NHAP2 - ECOLI - GREMLIN Contacts

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NHAP2 - K(+)/H(+) antiporter NhaP2

UniProt:	P76007	Sequences: MDATTIISLFILGSILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFDNYPFAYMVSNLALAIILLDGGMRTQASSFRVALGPALSLATLGVLITSGLTGMMAAWLFNLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIAMIQHHESNISWMFIVDILQQFGLGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGILIFSLTTALEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAIPALILSAWMIFFARPLSVFAGLLPFRGFNLRERVFISWVGLRGAVPIILAVFPMMAGLENARLFFNVAFFVVLVSLLLQGTSLSWAAKKAKVVVPPVGRPVSRVGLDIHPENPWEQFVYQLSADKWCVGAALRDLHMPKETRIAALFRDNQLLHPTGSTRLREGDVLCVIGRERDLPALGKLFSQSPPVALDQRFFGDFILEASAKYADVALIYGLEDGREYRDKQQTLGEIVQQLLGAAPVVGDQVEFAGMIWTVAEKEDNEVLKIGVRVAEEEAES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13896
Length:	578 (474)
Sequences:	5269 (3919)
Seq/√Len:	180.0

ECOLI - NHAP2 YJCE KEFB KEFC YBAL
BACSU - NHAK YJBQ YHAU
HALSA - Q9HNK1
SULSO - Q97UN8 Q980D8 Q97Z08

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
112_A	119_L	3.822	1.00
338_W	382_S	3.787	1.00
234_I	252_C	3.785	1.00
307_A	374_V	3.652	1.00
415_E	419_Y	3.475	1.00
197_L	243_G	3.409	1.00
385_W	389_K	3.327	1.00
208_L	211_Q	3.223	1.00
189_V	193_Q	3.115	1.00
109_M	119_L	3.109	1.00
109_M	113_W	3.064	1.00
111_A	122_G	3.040	1.00
300_I	304_I	3.034	1.00
207_Y	211_Q	3.014	1.00
346_P	368_A	3.003	1.00
209_L	230_G	2.994	1.00
108_G	119_L	2.926	1.00
211_Q	215_R	2.921	1.00
304_I	308_W	2.840	1.00
118_D	121_E	2.822	1.00
188_I	192_L	2.760	1.00
430_A	434_D	2.708	1.00
416_Q	419_Y	2.707	1.00
193_Q	197_L	2.650	1.00
110_M	309_M	2.625	1.00
109_M	112_A	2.600	1.00
415_E	418_V	2.581	1.00
86_R	89_L	2.528	1.00
112_A	122_G	2.516	1.00
205_G	234_I	2.512	1.00
418_V	421_L	2.463	1.00
441_T	446_L	2.451	1.00
432_L	443_I	2.406	1.00
360_N	363_L	2.295	1.00
203_L	255_L	2.284	1.00
481_K	485_Q	2.279	1.00
128_I	350_A	2.256	1.00
95_L	318_V	2.190	1.00
166_V	349_L	2.164	1.00
446_L	450_N	2.135	1.00
386_A	389_K	2.129	1.00
303_L	370_F	2.125	1.00
374_V	378_L	2.121	1.00
108_G	112_A	2.117	1.00
85_F	92_A	2.100	1.00
444_A	448_R	2.097	1.00
203_L	207_Y	2.054	1.00
446_L	449_D	2.046	1.00
421_L	461_L	2.041	1.00
48_D	293_S	1.947	1.00
447_F	450_N	1.929	1.00
301_P	305_L	1.920	1.00
478_A	481_K	1.899	1.00
441_T	444_A	1.895	1.00
475_D	478_A	1.893	1.00
108_G	123_L	1.880	1.00
190_D	193_Q	1.871	1.00
329_N	332_E	1.851	1.00
414_W	419_Y	1.837	1.00
431_A	434_D	1.813	1.00
106_L	313_A	1.794	1.00
105_G	109_M	1.785	1.00
306_S	371_V	1.782	1.00
159_G	250_Y	1.771	1.00
286_L	344_A	1.763	1.00
435_L	439_K	1.716	1.00
