BLUR - ECOLI - GREMLIN Contacts

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BLUR - HTH-type transcriptional repressor BluR

UniProt:	P75989	Sequences: MAYYSIGDVAERCGINPVTLRAWQRRYGLLKPQRSEGGHRLFDEEDIQRIEEIKRWISNGVPVGKVKALLETTSQDTEDDWSRLQEEMMSILRMANPAKLRARIISLGREYPVDQLINHVYLPVRQRLVLDHNTSRIMSSMFDGALIEYAATSLFEMRRKPGKEAILMAWNVEERARLWLEAWRLSLSGWHISVLADPIESPRPELFPTQTLIVWTGMAPTRRQNELLQHWGEQGYKVIFHAP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13886
Length:	243 (222)
Sequences:	1188 (855)
Seq/√Len:	57.4

ECOLI - BLUR MLRA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
9_V	47_I	4.089	1.00
4_Y	44_E	3.863	1.00
12_R	51_E	3.333	1.00
129_V	132_H	3.273	1.00
171_N	198_P	3.215	1.00
167_L	178_L	3.091	1.00
129_V	174_E	2.978	1.00
139_S	143_D	2.962	1.00
9_V	50_I	2.783	1.00
140_S	143_D	2.678	1.00
9_V	13_C	2.615	1.00
174_E	177_R	2.542	1.00
10_A	17_P	2.381	1.00
140_S	174_E	2.274	1.00
147_I	175_R	2.243	1.00
43_D	46_D	2.229	1.00
84_L	107_L	2.125	1.00
16_N	19_T	2.037	1.00
53_I	63_V	1.961	1.00
22_A	25_R	1.924	1.00
129_V	177_R	1.899	1.00
48_Q	51_E	1.852	1.00
9_V	30_L	1.847	1.00
10_A	22_A	1.789	0.99
129_V	139_S	1.778	0.99
132_H	177_R	1.775	0.99
140_S	200_E	1.764	0.99
112_P	116_L	1.751	0.99
24_Q	34_R	1.745	0.99
35_S	38_G	1.728	0.99
13_C	50_I	1.716	0.99
165_A	185_L	1.713	0.99
6_I	32_P	1.711	0.99
53_I	66_V	1.704	0.99
34_R	38_G	1.683	0.99
139_S	174_E	1.675	0.99
132_H	140_S	1.618	0.99
24_Q	32_P	1.607	0.99
111_Y	120_V	1.598	0.99
108_G	116_L	1.597	0.99
88_M	100_L	1.597	0.99
29_L	53_I	1.575	0.98
132_H	174_E	1.574	0.98
6_I	24_Q	1.535	0.98
132_H	139_S	1.530	0.98
139_S	196_A	1.529	0.98
22_A	41_L	1.529	0.98
143_D	174_E	1.512	0.98
54_K	58_S	1.506	0.98
141_M	145_A	1.504	0.98
132_H	196_A	1.493	0.98
181_E	184_R	1.468	0.97
52_E	56_W	1.447	0.97
66_V	70_L	1.425	0.97
15_I	20_L	1.400	0.97
105_I	109_R	1.399	0.97
174_E	200_E	1.393	0.96
92_L	100_L	1.387	0.96
129_V	196_A	1.366	0.96
113_V	170_W	1.361	0.96
135_S	203_R	1.357	0.96
49_R	71_E	1.349	0.96
6_I	34_R	1.348	0.96
22_A	30_L	1.346	0.96
94_M	99_K	1.343	0.96
155_F	158_R	1.342	0.96
21_R	27_Y	1.333	0.95
174_E	196_A	1.317	0.95
53_I	56_W	1.307	0.95
53_I	70_L	1.306	0.95
140_S	177_R	1.302	0.95
21_R	26_R	1.283	0.94
125_R	132_H	1.267	0.94
101_R	105_I	1.253	0.94
172_V	178_L	1.236	0.93
129_V	140_S	1.228	0.93
53_I	67_K	1.218	0.93
112_P	115_Q	1.204	0.92
165_A	169_A	1.191	0.92
107_L	120_V	1.182	0.92
15_I	19_T	1.180	0.92
32_P	41_L	1.177	0.91
6_I	21_R	1.174	0.91
50_I	80_D	1.169	0.91
62_P	100_L	1.163	0.91
216_T	221_T	1.163	0.91
165_A	191_H	1.145	0.90
213_I	216_T	1.134	0.90
5_S	8_D	1.132	0.90
177_R	196_A	1.131	0.90
93_R	131_D	1.129	0.90
165_A	190_W	1.125	0.89
137_I	178_L	1.120	0.89
150_A	164_E	1.115	0.89
205_E	209_T	1.104	0.89
29_L	67_K	1.104	0.89
33_Q	36_E	1.099	0.88
166_I	169_A	1.094	0.88
99_K	103_R	1.085	0.88
105_I	149_Y	1.071	0.87
6_I	18_V	1.070	0.87
