GREMLIN Database
YCIW - Uncharacterized protein YciW
UniProt: P76035 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14262
Length: 375 (337)
Sequences: 191 (147)
Seq/√Len: 8.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_Y164_S6.4611.00
281_C365_N4.2340.98
84_E124_R4.0790.98
322_A333_F3.9360.97
207_D290_N3.6540.95
300_R304_N3.5170.94
342_L348_S3.0550.88
64_A172_F3.0100.88
347_S350_Q2.8960.85
179_T355_L2.8720.85
60_A172_F2.7850.83
325_W337_Q2.6850.81
95_V136_A2.6440.80
266_Q285_C2.5210.76
79_T159_D2.5120.76
216_Y323_I2.4550.74
210_L259_G2.4350.73
276_N281_C2.4030.72
90_L109_L2.2980.69
107_A111_P2.1940.65
43_V51_A2.1730.64
269_A281_C2.1660.64
276_N365_N2.1580.64
138_S141_I2.1570.64
182_A333_F2.1420.63
68_F176_T2.0790.61
220_K223_E2.0680.60
269_A365_N2.0380.59
94_Q111_P1.9930.57
93_A334_S1.9860.57
133_R178_A1.9830.57
105_Y277_G1.9480.55
187_P192_P1.9350.55
158_W242_L1.9320.55
265_N285_C1.8820.53
250_L364_I1.8780.53
83_Y192_P1.8670.52
167_I170_I1.8630.52
195_E198_N1.8430.51
351_I358_S1.8420.51
220_K224_E1.8360.51
97_G193_G1.8220.50
42_D45_L1.7830.49
128_I155_L1.7430.47
171_G362_G1.7390.47
94_Q102_C1.7390.47
236_L273_A1.7040.45
271_L359_G1.7030.45
303_E360_L1.6940.45
106_S115_P1.6840.45
243_H246_S1.6680.44
142_I370_A1.6280.42
219_E224_E1.6280.42
63_L66_D1.6210.42
336_A354_L1.6160.42
92_V124_R1.6160.42
264_D270_L1.6140.42
236_L250_L1.6090.42
268_A272_C1.5730.40
301_K304_N1.5610.40
147_R164_S1.5480.39
144_N205_F1.5470.39
181_Q354_L1.5360.39
39_F109_L1.5330.39
279_P298_L1.5270.38
168_G174_A1.5180.38
295_I298_L1.5160.38
238_E269_A1.5080.38
161_V344_H1.4980.37
353_N361_C1.4860.37
315_V318_A1.4750.36
172_F180_F1.4700.36
131_Y270_L1.4700.36
270_L357_W1.4690.36
274_R327_T1.4640.36
127_Q153_V1.4510.35
284_T353_N1.4480.35
131_Y298_L1.4360.35
52_P110_T1.4320.35
188_V193_G1.4300.35
143_D146_S1.4170.34
146_S287_D1.4110.34
85_R330_P1.4080.34
63_L68_F1.4020.34
224_E232_E1.3950.33
173_Q277_G1.3820.33
364_I369_I1.3790.33
102_C192_P1.3610.32
225_H348_S1.3610.32
82_A138_S1.3520.32
80_F84_E1.3460.32
80_F155_L1.3450.32
231_A241_S1.3350.31
91_T142_I1.3140.31
104_Y111_P1.3110.30
133_R182_A1.3090.30
39_F43_V1.2970.30
159_D340_P1.2840.30
86_L109_L1.2830.29
259_G284_T1.2790.29
237_A360_L1.2740.29
97_G136_A1.2730.29
112_L131_Y1.2690.29
210_L353_N1.2610.29
290_N296_S1.2590.29
51_A269_A1.2510.28
325_W329_A1.2490.28
238_E242_L1.2470.28
215_S364_I1.2470.28
336_A343_E1.2450.28
90_L133_R1.2320.28
80_F172_F1.2250.28
125_L202_A1.2230.27
86_L108_R1.2220.27
180_F263_P1.2120.27
130_Q168_G1.1760.26
237_A303_E1.1760.26
259_G265_N1.1680.26
364_I368_K1.1640.26
286_M290_N1.1570.25
112_L178_A1.1520.25
148_Q176_T1.1510.25
85_R173_Q1.1500.25
183_Y355_L1.1470.25