390_A	393_V	1.712	1.00
50_V	53_I	1.692	1.00
454_H	457_G	1.685	1.00
446_L	459_T	1.684	1.00
319_F	330_L	1.682	1.00
104_S	130_G	1.668	1.00
417_F	421_L	1.663	1.00
405_G	408_I	1.645	1.00
196_G	200_V	1.631	1.00
124_L	353_P	1.629	1.00
40_A	44_L	1.625	1.00
150_V	332_E	1.622	1.00
192_L	196_G	1.614	1.00
435_L	438_P	1.594	1.00
464_G	468_C	1.592	1.00
49_G	53_I	1.582	1.00
422_S	426_W	1.576	1.00
134_A	158_S	1.556	1.00
211_Q	214_N	1.550	1.00
204_G	207_Y	1.541	1.00
441_T	448_R	1.501	1.00
406_L	409_H	1.500	1.00
319_F	334_V	1.500	1.00
443_I	450_N	1.499	1.00
194_Q	242_E	1.492	1.00
193_Q	243_G	1.489	1.00
108_G	126_G	1.471	1.00
47_V	291_N	1.465	1.00
104_S	168_L	1.465	1.00
415_E	421_L	1.465	1.00
443_I	447_F	1.458	1.00
238_T	243_G	1.458	1.00
400_P	404_V	1.454	1.00
468_C	472_R	1.449	1.00
443_I	449_D	1.448	1.00
419_Y	423_A	1.447	1.00
102_I	317_S	1.443	1.00
315_P	337_S	1.442	1.00
412_N	419_Y	1.439	1.00
57_N	61_A	1.429	1.00
282_M	344_A	1.421	1.00
132_T	344_A	1.420	1.00
171_T	187_F	1.403	1.00
227_A	267_I	1.396	1.00
91_P	153_T	1.394	1.00
469_V	472_R	1.389	1.00
461_L	465_D	1.380	1.00
111_A	117_L	1.379	1.00
389_K	393_V	1.379	1.00
404_V	408_I	1.379	1.00
415_E	420_Q	1.364	1.00
407_D	410_P	1.359	1.00
453_L	459_T	1.358	1.00
307_A	311_F	1.357	1.00
479_L	483_F	1.356	1.00
402_S	406_L	1.356	1.00
320_A	324_P	1.349	1.00
389_K	395_P	1.333	1.00
161_N	340_G	1.331	1.00
19_S	45_A	1.328	1.00
294_D	297_P	1.326	1.00
455_P	465_D	1.326	1.00
319_F	337_S	1.322	1.00
23_L	41_I	1.320	1.00
201_I	238_T	1.308	1.00
396_P	399_R	1.301	1.00
443_I	448_R	1.296	1.00
133_D	161_N	1.272	1.00
196_G	199_I	1.261	1.00
434_D	437_M	1.256	1.00
444_A	449_D	1.255	1.00
439_K	443_I	1.253	1.00
150_V	336_I	1.251	1.00
173_I	353_P	1.251	1.00
443_I	455_P	1.241	1.00
266_G	270_N	1.239	1.00
70_A	235_F	1.235	1.00
191_I	195_F	1.229	1.00
137_V	141_L	1.228	1.00
303_L	307_A	1.226	1.00
444_A	447_F	1.225	1.00
294_D	366_N	1.218	1.00
442_R	450_N	1.218	1.00
428_V	463_E	1.213	1.00
418_V	422_S	1.212	1.00
296_L	300_I	1.209	1.00
391_K	395_P	1.200	1.00
354_M	365_F	1.198	1.00
233_L	237_L	1.197	1.00
442_R	449_D	1.194	1.00
448_R	465_D	1.193	1.00
133_D	157_E	1.190	1.00
445_A	450_N	1.188	1.00
439_K	442_R	1.188	1.00
401_V	404_V	1.185	1.00
421_L	425_K	1.185	1.00
342_R	346_P	1.184	1.00
455_P	471_G	1.184	1.00
58_Y	61_A	1.183	1.00
109_M	114_L	1.177	1.00
305_L	308_W	1.176	1.00
444_A	450_N	1.170	1.00
443_I	446_L	1.165	1.00
235_F	245_G	1.164	1.00
117_L	122_G	1.160	1.00
201_I	241_L	1.159	1.00
234_I	248_A	1.158	1.00
89_L	93_L	1.147	1.00
422_S	425_K	1.147	1.00
402_S	407_D	1.146	1.00
413_P	419_Y	1.145	1.00
