	245_T	0.725	1.00
434_G	438_L	0.720	1.00
53_G	261_Q	0.719	1.00
219_L	374_F	0.719	1.00
334_H	338_R	0.718	1.00
203_H	206_P	0.712	1.00
90_A	380_S	0.709	1.00
382_F	386_W	0.708	1.00
288_L	291_S	0.707	1.00
122_K	125_L	0.705	1.00
208_I	414_V	0.703	1.00
93_S	383_N	0.701	1.00
119_L	362_A	0.699	1.00
47_V	51_S	0.698	1.00
397_D	401_Y	0.697	1.00
76_L	89_Y	0.697	1.00
358_D	361_T	0.696	1.00
401_Y	408_G	0.694	1.00
36_T	167_Q	0.694	1.00
287_K	291_S	0.692	1.00
182_L	259_F	0.690	1.00
36_T	252_I	0.689	1.00
175_I	256_A	0.687	1.00
68_F	72_S	0.687	1.00
25_W	158_N	0.686	1.00
87_Y	91_Q	0.685	1.00
329_V	346_M	0.685	1.00
406_L	417_V	0.683	1.00
36_T	39_T	0.680	1.00
309_H	313_S	0.679	1.00
198_I	207_I	0.678	1.00
351_A	354_A	0.678	1.00
94_I	380_S	0.677	1.00
40_V	256_A	0.676	1.00
56_P	60_L	0.675	1.00
386_W	402_L	0.674	1.00
320_G	330_F	0.674	1.00
57_A	60_L	0.674	1.00
329_V	333_V	0.673	1.00
233_D	239_P	0.672	1.00
193_S	197_F	0.672	1.00
430_W	437_Y	0.671	1.00
316_L	346_M	0.671	1.00
268_S	272_D	0.669	1.00
66_V	221_F	0.668	1.00
198_I	203_H	0.663	1.00
340_P	343_N	0.663	1.00
269_R	272_D	0.662	1.00
149_N	344_V	0.661	1.00
73_Y	377_V	0.661	1.00
57_A	61_L	0.660	1.00
28_V	31_G	0.660	1.00
195_Q	198_I	0.659	1.00
75_K	398_H	0.659	1.00
348_G	352_L	0.659	1.00
407_V	411_T	0.659	1.00
68_F	404_M	0.656	1.00
407_V	410_L	0.654	1.00
380_S	384_H	0.652	1.00
21_S	25_W	0.650	1.00
109_D	370_A	0.650	1.00
110_Y	308_S	0.646	1.00
402_L	417_V	0.646	1.00
106_S	110_Y	0.645	1.00
397_D	404_M	0.645	1.00
177_L	285_G	0.642	1.00
423_S	426_L	0.640	1.00
431_A	434_G	0.640	1.00
394_S	399_F	0.639	1.00
360_V	363_T	0.639	1.00
155_L	158_N	0.638	1.00
438_L	442_I	0.637	1.00
93_S	384_H	0.637	1.00
433_L	436_A	0.636	1.00
113_L	366_I	0.636	1.00
430_W	433_L	0.634	1.00
87_Y	103_G	0.632	1.00
143_A	146_T	0.631	1.00
248_Y	252_I	0.629	1.00
157_A	161_T	0.629	1.00
314_R	317_Y	0.629	1.00
142_V	355_L	0.629	1.00
150_L	337_W	0.629	1.00
150_L	344_V	0.628	1.00
44_F	257_S	0.626	1.00
83_A	317_Y	0.625	1.00
111_L	347_V	0.625	1.00
436_A	439_W	0.624	1.00
225_T	242_I	0.624	1.00
404_M	407_V	0.623	1.00
105_S	373_A	0.622	1.00
17_R	20_K	0.622	1.00
378_N	409_A	0.619	1.00
115_M	362_A	0.619	1.00
33_A	164_V	0.618	1.00
313_S	343_N	0.615	1.00
183_H	191_V	0.613	1.00
56_P	254_I	0.613	1.00
145_L	302_L	0.610	1.00
256_A	260_M	0.610	1.00
166_V	296_T	0.610	1.00
238_I	242_I	0.610	1.00
256_A	277_L	0.609	1.00
428_L	443_R	0.609	1.00
401_Y	406_L	0.608	1.00
34_Y	308_S	0.607	1.00
229_E	317_Y	0.607	1.00
50_I	209_T	0.606	1.00
423_S	427_G	0.605	1.00
431_A	435_G	0.605	1.00
74_G	78_R	0.604	1.00
149_N	310_A	0.603	1.00
55_V	257_S	0.603	1.00
118_V	122_K	0.602	1.00
127_A	294_L	0.602	1.00
71_I	398_H	0.601	1.00
18_L	21_S	0.601	1.00
113_L	116_I	0.600	1.00
401_Y	415_L	0.599	1.00
330_F	343_N	0.599	1.00
244_L	247_V	0.597	1.00
369_G	373_A	0.596	1.00
401_Y	417_V	0.596	1.00
393_K	397_D	0.595	1.00
426_L	430_W	0.591	1.00
421_S	428_L	0.590	1.00
295_C	299_V	0.590	1.00
397_D	405_P	0.589	1.00
312_V	316_L	0.589	1.00
69_T	412_V	0.588	1.00
130_P	135_W	0.588	1.00
86_A	222_D	0.588	1.00
95_N	99_G	0.588	1.00
77_V	225_T	0.587	1.00
219_L	222_D	0.587	1.00
425_T	428_L	0.586	1.00
300_N	303_A	0.585	1.00
34_Y	307_A	0.582	1.00
403_L	417_V	0.582	1.00
