GREMLIN Database
YMGE - UPF0410 protein ymge
UniProt: P76011 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14338
Length: 84 (81)
Sequences: 539 (263)
Seq/√Len: 29.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_V74_V3.5981.00
25_D79_R3.1411.00
47_A66_V2.8311.00
9_F64_F2.7601.00
16_I19_L2.7391.00
58_G64_F2.3530.99
34_I38_V2.2170.98
29_F33_C2.1520.98
33_C37_I2.0480.97
46_L49_M2.0430.97
26_G35_L1.9830.97
13_A68_V1.9130.96
59_F64_F1.8860.95
55_S63_S1.8680.95
18_K27_G1.6940.92
66_V71_A1.5780.89
71_A75_L1.5340.88
16_I68_V1.4660.85
65_L69_V1.4290.83
15_I29_F1.4060.82
26_G79_R1.3650.81
77_I81_L1.2780.76
26_G31_L1.2770.76
61_L67_A1.2750.76
32_T35_L1.2680.75
21_M76_G1.2350.73
21_M29_F1.2320.73
26_G74_V1.2200.72
53_G62_H1.1710.69
56_I62_H1.1600.68
51_G54_G1.1430.67
4_I8_I1.1110.65
72_I76_G1.0970.64
46_L69_V1.0860.63
25_D35_L1.0820.63
31_L34_I1.0730.62
76_G80_L1.0680.62
25_D78_F1.0530.61
75_L78_F1.0270.59
65_L80_L0.9930.56
56_I60_N0.9920.56
32_T71_A0.9500.53
15_I19_L0.9470.53
13_A67_A0.9460.53
69_V72_I0.9350.52
58_G63_S0.9250.51
56_I63_S0.9220.51
8_I29_F0.9190.51
31_L76_G0.8920.48
35_L74_V0.8810.48
31_L78_F0.8790.47
60_N63_S0.8690.47
31_L35_L0.8680.47
62_H66_V0.8410.44
17_A75_L0.8330.44
5_A80_L0.8230.43
20_I38_V0.8200.43
32_T75_L0.8190.43
74_V80_L0.8180.43
64_F68_V0.8090.42
20_I25_D0.8070.42
2_G60_N0.7870.40
42_V74_V0.7780.40
8_I15_I0.7690.39
23_G32_T0.7660.39
16_I64_F0.7620.38
3_I37_I0.7590.38
57_S60_N0.7500.38
50_F53_G0.7470.37
59_F81_L0.7360.37
38_V69_V0.7310.36
47_A51_G0.7270.36
1_M33_C0.7160.35
41_V48_T0.7130.35
13_A32_T0.6930.33
12_I65_L0.6920.33
22_P35_L0.6840.33
6_W79_R0.6830.33
61_L68_V0.6720.32
35_L42_V0.6650.32
16_I71_A0.6640.31
4_I19_L0.6580.31
21_M72_I0.6560.31
3_I61_L0.6540.31
72_I79_R0.6400.30
29_F37_I0.6310.29
26_G78_F0.6140.28
54_G81_L0.6120.28
53_G59_F0.6120.28
3_I45_W0.6100.28
41_V59_F0.6100.28
15_I65_L0.6050.28
27_G67_A0.5920.27
16_I30_F0.5900.27
24_R81_L0.5880.27
41_V54_G0.5880.27
21_M35_L0.5830.26
9_F81_L0.5790.26
6_W37_I0.5780.26
5_A40_A0.5740.26
38_V41_V0.5690.25
5_A41_V0.5670.25
40_A51_G0.5590.25
55_S58_G0.5510.24
48_T69_V0.5450.24
61_L69_V0.5350.23
15_I77_I0.5350.23
55_S60_N0.5330.23
45_W49_M0.5290.23
48_T57_S0.5280.23
9_F59_F0.5210.23
6_W78_F0.5190.23
7_I69_V0.5190.23
33_C74_V0.5170.22
55_S62_H0.5130.22
7_I41_V0.5120.22
21_M25_D0.5110.22
46_L73_L0.5090.22
24_R31_L0.5060.22
5_A61_L0.5040.22
31_L42_V0.5010.22
12_I61_L0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tkrA 2 0.9881 59.3 0.878 Contact Map
2nq2A 2 0.881 50.5 0.884 Contact Map
3rlbA 1 0.9762 34.9 0.894 Contact Map
4g1uA 2 0.869 31.9 0.897 Contact Map
4hzuS 1 0.9762 26.4 0.901 Contact Map
3p5nA 2 0.9167 25.9 0.901 Contact Map
2qi9A 2 0.8929 25.3 0.902 Contact Map
4rfsS 1 0.9167 17.9 0.908 Contact Map
4dveA 3 0.9762 14 0.913 Contact Map
4m64A 1 0.9881 12.6 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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