126_G	130_G	1.144	1.00
403_R	406_L	1.141	1.00
329_N	333_R	1.139	1.00
189_V	192_L	1.137	1.00
401_V	408_I	1.131	1.00
242_E	249_V	1.131	1.00
223_Y	263_N	1.129	1.00
367_V	371_V	1.126	1.00
198_G	202_G	1.123	1.00
205_G	237_L	1.122	1.00
59_P	62_Y	1.122	1.00
199_I	251_L	1.117	1.00
125_I	368_A	1.117	1.00
419_Y	425_K	1.116	1.00
388_K	393_V	1.113	1.00
441_T	445_A	1.110	1.00
186_M	189_V	1.102	1.00
387_A	392_V	1.100	1.00
111_A	126_G	1.099	1.00
127_A	130_G	1.090	1.00
316_L	320_A	1.089	1.00
472_R	475_D	1.087	1.00
291_N	294_D	1.087	1.00
429_G	435_L	1.082	1.00
436_H	439_K	1.081	1.00
480_G	484_S	1.078	1.00
421_L	424_D	1.074	1.00
208_L	212_M	1.074	1.00
323_L	333_R	1.071	1.00
228_L	274_L	1.070	1.00
309_M	313_A	1.068	1.00
107_T	111_A	1.062	1.00
157_E	340_G	1.052	1.00
453_L	463_E	1.052	1.00
477_P	481_K	1.051	1.00
112_A	123_L	1.050	1.00
111_A	306_S	1.048	1.00
416_Q	421_L	1.048	1.00
102_I	313_A	1.045	1.00
323_L	326_R	1.045	1.00
106_L	308_W	1.044	1.00
202_G	206_G	1.042	1.00
478_A	482_L	1.039	1.00
207_Y	255_L	1.036	1.00
334_V	337_S	1.035	1.00
319_F	333_R	1.031	1.00
320_A	323_L	1.031	1.00
449_D	462_R	1.031	1.00
259_R	262_R	1.029	1.00
420_Q	423_A	1.029	1.00
404_V	409_H	1.026	0.99
455_P	460_R	1.026	0.99
433_R	439_K	1.021	0.99
132_T	137_V	1.018	0.99
311_F	315_P	1.013	0.99
210_L	259_R	1.009	0.99
200_V	204_G	1.009	0.99
238_T	248_A	1.008	0.99
294_D	362_R	1.006	0.99
104_S	127_A	1.006	0.99
458_S	461_L	1.002	0.99
467_L	477_P	0.999	0.99
433_R	438_P	0.999	0.99
128_I	349_L	0.993	0.99
398_G	401_V	0.992	0.99
328_F	333_R	0.991	0.99
205_G	209_L	0.990	0.99
200_V	203_L	0.989	0.99
442_R	447_F	0.988	0.99
120_I	176_I	0.988	0.99
468_C	471_G	0.987	0.99
73_L	131_S	0.983	0.99
483_F	486_S	0.981	0.99
302_A	367_V	0.980	0.99
135_A	279_Q	0.974	0.99
302_A	305_L	0.974	0.99
226_L	230_G	0.973	0.99
290_V	373_L	0.968	0.99
420_Q	425_K	0.968	0.99
415_E	426_W	0.968	0.99
403_R	407_D	0.964	0.99
51_G	54_P	0.963	0.99
117_L	121_E	0.963	0.99
105_G	108_G	0.961	0.99
74_L	253_G	0.961	0.99
106_L	317_S	0.959	0.99
178_H	181_S	0.957	0.99
402_S	405_G	0.956	0.99
439_K	448_R	0.948	0.99
141_L	154_L	0.941	0.99
456_T	459_T	0.939	0.99
28_S	31_G	0.935	0.99
311_F	378_L	0.931	0.99
129_V	371_V	0.928	0.99
49_G	52_G	0.928	0.99
110_M	308_W	0.927	0.99
82_A	86_R	0.921	0.99
438_P	441_T	0.921	0.99
75_D	79_R	0.920	0.99
118_D	122_G	0.914	0.99
108_G	111_A	0.913	0.99
157_E	161_N	0.912	0.99
432_L	455_P	0.912	0.99
27_S	37_I	0.910	0.99
480_G	483_F	0.910	0.99
458_S	471_G	0.909	0.99
403_R	410_P	0.907	0.99
401_V	406_L	0.904	0.99
113_W	116_N	0.903	0.99
310_I	371_V	0.901	0.99
339_V	342_R	0.901	0.99