141_F	305_G	0.582	1.00
146_T	309_H	0.581	1.00
70_A	221_F	0.581	1.00
177_L	181_G	0.580	1.00
353_S	356_F	0.580	1.00
437_Y	443_R	0.579	1.00
125_L	141_F	0.577	1.00
336_K	341_A	0.577	1.00
61_L	211_A	0.575	1.00
59_Y	217_S	0.574	1.00
382_F	402_L	0.574	1.00
128_L	294_L	0.573	1.00
128_L	295_C	0.571	1.00
77_V	238_I	0.570	1.00
112_F	365_L	0.569	1.00
46_I	49_G	0.569	1.00
152_S	155_L	0.569	1.00
435_G	438_L	0.568	1.00
191_V	198_I	0.567	1.00
439_W	442_I	0.567	1.00
87_Y	99_G	0.567	1.00
200_E	203_H	0.566	1.00
384_H	388_R	0.565	1.00
255_A	259_F	0.565	1.00
403_L	411_T	0.565	1.00
419_L	425_T	0.565	1.00
86_A	226_T	0.564	1.00
190_T	199_S	0.563	1.00
46_I	360_V	0.563	1.00
206_P	209_T	0.562	1.00
195_Q	199_S	0.561	1.00
76_L	93_S	0.561	1.00
120_L	124_Y	0.561	1.00
156_V	310_A	0.561	1.00
62_A	215_C	0.561	1.00
231_T	238_I	0.559	1.00
62_A	218_F	0.558	1.00
434_G	442_I	0.558	1.00
234_A	237_V	0.558	1.00
248_Y	251_V	0.556	1.00
109_D	369_G	0.556	1.00
226_T	311_S	0.556	1.00
354_A	357_F	0.556	1.00
421_S	427_G	0.555	1.00
401_Y	416_W	0.554	1.00
32_L	164_V	0.554	1.00
31_G	35_L	0.554	1.00
341_A	344_V	0.553	1.00
275_A	278_P	0.550	1.00
387_R	391_M	0.547	1.00
43_T	363_T	0.546	1.00
161_T	165_L	0.544	1.00
157_A	306_L	0.544	1.00
427_G	434_G	0.542	1.00
164_V	167_Q	0.542	1.00
32_L	35_L	0.539	1.00
144_I	148_A	0.539	1.00
438_L	441_L	0.539	1.00
437_Y	444_R	0.538	1.00
25_W	28_V	0.538	1.00
141_F	302_L	0.537	1.00
166_V	170_I	0.537	1.00
346_M	350_V	0.536	1.00
102_V	373_A	0.536	1.00
117_N	301_T	0.536	1.00
394_S	397_D	0.536	1.00
248_Y	255_A	0.533	1.00
235_A	392_N	0.533	1.00
219_L	366_I	0.533	1.00
432_S	435_G	0.532	1.00
70_A	74_G	0.531	1.00
117_N	305_G	0.531	1.00
170_I	292_I	0.531	1.00
292_I	296_T	0.529	1.00
79_Q	389_K	0.526	1.00
124_Y	297_T	0.526	1.00
153_V	227_L	0.525	1.00
181_G	184_K	0.525	1.00
40_V	171_M	0.525	1.00
40_V	43_T	0.525	1.00
182_L	263_F	0.525	1.00
126_S	134_P	0.524	1.00
85_S	225_T	0.524	1.00
316_L	320_G	0.523	1.00
95_N	442_I	0.522	1.00
411_T	417_V	0.521	1.00
177_L	286_G	0.521	1.00
196_P	203_H	0.521	1.00
404_M	411_T	0.520	1.00
434_G	440_Y	0.519	1.00
259_F	262_L	0.519	1.00
236_R	239_P	0.518	1.00
128_L	298_F	0.516	1.00
155_L	159_F	0.515	1.00
397_D	402_L	0.515	1.00
281_A	285_G	0.514	1.00
34_Y	223_A	0.513	1.00
117_N	120_L	0.512	1.00
86_A	377_V	0.512	1.00
47_V	214_V	0.511	1.00
122_K	134_P	0.511	1.00
309_H	344_V	0.510	1.00
18_L	83_A	0.510	1.00
131_E	135_W	0.509	1.00
264_F	279_E	0.508	1.00
408_G	415_L	0.507	1.00
197_F	201_N	0.506	1.00
428_L	434_G	0.504	1.00
27_V	237_V	0.504	1.00
370_A	373_A	0.504	1.00
181_G	284_V	0.503	1.00
27_V	227_L	0.503	1.00
36_T	41_F	0.502	1.00
439_W	444_R	0.502	1.00
58_S	61_L	0.501	1.00
172_V	175_I	0.500	1.00
427_G	430_W	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3l1lA	2	0.8915	100	0.263	Contact Map
3giaA	1	0.9154	100	0.342	Contact Map
4djkA	2	0.8764	100	0.345	Contact Map
2jlnA	1	0.9089	99.1	0.841	Contact Map
3dh4A	3	0.9154	99.1	0.844	Contact Map
2xq2A	2	0.9154	99	0.85	Contact Map
4wgvA	2	0.7896	98.2	0.885	Contact Map
4xp4A	1	0.9197	97	0.909	Contact Map
4us3A	1	0.8416	96.9	0.911	Contact Map
2a65A	2	0.9089	96.3	0.917	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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