GREMLIN Database
YCGV - Uncharacterized protein YcgV
UniProt: P76017 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13903
Length: 955 (764)
Sequences: 1113 (1047)
Seq/√Len: 37.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
860_S891_E6.6361.00
888_A912_N6.2071.00
931_Y950_G6.0771.00
740_Y763_G6.0491.00
832_Q864_R4.9841.00
562_L580_V4.7821.00
775_Y815_G4.7541.00
726_D765_Y4.3941.00
791_V847_A4.3921.00
837_Y859_E4.3631.00
742_G761_Y4.2771.00
890_R912_N4.1701.00
699_Y720_G4.0751.00
829_I867_M4.0611.00
778_L812_L3.9041.00
863_G892_F3.8871.00
532_M580_V3.7871.00
325_F329_A3.5401.00
828_Y870_G3.4521.00
486_W492_S3.2891.00
834_Q864_R3.2831.00
695_W726_D3.2721.00
863_G888_A3.1501.00
767_S777_D3.1371.00
522_E554_G3.0681.00
479_V502_S3.0491.00
917_G935_D3.0381.00
934_A945_K2.9501.00
701_G718_Y2.9241.00
832_Q887_G2.9161.00
861_L893_S2.8771.00
697_R722_Q2.8741.00
506_F517_A2.8411.00
782_A806_N2.8061.00
864_R887_G2.7971.00
761_Y783_S2.7831.00
775_Y813_E2.7601.00
486_W489_T2.7341.00
203_T260_T2.6901.00
695_W724_G2.6891.00
260_T265_A2.6601.00
791_V851_L2.6311.00
193_V250_V2.5981.00
579_T582_K2.5501.00
506_F516_F2.5161.00
885_K917_G2.4691.00
256_S304_S2.4621.00
830_E868_I2.4551.00
777_D811_S2.4551.00
811_S834_Q2.4531.00
774_F816_Q2.4501.00
556_S583_T2.4481.00
817_R830_E2.4061.00
741_I760_D2.3391.00
779_V811_S2.2750.99
883_Y919_G2.1820.99
497_L521_V2.1810.99
815_G890_R2.1690.99
290_G306_I2.1650.99
645_P651_P2.1640.99
148_L152_S2.1460.99
866_S887_G2.1300.99
827_F871_Y2.0700.99
530_F560_H2.0640.99
787_N805_A2.0600.99
147_D150_T2.0580.99
442_I446_V2.0510.99
780_I810_I2.0310.99
735_L768_Y2.0220.99
763_G781_K2.0110.99
555_S586_G1.9960.99
363_R366_S1.9830.99
801_A845_M1.9610.98
203_T234_V1.9580.98
847_A851_L1.9270.98
829_I869_L1.9260.98
234_V260_T1.9150.98
862_L891_E1.9150.98
342_G359_I1.9050.98
564_I581_V1.8920.98
579_T611_N1.8810.98
232_I258_I1.8730.98
787_N803_G1.8690.98
777_D834_Q1.8690.98
571_A578_L1.8660.98
735_L766_A1.8630.98
526_G530_F1.8410.98
506_F533_R1.8350.98
552_I556_S1.8340.98
805_A842_E1.8300.98
354_M357_T1.8280.98
759_S785_Q1.8250.98
562_L581_V1.8160.97
916_N938_Q1.8080.97
683_G697_R1.8070.97
428_G432_S1.7900.97
683_G813_E1.7720.97
882_V920_V1.7700.97
465_G486_W1.7610.97
461_S486_W1.7460.97
865_A888_A1.7450.97
538_G544_N1.7450.97
453_I457_M1.7450.97
657_A847_A1.7330.97
555_S585_D1.7120.96
506_F532_M1.7110.96
839_H859_E1.7100.96
775_Y811_S1.7090.96
479_V484_S1.7020.96
436_A440_M1.6990.96
484_S502_S1.6930.96
