GREMLIN Database
DHAL - PTS-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL
UniProt: P76014 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13900
Length: 210 (193)
Sequences: 2567 (1875)
Seq/√Len: 135.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_Q195_T3.8961.00
102_T105_E3.6661.00
111_R142_R3.5021.00
127_D175_R3.3371.00
163_E202_Q3.1881.00
22_E25_Y2.6731.00
15_C200_M2.5091.00
167_Q170_I2.5061.00
125_P135_V2.4621.00
13_T54_P2.4511.00
60_D63_F2.3371.00
131_C135_V2.3101.00
111_R115_D2.2521.00
163_E167_Q2.2441.00
160_S164_S2.1941.00
166_A198_M2.1851.00
114_A131_C2.1591.00
164_S168_S2.1341.00
161_I165_A2.0641.00
173_Q187_I2.0501.00
135_V139_E2.0351.00
87_F113_G2.0341.00
133_V165_A2.0071.00
159_S205_A2.0021.00
20_S43_N1.9701.00
17_D21_T1.9621.00
118_I124_E1.9541.00
125_P139_E1.9171.00
114_A135_V1.9061.00
9_V13_T1.8941.00
114_A138_V1.8791.00
23_S43_N1.8451.00
95_T109_M1.7851.00
13_T50_V1.7741.00
43_N47_S1.6971.00
38_H196_S1.6681.00
118_I135_V1.6481.00
17_D50_V1.6421.00
98_R105_E1.6001.00
159_S198_M1.5911.00
90_R116_G1.5791.00
69_G92_A1.5681.00
20_S47_S1.5451.00
133_V137_V1.5221.00
140_S144_S1.5211.00
139_E143_Q1.4751.00
25_Y28_G1.4611.00
156_E160_S1.4431.00
18_I199_F1.4421.00
12_L68_T1.3811.00
18_I22_E1.3651.00
108_Q142_R1.3641.00
90_R119_S1.3481.00
24_E28_G1.3451.00
49_V53_L1.3431.00
134_W197_V1.3351.00
182_L185_R1.3331.00
168_S171_T1.2961.00
86_T116_G1.2711.00
91_A109_M1.2651.00
173_Q184_E1.2551.00
141_L158_A1.2331.00
32_E189_H1.2311.00
69_G73_L1.2261.00
29_L192_P1.2101.00
22_E199_F1.1971.00
110_F141_L1.1961.00
27_T40_L1.1921.00
110_F138_V1.1880.99
140_S143_Q1.1880.99
86_T90_R1.1750.99
136_P165_A1.1500.99
87_F117_V1.1310.99
19_F46_F1.1250.99
68_T88_F1.1090.99
107_Y138_V1.1000.99
168_S172_M1.0920.99
115_D118_I1.0790.99
170_I190_Q1.0780.99
14_R206_L1.0710.99
140_S161_I1.0680.99
18_I203_M1.0510.99
28_G32_E1.0390.99
133_V136_P1.0350.99
18_I206_L1.0340.99
157_A160_S1.0310.99
137_V165_A1.0170.98
118_I131_C1.0160.98
62_G92_A1.0160.98
16_G50_V1.0130.98
117_V121_G1.0040.98
69_G89_I0.9990.98
166_A190_Q0.9960.98
15_C46_F0.9960.98
137_V201_M0.9920.98
20_S50_V0.9830.98
33_I179_A0.9820.98
48_K75_S0.9790.98
80_S130_M0.9770.98
104_E108_Q0.9740.98
198_M202_Q0.9710.98
165_A168_S0.9550.98
20_S23_S0.9530.98
11_W204_L0.9510.98
125_P131_C0.9380.97
48_K51_E0.9370.97
14_R17_D0.9360.97
115_D119_S0.9310.97
91_A113_G0.9290.97
107_Y145_S0.9220.97
133_V161_I0.9200.97
16_G20_S0.9180.97
103_L107_Y0.9170.97
166_A194_A0.9170.97
26_L39_G0.8980.97
171_T187_I0.8860.96
49_V68_T0.8790.96
84_F197_V0.8750.96
60_D97_A0.8690.96
62_G96_Q0.8690.96
87_F91_A0.8650.96
86_T120_R0.8650.96
42_M196_S0.8640.96
33_I79_A0.8540.95
161_I164_S0.8490.95
41_N76_V0.8460.95
18_I202_Q0.8380.95
128_K174_A0.8370.95
14_R18_I0.8340.95
52_K67_N0.8330.95
125_P172_M0.8320.95
46_F49_V0.8250.94
28_G31_R0.8220.94
139_E142_R0.8220.94
130_M197_V0.8090.94
123_A131_C0.8090.94
18_I21_T0.8090.94
65_L91_A0.8020.94
15_C203_M0.8000.93
142_R146_E0.7970.93
26_L199_F0.7930.93
11_W15_C0.7930.93
25_Y195_T0.7910.93
42_M76_V0.7900.93
114_A118_I0.7900.93
49_V71_T0.7860.93
76_V82_P0.7840.93
71_T75_S0.7820.93
14_R203_M0.7820.93
137_V161_I0.7810.93
41_N180_S0.7750.92
