GREMLIN Database
YCIT - Uncharacterized HTH-type transcriptional regulator YciT
UniProt: P76034 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13905
Length: 249 (241)
Sequences: 7675 (5591)
Seq/√Len: 360.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_E162_K3.3131.00
79_F82_S3.1341.00
101_L200_L2.9531.00
131_E138_V2.7521.00
163_A194_E2.6111.00
11_M26_A2.3731.00
93_E187_V2.3421.00
203_S226_D2.2591.00
191_L215_G2.2511.00
103_R124_L2.2231.00
198_I222_R2.1221.00
156_Q189_A2.1111.00
85_Q88_E2.0991.00
7_T10_Q2.0521.00
11_M15_Q2.0331.00
162_K198_I2.0141.00
74_R100_L2.0111.00
78_E104_T1.9951.00
91_F160_F1.9751.00
191_L197_A1.9691.00
213_S216_P1.9401.00
153_Q156_Q1.9291.00
92_I98_N1.9291.00
162_K196_E1.8611.00
91_F190_V1.8411.00
229_I234_L1.8341.00
196_E222_R1.7991.00
100_L103_R1.7931.00
86_P110_K1.7451.00
234_L238_E1.7391.00
115_I160_F1.7351.00
153_Q157_Q1.6951.00
216_P219_R1.6721.00
80_A164_F1.6571.00
160_F190_V1.6151.00
152_R185_D1.6111.00
80_A200_L1.6081.00
134_L146_M1.5941.00
189_A192_E1.5771.00
122_A134_L1.5671.00
135_L154_C1.5611.00
101_L164_F1.5441.00
69_N204_S1.5231.00
29_V34_I1.5221.00
176_F220_F1.5211.00
161_S195_C1.5211.00
17_Q55_V1.5021.00
176_F199_V1.4991.00
81_A104_T1.4941.00
235_M239_H1.4861.00
156_Q192_E1.4611.00
86_P109_K1.4581.00
23_L34_I1.4391.00
74_R104_T1.4371.00
135_L146_M1.4371.00
151_T186_V1.4361.00
48_R57_L1.4331.00
230_R233_D1.4291.00
5_Q44_L1.4231.00
8_I23_L1.4101.00
7_T11_M1.4001.00
11_M18_V1.4001.00
114_I125_L1.4001.00
77_A104_T1.3981.00
13_I56_S1.3961.00
69_N72_L1.3941.00
189_A193_K1.3871.00
94_N145_S1.3741.00
83_L224_I1.3701.00
15_Q22_D1.3701.00
6_Q10_Q1.3671.00
199_V220_F1.3631.00
83_L198_I1.3591.00
88_E161_S1.3521.00
203_S228_K1.3491.00
38_L54_A1.3491.00
21_T31_E1.3371.00
50_A53_F1.3311.00
72_L226_D1.3191.00
106_G128_A1.3121.00
5_Q40_T1.3091.00
139_Y146_M1.3071.00
86_P111_N1.3071.00
70_Y100_L1.3051.00
114_I130_C1.2921.00
138_V182_M1.2901.00
9_L46_Y1.2831.00
19_S22_D1.2651.00
215_G219_R1.2641.00
170_W206_F1.2601.00
73_K96_S1.2551.00
231_A235_M1.2371.00
79_F83_L1.2311.00
135_L151_T1.2221.00
87_G111_N1.2191.00
196_E221_N1.2191.00
74_R103_R1.2131.00
7_T26_A1.2031.00
32_V36_Q1.1991.00
113_T133_I1.1981.00
84_V105_L1.1951.00
7_T27_T1.1921.00
192_E219_R1.1801.00
91_F193_K1.1741.00
235_M238_E1.1721.00
167_I201_T1.1491.00
70_Y74_R1.1421.00
12_V47_L1.1331.00
222_R243_T1.1291.00
171_Q174_T1.1281.00
39_N43_K1.1271.00
152_R186_V1.1251.00
72_L203_S1.1211.00
164_F198_I1.1191.00
102_A125_L1.1191.00
71_T74_R1.1121.00
10_Q14_D1.1111.00
150_L154_C1.1081.00
9_L12_V1.1031.00
85_Q162_K1.0941.00
113_T131_E1.0941.00
