GREMLIN Database
PUUP - Putrescine importer PuuP
UniProt: P76037 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13907
Length: 461 (420)
Sequences: 24937 (16376)
Seq/√Len: 799.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
329_V342_L4.3891.00
146_T348_G4.3211.00
63_L250_G3.1481.00
332_Y342_L3.0761.00
236_R240_K2.9841.00
334_H337_W2.9261.00
23_K232_P2.8741.00
383_N387_R2.8471.00
87_Y322_D2.6671.00
231_T237_V2.6631.00
375_T409_A2.6431.00
233_D236_R2.6261.00
103_G319_M2.5651.00
178_V259_F2.5571.00
329_V332_Y2.5351.00
334_H341_A2.4781.00
28_V244_L2.4431.00
320_G331_G2.4331.00
24_L244_L2.3791.00
176_F180_Q2.3221.00
288_L292_I2.2391.00
91_Q99_G2.2131.00
229_E321_R2.2131.00
75_K385_F2.2041.00
230_E314_R2.1301.00
24_L237_V2.1131.00
345_I349_I2.0931.00
317_Y321_R2.0881.00
279_E282_L2.0681.00
139_V355_L2.0681.00
27_V231_T2.0651.00
147_A151_K2.0531.00
154_N158_N2.0431.00
24_L28_V2.0291.00
150_L341_A2.0161.00
146_T344_V2.0141.00
240_K244_L1.9791.00
406_L410_L1.9751.00
403_L407_V1.9701.00
436_A440_Y1.9631.00
91_Q96_P1.9581.00
323_N327_E1.9541.00
72_S378_N1.9471.00
165_L169_S1.9131.00
107_L347_V1.9091.00
18_L333_V1.9051.00
401_Y405_P1.8971.00
23_K26_Q1.8861.00
47_V55_V1.8781.00
139_V352_L1.8591.00
94_I383_N1.8471.00
378_N408_G1.8191.00
64_A68_F1.8101.00
330_F346_M1.8071.00
130_P133_P1.7961.00
94_I379_L1.7931.00
233_D237_V1.7871.00
279_E283_Y1.7771.00
243_F247_V1.7171.00
420_E423_S1.7081.00
102_V376_F1.6981.00
193_S196_P1.6941.00
269_R283_Y1.6921.00
26_Q161_T1.6861.00
169_S173_V1.6861.00
90_A102_V1.6861.00
143_A348_G1.6851.00
149_N306_L1.6381.00
337_W341_A1.6251.00
421_S424_L1.6021.00
58_S210_G1.5891.00
334_H339_T1.5821.00
150_L345_I1.5701.00
410_L414_V1.5651.00
95_N98_V1.5651.00
28_V248_Y1.5621.00
54_H207_I1.5601.00
399_F404_M1.5381.00
22_L26_Q1.5371.00
435_G439_W1.5271.00
383_N386_W1.5241.00
138_V355_L1.5201.00
342_L346_M1.5141.00
31_G245_T1.5061.00
104_W434_G1.5031.00
196_P199_S1.5011.00
118_V305_G1.5001.00
193_S199_S1.4921.00
227_L310_A1.4871.00
428_L432_S1.4731.00
247_V251_V1.4711.00
430_W434_G1.4691.00
191_V194_L1.4641.00
190_T194_L1.4571.00
125_L137_W1.4541.00
151_K337_W1.4311.00
133_P136_V1.4291.00
118_V142_V1.4241.00
388_R391_M1.4171.00
282_L290_Q1.4151.00
312_V347_V1.4091.00
121_A141_F1.4001.00
90_A376_F1.4001.00
317_Y333_V1.3931.00
64_A407_V1.3901.00
379_L383_N1.3891.00
70_A246_A1.3871.00
282_L287_K1.3871.00
316_L343_N1.3861.00
62_A214_V1.3841.00
291_S295_C1.3831.00
121_A298_F1.3811.00
327_E331_G1.3801.00
146_T345_I1.3761.00
18_L317_Y1.3761.00
412_V415_L1.3701.00
405_P409_A1.3681.00
26_Q157_A1.3681.00
233_D240_K1.3631.00
265_P268_S1.3521.00
399_F402_L1.3491.00
