JAYE - ECOLI - GREMLIN Contacts

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JAYE - Putative protein JayE from lambdoid prophage e14 region

UniProt:	P75981	Sequences: MWYMRWEGVSDGLKVTAGSVIQRDDLVQYTTTDDATSSGGVLRVPIACSSAGAVGNADDGTALILVTPVNGLPSSGVADTLTGGFDTEELETWRARVIERYYWTPQGGADGDYVVWAKEVPGITRAWTYRHLMGTGTVGVMIASSDLINPIPEESTETAARQHIGPLAPVAGSDLYVFRPVAHTVDFHIRVTPDTPEIRAAITAELRSFLLRDGYPQGELKVSRISEAISGANGEYSHQLLAPVDNISIAKNELAVLGTISWT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14254
Length:	263 (244)
Sequences:	2240 (1994)
Seq/√Len:	127.7

ECOLI - JAYE
BACSU - YQBT XKDT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
183_H	253_E	3.953	1.00
154_E	158_T	3.767	1.00
88_E	96_R	3.758	1.00
89_E	92_T	3.446	1.00
32_T	47_A	3.440	1.00
202_I	229_I	3.338	1.00
250_A	253_E	3.159	1.00
165_G	168_A	2.920	1.00
181_V	253_E	2.850	1.00
203_T	207_R	2.777	1.00
152_P	179_R	2.681	1.00
20_V	28_Q	2.525	1.00
114_V	118_K	2.488	1.00
249_I	255_A	2.301	1.00
35_A	42_L	2.256	1.00
114_V	128_T	2.228	1.00
53_A	86_D	2.190	1.00
199_R	203_T	2.121	1.00
129_Y	141_M	2.085	1.00
29_Y	57_A	1.989	1.00
189_I	229_I	1.983	1.00
213_D	216_P	1.972	1.00
119_E	163_H	1.943	1.00
134_G	137_T	1.910	1.00
62_A	77_V	1.908	1.00
191_V	202_I	1.905	1.00
30_T	47_A	1.905	1.00
237_S	246_N	1.890	1.00
226_S	238_H	1.888	1.00
139_G	178_F	1.879	1.00
220_L	255_A	1.875	1.00
31_T	44_V	1.837	1.00
118_K	126_A	1.808	1.00
120_V	160_A	1.776	1.00
20_V	67_T	1.729	1.00
48_C	55_G	1.714	1.00
20_V	30_T	1.702	1.00
14_K	34_D	1.702	1.00
196_P	199_R	1.690	1.00
117_A	140_V	1.662	1.00
30_T	49_S	1.657	1.00
48_C	54_V	1.649	1.00
46_I	81_L	1.649	1.00
35_A	44_V	1.609	1.00
204_A	208_S	1.598	1.00
142_I	160_A	1.585	1.00
190_R	239_Q	1.584	1.00
158_T	162_Q	1.583	1.00
140_V	164_I	1.579	1.00
197_E	201_A	1.578	1.00
224_R	228_A	1.565	1.00
157_E	179_R	1.564	1.00
21_I	31_T	1.560	1.00
99_E	118_K	1.536	1.00
91_E	94_R	1.519	1.00
90_L	93_W	1.516	1.00
157_E	161_R	1.512	1.00
209_F	228_A	1.512	1.00
161_R	165_G	1.508	1.00
116_W	163_H	1.496	1.00
168_A	171_A	1.487	1.00
210_L	257_L	1.485	1.00
205_E	232_A	1.446	1.00
110_D	130_R	1.443	1.00
223_S	226_S	1.436	1.00
117_A	160_A	1.431	1.00
58_D	61_T	1.407	1.00
56_N	84_G	1.398	1.00
37_S	42_L	1.384	1.00
163_H	167_L	1.381	1.00
23_R	27_V	1.358	1.00
60_G	76_G	1.343	1.00
132_L	139_G	1.312	1.00
144_S	156_T	1.307	1.00
108_G	169_P	1.303	1.00
117_A	126_A	1.299	1.00
27_V	55_G	1.295	1.00
59_D	80_T	1.291	1.00
141_M	178_F	1.283	1.00
37_S	40_G	1.277	1.00
16_T	19_S	1.277	1.00
113_Y	138_V	1.269	1.00
23_R	57_A	1.254	1.00
200_A	203_T	1.253	1.00
153_E	156_T	1.249	1.00
31_T	35_A	1.237	1.00
63_L	77_V	1.229	1.00
18_G	30_T	1.192	0.99
235_E	238_H	1.190	0.99
93_W	97_V	1.179	0.99
11_D	37_S	1.178	0.99
19_S	65_L	1.178	0.99
52_G	56_N	1.177	0.99
113_Y	169_P	1.169	0.99
200_A	204_A	1.167	0.99
19_S	31_T	1.160	0.99
29_Y	81_L	1.145	0.99
142_I	157_E	1.138	0.99
97_V	101_Y	1.137	0.99
140_V	177_V	1.131	0.99
57_A	81_L	1.108	0.99
108_G	112_D	1.095	0.99
223_S	230_S	1.093	0.99
28_Q	49_S	1.091	0.99
184_T	256_V	1.089	0.99
32_T	45_P	1.075	0.99
