GREMLIN Database
BLUR - HTH-type transcriptional repressor BluR
UniProt: P75989 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13886
Length: 243 (222)
Sequences: 1188 (855)
Seq/√Len: 57.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_V47_I4.0891.00
4_Y44_E3.8631.00
12_R51_E3.3331.00
129_V132_H3.2731.00
171_N198_P3.2151.00
167_L178_L3.0911.00
129_V174_E2.9781.00
139_S143_D2.9621.00
9_V50_I2.7831.00
140_S143_D2.6781.00
9_V13_C2.6151.00
174_E177_R2.5421.00
10_A17_P2.3811.00
140_S174_E2.2741.00
147_I175_R2.2431.00
43_D46_D2.2291.00
84_L107_L2.1251.00
16_N19_T2.0371.00
53_I63_V1.9611.00
22_A25_R1.9241.00
129_V177_R1.8991.00
48_Q51_E1.8521.00
9_V30_L1.8471.00
10_A22_A1.7890.99
129_V139_S1.7780.99
132_H177_R1.7750.99
140_S200_E1.7640.99
112_P116_L1.7510.99
24_Q34_R1.7450.99
35_S38_G1.7280.99
13_C50_I1.7160.99
165_A185_L1.7130.99
6_I32_P1.7110.99
53_I66_V1.7040.99
34_R38_G1.6830.99
139_S174_E1.6750.99
132_H140_S1.6180.99
24_Q32_P1.6070.99
111_Y120_V1.5980.99
108_G116_L1.5970.99
88_M100_L1.5970.99
29_L53_I1.5750.98
132_H174_E1.5740.98
6_I24_Q1.5350.98
132_H139_S1.5300.98
139_S196_A1.5290.98
22_A41_L1.5290.98
143_D174_E1.5120.98
54_K58_S1.5060.98
141_M145_A1.5040.98
132_H196_A1.4930.98
181_E184_R1.4680.97
52_E56_W1.4470.97
66_V70_L1.4250.97
15_I20_L1.4000.97
105_I109_R1.3990.97
174_E200_E1.3930.96
92_L100_L1.3870.96
129_V196_A1.3660.96
113_V170_W1.3610.96
135_S203_R1.3570.96
49_R71_E1.3490.96
6_I34_R1.3480.96
22_A30_L1.3460.96
94_M99_K1.3430.96
155_F158_R1.3420.96
21_R27_Y1.3330.95
174_E196_A1.3170.95
53_I56_W1.3070.95
53_I70_L1.3060.95
140_S177_R1.3020.95
21_R26_R1.2830.94
125_R132_H1.2670.94
101_R105_I1.2530.94
172_V178_L1.2360.93
129_V140_S1.2280.93
53_I67_K1.2180.93
112_P115_Q1.2040.92
165_A169_A1.1910.92
107_L120_V1.1820.92
15_I19_T1.1800.92
32_P41_L1.1770.91
6_I21_R1.1740.91
50_I80_D1.1690.91
62_P100_L1.1630.91
216_T221_T1.1630.91
165_A191_H1.1450.90
213_I216_T1.1340.90
5_S8_D1.1320.90
177_R196_A1.1310.90
93_R131_D1.1290.90
165_A190_W1.1250.89
137_I178_L1.1200.89
150_A164_E1.1150.89
205_E209_T1.1040.89
29_L67_K1.1040.89
33_Q36_E1.0990.88
166_I169_A1.0940.88
99_K103_R1.0850.88
105_I149_Y1.0710.87
6_I18_V1.0700.87
173_E198_P1.0670.87
46_D67_K1.0670.87
21_R32_P1.0650.87
147_I179_W1.0640.87
18_V38_G1.0610.86
81_W119_H1.0550.86
125_R142_F1.0460.86
29_L57_I1.0430.86
216_T219_A1.0350.85
44_E48_Q1.0310.85