322_A351_I1.1470.25
176_T327_T1.1440.25
339_S343_E1.1420.25
92_V126_A1.1270.24
103_N117_S1.1140.24
86_L90_L1.1090.24
285_C364_I1.1080.24
109_L125_L1.1060.24
90_L192_P1.1050.24
178_A182_A1.1040.24
101_L253_L1.0990.24
90_L178_A1.0950.23
136_A168_G1.0920.23
234_C283_A1.0880.23
53_F351_I1.0860.23
281_C371_L1.0800.23
266_Q278_S1.0750.23
206_A286_M1.0740.23
146_S226_T1.0720.23
132_A160_C1.0720.23
104_Y124_R1.0700.23
97_G192_P1.0700.23
59_P312_R1.0630.23
106_S355_L1.0610.23
265_N353_N1.0610.23
133_R277_G1.0580.22
103_N181_Q1.0550.22
86_L94_Q1.0530.22
152_D193_G1.0520.22
268_A323_I1.0520.22
91_T333_F1.0460.22
80_F238_E1.0460.22
173_Q330_P1.0430.22
302_G309_W1.0350.22
131_Y358_S1.0280.22
42_D337_Q1.0210.21
236_L259_G1.0200.21
126_A138_S1.0200.21
85_R247_L1.0140.21
98_V168_G1.0130.21
96_C359_G1.0100.21
172_F238_E1.0090.21
365_N371_L1.0040.21
37_D133_R1.0030.21
186_H220_K1.0000.21
95_V274_R0.9890.21
214_S220_K0.9870.20
221_L224_E0.9760.20
155_L182_A0.9740.20
91_T170_I0.9730.20
221_L370_A0.9710.20
272_C323_I0.9680.20
67_L172_F0.9680.20
187_P193_G0.9660.20
239_I256_S0.9590.20
260_N346_K0.9590.20
64_A244_P0.9550.20
301_K355_L0.9540.20
256_S360_L0.9530.20
80_F124_R0.9500.19
101_L275_I0.9490.19
97_G178_A0.9490.19
272_C352_I0.9480.19
64_A176_T0.9420.19
55_S106_S0.9400.19
41_L130_Q0.9400.19
215_S266_Q0.9380.19
64_A369_I0.9370.19
140_S163_I0.9340.19
187_P319_T0.9320.19
163_I179_T0.9310.19
237_A369_I0.9290.19
105_Y173_Q0.9260.19
333_F358_S0.9240.19
271_L320_V0.9220.19
255_N292_Y0.9210.19
162_I243_H0.9210.19
99_Q103_N0.9130.19
179_T284_T0.9130.19
259_G286_M0.9130.19
87_S159_D0.9120.19
41_L121_S0.9100.18
281_C368_K0.9080.18
181_Q362_G0.9060.18
111_P332_R0.9050.18
86_L105_Y0.9050.18
252_K292_Y0.9010.18
240_L247_L0.8960.18
269_A353_N0.8910.18
80_F163_I0.8910.18
210_L283_A0.8880.18
55_S253_L0.8840.18
365_N369_I0.8810.18
161_V257_T0.8790.18
301_K310_A0.8790.18
109_L138_S0.8760.18
301_K311_D0.8730.18
176_T292_Y0.8710.18
59_P147_R0.8640.17
206_A353_N0.8610.17
99_Q102_C0.8590.17
171_G270_L0.8580.17
108_R122_N0.8580.17
238_E283_A0.8560.17
250_L273_A0.8550.17
164_S264_D0.8540.17
61_R332_R0.8510.17
283_A368_K0.8510.17
262_Q265_N0.8480.17
272_C298_L0.8390.17
162_I287_D0.8370.17
66_D286_M0.8360.17
84_E170_I0.8330.17
60_A356_V0.8310.17
124_R340_P0.8310.17
262_Q285_C0.8300.17
87_S138_S0.8300.17
128_I178_A0.8300.17
183_Y329_A0.8260.16
205_F214_S0.8240.16
170_I225_H0.8230.16
145_R270_L0.8220.16
210_L262_Q0.8210.16
239_I269_A0.8160.16
214_S238_E0.8120.16
135_L277_G0.8080.16
162_I238_E0.8050.16
365_N368_K0.8040.16
96_C172_F0.8030.16
256_S272_C0.8030.16
113_P314_S0.8010.16
227_K323_I0.8000.16
122_N155_L0.7970.16
83_Y111_P0.7970.16
213_R327_T0.7890.16
