GREMLIN Database
DHAK - PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK
UniProt: P76015 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13901
Length: 356 (327)
Sequences: 2229 (1385)
Seq/√Len: 76.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_S172_A3.9391.00
166_R341_A3.4441.00
90_A101_L3.3391.00
174_A178_R3.2301.00
128_T174_A3.1071.00
209_N227_P3.0171.00
178_R182_N2.9451.00
232_D299_R2.9191.00
280_A300_L2.9161.00
128_T171_D2.9101.00
163_A168_D2.8771.00
277_R340_L2.8111.00
17_A298_N2.7471.00
236_D299_R2.6401.00
296_V328_F2.6171.00
276_D334_K2.5111.00
279_I335_V2.4611.00
160_V177_G2.3701.00
277_R310_T2.3641.00
87_F123_S2.3561.00
126_K171_D2.3241.00
160_V173_C2.3071.00
313_R344_D2.2211.00
152_N184_G2.1761.00
54_S74_P2.1731.00
66_Q165_E2.1571.00
163_A176_L2.1311.00
48_L102_I2.1231.00
45_K70_S2.1191.00
23_H294_Y2.0961.00
91_M123_S2.0811.00
224_D237_E2.0721.00
14_E298_N2.0551.00
133_D181_N2.0031.00
235_V296_V1.9941.00
10_D14_E1.9851.00
239_F303_R1.9531.00
7_D10_D1.9391.00
45_K165_E1.9341.00
284_N318_A1.9241.00
44_G97_E1.9231.00
179_K336_D1.9171.00
162_A342_L1.8891.00
60_H104_K1.8881.00
175_E179_K1.8731.00
155_L279_I1.8531.00
236_D240_D1.8501.00
184_G333_L1.8361.00
229_S233_Q1.8251.00
87_F120_L1.8211.00
189_I234_T1.8061.00
232_D298_N1.7911.00
236_D303_R1.7841.00
231_L299_R1.7801.00
211_M234_T1.7651.00
297_Y314_N1.7581.00
180_L333_L1.7531.00
166_R345_A1.7481.00
173_C177_G1.6991.00
279_I343_W1.6931.00
210_E227_P1.6921.00
299_R302_T1.6681.00
172_A175_E1.6491.00
210_E225_R1.6401.00
155_L333_L1.6291.00
2_K209_N1.6241.00
166_R342_L1.6151.00
150_V186_S1.6141.00
183_Q334_K1.6061.00
230_S233_Q1.6061.00
240_D244_V1.6001.00
71_G89_C1.5931.00
155_L331_T1.5820.99
335_V340_L1.5810.99
277_R312_E1.5690.99
187_I238_M1.5660.99
90_A120_L1.5600.99
4_L234_T1.5440.99
87_F91_M1.5280.99
37_R165_E1.5260.99
128_T178_R1.5190.99
168_D172_A1.5090.99
207_A210_E1.4630.99
107_T111_L1.4530.99
312_E344_D1.4380.99
280_A332_L1.4200.99
318_A321_T1.4200.99
102_I132_I1.4200.99
29_H32_P1.4150.99
278_V332_L1.4070.99
278_V309_L1.3970.99
168_D342_L1.3900.99
59_M320_C1.3820.99
49_L71_G1.3740.99
298_N302_T1.3680.98
49_L93_V1.3610.98
50_S69_L1.3340.98
101_L117_T1.3290.98
103_I129_T1.3230.98
21_K298_N1.3140.98
155_L281_L1.2970.98
99_V125_V1.2920.98
100_L170_L1.2850.98
110_I131_V1.2810.98
104_K153_T1.2800.98
279_I333_L1.2790.98
35_V64_I1.2790.98
215_V285_L1.2730.98
160_V176_L1.2660.97
15_Q291_S1.2640.97
240_D303_R1.2640.97
6_N14_E1.2580.97
11_V295_G1.2550.97
153_T157_E1.2520.97
66_Q348_H1.2430.97
143_Y146_G1.2400.97
151_A281_L1.2310.97
277_R337_D1.2200.97