43_D94_M1.0100.84
18_V35_S1.0080.84
23_W26_R1.0080.84
129_V172_V1.0050.83
80_D171_N1.0050.83
8_D158_R1.0040.83
140_S179_W1.0010.83
16_N63_V1.0010.83
22_A32_P0.9960.83
102_A202_P0.9950.83
217_G220_P0.9930.83
103_R107_L0.9920.83
17_P39_H0.9870.82
199_I207_F0.9810.82
29_L46_D0.9660.81
96_N99_K0.9630.81
204_P208_P0.9580.80
121_Y146_L0.9470.80
104_I121_Y0.9440.79
73_T76_D0.9440.79
35_S39_H0.9380.79
8_D11_E0.9370.79
97_P141_M0.9360.79
95_A141_M0.9350.79
145_A149_Y0.9340.79
26_R42_F0.9320.78
142_F194_V0.9180.77
19_T39_H0.9180.77
22_A70_L0.9100.77
18_V25_R0.9030.76
140_S172_V0.8990.76
16_N47_I0.8940.75
7_G18_V0.8920.75
9_V16_N0.8890.75
13_C32_P0.8880.75
72_T223_R0.8620.73
132_H172_V0.8580.72
84_L87_E0.8530.72
181_E185_L0.8500.72
87_E94_M0.8450.71
182_A192_I0.8440.71
37_G57_I0.8410.71
8_D13_C0.8400.71
132_H143_D0.8350.70
132_H200_E0.8330.70
18_V22_A0.8310.70
168_M196_A0.8270.70
158_R186_S0.8120.68
33_Q46_D0.8090.68
50_I158_R0.8080.68
29_L59_N0.8050.68
10_A193_S0.8040.67
140_S199_I0.8030.67
179_W194_V0.8010.67
86_E90_S0.7980.67
154_L183_W0.7910.66
53_I57_I0.7860.66
88_M124_V0.7830.65
90_S176_A0.7780.65
39_H53_I0.7750.65
18_V70_L0.7740.64
13_C22_A0.7720.64
169_A181_E0.7710.64
124_V146_L0.7710.64
149_Y152_T0.7650.64
33_Q109_R0.7640.63
78_E121_Y0.7640.63
20_L25_R0.7580.63
70_L74_S0.7560.63
66_V181_E0.7550.63
102_A105_I0.7540.62
216_T224_Q0.7530.62
39_H66_V0.7520.62
20_L92_L0.7520.62
144_G151_A0.7510.62
52_E55_R0.7510.62
212_L215_W0.7490.62
29_L35_S0.7470.62
211_T215_W0.7420.61
5_S41_L0.7380.61
115_Q119_H0.7350.60
6_I42_F0.7350.60
18_V56_W0.7320.60
18_V34_R0.7310.60
46_D49_R0.7300.60
125_R129_V0.7250.59
138_M210_Q0.7230.59
125_R143_D0.7230.59
77_T90_S0.7220.59
24_Q132_H0.7220.59
108_G112_P0.7200.59
126_Q130_L0.7170.59
81_W85_Q0.7140.58
78_E84_L0.7110.58
45_E77_T0.7100.58
20_L117_I0.7090.58
147_I150_A0.7090.58
42_F50_I0.7060.57
182_A194_V0.7050.57
164_E191_H0.7020.57
33_Q43_D0.7000.57
93_R119_H0.7000.57
129_V143_D0.6970.56
211_T219_A0.6920.56
169_A196_A0.6910.56
86_E127_R0.6890.56
159_R202_P0.6830.55
120_V178_L0.6770.54
172_V196_A0.6750.54
91_I204_P0.6740.54
18_V39_H0.6720.54
13_C66_V0.6690.53
139_S146_L0.6680.53
14_G26_R0.6650.53
23_W40_R0.6620.53
125_R174_E0.6590.52
5_S112_P0.6580.52
16_N34_R0.6550.52
26_R32_P0.6540.52
89_M124_V0.6500.51
21_R42_F0.6500.51
220_P224_Q0.6490.51
214_V217_G0.6470.51
104_I145_A0.6460.51
176_A183_W0.6460.51