173_E	198_P	1.067	0.87
46_D	67_K	1.067	0.87
21_R	32_P	1.065	0.87
147_I	179_W	1.064	0.87
18_V	38_G	1.061	0.86
81_W	119_H	1.055	0.86
125_R	142_F	1.046	0.86
29_L	57_I	1.043	0.86
216_T	219_A	1.035	0.85
44_E	48_Q	1.031	0.85
43_D	94_M	1.010	0.84
18_V	35_S	1.008	0.84
23_W	26_R	1.008	0.84
129_V	172_V	1.005	0.83
80_D	171_N	1.005	0.83
8_D	158_R	1.004	0.83
140_S	179_W	1.001	0.83
16_N	63_V	1.001	0.83
22_A	32_P	0.996	0.83
102_A	202_P	0.995	0.83
217_G	220_P	0.993	0.83
103_R	107_L	0.992	0.83
17_P	39_H	0.987	0.82
199_I	207_F	0.981	0.82
29_L	46_D	0.966	0.81
96_N	99_K	0.963	0.81
204_P	208_P	0.958	0.80
121_Y	146_L	0.947	0.80
104_I	121_Y	0.944	0.79
73_T	76_D	0.944	0.79
35_S	39_H	0.938	0.79
8_D	11_E	0.937	0.79
97_P	141_M	0.936	0.79
95_A	141_M	0.935	0.79
145_A	149_Y	0.934	0.79
26_R	42_F	0.932	0.78
142_F	194_V	0.918	0.77
19_T	39_H	0.918	0.77
22_A	70_L	0.910	0.77
18_V	25_R	0.903	0.76
140_S	172_V	0.899	0.76
16_N	47_I	0.894	0.75
7_G	18_V	0.892	0.75
9_V	16_N	0.889	0.75
13_C	32_P	0.888	0.75
72_T	223_R	0.862	0.73
132_H	172_V	0.858	0.72
84_L	87_E	0.853	0.72
181_E	185_L	0.850	0.72
87_E	94_M	0.845	0.71
182_A	192_I	0.844	0.71
37_G	57_I	0.841	0.71
8_D	13_C	0.840	0.71
132_H	143_D	0.835	0.70
132_H	200_E	0.833	0.70
18_V	22_A	0.831	0.70
168_M	196_A	0.827	0.70
158_R	186_S	0.812	0.68
33_Q	46_D	0.809	0.68
50_I	158_R	0.808	0.68
29_L	59_N	0.805	0.68
10_A	193_S	0.804	0.67
140_S	199_I	0.803	0.67
179_W	194_V	0.801	0.67
86_E	90_S	0.798	0.67
154_L	183_W	0.791	0.66
53_I	57_I	0.786	0.66
88_M	124_V	0.783	0.65
90_S	176_A	0.778	0.65
39_H	53_I	0.775	0.65
18_V	70_L	0.774	0.64
13_C	22_A	0.772	0.64
169_A	181_E	0.771	0.64
124_V	146_L	0.771	0.64
149_Y	152_T	0.765	0.64
33_Q	109_R	0.764	0.63
78_E	121_Y	0.764	0.63
20_L	25_R	0.758	0.63
70_L	74_S	0.756	0.63
66_V	181_E	0.755	0.63
102_A	105_I	0.754	0.62
216_T	224_Q	0.753	0.62
39_H	66_V	0.752	0.62
20_L	92_L	0.752	0.62
144_G	151_A	0.751	0.62
52_E	55_R	0.751	0.62
212_L	215_W	0.749	0.62
29_L	35_S	0.747	0.62
211_T	215_W	0.742	0.61
5_S	41_L	0.738	0.61
115_Q	119_H	0.735	0.60
6_I	42_F	0.735	0.60
18_V	56_W	0.732	0.60
18_V	34_R	0.731	0.60
46_D	49_R	0.730	0.60
125_R	129_V	0.725	0.59
138_M	210_Q	0.723	0.59
125_R	143_D	0.723	0.59
77_T	90_S	0.722	0.59
24_Q	132_H	0.722	0.59
108_G	112_P	0.720	0.59
126_Q	130_L	0.717	0.59
81_W	85_Q	0.714	0.58
78_E	84_L	0.711	0.58
45_E	77_T	0.710	0.58
20_L	117_I	0.709	0.58
147_I	150_A	0.709	0.58
42_F	50_I	0.706	0.57
182_A	194_V	0.705	0.57
164_E	191_H	0.702	0.57
33_Q	43_D	0.700	0.57
93_R	119_H	0.700	0.57
129_V	143_D	0.697	0.56
211_T	219_A	0.692	0.56
169_A	196_A	0.691	0.56
86_E	127_R	0.689	0.56
159_R	202_P	0.683	0.55
120_V	178_L	0.677	0.54
172_V	196_A	0.675	0.54
91_I	204_P	0.674	0.54
18_V	39_H	0.672	0.54
13_C	66_V	0.669	0.53
139_S	146_L	0.668	0.53
14_G	26_R	0.665	0.53
23_W	40_R	0.662	0.53
125_R	174_E	0.659	0.52
5_S	112_P	0.658	0.52
16_N	34_R	0.655	0.52