68_M349_T1.2180.97
11_V291_S1.2050.97
287_A326_T1.1950.96
64_I72_A1.1930.96
27_T38_A1.1890.96
192_G326_T1.1600.96
179_K338_E1.1580.96
171_D174_A1.1510.96
4_L296_V1.1500.96
22_A297_Y1.1250.95
21_K301_T1.1220.95
5_I11_V1.1180.95
213_F238_M1.1100.95
312_E340_L1.1090.95
185_H245_N1.1020.94
187_I242_L1.0990.94
229_S237_E1.0950.94
160_V180_L1.0920.94
67_G345_A1.0870.94
104_K157_E1.0770.94
163_A166_R1.0690.93
340_L344_D1.0690.93
274_S308_G1.0650.93
151_A329_S1.0620.93
132_I156_I1.0610.93
211_M228_F1.0580.93
60_H157_E1.0560.93
282_V330_I1.0500.93
60_H153_T1.0470.93
88_E91_M1.0420.92
239_F304_C1.0400.92
17_A302_T1.0360.92
243_L307_A1.0190.92
336_D339_T1.0190.92
273_Q276_D1.0180.92
193_A203_S1.0130.91
33_V76_E1.0110.91
300_L330_I1.0070.91
347_V352_L1.0020.91
304_C309_L1.0010.91
91_M125_V1.0010.91
130_V174_A0.9940.91
349_T352_L0.9920.91
86_I101_L0.9890.90
348_H353_N0.9810.90
235_V330_I0.9790.90
315_L343_W0.9660.89
101_L120_L0.9650.89
301_T305_Q0.9650.89
315_L319_Y0.9610.89
107_T145_A0.9570.89
235_V328_F0.9540.89
233_Q236_D0.9490.88
19_L26_L0.9460.88
168_D176_L0.9440.88
4_L328_F0.9430.88
90_A99_V0.9400.88
40_A95_G0.9370.88
42_V95_G0.9360.88
136_V242_L0.9350.88
231_L295_G0.9350.88
117_T129_T0.9330.88
39_D66_Q0.9290.87
315_L352_L0.9260.87
93_V99_V0.9240.87
282_V297_Y0.9230.87
103_I114_E0.9180.87
20_A28_L0.9170.87
295_G298_N0.9090.86
243_L272_L0.9070.86
73_C86_I0.9030.86
173_C176_L0.9000.86
21_K305_Q0.9000.86
195_T324_D0.9000.86
13_D33_V0.8960.85
120_L127_V0.8920.85
26_L348_H0.8910.85
162_A345_A0.8890.85
159_L333_L0.8870.85
235_V300_L0.8840.85
187_I213_F0.8840.85
239_F300_L0.8810.84
212_E225_R0.8810.84
76_E79_T0.8730.84
279_I340_L0.8730.84
29_H34_Y0.8710.84
282_V300_L0.8670.83
100_L173_C0.8650.83
49_L101_L0.8630.83
80_S106_Y0.8620.83
189_I213_F0.8620.83
36_T92_Q0.8620.83
94_D125_V0.8610.83
242_L332_L0.8570.83
299_R303_R0.8530.82
303_R307_A0.8520.82
297_Y301_T0.8480.82
155_L343_W0.8470.82
19_L61_C0.8470.82
13_D17_A0.8470.82
67_G165_E0.8460.82
104_K217_I0.8450.82
35_V61_C0.8440.82
164_A173_C0.8430.82
19_L24_P0.8410.82
226_R237_E0.8410.82
141_S144_T0.8400.82
94_D99_V0.8370.81
231_L296_V0.8350.81
140_D143_Y0.8260.80
34_Y89_C0.8240.80
16_L74_P0.8220.80
153_T217_I0.8220.80
343_W352_L0.8210.80
338_E341_A0.8200.80
150_V215_V0.8180.80
27_T36_T0.8170.80
293_L328_F0.8130.79
136_V187_I0.8120.79
139_K143_Y0.8090.79
156_I177_G0.8070.79
21_K302_T0.8050.79
5_I295_G0.8020.78
272_L332_L0.7990.78
226_R229_S0.7970.78
206_L210_E0.7940.78
153_T320_C0.7900.77
68_M347_V0.7870.77
47_A99_V0.7850.77
3_K324_D0.7850.77
207_A225_R0.7850.77
238_M328_F0.7830.77
180_L339_T0.7800.76