48_R55_V1.0941.00
15_Q26_A1.0931.00
206_F229_I1.0761.00
167_I214_I1.0661.00
197_A220_F1.0631.00
40_T44_L1.0461.00
47_L54_A1.0401.00
133_I138_V1.0321.00
12_V56_S1.0231.00
198_I224_I1.0131.00
233_D236_H1.0101.00
20_V38_L1.0101.00
115_I158_V1.0051.00
24_A31_E1.0041.00
83_L222_R1.0041.00
80_A101_L0.9961.00
169_G177_T0.9931.00
62_V96_S0.9921.00
150_L158_V0.9851.00
3_S7_T0.9811.00
81_A84_V0.9751.00
84_V164_F0.9721.00
81_A101_L0.9711.00
72_L76_L0.9691.00
135_L155_I0.9621.00
92_I101_L0.9601.00
170_W201_T0.9491.00
206_F223_V0.9431.00
77_A81_A0.9411.00
102_A124_L0.9391.00
74_R78_E0.9371.00
168_D178_G0.9341.00
98_N121_I0.9321.00
185_D188_N0.9301.00
40_T43_K0.9271.00
218_E240_S0.9261.00
11_M14_D0.9241.00
39_N42_E0.9241.00
152_R189_A0.9141.00
95_G98_N0.9121.00
184_T212_Y0.9111.00
167_I199_V0.9101.00
73_K205_K0.9081.00
76_L97_S0.9071.00
157_Q188_N0.9021.00
97_S202_D0.8931.00
120_Y144_E0.8931.00
171_Q209_V0.8881.00
98_N101_L0.8871.00
163_A190_V0.8871.00
159_H174_T0.8831.00
22_D26_A0.8821.00
234_L244_I0.8801.00
73_K97_S0.8791.00
24_A34_I0.8771.00
101_L104_T0.8761.00
159_H195_C0.8751.00
97_S205_K0.8751.00
69_N202_D0.8741.00
77_A101_L0.8631.00
3_S6_Q0.8621.00
132_V139_Y0.8561.00
118_S121_I0.8541.00
18_V54_A0.8521.00
126_K144_E0.8461.00
150_L157_Q0.8461.00
18_V23_L0.8421.00
236_H239_H0.8421.00
9_L13_I0.8411.00
106_G109_K0.8411.00
102_A121_I0.8401.00
77_A100_L0.8391.00
41_L46_Y0.8341.00
158_V181_M0.8281.00
106_G124_L0.8221.00
143_S168_D0.8191.00
195_C209_V0.8181.00
59_S65_R0.8031.00
197_A221_N0.8011.00
181_M212_Y0.7991.00
178_G184_T0.7991.00
159_H209_V0.7991.00
159_H213_S0.7981.00
75_E78_E0.7971.00
10_Q13_I0.7951.00
155_I190_V0.7931.00
174_T209_V0.7861.00
65_R168_D0.7741.00
3_S17_Q0.7721.00
164_F200_L0.7701.00
39_N49_R0.7691.00
155_I189_A0.7661.00
80_A224_I0.7651.00
98_N200_L0.7591.00
91_F155_I0.7581.00
96_S205_K0.7581.00
170_W176_F0.7561.00
69_N203_S0.7521.00
106_G110_K0.7481.00
123_H144_E0.7471.00
16_G56_S0.7441.00
22_D25_K0.7421.00
229_I244_I0.7351.00
167_I176_F0.7311.00
61_D64_T0.7301.00
92_I102_A0.7291.00
172_P175_G0.7281.00
99_A124_L0.7261.00
159_H193_K0.7241.00
177_T209_V0.7220.99
140_Q183_R0.7200.99
157_Q213_S0.7200.99
122_A139_Y0.7190.99
191_L214_I0.7170.99
100_L104_T0.7160.99
71_T75_E0.7160.99
124_L127_D0.7140.99
172_P236_H0.7070.99
92_I114_I0.7050.99
5_Q9_L0.7040.99
140_Q147_V0.6990.99
176_F214_I0.6920.99
229_I233_D0.6880.99
136_G154_C0.6840.99
163_A197_A0.6830.99
90_I114_I0.6830.99
178_G214_I0.6810.99
66_M99_A0.6770.99
38_L49_R0.6730.99
94_N143_S0.6720.99
9_L41_L0.6720.99
170_W217_V0.6710.99
122_A146_M0.6670.99
89_T115_I0.6670.99
50_A55_V0.6650.99