26_R	32_P	0.654	0.52
89_M	124_V	0.650	0.51
21_R	42_F	0.650	0.51
220_P	224_Q	0.649	0.51
214_V	217_G	0.647	0.51
104_I	145_A	0.646	0.51
176_A	183_W	0.646	0.51
12_R	85_Q	0.645	0.51
188_S	222_R	0.643	0.51
206_L	210_Q	0.643	0.51
75_Q	222_R	0.639	0.50
54_K	57_I	0.637	0.50
143_D	177_R	0.634	0.50
140_S	196_A	0.633	0.49
72_T	89_M	0.633	0.49
23_W	42_F	0.632	0.49
127_R	131_D	0.631	0.49
114_D	187_L	0.625	0.49
48_Q	94_M	0.622	0.48
4_Y	12_R	0.620	0.48
7_G	36_E	0.619	0.48
13_C	37_G	0.613	0.47
18_V	63_V	0.612	0.47
118_N	184_R	0.609	0.47
151_A	176_A	0.609	0.47
202_P	209_T	0.609	0.47
15_I	121_Y	0.605	0.46
24_Q	27_Y	0.601	0.46
57_I	69_L	0.601	0.46
37_G	92_L	0.600	0.46
144_G	203_R	0.591	0.45
18_V	66_V	0.587	0.44
79_D	189_G	0.587	0.44
114_D	188_S	0.586	0.44
101_R	118_N	0.582	0.44
36_E	120_V	0.576	0.43
214_V	219_A	0.576	0.43
216_T	222_R	0.572	0.43
10_A	39_H	0.571	0.43
102_A	156_E	0.571	0.43
169_A	172_V	0.570	0.43
78_E	119_H	0.569	0.42
75_Q	79_D	0.568	0.42
56_W	61_V	0.566	0.42
144_G	179_W	0.565	0.42
158_R	178_L	0.564	0.42
32_P	42_F	0.564	0.42
46_D	117_I	0.560	0.41
165_A	208_P	0.557	0.41
141_M	150_A	0.557	0.41
165_A	170_W	0.557	0.41
56_W	199_I	0.556	0.41
176_A	190_W	0.556	0.41
91_I	103_R	0.555	0.41
102_A	162_G	0.553	0.41
51_E	58_S	0.553	0.41
47_I	209_T	0.547	0.40
76_D	127_R	0.546	0.40
219_A	222_R	0.545	0.40
43_D	150_A	0.544	0.40
48_Q	167_L	0.542	0.40
206_L	209_T	0.542	0.40
78_E	106_S	0.542	0.40
73_T	157_M	0.540	0.39
6_I	38_G	0.540	0.39
37_G	67_K	0.540	0.39
52_E	67_K	0.540	0.39
42_F	150_A	0.539	0.39
74_S	121_Y	0.539	0.39
68_A	78_E	0.538	0.39
31_K	202_P	0.537	0.39
90_S	99_K	0.535	0.39
29_L	61_V	0.533	0.39
113_V	180_L	0.532	0.39
116_L	120_V	0.531	0.38
6_I	16_N	0.531	0.38
175_R	194_V	0.530	0.38
97_P	124_V	0.529	0.38
85_Q	127_R	0.527	0.38
81_W	109_R	0.526	0.38
10_A	180_L	0.524	0.38
59_N	66_V	0.523	0.38
185_L	204_P	0.522	0.37
17_P	24_Q	0.519	0.37
45_E	161_P	0.519	0.37
178_L	194_V	0.517	0.37
9_V	182_A	0.516	0.37
34_R	40_R	0.515	0.37
45_E	79_D	0.514	0.37
136_R	219_A	0.514	0.37
124_V	138_M	0.513	0.37
4_Y	183_W	0.512	0.36
16_N	22_A	0.512	0.36
5_S	39_H	0.512	0.36
107_L	132_H	0.511	0.36
57_I	66_V	0.509	0.36
31_K	117_I	0.508	0.36
139_S	147_I	0.506	0.36
82_S	219_A	0.505	0.36
6_I	10_A	0.503	0.36
169_A	174_E	0.502	0.35
26_R	40_R	0.501	0.35
7_G	52_E	0.500	0.35
176_A	197_D	0.500	0.35

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3whpA	1	0.6626	100	0.415	Contact Map
3ezxA	2	0.6626	99.7	0.721	Contact Map
4hh3C	1	0.679	99.7	0.722	Contact Map
1y80A	1	0.3498	99.7	0.725	Contact Map
2i2xB	1	0.8107	99.7	0.726	Contact Map
4hh0A	2	0.9588	99.7	0.727	Contact Map
3bulA	1	0.6831	99.7	0.73	Contact Map
4jgiA	2	0.6543	99.7	0.735	Contact Map
3hh0A	4	0.5185	99.7	0.736	Contact Map
2dg6A	2	0.7819	99.7	0.74	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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