272_L309_L0.7780.76
176_L339_T0.7770.76
190_A215_V0.7650.75
59_M157_E0.7640.75
85_K110_I0.7640.75
86_I113_F0.7610.75
89_C93_V0.7610.75
56_H218_H0.7580.74
213_F237_E0.7530.74
114_E129_T0.7510.74
150_V188_G0.7490.74
237_E241_T0.7490.74
213_F226_R0.7470.73
192_G202_P0.7430.73
173_C180_L0.7380.72
29_H33_V0.7370.72
107_T146_G0.7360.72
283_N329_S0.7350.72
61_C74_P0.7330.72
50_S153_T0.7330.72
159_L180_L0.7330.72
281_L331_T0.7320.72
130_V177_G0.7280.71
25_S348_H0.7270.71
6_N231_L0.7250.71
102_I156_I0.7240.71
187_I241_T0.7220.71
147_R245_N0.7220.71
22_A316_I0.7220.71
272_L334_K0.7210.71
138_V141_S0.7210.71
159_L339_T0.7190.70
279_I315_L0.7190.70
94_D126_K0.7130.70
171_D175_E0.7110.70
71_G93_V0.7090.69
88_E92_Q0.7090.69
158_K345_A0.7080.69
136_V239_F0.7050.69
180_L184_G0.7040.69
57_E291_S0.7010.69
6_N232_D0.6990.68
44_G96_G0.6980.68
272_L276_D0.6970.68
338_E342_L0.6970.68
59_M153_T0.6960.68
244_V306_Q0.6940.68
240_D307_A0.6920.68
50_S157_E0.6910.67
47_A93_V0.6900.67
165_E345_A0.6890.67
284_N288_T0.6840.67
60_H68_M0.6830.67
193_A205_T0.6760.66
235_V282_V0.6760.66
176_L338_E0.6750.66
60_H217_I0.6710.65
121_H124_G0.6660.65
185_H271_P0.6660.65
16_L28_L0.6640.64
4_L194_C0.6630.64
19_L35_V0.6610.64
156_I160_V0.6600.64
157_E320_C0.6590.64
168_D175_E0.6550.63
72_A153_T0.6530.63
20_A35_V0.6520.63
2_K210_E0.6520.63
287_A324_D0.6510.63
23_H350_P0.6460.62
175_E338_E0.6450.62
15_Q294_Y0.6450.62
229_S234_T0.6440.62
97_E169_S0.6420.62
183_Q339_T0.6420.62
319_Y353_N0.6420.62
239_F242_L0.6410.62
73_C89_C0.6410.62
157_E217_I0.6380.61
102_I157_E0.6360.61
36_T39_D0.6350.61
195_T198_A0.6350.61
121_H126_K0.6340.61
304_C332_L0.6320.61
43_A95_G0.6320.61
154_V320_C0.6320.61
29_H36_T0.6310.60
138_V143_Y0.6300.60
195_T202_P0.6300.60
60_H103_I0.6290.60
67_G162_A0.6280.60
14_E17_A0.6280.60
63_Y320_C0.6280.60
48_L160_V0.6270.60
163_A338_E0.6270.60
301_T314_N0.6260.60
163_A342_L0.6260.60
159_L342_L0.6260.60
100_L177_G0.6250.60
184_G331_T0.6250.60
313_R343_W0.6250.60
4_L189_I0.6250.60
132_I157_E0.6250.60
14_E232_D0.6230.59
77_I324_D0.6230.59
150_V285_L0.6220.59
179_K339_T0.6210.59
178_R181_N0.6200.59
47_A70_S0.6180.59
57_E107_T0.6170.59
138_V142_L0.6160.59
113_F188_G0.6140.58
82_T85_K0.6130.58
63_Y226_R0.6130.58
69_L103_I0.6130.58
73_C90_A0.6130.58
243_L304_C0.6110.58
48_L164_A0.6100.58
294_Y316_I0.6080.58
281_L343_W0.6080.58
49_L99_V0.6060.57
211_M229_S0.6060.57
139_K142_L0.6040.57
196_V287_A0.6040.57
83_P86_I0.6030.57
59_M63_Y0.6020.57
132_I331_T0.6000.57
80_S323_L0.6000.57
10_D13_D0.5990.56
100_L174_A0.5980.56
76_E82_T0.5980.56
179_K183_Q0.5960.56
2_K228_F0.5950.56