451_Q	458_S	0.900	0.99
419_Y	422_S	0.899	0.99
44_L	47_V	0.898	0.99
431_A	435_L	0.895	0.99
401_V	409_H	0.890	0.99
400_P	403_R	0.890	0.99
440_E	447_F	0.886	0.99
471_G	476_L	0.884	0.98
88_A	92_A	0.883	0.98
417_F	420_Q	0.883	0.98
141_L	146_L	0.881	0.98
110_M	113_W	0.879	0.98
184_S	188_I	0.878	0.98
251_L	255_L	0.878	0.98
401_V	405_G	0.878	0.98
460_R	463_E	0.873	0.98
417_F	425_K	0.872	0.98
430_A	441_T	0.871	0.98
420_Q	427_C	0.871	0.98
157_E	343_G	0.869	0.98
415_E	422_S	0.868	0.98
405_G	409_H	0.867	0.98
435_L	444_A	0.866	0.98
419_Y	424_D	0.865	0.98
476_L	479_L	0.865	0.98
417_F	423_A	0.864	0.98
435_L	447_F	0.860	0.98
169_T	352_F	0.859	0.98
430_A	433_R	0.855	0.98
228_L	269_Q	0.854	0.98
120_I	172_L	0.854	0.98
18_T	22_L	0.846	0.98
481_K	484_S	0.845	0.98
127_A	172_L	0.844	0.98
141_L	151_G	0.843	0.98
473_E	480_G	0.842	0.98
377_L	381_T	0.841	0.98
354_M	361_A	0.839	0.98
389_K	392_V	0.837	0.98
333_R	337_S	0.836	0.98
423_A	426_W	0.835	0.98
402_S	409_H	0.835	0.98
452_L	470_I	0.833	0.98
110_M	114_L	0.832	0.98
412_N	420_Q	0.828	0.98
388_K	395_P	0.828	0.98
133_D	136_A	0.827	0.98
432_L	435_L	0.826	0.98
436_H	450_N	0.826	0.98
119_L	123_L	0.823	0.98
423_A	463_E	0.823	0.98
122_G	126_G	0.823	0.98
318_V	337_S	0.822	0.98
429_G	433_R	0.821	0.98
438_P	442_R	0.820	0.98
160_S	247_L	0.817	0.97
166_V	244_S	0.813	0.97
237_L	241_L	0.812	0.97
419_Y	426_W	0.811	0.97
131_S	165_A	0.811	0.97
399_R	405_G	0.809	0.97
412_N	418_V	0.808	0.97
132_T	161_N	0.808	0.97
399_R	402_S	0.807	0.97
80_T	85_F	0.805	0.97
436_H	440_E	0.803	0.97
476_L	480_G	0.802	0.97
20_S	23_L	0.801	0.97
404_V	407_D	0.801	0.97
398_G	406_L	0.801	0.97
426_W	430_A	0.800	0.97
442_R	446_L	0.800	0.97
134_A	154_L	0.799	0.97
342_R	375_S	0.795	0.97
74_L	231_G	0.793	0.97
310_I	342_R	0.793	0.97
465_D	474_R	0.792	0.97
201_I	205_G	0.792	0.97
399_R	403_R	0.791	0.97
432_L	457_G	0.791	0.97
48_D	291_N	0.790	0.97
415_E	423_A	0.789	0.97
214_N	217_A	0.789	0.97
368_A	372_V	0.786	0.97
439_K	446_L	0.784	0.97
431_A	438_P	0.784	0.97
394_V	397_V	0.784	0.97
402_S	408_I	0.781	0.97
183_I	188_I	0.781	0.97
132_T	340_G	0.779	0.97
480_G	485_Q	0.779	0.97
125_I	367_V	0.778	0.97
403_R	409_H	0.777	0.97
133_D	340_G	0.776	0.97
473_E	477_P	0.776	0.97
299_A	302_A	0.775	0.97
384_S	388_K	0.775	0.97
459_T	462_R	0.770	0.96
99_G	103_T	0.768	0.96
42_G	46_G	0.767	0.96
453_L	460_R	0.767	0.96
416_Q	422_S	0.766	0.96
475_D	479_L	0.765	0.96
20_S	280_I	0.763	0.96
397_V	400_P	0.761	0.96
83_S	87_V	0.761	0.96
385_W	388_K	0.760	0.96
403_R	408_I	0.760	0.96
137_V	341_L	0.760	0.96
317_S	321_G	0.755	0.96
157_E	318_V	0.754	0.96
