GREMLIN Database
OPPD - Oligopeptide transport ATP-binding protein OppD
UniProt: P76027 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10677
Length: 337 (273)
Sequences: 49533 (30772)
Seq/√Len: 1862.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_E238_K4.2871.00
105_Q188_K3.5971.00
24_D41_D3.3881.00
21_N45_S3.3751.00
23_K82_S3.2711.00
37_T40_N2.9321.00
27_V68_A2.9091.00
52_L240_L2.8261.00
82_S89_E2.7391.00
252_N255_D2.6161.00
53_G236_C2.5761.00
47_R50_E2.5551.00
86_N188_K2.5051.00
238_K250_Y2.4861.00
240_L247_T2.4001.00
21_N84_T2.3891.00
28_T37_T2.3771.00
40_N246_R2.3381.00
161_R164_M2.3361.00
22_V25_L2.2411.00
138_S141_E2.2291.00
26_R80_G2.2241.00
26_R41_D2.1961.00
66_A225_I2.1271.00
233_A254_R2.1021.00
89_E92_N2.0871.00
48_A188_K2.0371.00
251_G256_V2.0231.00
23_K84_T2.0091.00
145_E148_R2.0041.00
149_M184_L1.9971.00
29_F64_Q1.9311.00
121_M125_E1.9161.00
226_T232_V1.8641.00
145_E186_R1.8361.00
147_V162_M1.7761.00
66_A191_I1.7621.00
71_G98_L1.7471.00
26_R37_T1.7361.00
18_A21_N1.7311.00
53_G232_V1.7091.00
240_L250_Y1.6991.00
18_A47_R1.6771.00
143_F147_V1.6401.00
148_R152_A1.6391.00
157_E160_K1.6341.00
27_V73_L1.6331.00
22_V44_F1.6001.00
164_M168_E1.5901.00
29_F38_A1.5681.00
128_M142_A1.5541.00
25_L75_A1.5531.00
212_N215_K1.5451.00
251_G255_D1.5401.00
28_T35_D1.5311.00
86_N105_Q1.5291.00
124_G163_K1.5261.00
24_D43_N1.5251.00
255_D259_Q1.4931.00
214_L220_T1.4901.00
124_G162_M1.4771.00
132_M142_A1.4761.00
212_N234_G1.4651.00
161_R169_F1.4601.00
51_T215_K1.4411.00
98_L102_R1.4401.00
128_M146_S1.4261.00
149_M152_A1.4201.00
26_R40_N1.4121.00
27_V76_N1.4111.00
114_M174_R1.3981.00
192_A222_I1.3861.00
122_R125_E1.3651.00
22_V69_L1.3571.00
46_L52_L1.3501.00
127_L150_L1.3391.00
156_P160_K1.3171.00
17_D48_A1.3051.00
208_M231_V1.3031.00
144_E148_R1.3021.00
124_G143_F1.3001.00
109_I192_A1.2831.00
44_F240_L1.2781.00
23_K45_S1.2771.00
44_F65_T1.2761.00
124_G128_M1.2751.00
160_K164_M1.2631.00
51_T222_I1.2551.00
28_T76_N1.2531.00
169_F177_V1.2511.00
143_F162_M1.2491.00
50_E237_D1.2451.00
71_G74_A1.2321.00
73_L76_N1.2291.00
266_I270_N1.2261.00
141_E144_E1.2231.00
148_R151_D1.2111.00
211_L222_I1.2091.00
70_M108_M1.2081.00
18_A45_S1.1991.00
51_T236_C1.1951.00
122_R163_K1.1941.00
88_R93_L1.1741.00
42_L65_T1.1711.00
23_K43_N1.1711.00
125_E128_M1.1671.00
48_A86_N1.1631.00
52_L238_K1.1601.00
126_Q181_M1.1491.00
186_R220_T1.1471.00
54_I223_I1.1431.00
254_R258_Y1.1401.00
297_K302_Q1.1331.00
142_A146_S1.1221.00
84_T89_E1.1121.00
93_L98_L1.1061.00
152_A213_E1.1051.00
263_P266_I1.0911.00
137_M141_E1.0901.00
52_L250_Y1.0891.00
65_T242_M1.0851.00
120_Y167_H1.0761.00
140_A144_E1.0651.00
190_L220_T1.0641.00
47_R238_K1.0601.00
215_K222_I1.0531.00
127_L184_L1.0531.00
121_M129_E1.0501.00
135_K145_E1.0481.00
239_V253_A1.0451.00
46_L189_L1.0441.00
199_L207_I1.0381.00
68_A75_A1.0151.00
24_D80_G1.0141.00
215_K237_D1.0121.00
107_S187_P1.0061.00
150_L162_M1.0061.00
224_M235_I0.9991.00