833_T865_A1.6900.96
308_S311_G1.6880.96
681_R777_D1.6860.96
781_K809_S1.6840.96
815_G864_R1.6750.96
775_Y832_Q1.6720.96
827_F869_L1.6710.96
197_S254_T1.6690.96
314_L343_A1.6630.96
381_G384_L1.6470.95
832_Q883_Y1.6450.95
583_T586_G1.6410.95
703_L716_M1.6280.95
241_G290_G1.6260.95
497_L504_V1.6250.95
827_F832_Q1.6130.95
523_N555_S1.6040.95
830_E870_G1.6020.95
782_A912_N1.5980.95
428_G449_K1.5980.95
325_F328_T1.5920.95
777_D815_G1.5910.94
811_S864_R1.5910.94
700_G719_S1.5890.94
556_S585_D1.5840.94
757_A803_G1.5720.94
555_S583_T1.5640.94
532_M562_L1.5550.94
716_M746_A1.5440.94
738_G765_Y1.5300.93
928_H953_F1.5240.93
671_N838_S1.5160.93
463_W467_S1.5160.93
696_L723_F1.5150.93
767_S775_Y1.5070.93
722_Q864_R1.5040.93
775_Y834_Q1.4990.93
775_Y864_R1.4910.92
592_A605_V1.4900.92
507_A517_A1.4880.92
290_G342_G1.4800.92
804_T843_M1.4770.92
571_A577_V1.4710.92
816_Q917_G1.4630.92
665_N668_Y1.4610.92
201_I258_I1.4570.91
255_N303_D1.4510.91
457_M484_S1.4400.91
580_V605_V1.4400.91
791_V849_N1.4350.91
492_S506_F1.4330.91
884_V918_V1.4330.91
204_D218_N1.4270.91
699_Y744_T1.4210.90
863_G890_R1.4160.90
886_T916_N1.4160.90
703_L849_N1.4150.90
880_L920_V1.4050.90
379_I467_S1.4050.90
836_T864_R1.3990.90
301_G304_S1.3980.90
486_W497_L1.3840.89
712_S750_Y1.3830.89
863_G912_N1.3800.89
880_L922_A1.3680.89
921_S931_Y1.3640.88
750_Y805_A1.3560.88
252_L256_S1.3530.88
834_Q883_Y1.3530.88
891_E894_G1.3510.88
832_Q847_A1.3470.88
524_L530_F1.3430.88
517_A533_R1.3390.87
250_V407_S1.3390.87
553_S584_T1.3340.87
234_V283_V1.3340.87
775_Y836_T1.3220.87
274_V298_T1.3210.87
704_D715_D1.3190.87
492_S497_L1.3180.87
160_G176_I1.3120.86
696_L721_I1.3040.86
434_I438_G1.3010.86
492_S517_A1.2980.86
227_A230_L1.2970.86
860_S955_F1.2960.86
530_F534_A1.2960.86
306_I325_F1.2910.85
813_E836_T1.2870.85
532_M581_V1.2850.85
765_Y866_S1.2820.85
882_V919_G1.2780.85
520_N553_S1.2780.85
678_L763_G1.2760.85
693_N726_D1.2750.85
788_S802_N1.2730.85
556_S581_V1.2700.84
745_H758_R1.2690.84
401_S614_L1.2650.84
363_R370_G1.2610.84
405_L409_L1.2550.84
698_S720_G1.2520.84
556_S588_A1.2520.84
623_P645_P1.2510.84
534_A547_G1.2500.84
697_R864_R1.2460.83
474_G477_L1.2450.83
784_R806_N1.2440.83
716_M748_P1.2410.83
767_S813_E1.2380.83
183_G241_G1.2330.83
678_L767_S1.2260.82
488_V506_F1.2190.82
740_Y781_K1.2190.82
917_G933_E1.2180.82
160_G169_L1.2150.82
645_P649_P1.2130.82
322_I330_A1.2120.82
726_D738_G1.2100.81
252_L300_I1.2080.81
308_S313_G1.2050.81
403_I408_D1.1990.81
889_I915_N1.1980.81