328_F	332_E	0.754	0.96
413_P	416_Q	0.754	0.96
464_G	470_I	0.752	0.96
18_T	229_S	0.751	0.96
396_P	401_V	0.751	0.96
471_G	474_R	0.747	0.96
201_I	243_G	0.747	0.96
461_L	464_G	0.747	0.96
302_A	306_S	0.746	0.96
418_V	423_A	0.744	0.96
433_R	446_L	0.743	0.96
322_L	333_R	0.743	0.96
465_D	472_R	0.741	0.96
120_I	123_L	0.739	0.95
431_A	460_R	0.739	0.95
338_W	341_L	0.738	0.95
457_G	464_G	0.737	0.95
20_S	24_S	0.735	0.95
160_S	244_S	0.733	0.95
210_L	256_L	0.733	0.95
318_V	336_I	0.733	0.95
376_L	379_Q	0.731	0.95
467_L	471_G	0.730	0.95
429_G	432_L	0.729	0.95
88_A	153_T	0.729	0.95
452_L	458_S	0.729	0.95
434_D	438_P	0.728	0.95
451_Q	460_R	0.727	0.95
54_P	61_A	0.726	0.95
418_V	426_W	0.726	0.95
210_L	260_P	0.725	0.95
98_L	102_I	0.723	0.95
9_L	13_G	0.722	0.95
108_G	122_G	0.721	0.95
458_S	464_G	0.720	0.95
433_R	445_A	0.719	0.95
454_H	461_L	0.716	0.95
68_A	282_M	0.715	0.95
435_L	443_I	0.714	0.95
179_H	182_N	0.712	0.94
85_F	254_F	0.711	0.94
476_L	483_F	0.707	0.94
241_L	296_L	0.707	0.94
430_A	435_L	0.707	0.94
413_P	426_W	0.707	0.94
138_F	155_E	0.706	0.94
418_V	428_V	0.704	0.94
150_V	335_F	0.704	0.94
97_T	101_L	0.703	0.94
129_V	342_R	0.703	0.94
462_R	466_V	0.702	0.94
203_L	251_L	0.701	0.94
133_D	158_S	0.701	0.94
104_S	165_A	0.701	0.94
119_L	122_G	0.699	0.94
131_S	134_A	0.699	0.94
204_G	208_L	0.696	0.94
478_A	486_S	0.696	0.94
470_I	474_R	0.693	0.94
50_V	54_P	0.693	0.94
93_L	373_L	0.692	0.94
62_Y	66_N	0.692	0.94
99_G	314_R	0.692	0.94
199_I	203_L	0.691	0.94
132_T	343_G	0.690	0.93
421_L	426_W	0.688	0.93
338_W	379_Q	0.687	0.93
93_L	97_T	0.686	0.93
413_P	418_V	0.686	0.93
438_P	443_I	0.684	0.93
132_T	157_E	0.683	0.93
244_S	274_L	0.682	0.93
227_A	256_L	0.681	0.93
368_A	376_L	0.681	0.93
469_V	474_R	0.680	0.93
107_T	126_G	0.680	0.93
424_D	428_V	0.679	0.93
298_I	302_A	0.678	0.93
415_E	425_K	0.678	0.93
80_T	156_I	0.677	0.93
416_Q	426_W	0.673	0.93
127_A	168_L	0.673	0.93
326_R	329_N	0.672	0.93
91_P	328_F	0.672	0.93
134_A	288_L	0.668	0.92
124_L	172_L	0.668	0.92
304_I	374_V	0.668	0.92
107_T	254_F	0.668	0.92
73_L	345_V	0.668	0.92
16_L	24_S	0.667	0.92
447_F	466_V	0.667	0.92
431_A	437_M	0.667	0.92
213_I	230_G	0.663	0.92
455_P	463_E	0.663	0.92
158_S	161_N	0.663	0.92
417_F	427_C	0.662	0.92
446_L	453_L	0.660	0.92
412_N	416_Q	0.660	0.92
429_G	444_A	0.658	0.92
16_L	20_S	0.657	0.92
471_G	475_D	0.654	0.92
433_R	441_T	0.654	0.92
91_P	94_S	0.652	0.91
394_V	398_G	0.651	0.91
19_S	23_L	0.650	0.91
316_L	395_P	0.650	0.91
440_E	478_A	0.649	0.91
482_L	486_S	0.649	0.91
455_P	461_L	0.648	0.91
256_L	267_I	0.647	0.91
110_M	305_L	0.647	0.91