21_T25_K0.6610.99
78_E82_S0.6610.99
188_N192_E0.6610.99
201_T223_V0.6600.99
127_D144_E0.6570.99
42_E47_L0.6570.99
232_S236_H0.6560.99
107_E128_A0.6550.99
178_G183_R0.6510.99
156_Q193_K0.6510.99
149_P153_Q0.6510.99
153_Q185_D0.6490.99
202_D205_K0.6490.99
160_F194_E0.6470.99
198_I221_N0.6460.99
148_G151_T0.6460.99
29_V32_V0.6420.99
75_E79_F0.6420.99
136_G151_T0.6420.99
231_A234_L0.6410.99
23_L38_L0.6370.99
90_I162_K0.6300.99
168_D210_H0.6270.99
116_T122_A0.6270.99
20_V34_I0.6260.99
215_G220_F0.6230.99
42_E49_R0.6220.99
99_A120_Y0.6210.98
149_P185_D0.6210.98
76_L200_L0.6160.98
165_I194_E0.6160.98
158_V212_Y0.6150.98
119_S146_M0.6140.98
119_S134_L0.6110.98
236_H240_S0.6050.98
117_V190_V0.5990.98
72_L228_K0.5960.98
12_V18_V0.5950.98
32_V118_S0.5910.98
27_T34_I0.5890.98
184_T214_I0.5880.98
228_K234_L0.5880.98
194_E197_A0.5870.98
203_S229_I0.5870.98
109_K112_V0.5850.98
93_E98_N0.5780.98
140_Q180_D0.5760.98
145_S183_R0.5750.98
233_D237_L0.5740.98
151_T154_C0.5690.97
119_S123_H0.5690.97
115_I211_S0.5690.97
115_I133_I0.5670.97
182_M185_D0.5650.97
149_P152_R0.5650.97
75_E227_S0.5640.97
129_P141_K0.5630.97
84_V101_L0.5620.97
196_E243_T0.5600.97
89_T211_S0.5590.97
206_F233_D0.5580.97
120_Y123_H0.5580.97
179_R210_H0.5570.97
152_R156_Q0.5540.97
95_G166_G0.5540.97
168_D183_R0.5510.97
165_I214_I0.5510.97
4_R37_D0.5500.97
66_M100_L0.5500.97
187_V214_I0.5470.97
165_I191_L0.5450.97
8_I27_T0.5430.97
90_I101_L0.5400.96
206_F225_T0.5380.96
168_D179_R0.5360.96
90_I164_F0.5360.96
118_S183_R0.5330.96
176_F215_G0.5330.96
186_V189_A0.5300.96
165_I197_A0.5300.96
111_N131_E0.5290.96
171_Q177_T0.5280.96
91_F163_A0.5260.96
94_N183_R0.5240.96
197_A219_R0.5230.96
59_S140_Q0.5210.96
32_V168_D0.5210.96
125_L130_C0.5200.96
150_L153_Q0.5190.96
73_K202_D0.5180.95
36_Q170_W0.5160.95
65_R93_E0.5160.95
169_G210_H0.5130.95
166_G178_G0.5130.95
153_Q188_N0.5110.95
172_P233_D0.5100.95
146_M154_C0.5100.95
25_K28_G0.5080.95
231_A238_E0.5080.95
131_E141_K0.5080.95
65_R96_S0.5060.95
169_G208_A0.5050.95
72_L75_E0.5040.95
92_I121_I0.5020.95
168_D187_V0.5020.95
20_V24_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1stzA 3 0.9398 100 0.518 Contact Map
3rrlB 1 0.6827 100 0.531 Contact Map
2w48A 3 0.9398 100 0.587 Contact Map
3l7oA 2 0.6185 100 0.602 Contact Map
1o8bA 2 0.6064 100 0.605 Contact Map
1m0sA 2 0.6305 100 0.613 Contact Map
1lk5A 4 0.6225 100 0.616 Contact Map
3uw1A 2 0.6386 100 0.619 Contact Map
1uj6A 2 0.6265 100 0.619 Contact Map
3ixqA 4 0.6345 100 0.62 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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