486_W517_A1.1980.81
775_Y779_V1.1970.81
759_S783_S1.1950.81
820_L829_I1.1930.81
623_P651_P1.1880.80
256_S268_L1.1850.80
258_I314_L1.1850.80
725_G728_R1.1810.80
695_W765_Y1.1780.80
428_G442_I1.1770.80
529_T562_L1.1750.80
283_V311_G1.1720.79
662_N665_N1.1720.79
783_S807_G1.1710.79
651_P654_T1.1690.79
350_A359_I1.1660.79
681_R775_Y1.1660.79
849_N901_N1.1660.79
267_G281_V1.1640.79
592_A596_V1.1610.79
699_Y757_A1.1610.79
526_G558_G1.1600.79
777_D864_R1.1600.79
278_A281_V1.1580.78
674_E781_K1.1560.78
556_S589_S1.1550.78
847_A855_L1.1530.78
663_Y740_Y1.1520.78
722_Q887_G1.1520.78
687_N837_Y1.1510.78
830_E924_Y1.1500.78
722_Q832_Q1.1470.78
779_V803_G1.1460.78
883_Y933_E1.1450.78
780_I924_Y1.1440.78
571_A574_G1.1420.78
791_V864_R1.1420.78
782_A808_M1.1400.77
783_S809_S1.1380.77
228_T277_N1.1260.77
931_Y952_R1.1200.76
851_L905_E1.1190.76
260_T283_V1.1180.76
726_D809_S1.1170.76
308_S383_S1.1150.76
742_G763_G1.1140.76
623_P649_P1.1140.76
499_L502_S1.1130.76
693_N952_R1.1110.76
832_Q836_T1.1090.75
649_P652_K1.1090.75
395_I405_L1.1090.75
229_D255_N1.1080.75
614_L695_W1.1030.75
558_G612_W1.0980.75
788_S955_F1.0980.75
679_M684_D1.0970.75
928_H951_Y1.0970.75
777_D832_Q1.0950.74
558_G777_D1.0930.74
149_G158_D1.0920.74
205_G412_D1.0910.74
801_A847_A1.0900.74
813_E834_Q1.0880.74
265_A285_G1.0870.74
226_T230_L1.0830.74
836_T862_L1.0820.74
775_Y809_S1.0800.73
681_R697_R1.0800.73
506_F518_T1.0790.73
779_V917_G1.0780.73
195_L252_L1.0780.73
813_E868_I1.0770.73
194_D210_Y1.0730.73
757_A787_N1.0720.73
592_A603_Y1.0690.73
837_Y861_L1.0690.73
774_F778_L1.0670.73
191_T210_Y1.0660.72
258_I276_A1.0660.72
887_G955_F1.0660.72
300_I304_S1.0640.72
281_V306_I1.0640.72
864_R915_N1.0600.72
697_R832_Q1.0590.72
779_V834_Q1.0570.72
500_S524_L1.0570.72
777_D919_G1.0560.72
813_E830_E1.0560.72
660_G664_L1.0540.72
743_S760_D1.0540.72
649_P653_P1.0520.71
801_A849_N1.0500.71
146_A149_G1.0470.71
763_G807_G1.0440.71
151_G158_D1.0430.71
744_T759_S1.0420.71
667_G671_N1.0380.70
753_G779_V1.0380.70
773_G777_D1.0380.70
830_E883_Y1.0350.70
523_N554_G1.0330.70
724_G831_P1.0330.70
813_E864_R1.0300.70
834_Q887_G1.0290.70
435_N456_D1.0250.69
729_L737_V1.0240.69
603_Y616_A1.0210.69
663_Y667_G1.0200.69
935_D946_Q1.0160.69
579_T613_E1.0150.69
278_A294_R1.0140.69
715_D749_D1.0140.69
875_A878_S1.0130.69
888_A914_W1.0110.68
300_I317_S1.0080.68
566_N571_A1.0040.68
248_S365_G1.0020.68
753_G803_G0.9990.67
836_T889_I0.9990.67
728_R736_Y0.9990.67
694_I725_G0.9980.67
799_V850_G0.9960.67