12_R85_Q0.6450.51
188_S222_R0.6430.51
206_L210_Q0.6430.51
75_Q222_R0.6390.50
54_K57_I0.6370.50
143_D177_R0.6340.50
140_S196_A0.6330.49
72_T89_M0.6330.49
23_W42_F0.6320.49
127_R131_D0.6310.49
114_D187_L0.6250.49
48_Q94_M0.6220.48
4_Y12_R0.6200.48
7_G36_E0.6190.48
13_C37_G0.6130.47
18_V63_V0.6120.47
118_N184_R0.6090.47
151_A176_A0.6090.47
202_P209_T0.6090.47
15_I121_Y0.6050.46
24_Q27_Y0.6010.46
57_I69_L0.6010.46
37_G92_L0.6000.46
144_G203_R0.5910.45
18_V66_V0.5870.44
79_D189_G0.5870.44
114_D188_S0.5860.44
101_R118_N0.5820.44
36_E120_V0.5760.43
214_V219_A0.5760.43
216_T222_R0.5720.43
10_A39_H0.5710.43
102_A156_E0.5710.43
169_A172_V0.5700.43
78_E119_H0.5690.42
75_Q79_D0.5680.42
56_W61_V0.5660.42
144_G179_W0.5650.42
158_R178_L0.5640.42
32_P42_F0.5640.42
46_D117_I0.5600.41
165_A208_P0.5570.41
141_M150_A0.5570.41
165_A170_W0.5570.41
56_W199_I0.5560.41
176_A190_W0.5560.41
91_I103_R0.5550.41
102_A162_G0.5530.41
51_E58_S0.5530.41
47_I209_T0.5470.40
76_D127_R0.5460.40
219_A222_R0.5450.40
43_D150_A0.5440.40
48_Q167_L0.5420.40
206_L209_T0.5420.40
78_E106_S0.5420.40
73_T157_M0.5400.39
6_I38_G0.5400.39
37_G67_K0.5400.39
52_E67_K0.5400.39
42_F150_A0.5390.39
74_S121_Y0.5390.39
68_A78_E0.5380.39
31_K202_P0.5370.39
90_S99_K0.5350.39
29_L61_V0.5330.39
113_V180_L0.5320.39
116_L120_V0.5310.38
6_I16_N0.5310.38
175_R194_V0.5300.38
97_P124_V0.5290.38
85_Q127_R0.5270.38
81_W109_R0.5260.38
10_A180_L0.5240.38
59_N66_V0.5230.38
185_L204_P0.5220.37
17_P24_Q0.5190.37
45_E161_P0.5190.37
178_L194_V0.5170.37
9_V182_A0.5160.37
34_R40_R0.5150.37
45_E79_D0.5140.37
136_R219_A0.5140.37
124_V138_M0.5130.37
4_Y183_W0.5120.36
16_N22_A0.5120.36
5_S39_H0.5120.36
107_L132_H0.5110.36
57_I66_V0.5090.36
31_K117_I0.5080.36
139_S147_I0.5060.36
82_S219_A0.5050.36
6_I10_A0.5030.36
169_A174_E0.5020.35
26_R40_R0.5010.35
7_G52_E0.5000.35
176_A197_D0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3whpA 1 0.6626 100 0.415 Contact Map
3ezxA 2 0.6626 99.7 0.721 Contact Map
4hh3C 1 0.679 99.7 0.722 Contact Map
1y80A 1 0.3498 99.7 0.725 Contact Map
2i2xB 1 0.8107 99.7 0.726 Contact Map
4hh0A 2 0.9588 99.7 0.727 Contact Map
3bulA 1 0.6831 99.7 0.73 Contact Map
4jgiA 2 0.6543 99.7 0.735 Contact Map
3hh0A 4 0.5185 99.7 0.736 Contact Map
2dg6A 2 0.7819 99.7 0.74 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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