170_I296_T1.3491.00
179_V259_F1.3421.00
19_R338_R1.3421.00
439_W443_R1.3381.00
168_I172_V1.3381.00
402_L406_L1.3371.00
440_Y443_R1.3251.00
420_E424_L1.3251.00
68_F407_V1.3251.00
332_Y341_A1.3221.00
440_Y444_R1.3221.00
265_P269_R1.3211.00
139_V143_A1.3211.00
24_L240_K1.3191.00
418_N421_S1.3151.00
421_S425_T1.3131.00
94_I98_V1.3041.00
313_S344_V1.3031.00
142_V348_G1.2991.00
419_L424_L1.2961.00
65_G411_T1.2951.00
234_A239_P1.2941.00
194_L197_F1.2831.00
25_W29_M1.2721.00
70_A242_I1.2721.00
175_I255_A1.2721.00
80_F92_K1.2701.00
285_G289_F1.2671.00
83_A229_E1.2641.00
251_V255_A1.2591.00
182_L262_L1.2501.00
190_T195_Q1.2501.00
413_G417_V1.2491.00
69_T378_N1.2481.00
191_V196_P1.2481.00
237_V240_K1.2441.00
22_L27_V1.2381.00
22_L157_A1.2371.00
178_V263_F1.2331.00
145_L305_G1.2331.00
42_D120_L1.2231.00
88_T92_K1.2181.00
117_N304_S1.2161.00
437_Y440_Y1.2141.00
143_A352_L1.2101.00
93_S380_S1.2041.00
192_W195_Q1.2021.00
35_L249_G1.1981.00
56_P258_F1.1951.00
196_P200_E1.1901.00
142_V351_A1.1901.00
71_I243_F1.1871.00
405_P411_T1.1831.00
326_P329_V1.1661.00
180_Q185_G1.1621.00
429_V433_L1.1611.00
342_L345_I1.1571.00
190_T193_S1.1501.00
114_P351_A1.1441.00
107_L316_L1.1391.00
73_Y86_A1.1341.00
426_L429_V1.1331.00
82_E88_T1.1311.00
273_P279_E1.1291.00
32_L248_Y1.1221.00
316_L325_F1.1211.00
327_E332_Y1.1161.00
405_P412_V1.1101.00
190_T196_P1.1101.00
193_S198_I1.1081.00
419_L423_S1.0961.00
79_Q393_K1.0961.00
379_L409_A1.0951.00
97_H441_L1.0921.00
437_Y441_L1.0891.00
27_V241_A1.0861.00
174_F178_V1.0861.00
48_S55_V1.0851.00
232_P237_V1.0851.00
90_A98_V1.0831.00
321_R331_G1.0811.00
77_V89_Y1.0781.00
148_A159_F1.0771.00
72_S405_P1.0751.00
31_G224_V1.0731.00
408_G411_T1.0721.00
125_L298_F1.0721.00
403_L406_L1.0661.00
422_T425_T1.0651.00
179_V183_H1.0621.00
125_L129_F1.0601.00
192_W196_P1.0591.00
419_L422_T1.0571.00
408_G412_V1.0551.00
173_V177_L1.0481.00
172_V176_F1.0481.00
266_D269_R1.0471.00
333_V338_R1.0471.00
197_F200_E1.0461.00
265_P283_Y1.0451.00
21_S232_P1.0441.00
158_N162_L1.0431.00
432_S436_A1.0371.00
30_M227_L1.0341.00
434_G437_Y1.0331.00
180_Q184_K1.0281.00
92_K388_R1.0231.00
140_T144_I1.0221.00
159_F163_F1.0201.00
132_V136_V1.0181.00
79_Q391_M1.0121.00
136_V140_T1.0081.00
402_L405_P1.0071.00
122_K137_W1.0071.00
160_N306_L1.0051.00
82_E92_K1.0051.00
75_K78_R1.0011.00
198_I201_N0.9981.00
143_A147_A0.9951.00
412_V416_W0.9901.00
194_L199_S0.9891.00
32_L249_G0.9861.00
100_F104_W0.9811.00
60_L254_I0.9811.00
191_V195_Q0.9721.00
146_T150_L0.9711.00
389_K392_N0.9681.00
409_A412_V0.9671.00
204_L207_I0.9591.00
104_W325_F0.9521.00
386_W389_K0.9451.00
87_Y318_V0.9421.00
401_Y404_M0.9401.00
219_L370_A0.9391.00