606_R615_Y0.9920.67
697_R813_E0.9920.67
327_G338_G0.9910.67
522_E585_D0.9900.67
446_V453_I0.9890.67
419_M436_A0.9860.66
400_N409_L0.9860.66
755_G789_F0.9850.66
453_I475_G0.9840.66
864_R889_I0.9810.66
815_G834_Q0.9810.66
684_D697_R0.9790.66
653_P656_T0.9790.66
145_H151_G0.9790.66
336_F340_S0.9750.66
779_V888_A0.9740.65
842_E847_A0.9740.65
335_I340_S0.9720.65
497_L506_F0.9690.65
702_S717_G0.9680.65
148_L151_G0.9650.65
748_P757_A0.9630.65
726_D767_S0.9630.65
698_S719_S0.9560.64
576_E580_V0.9560.64
811_S832_Q0.9540.64
152_S236_G0.9530.64
810_I920_V0.9510.64
782_A888_A0.9510.64
844_T852_N0.9510.64
373_A377_G0.9500.63
488_V519_L0.9490.63
592_A595_Q0.9470.63
212_G222_A0.9470.63
492_S507_A0.9450.63
875_A880_L0.9450.63
267_G283_V0.9450.63
842_E856_N0.9440.63
518_T549_L0.9420.63
234_V239_A0.9410.63
892_F912_N0.9390.63
614_L813_E0.9380.62
321_A388_G0.9370.62
777_D892_F0.9370.62
241_G260_T0.9350.62
313_G345_A0.9340.62
750_Y753_G0.9320.62
160_G183_G0.9320.62
359_I818_F0.9320.62
842_E945_K0.9300.62
776_S886_T0.9300.62
613_E616_A0.9300.62
942_F945_K0.9290.62
378_R381_G0.9270.62
537_V545_N0.9270.62
883_Y931_Y0.9260.61
339_G400_N0.9260.61
697_R834_Q0.9220.61
720_G742_G0.9220.61
674_E740_Y0.9220.61
780_I808_M0.9200.61
254_T306_I0.9200.61
755_G763_G0.9180.61
603_Y883_Y0.9170.61
338_G343_A0.9160.61
845_M853_I0.9140.60
697_R775_Y0.9140.60
188_D239_A0.9130.60
782_A891_E0.9120.60
697_R767_S0.9100.60
449_K453_I0.9100.60
236_G268_L0.9080.60
748_P755_G0.9080.60
486_W506_F0.9060.60
702_S715_D0.9060.60
717_G756_T0.9050.60
428_G434_I0.9040.60
677_T681_R0.9020.59
255_N323_I0.8990.59
759_S777_D0.8970.59
592_A601_Y0.8930.59
508_S517_A0.8930.59
590_F614_L0.8930.59
789_F847_A0.8920.59
181_G185_T0.8880.58
176_I225_F0.8870.58
382_D392_A0.8840.58
939_G945_K0.8840.58
171_A174_F0.8830.58
779_V912_N0.8820.58
697_R777_D0.8810.58
670_L674_E0.8800.58
564_I580_V0.8800.58
330_A337_S0.8780.57
760_D783_S0.8760.57
203_T265_A0.8760.57
201_I491_N0.8740.57
296_G955_F0.8730.57
479_V506_F0.8730.57
303_D306_I0.8720.57
811_S950_G0.8710.57
740_Y836_T0.8700.57
860_S892_F0.8680.56
936_Y944_Q0.8680.56
779_V836_T0.8670.56
494_L521_V0.8670.56
670_L884_V0.8660.56
727_K739_L0.8660.56
524_L552_I0.8650.56
313_G343_A0.8650.56
651_P656_T0.8640.56
397_A401_S0.8630.56
453_I467_S0.8630.56
767_S834_Q0.8620.56
666_V917_G0.8610.56
865_A890_R0.8600.56
302_A306_I0.8580.56
461_S477_L0.8560.55
775_Y890_R0.8560.55
749_D754_D0.8540.55
176_I187_N0.8530.55
838_S860_S0.8530.55
300_I325_F0.8530.55