99_Q159_D0.7880.16
284_T361_C0.7850.16
95_V174_A0.7840.16
274_R288_S0.7840.16
210_L265_N0.7840.16
65_V262_Q0.7830.16
99_Q122_N0.7830.16
177_I221_L0.7810.16
60_A369_I0.7800.15
280_A365_N0.7770.15
92_V106_S0.7750.15
124_R156_T0.7730.15
72_L268_A0.7720.15
83_Y94_Q0.7720.15
247_L330_P0.7700.15
271_L313_H0.7690.15
41_L120_E0.7670.15
79_T114_G0.7660.15
250_L259_G0.7640.15
110_T335_A0.7630.15
214_S263_P0.7620.15
72_L351_I0.7620.15
86_L136_A0.7580.15
215_S285_C0.7570.15
198_N344_H0.7560.15
93_A193_G0.7550.15
212_W372_G0.7540.15
231_A237_A0.7530.15
192_P332_R0.7520.15
274_R333_F0.7520.15
309_W319_T0.7480.15
259_G280_A0.7460.15
118_T121_S0.7460.15
269_A276_N0.7440.15
216_Y319_T0.7410.15
117_S189_R0.7390.15
161_V347_S0.7370.15
100_R332_R0.7360.15
84_E95_V0.7360.15
85_R132_A0.7310.14
136_A334_S0.7280.14
229_S248_S0.7270.14
200_A328_R0.7260.14
100_R156_T0.7260.14
265_N269_A0.7260.14
225_H323_I0.7240.14
179_T292_Y0.7230.14
122_N133_R0.7220.14
280_A368_K0.7220.14
37_D41_L0.7210.14
71_Q285_C0.7200.14
36_S266_Q0.7190.14
206_A315_V0.7160.14
103_N121_S0.7150.14
250_L280_A0.7140.14
210_L269_A0.7140.14
236_L364_I0.7130.14
162_I209_S0.7130.14
107_A114_G0.7120.14
130_Q185_G0.7070.14
86_L104_Y0.7060.14
254_L360_L0.7060.14
218_V338_F0.7050.14
245_I248_S0.7050.14
234_C269_A0.7020.14
235_Q243_H0.7020.14
122_N129_T0.7010.14
224_E370_A0.6980.14
263_P342_L0.6970.14
113_P297_T0.6970.14
251_E370_A0.6960.14
134_Q278_S0.6950.14
117_S233_L0.6900.14
248_S349_T0.6890.14
136_A140_S0.6880.14
283_A361_C0.6850.14
83_Y134_Q0.6810.13
195_E199_Y0.6810.13
256_S303_E0.6800.13
108_R178_A0.6780.13
82_A163_I0.6770.13
133_R141_I0.6760.13
333_F351_I0.6760.13
179_T250_L0.6740.13
234_C361_C0.6720.13
122_N192_P0.6720.13
288_S312_R0.6710.13
107_A112_L0.6710.13
210_L284_T0.6680.13
79_T90_L0.6670.13
103_N114_G0.6660.13
166_I351_I0.6660.13
273_A353_N0.6650.13
266_Q361_C0.6640.13
112_L275_I0.6620.13
206_A350_Q0.6620.13
328_R333_F0.6610.13
219_E241_S0.6600.13
87_S90_L0.6590.13
91_T133_R0.6590.13
351_I355_L0.6570.13
268_A271_L0.6550.13
109_L167_I0.6550.13
301_K335_A0.6540.13
128_I360_L0.6500.13
82_A126_A0.6500.13
202_A303_E0.6490.13
71_Q266_Q0.6470.13
173_Q247_L0.6470.13
166_I347_S0.6470.13
37_D164_S0.6450.13
153_V369_I0.6430.13
79_T99_Q0.6410.13
41_L129_T0.6400.13
130_Q149_H0.6390.13
65_V173_Q0.6370.13
133_R170_I0.6340.13
101_L182_A0.6330.13
212_W326_L0.6320.13
81_T100_R0.6320.13
278_S285_C0.6310.13
204_L373_E0.6300.13
184_L296_S0.6280.12
171_G267_L0.6210.12
87_S130_Q0.6200.12
68_F104_Y0.6190.12
104_Y178_A0.6180.12
81_T109_L0.6170.12
133_R136_A0.6170.12
241_S346_K0.6170.12
189_R193_G0.6160.12
156_T296_S0.6150.12
124_R233_L0.6150.12
157_A216_Y0.6140.12
79_T124_R0.6130.12
102_C106_S0.6110.12