414_V417_V0.9381.00
391_M394_S0.9371.00
150_L339_T0.9371.00
382_F406_L0.9371.00
163_F303_A0.9331.00
29_M161_T0.9321.00
389_K393_K0.9291.00
116_I363_T0.9221.00
258_F262_L0.9211.00
393_K396_K0.9201.00
132_V135_W0.9191.00
418_N424_L0.9151.00
325_F330_F0.9141.00
135_W139_V0.9141.00
153_V310_A0.9141.00
228_S238_I0.9131.00
54_H198_I0.9081.00
427_G431_A0.9071.00
122_K138_V0.9071.00
422_T426_L0.9021.00
174_F281_A0.9001.00
175_I259_F0.8951.00
97_H435_G0.8951.00
222_D226_T0.8931.00
275_A279_E0.8901.00
97_H101_M0.8891.00
441_L444_R0.8891.00
244_L248_Y0.8881.00
144_I302_L0.8861.00
425_T429_V0.8841.00
21_S154_N0.8831.00
145_L306_L0.8801.00
375_T413_G0.8791.00
396_K399_F0.8761.00
250_G254_I0.8741.00
56_P261_Q0.8731.00
429_V432_S0.8721.00
368_F427_G0.8721.00
63_L218_F0.8711.00
26_Q158_N0.8711.00
381_V405_P0.8681.00
433_L437_Y0.8641.00
168_I252_I0.8641.00
167_Q300_N0.8621.00
404_M408_G0.8611.00
150_L334_H0.8591.00
330_F342_L0.8571.00
341_A345_I0.8521.00
411_T415_L0.8511.00
405_P416_W0.8501.00
84_G88_T0.8451.00
196_P201_N0.8441.00
375_T379_L0.8431.00
121_A302_L0.8421.00
91_Q322_D0.8391.00
309_H348_G0.8381.00
25_W161_T0.8331.00
273_P276_A0.8321.00
18_L230_E0.8311.00
18_L314_R0.8301.00
395_W398_H0.8281.00
398_H403_L0.8271.00
121_A301_T0.8231.00
116_I216_F0.8201.00
204_L208_I0.8191.00
390_G393_K0.8171.00
405_P408_G0.8171.00
409_A413_G0.8101.00
349_I353_S0.8091.00
399_F405_P0.8061.00
84_G87_Y0.8041.00
263_F280_I0.8031.00
57_A207_I0.8021.00
424_L427_G0.7981.00
78_R394_S0.7981.00
365_L369_G0.7981.00
175_I179_V0.7971.00
410_L413_G0.7951.00
223_A311_S0.7941.00
24_L241_A0.7901.00
194_L198_I0.7891.00
182_L185_G0.7881.00
398_H401_Y0.7871.00
158_N161_T0.7841.00
179_V255_A0.7811.00
131_E134_P0.7771.00
209_T213_I0.7761.00
180_Q183_H0.7751.00
137_W140_T0.7741.00
239_P242_I0.7701.00
98_V376_F0.7701.00
394_S398_H0.7701.00
411_T416_W0.7701.00
405_P417_V0.7661.00
151_K155_L0.7661.00
67_L71_I0.7661.00
428_L431_A0.7591.00
145_L309_H0.7571.00
385_F389_K0.7551.00
424_L428_L0.7541.00
28_V241_A0.7531.00
79_Q394_S0.7511.00
147_A150_L0.7501.00
401_Y409_A0.7501.00
352_L355_L0.7491.00
60_L64_A0.7491.00
399_F403_L0.7481.00
387_R390_G0.7461.00
67_L243_F0.7461.00
381_V385_F0.7461.00
21_S153_V0.7421.00
420_E425_T0.7401.00
76_L381_V0.7381.00
352_L356_F0.7351.00
406_L409_A0.7321.00
191_V197_F0.7321.00
382_F405_P0.7311.00
111_L350_V0.7281.00
286_G289_F0.7271.00
35_L245_T0.7251.00
434_G438_L0.7201.00
53_G261_Q0.7191.00
219_L374_F0.7191.00
334_H338_R0.7181.00
203_H206_P0.7121.00
90_A380_S0.7091.00
382_F386_W0.7081.00
288_L291_S0.7071.00
122_K125_L0.7051.00
208_I414_V0.7031.00
93_S383_N0.7011.00
119_L362_A0.6991.00
47_V51_S0.6981.00
