GREMLIN Database
PLIG - Inhibitor of g-type lysozyme
UniProt: P76002 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13892
Length: 133 (106)
Sequences: 1153 (1101)
Seq/√Len: 106.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_D126_Y3.7761.00
55_Y106_K2.6221.00
76_F110_R2.4681.00
56_A101_L2.4321.00
53_T106_K2.2451.00
24_G30_E2.2381.00
22_A25_K2.1461.00
66_I73_T2.1461.00
57_K104_S2.1421.00
63_H98_Q2.1221.00
73_T95_S2.0671.00
79_G83_S1.8901.00
76_F84_V1.8101.00
76_F112_L1.8091.00
78_P84_V1.7881.00
82_D85_D1.7771.00
56_A105_G1.7551.00
53_T108_E1.6781.00
56_A104_S1.6471.00
26_N29_V1.6331.00
77_G99_Y1.6311.00
22_A30_E1.5621.00
49_Y110_R1.5551.00
66_I111_V1.5421.00
59_G104_S1.5401.00
25_K30_E1.5331.00
109_L128_V1.5011.00
51_T108_E1.4641.00
81_D85_D1.4641.00
87_S90_S1.4451.00
54_F130_I1.4411.00
72_D89_Y1.3621.00
77_G97_G1.3120.99
72_D95_S1.2880.99
51_T78_P1.2570.99
77_G109_L1.2340.99
21_F24_G1.2340.99
77_G107_Y1.2110.99
54_F101_L1.2040.99
48_D108_E1.1970.99
61_K100_S1.1780.99
27_V30_E1.1740.99
72_D114_T1.1620.99
75_L95_S1.1450.98
23_A29_V1.1340.98
51_T110_R1.1300.98
27_V51_T1.1280.98
74_Y89_Y1.1230.98
88_R95_S1.1100.98
75_L97_G1.0990.98
79_G108_E1.0930.98
78_P110_R1.0900.98
33_K39_Q1.0810.98
75_L111_V1.0750.98
74_Y95_S1.0740.98
94_D130_I1.0400.97
57_K60_Q0.9970.96
80_I108_E0.9870.96
23_A31_F0.9760.96
58_K104_S0.9750.96
56_A59_G0.9720.96
22_A50_D0.9590.95
56_A102_P0.9380.95
41_S52_Y0.9250.94
64_V109_L0.9240.94
30_E33_K0.9230.94
49_Y112_L0.9180.94
113_Q117_D0.8980.93
25_K29_V0.8890.93
48_D75_L0.8790.93
52_Y111_V0.8710.92
62_V107_Y0.8640.92
72_D88_R0.8340.90
84_V110_R0.8290.90
24_G31_F0.8270.90
36_S39_Q0.8260.90
23_A52_Y0.8220.90
58_K69_E0.8160.89
50_D108_E0.8150.89
68_N71_A0.8130.89
52_Y62_V0.8110.89
59_G101_L0.8010.89
69_E94_D0.7920.88
80_I106_K0.7920.88
71_A93_L0.7910.88
29_V33_K0.7850.88
43_E123_T0.7810.87
60_Q100_S0.7790.87
66_I128_V0.7690.87
54_F109_L0.7520.85
65_S96_H0.7500.85
68_N124_K0.7450.85
22_A31_F0.7290.83
64_V130_I0.7200.83
38_A93_L0.7150.82
36_S130_I0.7140.82
124_K127_N0.7090.82
46_G127_N0.7090.82
33_K36_S0.7030.81
52_Y128_V0.6970.81
60_Q104_S0.6970.81
39_Q52_Y0.6870.80
56_A60_Q0.6860.80
22_A52_Y0.6800.79
44_I62_V0.6740.78
22_A48_D0.6650.77
65_S129_D0.6550.76
43_E48_D0.6530.76
66_I95_S0.6510.76
37_S58_K0.6510.76
88_R92_E0.6500.76
58_K82_D0.6400.75
90_S95_S0.6350.74
36_S41_S0.6330.74
60_Q65_S0.6290.73
63_H93_L0.6270.73
45_K48_D0.6270.73
53_T99_Y0.6260.73
54_F62_V0.6190.72
75_L94_D0.6190.72
37_S70_G0.6140.72
54_F107_Y0.6120.71
35_H125_K0.6070.71
39_Q128_V0.6010.70
101_L104_S0.5970.70
77_G82_D0.5950.69
31_F39_Q0.5840.68
68_N73_T0.5770.67
64_V93_L0.5660.66
109_L115_R0.5650.65
23_A30_E0.5630.65
43_E51_T0.5630.65
73_T124_K0.5620.65
76_F114_T0.5610.65
111_V128_V0.5600.65
63_H69_E0.5600.65
34_G40_Y0.5580.64
99_Y102_P0.5540.64
73_T111_V0.5530.64
106_K128_V0.5530.64
98_Q117_D0.5490.63
65_S79_G0.5490.63
62_V101_L0.5460.63
46_G118_A0.5440.62
27_V82_D0.5400.62
48_D110_R0.5370.61
38_A129_D0.5370.61
59_G100_S0.5270.60
32_R98_Q0.5270.60
25_K33_K0.5260.60
82_D117_D0.5220.59
72_D94_D0.5180.59
61_K98_Q0.5130.58
115_R129_D0.5100.58
74_Y114_T0.5080.57
47_Y51_T0.5050.57
42_G47_Y0.5030.57
26_N64_V0.5020.56
118_A124_K0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jqwA 1 0.8722 99.7 0.316 Contact Map
1nqjA 1 0.8271 99.6 0.371 Contact Map
4dzgA 1 0.7744 98.9 0.547 Contact Map
4g9sB 1 0.782 98.6 0.6 Contact Map
2luwA 1 0.7218 97.8 0.677 Contact Map
3afgA 1 0.9474 97 0.718 Contact Map
1wmdA 1 0.9624 90.8 0.798 Contact Map
3c12A 2 0.7218 69.9 0.84 Contact Map
3osvA 2 0.6842 66.6 0.844 Contact Map
3d33A 1 0.6692 48.7 0.86 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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