GREMLIN Database
LDCA - Murein tetrapeptide carboxypeptidase
UniProt: P76008 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13898
Length: 304 (282)
Sequences: 2952 (2256)
Seq/√Len: 134.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_E284_I4.7451.00
2_S68_T3.9151.00
5_H60_L3.8001.00
10_S79_A3.5141.00
3_L32_Q3.4681.00
49_T52_E3.0661.00
41_R52_E2.9861.00
193_E224_R2.9171.00
50_E81_R2.8541.00
169_E282_H2.7951.00
34_N63_L2.7871.00
3_L34_N2.7661.00
31_H151_R2.7131.00
8_A73_V2.6971.00
4_F31_H2.5201.00
6_L73_V2.3021.00
23_I27_T2.2331.00
58_N90_A2.2131.00
167_R286_N2.2081.00
217_Y257_R2.1771.00
54_L85_D2.1721.00
196_I283_A2.1541.00
167_R284_I2.1491.00
194_N226_K2.1471.00
172_L277_L2.1341.00
69_I101_L2.0931.00
227_A285_L2.0591.00
55_E59_S2.0101.00
171_T195_G2.0001.00
38_V56_D1.9991.00
34_N66_P1.9971.00
189_M221_I1.9731.00
38_V41_R1.9261.00
225_Q228_I1.8831.00
165_T288_T1.8781.00
199_L230_L1.8321.00
228_I260_I1.8061.00
197_L225_Q1.8051.00
54_L58_N1.7961.00
27_T32_Q1.7711.00
64_T98_D1.7491.00
139_N273_R1.7451.00
5_H66_P1.7081.00
35_N39_I1.6881.00
147_W151_R1.6611.00
22_G129_L1.6371.00
7_I60_L1.6351.00
229_I266_L1.6331.00
29_A147_W1.6171.00
23_I35_N1.5871.00
58_N62_R1.5691.00
24_Q27_T1.5601.00
3_L65_T1.5601.00
198_V279_L1.5511.00
57_L61_A1.5511.00
37_E59_S1.5311.00
23_I33_V1.5291.00
229_I285_L1.5261.00
3_L66_P1.5221.00
51_T85_D1.5151.00
122_I281_A1.5081.00
172_L283_A1.5041.00
24_Q28_D1.4901.00
62_R90_A1.4361.00
144_H148_L1.4181.00
141_F275_V1.4161.00
197_L222_L1.4111.00
228_I255_R1.3811.00
31_H147_W1.3791.00
68_T98_D1.3621.00
222_L260_I1.3621.00
171_T282_H1.3481.00
51_T55_E1.3401.00
8_A39_I1.3391.00
192_I221_I1.3381.00
184_I219_A1.3311.00
198_V277_L1.3221.00
5_H34_N1.3041.00
112_Q123_T1.2811.00
214_L254_L1.2751.00
124_F276_T1.2631.00
116_L279_L1.2631.00
125_S176_N1.2541.00
61_A121_V1.2531.00
225_Q260_I1.2511.00
20_L23_I1.2471.00
88_W114_G1.2421.00
61_A91_L1.2311.00
38_V52_E1.2271.00
168_A227_A1.2191.00
71_L103_C1.2181.00
112_Q125_S1.2111.00
101_L124_F1.2091.00
7_I86_I1.2081.00
232_S267_D1.2081.00
112_Q279_L1.2071.00
125_S274_T1.2011.00
246_N249_S1.1991.00
84_A218_H1.1900.99
248_E264_T1.1850.99
79_A111_I1.1780.99
25_R29_A1.1780.99
115_L119_G1.1660.99
9_P108_F1.1610.99
36_V56_D1.1580.99
230_L233_F1.1480.99
206_P250_V1.1290.99
184_I189_M1.1230.99
174_G198_V1.1120.99
144_H147_W1.1100.99
103_C126_G1.1060.99
181_I184_I1.1040.99
81_R210_E1.1020.99
112_Q116_L1.0970.99
6_L129_L1.0940.99
286_N292_T1.0890.99
286_N289_R1.0850.99
188_W218_H1.0730.99
159_W162_E1.0720.99
5_H36_V1.0700.99
86_I91_L1.0600.99
16_Q20_L1.0580.99
83_L110_A1.0570.99
103_C276_T1.0550.99
102_I115_L1.0420.99
204_E208_R1.0410.99
72_A108_F1.0300.99
180_L199_L1.0280.98
35_N40_A1.0280.98
232_S271_E1.0270.98
87_D91_L1.0200.98
52_E55_E1.0200.98
27_T33_V1.0130.98
228_I262_L1.0130.98
148_L152_N1.0120.98
204_E211_R1.0080.98
20_L24_Q1.0010.98
91_L119_G1.0010.98
284_I293_Q1.0010.98
219_A222_L0.9950.98
61_A98_D0.9930.98
4_F33_V0.9870.98
115_L123_T0.9860.98