26_L196_S0.7690.92
111_R139_E0.7680.92
7_Q10_N0.7660.92
10_N14_R0.7600.92
87_F134_W0.7580.91
112_D115_D0.7550.91
38_H77_G0.7530.91
52_K71_T0.7490.91
23_S27_T0.7480.91
202_Q206_L0.7470.91
197_V201_M0.7420.91
163_E198_M0.7370.90
38_H79_A0.7360.90
128_K186_S0.7320.90
95_T101_L0.7270.90
140_S157_A0.7250.90
66_K92_A0.7240.90
83_L130_M0.7220.89
47_S51_E0.7220.89
108_Q112_D0.7200.89
8_I61_I0.7140.89
89_I92_A0.7140.89
117_V134_W0.7120.89
133_V166_A0.7100.89
118_I125_P0.7060.88
80_S181_Y0.7050.88
67_N71_T0.7050.88
15_C18_I0.7000.88
27_T31_R0.6970.88
19_F42_M0.6930.87
133_V194_A0.6920.87
94_A108_Q0.6910.87
6_T10_N0.6870.87
103_L145_S0.6860.87
60_D96_Q0.6840.87
69_G195_T0.6830.87
169_T194_A0.6750.86
15_C19_F0.6750.86
73_L85_G0.6730.86
146_E157_A0.6700.86
107_Y141_L0.6670.85
133_V158_A0.6670.85
72_L79_A0.6660.85
156_E205_A0.6610.85
90_R121_G0.6600.85
162_A165_A0.6570.84
179_A182_L0.6510.84
111_R138_V0.6510.84
27_T181_Y0.6500.84
78_G85_G0.6490.84
67_N70_M0.6490.84
104_E145_S0.6450.83
38_H128_K0.6420.83
160_S163_E0.6410.83
13_T17_D0.6390.83
90_R93_Q0.6370.83
56_I71_T0.6370.83
66_K70_M0.6370.83
50_V54_P0.6340.82
38_H41_N0.6330.82
169_T172_M0.6310.82
185_R189_H0.6280.82
25_Y190_Q0.6270.82
163_E166_A0.6230.81
45_G76_V0.6180.81
9_V64_I0.6170.81
26_L42_M0.6170.81
41_N82_P0.6160.80
195_T198_M0.6130.80
195_T199_F0.6100.80
174_A179_A0.6060.79
61_I64_I0.6020.79
170_I195_T0.6020.79
87_F112_D0.6000.79
25_Y199_F0.6000.79
176_K192_P0.5970.78
51_E55_A0.5960.78
44_R79_A0.5950.78
80_S84_F0.5920.78
33_I192_P0.5910.78
159_S202_Q0.5870.77
89_I120_R0.5870.77
52_K55_A0.5850.77
112_D116_G0.5840.77
31_R36_A0.5810.77
41_N85_G0.5710.75
182_L186_S0.5710.75
138_V142_R0.5700.75
125_P136_P0.5690.75
38_H73_L0.5690.75
78_G113_G0.5660.75
94_A112_D0.5660.75
65_L109_M0.5640.74
105_E108_Q0.5560.73
41_N78_G0.5550.73
58_D63_F0.5540.73
125_P168_S0.5520.73
84_F181_Y0.5510.73
66_K96_Q0.5500.73
77_G81_G0.5500.73
137_V155_L0.5490.72
46_F72_L0.5470.72
16_G46_F0.5470.72
41_N80_S0.5460.72
104_E107_Y0.5450.72
88_F197_V0.5440.72
45_G196_S0.5440.72
84_F130_M0.5430.72
190_Q194_A0.5410.71
33_I174_A0.5410.71
75_S85_G0.5380.71
121_G131_C0.5370.71
42_M84_F0.5370.71
107_Y142_R0.5360.71
159_S201_M0.5350.71
76_V84_F0.5330.70
46_F50_V0.5320.70
159_S206_L0.5320.70
155_L158_A0.5320.70
33_I128_K0.5310.70
103_L141_L0.5280.70
137_V162_A0.5270.69
66_K89_I0.5270.69
174_A181_Y0.5240.69
74_S85_G0.5240.69
82_P183_G0.5220.69
158_A161_I0.5220.69
126_G136_P0.5190.68
200_M204_L0.5180.68
78_G181_Y0.5180.68
97_A115_D0.5180.68
33_I72_L0.5170.68
199_F202_Q0.5170.68
27_T36_A0.5080.67
52_K75_S0.5080.67
124_E175_R0.5030.66
24_E27_T0.5030.66
108_Q143_Q0.5010.66
11_W134_W0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pnlB 1 1 100 0.126 Contact Map
1un8A 2 0.8952 100 0.185 Contact Map
3cr3A 1 0.9143 100 0.196 Contact Map
1ashA 1 0.5524 25.9 0.95 Contact Map
3l2pA 1 0.8476 20.9 0.952 Contact Map
4htpA 1 0.6667 14 0.956 Contact Map
3jpzA 2 0.619 13.7 0.956 Contact Map
1mbaA 1 0.5571 11.8 0.957 Contact Map
3l2fA 6 0.619 9.9 0.959 Contact Map
3favA 1 0.3381 7.9 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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