238_M241_T0.5940.56
335_V343_W0.5920.56
176_L180_L0.5910.55
87_F119_L0.5910.55
28_L33_V0.5910.55
206_L225_R0.5900.55
117_T121_H0.5890.55
113_F217_I0.5870.55
193_A219_G0.5870.55
301_T311_I0.5860.55
49_L73_C0.5850.55
93_V101_L0.5850.55
106_Y212_E0.5840.55
278_V311_I0.5830.54
241_T244_V0.5830.54
151_A320_C0.5820.54
235_V299_R0.5820.54
213_F234_T0.5810.54
35_V72_A0.5810.54
8_V11_V0.5800.54
95_G99_V0.5780.54
223_I241_T0.5760.54
93_V96_G0.5760.54
337_D341_A0.5750.53
49_L89_C0.5730.53
121_H128_T0.5720.53
71_G347_V0.5710.53
47_A95_G0.5700.53
196_V199_A0.5700.53
274_S307_A0.5670.52
80_S108_G0.5620.52
185_H242_L0.5620.52
90_A127_V0.5610.52
232_D302_T0.5610.52
192_G287_A0.5610.52
82_T115_T0.5590.51
28_L32_P0.5580.51
347_V353_N0.5580.51
335_V339_T0.5570.51
190_A325_M0.5570.51
159_L176_L0.5570.51
341_A345_A0.5550.51
103_I153_T0.5550.51
311_I314_N0.5540.51
132_I153_T0.5530.51
80_S85_K0.5520.51
140_D144_T0.5510.50
168_D173_C0.5500.50
83_P115_T0.5490.50
177_G180_L0.5480.50
39_D42_V0.5480.50
141_S221_P0.5460.50
156_I181_N0.5450.50
194_C322_S0.5450.50
275_G308_G0.5430.49
305_Q310_T0.5430.49
79_T198_A0.5420.49
60_H102_I0.5420.49
275_G310_T0.5400.49
160_V184_G0.5400.49
290_L293_L0.5390.49
50_S104_K0.5370.49
148_R188_G0.5350.48
90_A93_V0.5350.48
103_I320_C0.5330.48
68_M161_G0.5330.48
76_E198_A0.5300.48
110_I114_E0.5300.48
230_S235_V0.5300.48
150_V329_S0.5270.47
235_V303_R0.5270.47
310_T337_D0.5270.47
86_I93_V0.5270.47
106_Y218_H0.5270.47
163_A173_C0.5260.47
147_R293_L0.5210.47
204_F325_M0.5210.47
233_Q237_E0.5210.47
139_K245_N0.5200.46
271_P276_D0.5190.46
199_A324_D0.5180.46
224_D241_T0.5170.46
142_L221_P0.5170.46
79_T215_V0.5160.46
208_D306_Q0.5150.46
63_Y154_V0.5140.46
73_C79_T0.5140.46
16_L20_A0.5130.46
49_L86_I0.5120.45
174_A177_G0.5120.45
187_I234_T0.5110.45
290_L294_Y0.5110.45
69_L153_T0.5110.45
245_N271_P0.5090.45
39_D93_V0.5090.45
24_P38_A0.5090.45
117_T127_V0.5080.45
120_L125_V0.5080.45
202_P205_T0.5080.45
195_T287_A0.5070.45
176_L342_L0.5050.45
32_P36_T0.5050.45
100_L160_V0.5050.45
111_L115_T0.5030.44
236_D306_Q0.5020.44
86_I116_A0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oi2A 2 0.9438 100 0.016 Contact Map
3ct4A 3 0.8876 100 0.053 Contact Map
2iu4A 2 0.9185 100 0.055 Contact Map
1un8A 2 0.9101 100 0.08 Contact Map
3b48A 2 0.3792 99.2 0.9 Contact Map
1mgpA 1 0.6545 64.1 0.97 Contact Map
1u7zA 2 0.5393 40.4 0.974 Contact Map
2e3jA 2 0.2697 30.4 0.976 Contact Map
2lekA 1 0.1713 25.4 0.977 Contact Map
4nmwA 1 0.2135 25.2 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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