34_N65_T0.9860.98
54_L86_I0.9810.98
201_D233_F0.9800.98
189_M192_I0.9730.98
184_I215_Q0.9730.98
146_F150_L0.9730.98
118_H187_P0.9730.98
110_A179_M0.9660.98
198_V268_F0.9570.98
196_I227_A0.9560.98
263_I287_N0.9490.97
113_C180_L0.9460.97
102_I108_F0.9380.97
36_V60_L0.9340.97
268_F277_L0.9320.97
283_A294_L0.9280.97
122_I278_P0.9150.97
63_L100_L0.9090.97
54_L82_L0.9080.97
192_I224_R0.9080.97
74_R78_G0.9040.97
3_L33_V0.9040.97
184_I216_L0.9010.97
32_Q65_T0.8980.96
78_G210_E0.8950.96
128_M131_A0.8940.96
178_A201_D0.8900.96
42_R48_G0.8900.96
176_N233_F0.8840.96
263_I285_L0.8840.96
3_L68_T0.8830.96
80_S179_M0.8800.96
204_E212_M0.8800.96
58_N86_I0.8790.96
221_I224_R0.8790.96
90_A98_D0.8760.96
2_S69_I0.8620.96
13_C73_V0.8610.95
209_V247_L0.8590.95
182_S215_Q0.8570.95
80_S218_H0.8560.95
4_F151_R0.8550.95
167_R288_T0.8510.95
255_R258_L0.8510.95
255_R262_L0.8510.95
57_L86_I0.8490.95
61_A102_I0.8470.95
29_A143_E0.8400.95
186_T215_Q0.8370.95
227_A287_N0.8370.95
21_R24_Q0.8370.95
26_L71_L0.8370.95
181_I212_M0.8360.95
205_H208_R0.8340.95
74_R128_M0.8330.95
148_L154_T0.8320.95
173_W195_G0.8300.95
22_G26_L0.8290.94
43_C49_T0.8270.94
214_L253_F0.8270.94
145_H276_T0.8240.94
149_A276_T0.8230.94
168_A285_L0.8220.94
6_L23_I0.8210.94
50_E210_E0.8210.94
77_Y207_F0.8190.94
181_I215_Q0.8190.94
156_T291_G0.8180.94
192_I195_G0.8160.94
186_T189_M0.8160.94
10_S108_F0.8130.94
158_E161_G0.8130.94
37_E55_E0.8080.94
78_G81_R0.8080.94
177_L216_L0.8080.94
278_P281_A0.8020.93
19_A23_I0.7990.93
156_T293_Q0.7980.93
116_L173_W0.7960.93
105_H274_T0.7950.93
166_C287_N0.7940.93
84_A188_W0.7920.93
50_E54_L0.7920.93
230_L264_T0.7900.93
177_L212_M0.7900.93
99_P121_V0.7900.93
7_I70_V0.7890.93
4_F71_L0.7880.93
148_L153_E0.7840.93
7_I56_D0.7750.92
20_L27_T0.7730.92
4_F69_I0.7710.92
179_M182_S0.7680.92
114_G188_W0.7670.92
80_S182_S0.7660.92
58_N88_W0.7650.92
35_N38_V0.7640.92
217_Y254_L0.7630.92
201_D204_E0.7600.91
173_W190_P0.7560.91
140_A144_H0.7530.91
178_A182_S0.7530.91
110_A183_L0.7510.91
57_L82_L0.7470.91
116_L123_T0.7420.91
9_P111_I0.7400.90
287_N292_T0.7400.90
46_F50_E0.7370.90
88_W119_G0.7360.90
232_S265_G0.7340.90
72_A102_I0.7340.90
147_W150_L0.7340.90
143_E147_W0.7320.90
145_H149_A0.7300.90
101_L150_L0.7300.90
217_Y253_F0.7270.90
177_L204_E0.7270.90
146_F149_A0.7250.89
50_E78_G0.7250.89
20_L40_A0.7230.89
160_Q163_G0.7210.89
217_Y258_L0.7200.89
83_L188_W0.7130.89
199_L213_L0.7130.89
23_I129_L0.7120.89
101_L122_I0.7100.88
57_L102_I0.7070.88
46_F78_G0.7050.88
80_S214_L0.7040.88
88_W91_L0.7030.88
204_E207_F0.6980.88
108_F111_I0.6970.88
178_A212_M0.6970.88
215_Q219_A0.6950.87
286_N293_Q0.6910.87
217_Y223_P0.6910.87
9_P57_L0.6900.87
203_N235_G0.6880.87
285_L294_L0.6820.86
6_L35_N0.6790.86
199_L228_I0.6780.86
286_N290_E0.6760.86
26_L33_V0.6750.86
11_G74_R0.6730.86
44_E48_G0.6720.86
248_E252_A0.6710.86
142_T273_R0.6710.86
105_H125_S0.6700.85
177_L209_V0.6690.85
190_P221_I0.6670.85
91_L115_L0.6660.85
19_A35_N0.6640.85
59_S63_L0.6620.85