438_P	446_L	0.647	0.91
209_L	226_L	0.646	0.91
442_R	445_A	0.646	0.91
57_N	60_F	0.645	0.91
244_S	343_G	0.645	0.91
197_L	206_G	0.645	0.91
33_P	134_A	0.644	0.91
463_E	466_V	0.643	0.91
93_L	109_M	0.642	0.91
412_N	423_A	0.642	0.91
121_E	176_I	0.640	0.91
414_W	420_Q	0.639	0.91
453_L	457_G	0.638	0.91
430_A	436_H	0.638	0.91
363_L	367_V	0.637	0.90
459_T	464_G	0.637	0.90
266_G	269_Q	0.637	0.90
131_S	346_P	0.636	0.90
416_Q	427_C	0.634	0.90
80_T	134_A	0.634	0.90
422_S	427_C	0.632	0.90
397_V	402_S	0.628	0.90
144_K	384_S	0.628	0.90
90_G	94_S	0.627	0.90
84_S	130_G	0.625	0.90
102_I	106_L	0.624	0.90
419_Y	429_G	0.623	0.89
136_A	376_L	0.621	0.89
173_I	176_I	0.621	0.89
70_A	232_I	0.620	0.89
479_L	486_S	0.620	0.89
437_M	447_F	0.619	0.89
420_Q	424_D	0.619	0.89
92_A	156_I	0.618	0.89
154_L	350_A	0.617	0.89
125_I	364_F	0.617	0.89
75_D	275_A	0.616	0.89
96_A	99_G	0.614	0.89
442_R	448_R	0.613	0.89
255_L	259_R	0.612	0.89
423_A	427_C	0.612	0.89
74_L	77_G	0.611	0.89
101_L	105_G	0.610	0.88
91_P	325_F	0.609	0.88
393_V	397_V	0.608	0.88
416_Q	424_D	0.608	0.88
356_A	360_N	0.604	0.88
338_W	380_G	0.603	0.88
280_I	375_S	0.603	0.88
162_D	244_S	0.601	0.88
395_P	402_S	0.601	0.88
307_A	375_S	0.600	0.88
396_P	409_H	0.600	0.88
131_S	161_N	0.599	0.88
17_V	24_S	0.599	0.88
85_F	156_I	0.597	0.87
190_D	194_Q	0.597	0.87
154_L	339_V	0.597	0.87
132_T	286_L	0.595	0.87
398_G	402_S	0.595	0.87
14_S	23_L	0.592	0.87
169_T	353_P	0.592	0.87
472_R	476_L	0.592	0.87
232_I	236_S	0.592	0.87
11_I	14_S	0.592	0.87
158_S	347_I	0.592	0.87
79_R	368_A	0.591	0.87
445_A	460_R	0.590	0.87
53_I	57_N	0.589	0.87
423_A	428_V	0.589	0.87
434_D	439_K	0.588	0.87
186_M	190_D	0.588	0.87
454_H	459_T	0.587	0.87
468_C	474_R	0.586	0.86
292_P	295_L	0.586	0.86
215_R	219_P	0.586	0.86
95_L	139_S	0.586	0.86
467_L	470_I	0.585	0.86
187_F	191_I	0.585	0.86
470_I	473_E	0.585	0.86
421_L	428_V	0.584	0.86
244_S	349_L	0.583	0.86
137_V	342_R	0.582	0.86
100_V	164_M	0.582	0.86
148_E	151_G	0.581	0.86
225_L	277_L	0.581	0.86
253_G	282_M	0.580	0.86
459_T	467_L	0.580	0.86
419_Y	431_A	0.580	0.86
236_S	240_A	0.579	0.86
458_S	462_R	0.577	0.86
457_G	469_V	0.577	0.86
157_E	245_G	0.576	0.85
109_M	424_D	0.575	0.85
209_L	256_L	0.575	0.85
382_S	385_W	0.574	0.85
80_T	258_N	0.573	0.85
44_L	298_I	0.573	0.85
174_A	178_H	0.573	0.85
436_H	451_Q	0.572	0.85
158_S	198_G	0.571	0.85
435_L	441_T	0.571	0.85
435_L	446_L	0.570	0.85
330_L	334_V	0.568	0.85
440_E	443_I	0.565	0.84
121_E	360_N	0.564	0.84
94_S	321_G	0.564	0.84
289_L	365_F	0.563	0.84
282_M	348_I	0.563	0.84
406_L	410_P	0.563	0.84
414_W	427_C	0.563	0.84
63_M	231_G	0.562	0.84