131_L184_L0.9951.00
22_V83_A0.9781.00
48_A219_N0.9771.00
145_E149_M0.9771.00
124_G146_S0.9751.00
101_L106_I0.9691.00
128_M143_F0.9671.00
47_R221_A0.9571.00
28_T40_N0.9521.00
106_I189_L0.9471.00
40_N300_P0.9451.00
54_I240_L0.9371.00
70_M191_I0.9331.00
69_L223_I0.9311.00
190_L222_I0.9301.00
255_D258_Y0.9261.00
296_P302_Q0.9241.00
19_L86_N0.9231.00
246_R300_P0.9201.00
107_S182_A0.9171.00
143_F163_K0.9121.00
54_I65_T0.8981.00
117_L174_R0.8971.00
204_Q228_D0.8941.00
39_V68_A0.8921.00
128_M132_M0.8901.00
139_K142_A0.8881.00
247_T250_Y0.8841.00
154_K213_E0.8841.00
147_V151_D0.8811.00
27_V64_Q0.8771.00
60_S242_M0.8701.00
25_L68_A0.8701.00
192_A211_L0.8691.00
67_F72_L0.8651.00
156_P161_R0.8641.00
147_V157_E0.8631.00
204_Q231_V0.8601.00
85_F105_Q0.8551.00
263_P267_G0.8511.00
144_E147_V0.8511.00
212_N235_I0.8501.00
257_F260_P0.8491.00
109_I179_I0.8471.00
154_K206_Q0.8411.00
20_L69_L0.8391.00
253_A264_Y0.8391.00
265_S269_L0.8361.00
149_M153_V0.8351.00
274_R277_A0.8341.00
18_A48_A0.8291.00
68_A83_A0.8261.00
295_L300_P0.8241.00
151_D157_E0.8241.00
253_A257_F0.8241.00
298_G301_F0.8191.00
122_R165_Y0.8161.00
298_G302_Q0.8161.00
141_E145_E0.8121.00
270_N283_L0.8111.00
194_E227_H0.8061.00
68_A73_L0.8051.00
121_M126_Q0.8021.00
38_A64_Q0.8021.00
231_V235_I0.8011.00
256_V265_S0.8011.00
51_T212_N0.7941.00
67_F73_L0.7921.00
27_V39_V0.7891.00
130_V181_M0.7871.00
123_V169_F0.7861.00
55_V232_V0.7861.00
155_M161_R0.7851.00
46_L223_I0.7851.00
46_L221_A0.7811.00
42_L247_T0.7761.00
88_R105_Q0.7751.00
41_D246_R0.7711.00
243_Y248_M0.7671.00
19_L85_F0.7641.00
205_A209_T0.7621.00
292_L295_L0.7611.00
137_M142_A0.7611.00
123_V177_V0.7611.00
210_L213_E0.7601.00
104_E135_K0.7591.00
118_N121_M0.7561.00
149_M180_A0.7561.00
39_V42_L0.7551.00
135_K186_R0.7511.00
157_E161_R0.7501.00
161_R173_M0.7451.00
134_H185_C0.7441.00
24_D27_V0.7361.00
130_V185_C0.7361.00
267_G271_A0.7331.00
283_L287_G0.7321.00
89_E93_L0.7321.00
138_S142_A0.7291.00
169_F173_M0.7281.00
289_P292_L0.7261.00
165_Y168_E0.7251.00
236_C239_V0.7241.00
146_S162_M0.7241.00
115_T174_R0.7231.00
151_D156_P0.7171.00
291_N294_R0.7101.00
191_I223_I0.7071.00
100_K104_E0.7061.00
17_D47_R0.7051.00
90_I101_L0.7011.00
262_H265_S0.6991.00
127_L146_S0.6981.00
196_T231_V0.6981.00
140_A143_F0.6981.00
238_K249_E0.6971.00
51_T235_I0.6951.00
171_G176_R0.6931.00
276_D279_G0.6931.00
208_M234_G0.6921.00
132_M139_K0.6901.00
236_C253_A0.6881.00
117_L177_V0.6871.00
224_M236_C0.6851.00
93_L101_L0.6841.00
271_A274_R0.6831.00
287_G290_P0.6831.00
241_V260_P0.6791.00
267_G270_N0.6791.00
82_S91_L0.6781.00
144_E151_D0.6781.00
286_P289_P0.6741.00
166_P177_V0.6731.00
282_M285_I0.6721.00
155_M173_M0.6721.00
297_K300_P0.6661.00
19_L189_L0.6661.00
291_N296_P0.6661.00
136_N139_K0.6661.00
243_Y246_R0.6661.00
290_P296_P0.6651.00
291_N295_L0.6651.00
145_E152_A0.6611.00
70_M106_I0.6601.00
212_N216_R0.6571.00
285_I289_P0.6571.00
52_L223_I0.6561.00
67_F108_M0.6551.00