165_T287_N0.6600.85
207_F210_E0.6540.84
89_Q96_Q0.6540.84
145_H148_L0.6540.84
157_I275_V0.6540.84
209_V236_S0.6520.84
178_A208_R0.6510.84
17_H21_R0.6500.84
5_H63_L0.6490.84
206_P236_S0.6490.84
63_L66_P0.6470.83
39_I73_V0.6460.83
83_L114_G0.6460.83
183_L190_P0.6400.83
79_A110_A0.6370.82
78_G202_I0.6360.82
254_L257_R0.6360.82
8_A232_S0.6320.82
214_L218_H0.6300.82
197_L221_I0.6300.82
216_L221_I0.6250.81
77_Y204_E0.6240.81
84_A217_Y0.6230.81
124_F278_P0.6230.81
114_G119_G0.6220.81
208_R212_M0.6200.81
60_L66_P0.6200.81
233_F247_L0.6160.80
101_L276_T0.6160.80
74_R202_I0.6130.80
171_T194_N0.6130.80
6_L22_G0.6120.80
286_N291_G0.6100.80
16_Q40_A0.6100.80
213_L254_L0.6070.79
178_A202_I0.6040.79
248_E265_G0.6030.79
79_A102_I0.6030.79
78_G201_D0.6010.79
252_A256_S0.5990.78
186_T218_H0.5960.78
3_L63_L0.5950.78
96_Q119_G0.5890.77
58_N87_D0.5880.77
217_Y222_L0.5860.77
77_Y210_E0.5850.77
50_E82_L0.5850.77
123_T279_L0.5780.76
281_A294_L0.5780.76
2_S99_P0.5770.76
79_A108_F0.5770.76
87_D99_P0.5770.76
72_A79_A0.5750.76
46_F81_R0.5750.76
227_A263_I0.5720.75
289_R293_Q0.5720.75
209_V212_M0.5650.74
36_V39_I0.5650.74
191_K195_G0.5640.74
223_P258_L0.5630.74
200_E231_G0.5620.74
252_A262_L0.5610.74
78_G207_F0.5580.73
11_G203_N0.5580.73
8_A47_A0.5580.73
177_L210_E0.5540.73
210_E254_L0.5520.73
29_A151_R0.5500.72
29_A218_H0.5500.72
221_I225_Q0.5500.72
116_L280_G0.5490.72
7_I36_V0.5480.72
168_A287_N0.5480.72
58_N122_I0.5480.72
160_Q164_P0.5480.72
58_N82_L0.5470.72
148_L155_F0.5470.72
285_L288_T0.5470.72
69_I99_P0.5460.72
13_C19_A0.5460.72
180_L216_L0.5450.72
58_N85_D0.5440.72
157_I160_Q0.5420.71
182_S211_R0.5400.71
2_S31_H0.5370.71
18_A135_A0.5290.69
117_A189_M0.5290.69
82_L86_I0.5280.69
251_Y264_T0.5280.69
101_L278_P0.5280.69
89_Q193_E0.5280.69
103_C124_F0.5270.69
251_Y255_R0.5260.69
59_S62_R0.5230.69
81_R207_F0.5220.68
109_T216_L0.5220.68
127_P276_T0.5220.68
191_K224_R0.5220.68
22_G134_G0.5220.68
196_I285_L0.5210.68
109_T175_G0.5200.68
199_L218_H0.5190.68
44_E244_G0.5190.68
58_N123_T0.5190.68
21_R25_R0.5180.68
210_E253_F0.5170.68
113_C190_P0.5160.68
149_A152_N0.5160.68
26_L224_R0.5140.67
198_V253_F0.5140.67
81_R204_E0.5130.67
230_L255_R0.5130.67
230_L251_Y0.5120.67
44_E245_Y0.5110.67
22_G73_V0.5100.67
284_I291_G0.5090.67
9_P126_G0.5080.66
201_D209_V0.5080.66
74_R204_E0.5060.66
7_I38_V0.5060.66
283_A292_T0.5050.66
74_R207_F0.5040.66
177_L237_T0.5040.66
137_E140_A0.5030.66
68_T101_L0.5030.66
113_C173_W0.5010.65
58_N61_A0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tlaA 2 0.9638 100 0.084 Contact Map
4e5sA 2 0.9539 100 0.095 Contact Map
4jvoA 2 0.9539 100 0.1 Contact Map
4injA 2 0.9507 100 0.107 Contact Map
1zl0A 1 0.9342 100 0.116 Contact Map
4eysA 3 0.9375 100 0.139 Contact Map
3g23A 2 0.8717 100 0.16 Contact Map
4z0nA 1 0.5329 79.9 0.95 Contact Map
4yleA 1 0.477 77.6 0.952 Contact Map
4jenA 2 0.3783 76.7 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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