38_F	280_I	0.561	0.84
479_L	484_S	0.561	0.84
100_V	103_T	0.560	0.84
458_S	466_V	0.559	0.84
449_D	457_G	0.558	0.84
91_P	156_I	0.557	0.84
184_S	189_V	0.557	0.84
456_T	462_R	0.557	0.84
305_L	309_M	0.557	0.84
411_E	419_Y	0.556	0.83
117_L	363_L	0.555	0.83
71_I	228_L	0.554	0.83
342_R	372_V	0.554	0.83
400_P	405_G	0.553	0.83
397_V	403_R	0.552	0.83
442_R	453_L	0.550	0.83
465_D	469_V	0.550	0.83
75_D	272_D	0.549	0.83
441_T	471_G	0.549	0.83
128_I	368_A	0.548	0.83
459_T	473_E	0.547	0.82
411_E	414_W	0.546	0.82
198_G	206_G	0.546	0.82
473_E	479_L	0.546	0.82
20_S	373_L	0.545	0.82
157_E	202_G	0.543	0.82
165_A	169_T	0.543	0.82
132_T	165_A	0.541	0.82
75_D	372_V	0.541	0.82
460_R	464_G	0.539	0.82
135_A	348_I	0.538	0.81
102_I	321_G	0.538	0.81
70_A	234_I	0.537	0.81
312_F	315_P	0.537	0.81
445_A	449_D	0.537	0.81
270_N	274_L	0.536	0.81
341_L	372_V	0.536	0.81
331_R	335_F	0.535	0.81
431_A	449_D	0.535	0.81
10_F	255_L	0.533	0.81
65_S	250_Y	0.532	0.81
439_K	447_F	0.532	0.81
474_R	478_A	0.532	0.81
395_P	405_G	0.532	0.81
82_A	257_G	0.531	0.81
471_G	486_S	0.528	0.80
420_Q	442_R	0.527	0.80
83_S	86_R	0.527	0.80
388_K	392_V	0.526	0.80
478_A	484_S	0.525	0.80
433_R	444_A	0.524	0.80
213_I	261_I	0.524	0.80
440_E	450_N	0.524	0.80
387_A	391_K	0.523	0.80
412_N	417_F	0.523	0.80
394_V	410_P	0.522	0.79
394_V	400_P	0.522	0.79
77_G	249_V	0.521	0.79
14_S	229_S	0.521	0.79
76_G	132_T	0.521	0.79
157_E	163_P	0.520	0.79
449_D	458_S	0.520	0.79
106_L	109_M	0.519	0.79
21_I	225_L	0.518	0.79
423_A	440_E	0.518	0.79
419_Y	428_V	0.518	0.79
424_D	427_C	0.517	0.79
267_I	371_V	0.516	0.79
433_R	467_L	0.514	0.78
335_F	383_L	0.513	0.78
411_E	440_E	0.512	0.78
39_L	286_L	0.512	0.78
92_A	107_T	0.511	0.78
103_T	107_T	0.510	0.78
23_L	37_I	0.510	0.78
210_L	255_L	0.509	0.78
447_F	452_L	0.509	0.78
29_R	116_N	0.509	0.78
331_R	390_A	0.508	0.78
212_M	233_L	0.508	0.78
440_E	446_L	0.506	0.77
170_I	174_A	0.505	0.77
246_I	249_V	0.503	0.77
250_Y	345_V	0.503	0.77
456_T	460_R	0.502	0.77
398_G	409_H	0.502	0.77
81_Q	84_S	0.502	0.77
464_G	483_F	0.502	0.77
387_A	401_V	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4czbA	2	0.6713	100	0.428	Contact Map
4cz8A	2	0.6661	100	0.436	Contact Map
4bwzA	2	0.6574	100	0.472	Contact Map
1zcdA	1	0.5934	99.9	0.772	Contact Map
2mdfA	1	0.0986	99.3	0.865	Contact Map
3zuxA	1	0.5138	98.2	0.908	Contact Map
2l0eA	1	0.0536	97.7	0.919	Contact Map
4n7wA	2	0.5173	97.6	0.922	Contact Map
2k3cA	1	0.0536	97.3	0.925	Contact Map
2htgA	1	0.0467	97.2	0.927	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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