681_R787_N0.8520.55
524_L560_H0.8520.55
229_D278_A0.8510.55
781_K791_V0.8510.55
534_A580_V0.8510.55
805_A863_G0.8510.55
183_G208_G0.8500.55
219_A227_A0.8500.55
386_I389_A0.8500.55
653_P660_G0.8500.55
146_A150_T0.8500.55
799_V849_N0.8490.55
555_S584_T0.8490.55
475_G488_V0.8490.55
348_A357_T0.8490.55
556_S868_I0.8490.55
536_V566_N0.8470.55
357_T361_V0.8460.55
675_N836_T0.8460.55
832_Q866_S0.8460.55
851_L887_G0.8460.55
882_V886_T0.8440.54
785_Q811_S0.8430.54
887_G915_N0.8430.54
434_I440_M0.8430.54
323_I547_G0.8430.54
453_I456_D0.8400.54
681_R767_S0.8400.54
803_G855_L0.8400.54
361_V366_S0.8390.54
596_V599_G0.8370.54
506_F515_T0.8360.54
722_Q883_Y0.8360.54
861_L891_E0.8360.54
832_Q885_K0.8330.53
857_H861_L0.8320.53
313_G337_S0.8310.53
932_L950_G0.8310.53
343_A354_M0.8300.53
612_W791_V0.8290.53
442_I463_W0.8280.53
256_S270_S0.8260.53
660_G671_N0.8250.53
166_S271_F0.8250.53
256_S279_L0.8250.53
840_Q900_L0.8240.53
864_R883_Y0.8230.52
195_L199_S0.8230.52
434_I808_M0.8220.52
303_D342_G0.8210.52
664_L668_Y0.8210.52
612_W849_N0.8210.52
458_H480_A0.8210.52
785_Q809_S0.8140.52
657_A664_L0.8140.52
697_R853_I0.8130.52
785_Q815_G0.8100.51
762_M812_L0.8090.51
805_A917_G0.8090.51
612_W773_G0.8080.51
778_L814_A0.8080.51
803_G842_E0.8070.51
836_T887_G0.8050.51
787_N842_E0.8040.51
428_G454_N0.8040.51
457_M461_S0.8030.51
776_S815_G0.8020.51
311_G322_I0.8010.51
149_G153_T0.7990.50
613_E955_F0.7980.50
360_T384_L0.7980.50
930_F951_Y0.7970.50
612_W775_Y0.7960.50
181_G552_I0.7930.50
528_S532_M0.7920.50
486_W516_F0.7920.50
670_L885_K0.7910.50
755_G939_G0.7900.50
762_M782_A0.7900.50
428_G453_I0.7900.50
767_S779_V0.7900.50
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900_L905_E0.5040.26
660_G669_L0.5040.26
750_Y931_Y0.5030.26
775_Y891_E0.5020.26
578_L612_W0.5020.26
194_D236_G0.5020.26
328_T451_G0.5020.26
498_A501_H0.5020.26
386_I497_L0.5020.26
614_L763_G0.5010.26
438_G483_N0.5010.26
826_G871_Y0.5010.26
661_G676_R0.5000.26
230_L234_V0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4meeA 1 0.2963 100 0.57 Contact Map
3sltA 1 0.3089 100 0.674 Contact Map
3qq2A 2 0.2555 100 0.68 Contact Map
3aehA 1 0.2838 100 0.683 Contact Map
1uynX 1 0.2785 100 0.711 Contact Map
3kvnX 1 0.5173 100 0.737 Contact Map
1dabA 5 0.488 100 0.785 Contact Map
3syjA 2 0.5738 100 0.789 Contact Map
3h09A 1 0.5592 100 0.796 Contact Map
4om9A 1 0.5225 99.9 0.826 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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