82_S92_N0.6541.00
85_F101_L0.6541.00
229_L257_F0.6541.00
51_T237_D0.6531.00
299_C302_Q0.6521.00
189_L223_I0.6521.00
18_A86_N0.6521.00
284_T288_N0.6511.00
85_F189_L0.6501.00
209_T234_G0.6501.00
189_L221_A0.6481.00
55_V241_V0.6481.00
128_M162_M0.6461.00
124_G127_L0.6461.00
143_F146_S0.6451.00
149_M183_L0.6441.00
209_T212_N0.6431.00
69_L83_A0.6411.00
19_L47_R0.6411.00
153_V180_A0.6371.00
20_L85_F0.6371.00
117_L126_Q0.6341.00
63_S67_F0.6311.00
292_L296_P0.6311.00
297_K301_F0.6281.00
94_P98_L0.6271.00
272_V276_D0.6261.00
131_L135_K0.6261.00
209_T213_E0.6261.00
28_T80_G0.6251.00
179_I207_I0.6251.00
72_L110_F0.6241.00
29_F73_L0.6221.00
139_K143_F0.6201.00
19_L45_S0.6181.00
41_D80_G0.6161.00
90_I106_I0.6141.00
137_M140_A0.6131.00
243_Y267_G0.6111.00
260_P265_S0.6101.00
84_T87_G0.6071.00
83_A91_L0.6061.00
24_D81_G0.6061.00
49_G221_A0.6041.00
109_I182_A0.6041.00
85_F90_I0.6041.00
183_L220_T0.6021.00
126_Q166_P0.6021.00
22_V65_T0.6001.00
253_A256_V0.5981.00
39_V65_T0.5981.00
295_L298_G0.5941.00
19_L48_A0.5941.00
19_L221_A0.5941.00
241_V256_V0.5931.00
90_I98_L0.5841.00
32_P35_D0.5831.00
251_G257_F0.5831.00
17_D86_N0.5811.00
264_Y267_G0.5801.00
20_L189_L0.5781.00
68_A76_N0.5771.00
122_R126_Q0.5741.00
112_D115_T0.5711.00
296_P301_F0.5701.00
57_E243_Y0.5691.00
164_M169_F0.5681.00
296_P300_P0.5671.00
150_L153_V0.5641.00
256_V260_P0.5631.00
48_A221_A0.5611.00
295_L301_F0.5591.00
94_P100_K0.5581.00
76_N80_G0.5571.00
58_S194_E0.5571.00
50_E250_Y0.5561.00
232_V236_C0.5561.00
208_M226_T0.5541.00
248_M262_H0.5541.00
281_T285_I0.5541.00
294_R297_K0.5521.00
157_E162_M0.5471.00
206_Q209_T0.5451.00
124_G147_V0.5441.00
292_L298_G0.5431.00
28_T38_A0.5431.00
288_N291_N0.5431.00
294_R298_G0.5411.00
293_L298_G0.5411.00
277_A280_E0.5391.00
127_L130_V0.5391.00
248_M300_P0.5371.00
51_T224_M0.5331.00
287_G291_N0.5331.00
289_P293_L0.5311.00
285_I288_N0.5301.00
196_T207_I0.5281.00
292_L300_P0.5281.00
57_E60_S0.5281.00
293_L300_P0.5271.00
88_R101_L0.5261.00
249_E261_V0.5261.00
232_V239_V0.5261.00
226_T231_V0.5261.00
116_S178_M0.5251.00
100_K105_Q0.5241.00
74_A91_L0.5221.00
284_T289_P0.5201.00
281_T284_T0.5191.00
131_L137_M0.5191.00
255_D261_V0.5171.00
293_L296_P0.5131.00
292_L299_C0.5111.00
45_S250_Y0.5101.00
131_L185_C0.5101.00
289_P295_L0.5101.00
291_N302_Q0.5091.00
272_V275_L0.5071.00
139_K144_E0.5061.00
135_K138_S0.5061.00
249_E260_P0.5041.00
285_I292_L0.5001.00
295_L299_C0.5001.00
293_L297_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 0.9021 100 0.206 Contact Map
4fwiB 1 0.9021 100 0.214 Contact Map
4ry2A 2 0.7151 100 0.226 Contact Map
4f4cA 1 0.7151 100 0.236 Contact Map
4ymuJ 2 0.7122 100 0.236 Contact Map
1oxxK 1 0.8961 100 0.237 Contact Map
4u00A 1 0.7151 100 0.237 Contact Map
2yyzA 1 0.8932 100 0.24 Contact Map
2oljA 2 0.7181 100 0.24 Contact Map
1b0uA 2 0.7329 100 0.242 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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