397_D401_Y0.6971.00
76_L89_Y0.6971.00
358_D361_T0.6961.00
401_Y408_G0.6941.00
36_T167_Q0.6941.00
287_K291_S0.6921.00
182_L259_F0.6901.00
36_T252_I0.6891.00
175_I256_A0.6871.00
68_F72_S0.6871.00
25_W158_N0.6861.00
87_Y91_Q0.6851.00
329_V346_M0.6851.00
406_L417_V0.6831.00
36_T39_T0.6801.00
309_H313_S0.6791.00
198_I207_I0.6781.00
351_A354_A0.6781.00
94_I380_S0.6771.00
40_V256_A0.6761.00
56_P60_L0.6751.00
386_W402_L0.6741.00
320_G330_F0.6741.00
57_A60_L0.6741.00
329_V333_V0.6731.00
233_D239_P0.6721.00
193_S197_F0.6721.00
430_W437_Y0.6711.00
316_L346_M0.6711.00
268_S272_D0.6691.00
66_V221_F0.6681.00
198_I203_H0.6631.00
340_P343_N0.6631.00
269_R272_D0.6621.00
149_N344_V0.6611.00
73_Y377_V0.6611.00
57_A61_L0.6601.00
28_V31_G0.6601.00
195_Q198_I0.6591.00
75_K398_H0.6591.00
348_G352_L0.6591.00
407_V411_T0.6591.00
68_F404_M0.6561.00
407_V410_L0.6541.00
380_S384_H0.6521.00
21_S25_W0.6501.00
109_D370_A0.6501.00
110_Y308_S0.6461.00
402_L417_V0.6461.00
106_S110_Y0.6451.00
397_D404_M0.6451.00
177_L285_G0.6421.00
423_S426_L0.6401.00
431_A434_G0.6401.00
394_S399_F0.6391.00
360_V363_T0.6391.00
155_L158_N0.6381.00
438_L442_I0.6371.00
93_S384_H0.6371.00
433_L436_A0.6361.00
113_L366_I0.6361.00
430_W433_L0.6341.00
87_Y103_G0.6321.00
143_A146_T0.6311.00
248_Y252_I0.6291.00
157_A161_T0.6291.00
314_R317_Y0.6291.00
142_V355_L0.6291.00
150_L337_W0.6291.00
150_L344_V0.6281.00
44_F257_S0.6261.00
83_A317_Y0.6251.00
111_L347_V0.6251.00
436_A439_W0.6241.00
225_T242_I0.6241.00
404_M407_V0.6231.00
105_S373_A0.6221.00
17_R20_K0.6221.00
378_N409_A0.6191.00
115_M362_A0.6191.00
33_A164_V0.6181.00
313_S343_N0.6151.00
183_H191_V0.6131.00
56_P254_I0.6131.00
145_L302_L0.6101.00
256_A260_M0.6101.00
166_V296_T0.6101.00
238_I242_I0.6101.00
256_A277_L0.6091.00
428_L443_R0.6091.00
401_Y406_L0.6081.00
34_Y308_S0.6071.00
229_E317_Y0.6071.00
50_I209_T0.6061.00
423_S427_G0.6051.00
431_A435_G0.6051.00
74_G78_R0.6041.00
149_N310_A0.6031.00
55_V257_S0.6031.00
118_V122_K0.6021.00
127_A294_L0.6021.00
71_I398_H0.6011.00
18_L21_S0.6011.00
113_L116_I0.6001.00
401_Y415_L0.5991.00
330_F343_N0.5991.00
244_L247_V0.5971.00
369_G373_A0.5961.00
401_Y417_V0.5961.00
393_K397_D0.5951.00
426_L430_W0.5911.00
421_S428_L0.5901.00
295_C299_V0.5901.00
397_D405_P0.5891.00
312_V316_L0.5891.00
69_T412_V0.5881.00
130_P135_W0.5881.00
86_A222_D0.5881.00
95_N99_G0.5881.00
77_V225_T0.5871.00
219_L222_D0.5871.00
425_T428_L0.5861.00
300_N303_A0.5851.00
34_Y307_A0.5821.00
403_L417_V0.5821.00
141_F305_G0.5821.00
146_T309_H0.5811.00
70_A221_F0.5811.00
177_L181_G0.5801.00
353_S356_F0.5801.00
437_Y443_R0.5791.00
125_L141_F0.5771.00
336_K341_A0.5771.00
61_L211_A0.5751.00