317_R362_G0.6110.12
207_D229_S0.6100.12
82_A370_A0.6100.12
93_A152_D0.6060.12
224_E360_L0.6040.12
87_S129_T0.6030.12
54_L65_V0.6020.12
260_N284_T0.6000.12
83_Y87_S0.6000.12
91_T94_Q0.5990.12
94_Q332_R0.5960.12
167_I188_V0.5960.12
52_P314_S0.5950.12
270_L359_G0.5950.12
329_A362_G0.5940.12
242_L309_W0.5940.12
186_H190_W0.5930.12
74_V288_S0.5930.12
262_Q266_Q0.5920.12
192_P200_A0.5920.12
42_D79_T0.5900.12
131_Y355_L0.5880.12
264_D318_A0.5880.12
161_V335_A0.5870.12
133_R177_I0.5870.12
69_P332_R0.5850.12
253_L292_Y0.5840.12
123_H164_S0.5840.12
109_L112_L0.5820.12
259_G283_A0.5810.12
105_Y109_L0.5810.12
108_R121_S0.5800.12
85_R124_R0.5800.12
348_S351_I0.5770.12
98_V131_Y0.5720.12
250_L282_F0.5700.11
273_A282_F0.5700.11
243_H306_I0.5690.11
64_A144_N0.5680.11
64_A84_E0.5670.11
90_L355_L0.5650.11
285_C353_N0.5650.11
109_L277_G0.5640.11
108_R111_P0.5630.11
76_R168_G0.5630.11
94_Q106_S0.5600.11
305_E323_I0.5590.11
39_F100_R0.5570.11
339_S357_W0.5570.11
80_F170_I0.5570.11
74_V78_Q0.5540.11
42_D359_G0.5540.11
94_Q133_R0.5540.11
222_P323_I0.5520.11
282_F285_C0.5520.11
183_Y323_I0.5490.11
222_P297_T0.5480.11
165_Q371_L0.5470.11
73_T218_V0.5470.11
90_L98_V0.5440.11
97_G191_L0.5440.11
49_T273_A0.5440.11
93_A143_D0.5440.11
142_I224_E0.5440.11
206_A259_G0.5440.11
69_P178_A0.5430.11
102_C108_R0.5410.11
98_V328_R0.5410.11
106_S109_L0.5400.11
159_D326_L0.5400.11
210_L282_F0.5390.11
79_T200_A0.5360.11
241_S316_E0.5340.11
155_L166_I0.5340.11
80_F96_C0.5340.11
105_Y135_L0.5320.11
62_V329_A0.5320.11
66_D226_T0.5300.11
71_Q284_T0.5280.11
69_P129_T0.5240.11
189_R332_R0.5240.11
115_P119_R0.5230.11
190_W200_A0.5230.11
124_R173_Q0.5220.11
172_F242_L0.5200.11
97_G129_T0.5190.11
149_H305_E0.5180.11
152_D163_I0.5180.11
260_N266_Q0.5180.11
262_Q374_T0.5170.11
83_Y127_Q0.5160.11
41_L79_T0.5140.11
264_D368_K0.5130.11
215_S369_I0.5130.11
70_D77_S0.5110.11
128_I153_V0.5110.11
98_V136_A0.5110.11
63_L86_L0.5090.11
95_V159_D0.5090.11
260_N286_M0.5080.11
114_G120_E0.5080.11
115_P118_T0.5070.10
237_A254_L0.5060.10
177_I226_T0.5050.10
108_R200_A0.5040.10
99_Q332_R0.5030.10
134_Q146_S0.5020.10
42_D97_G0.5020.10
101_L174_A0.5020.10
92_V121_S0.5020.10
89_A341_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oyoA 4 0.4373 99.9 0.834 Contact Map
2prrA 5 0.4453 99.9 0.834 Contact Map
2pfxA 3 0.4507 99.9 0.838 Contact Map
3c1lA 5 0.4667 99.9 0.84 Contact Map
3lvyA 2 0.4267 99.9 0.846 Contact Map
2gmyA 3 0.376 99.9 0.848 Contact Map
2o4dA 3 0.3733 99.9 0.856 Contact Map
3bjxA 2 0.7333 99.8 0.871 Contact Map
2ouwA 6 0.296 99.6 0.892 Contact Map
4n2xA 4 0.6747 99.5 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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