59_Y217_S0.5741.00
382_F402_L0.5741.00
128_L294_L0.5731.00
128_L295_C0.5711.00
77_V238_I0.5701.00
112_F365_L0.5691.00
46_I49_G0.5691.00
152_S155_L0.5691.00
435_G438_L0.5681.00
191_V198_I0.5671.00
439_W442_I0.5671.00
87_Y99_G0.5671.00
200_E203_H0.5661.00
384_H388_R0.5651.00
255_A259_F0.5651.00
403_L411_T0.5651.00
419_L425_T0.5651.00
86_A226_T0.5641.00
190_T199_S0.5631.00
46_I360_V0.5631.00
206_P209_T0.5621.00
195_Q199_S0.5611.00
76_L93_S0.5611.00
120_L124_Y0.5611.00
156_V310_A0.5611.00
62_A215_C0.5611.00
231_T238_I0.5591.00
62_A218_F0.5581.00
434_G442_I0.5581.00
234_A237_V0.5581.00
248_Y251_V0.5561.00
109_D369_G0.5561.00
226_T311_S0.5561.00
354_A357_F0.5561.00
421_S427_G0.5551.00
401_Y416_W0.5541.00
32_L164_V0.5541.00
31_G35_L0.5541.00
341_A344_V0.5531.00
275_A278_P0.5501.00
387_R391_M0.5471.00
43_T363_T0.5461.00
161_T165_L0.5441.00
157_A306_L0.5441.00
427_G434_G0.5421.00
164_V167_Q0.5421.00
32_L35_L0.5391.00
144_I148_A0.5391.00
438_L441_L0.5391.00
437_Y444_R0.5381.00
25_W28_V0.5381.00
141_F302_L0.5371.00
166_V170_I0.5371.00
346_M350_V0.5361.00
102_V373_A0.5361.00
117_N301_T0.5361.00
394_S397_D0.5361.00
248_Y255_A0.5331.00
235_A392_N0.5331.00
219_L366_I0.5331.00
432_S435_G0.5321.00
70_A74_G0.5311.00
117_N305_G0.5311.00
170_I292_I0.5311.00
292_I296_T0.5291.00
79_Q389_K0.5261.00
124_Y297_T0.5261.00
153_V227_L0.5251.00
181_G184_K0.5251.00
40_V171_M0.5251.00
40_V43_T0.5251.00
182_L263_F0.5251.00
126_S134_P0.5241.00
85_S225_T0.5241.00
316_L320_G0.5231.00
95_N442_I0.5221.00
411_T417_V0.5211.00
177_L286_G0.5211.00
196_P203_H0.5211.00
404_M411_T0.5201.00
434_G440_Y0.5191.00
259_F262_L0.5191.00
236_R239_P0.5181.00
128_L298_F0.5161.00
155_L159_F0.5151.00
397_D402_L0.5151.00
281_A285_G0.5141.00
34_Y223_A0.5131.00
117_N120_L0.5121.00
86_A377_V0.5121.00
47_V214_V0.5111.00
122_K134_P0.5111.00
309_H344_V0.5101.00
18_L83_A0.5101.00
131_E135_W0.5091.00
264_F279_E0.5081.00
408_G415_L0.5071.00
197_F201_N0.5061.00
428_L434_G0.5041.00
27_V237_V0.5041.00
370_A373_A0.5041.00
181_G284_V0.5031.00
27_V227_L0.5031.00
36_T41_F0.5021.00
439_W444_R0.5021.00
58_S61_L0.5011.00
172_V175_I0.5001.00
427_G430_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8915 100 0.263 Contact Map
3giaA 1 0.9154 100 0.342 Contact Map
4djkA 2 0.8764 100 0.345 Contact Map
2jlnA 1 0.9089 99.1 0.841 Contact Map
3dh4A 3 0.9154 99.1 0.844 Contact Map
2xq2A 2 0.9154 99 0.85 Contact Map
4wgvA 2 0.7896 98.2 0.885 Contact Map
4xp4A 1 0.9197 97 0.909 Contact Map
4us3A 1 0.8416 96.9 0.911 Contact Map
2a65A 2 0.9089 96.3 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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