227_E	230_S	1.065	0.99
114_V	127_W	1.063	0.99
144_S	153_E	1.054	0.98
62_A	81_L	1.054	0.98
185_V	220_L	1.050	0.98
15_V	69_V	1.046	0.98
219_E	248_S	1.039	0.98
117_A	120_V	1.031	0.98
122_G	145_S	1.031	0.98
57_A	62_A	1.030	0.98
232_A	235_E	1.030	0.98
22_Q	66_V	1.029	0.98
219_E	249_I	1.029	0.98
17_A	34_D	1.028	0.98
198_I	234_G	1.020	0.98
21_I	65_L	1.019	0.98
115_V	119_E	1.018	0.98
221_K	237_S	1.014	0.98
106_Q	112_D	1.005	0.98
27_V	50_S	1.003	0.98
222_V	246_N	1.000	0.98
33_D	45_P	0.985	0.98
57_A	77_V	0.984	0.98
170_V	173_S	0.982	0.98
187_F	210_L	0.947	0.97
205_E	228_A	0.944	0.97
212_R	216_P	0.944	0.97
224_R	227_E	0.943	0.97
209_F	225_I	0.941	0.97
76_G	80_T	0.934	0.97
113_Y	116_W	0.933	0.97
161_R	175_L	0.931	0.97
191_V	235_E	0.929	0.97
123_I	126_A	0.923	0.96
156_T	160_A	0.920	0.96
106_Q	109_A	0.920	0.96
65_L	69_V	0.920	0.96
249_I	253_E	0.915	0.96
14_K	36_T	0.912	0.96
207_R	257_L	0.905	0.96
188_H	241_L	0.900	0.96
155_S	159_A	0.896	0.96
108_G	116_W	0.895	0.96
113_Y	173_S	0.889	0.96
101_Y	104_T	0.881	0.95
15_V	72_L	0.879	0.95
112_D	115_V	0.877	0.95
139_G	176_Y	0.872	0.95
222_V	226_S	0.869	0.95
151_I	182_A	0.867	0.95
21_I	77_V	0.865	0.95
152_P	157_E	0.865	0.95
133_M	139_G	0.854	0.95
139_G	252_N	0.853	0.95
29_Y	77_V	0.849	0.94
202_I	232_A	0.848	0.94
194_D	236_Y	0.848	0.94
118_K	125_R	0.839	0.94
222_V	240_L	0.837	0.94
112_D	116_W	0.833	0.94
15_V	37_S	0.833	0.94
152_P	156_T	0.829	0.94
54_V	86_D	0.828	0.94
27_V	48_C	0.821	0.93
94_R	97_V	0.820	0.93
209_F	214_G	0.817	0.93
59_D	79_D	0.817	0.93
89_E	94_R	0.814	0.93
111_G	114_V	0.808	0.93
114_V	125_R	0.806	0.93
124_T	143_A	0.805	0.93
218_G	224_R	0.805	0.93
156_T	159_A	0.804	0.93
134_G	139_G	0.803	0.93
183_H	249_I	0.801	0.92
89_E	93_W	0.795	0.92
16_T	34_D	0.793	0.92
168_A	175_L	0.792	0.92
17_A	32_T	0.783	0.92
193_P	198_I	0.783	0.92
124_T	145_S	0.776	0.91
185_V	210_L	0.765	0.91
62_A	75_S	0.765	0.91
205_E	231_G	0.765	0.91
161_R	166_P	0.762	0.91
109_A	112_D	0.762	0.91
132_L	137_T	0.761	0.90
31_T	46_I	0.757	0.90
19_S	69_V	0.756	0.90
30_T	33_D	0.755	0.90
12_G	36_T	0.754	0.90
32_T	35_A	0.751	0.90
20_V	49_S	0.746	0.90
117_A	164_I	0.744	0.89
226_S	240_L	0.741	0.89
120_V	163_H	0.740	0.89
52_G	86_D	0.739	0.89
141_M	252_N	0.738	0.89
143_A	150_P	0.734	0.89
125_R	143_A	0.728	0.88
65_L	72_L	0.728	0.88
10_S	13_L	0.725	0.88
23_R	26_L	0.718	0.88
131_H	137_T	0.717	0.88
108_G	113_Y	0.715	0.88
152_P	180_P	0.714	0.87
224_R	230_S	0.714	0.87
104_T	210_L	0.713	0.87
90_L	112_D	0.711	0.87
132_L	141_M	0.710	0.87
50_S	55_G	0.710	0.87
132_L	176_Y	0.699	0.86
31_T	34_D	0.698	0.86
143_A	254_L	0.697	0.86
16_T	35_A	0.694	0.86
120_V	159_A	0.693	0.86
103_W	111_G	0.692	0.86
59_D	78_A	0.691	0.86
19_S	34_D	0.689	0.86
194_D	234_G	0.687	0.85
21_I	62_A	0.685	0.85
187_F	257_L	0.684	0.85
142_I	145_S	0.681	0.85
157_E	160_A	0.679	0.85
221_K	226_S	0.678	0.85
35_A	45_P	0.677	0.85
209_F	213_D	0.672	0.84
189_I	202_I	0.670	0.84
100_R	104_T	0.670	0.84
193_P	199_R	0.670	0.84
202_I	238_H	0.668	0.84
160_A	163_H	0.664	0.83
227_E	231_G	0.664	0.83
144_S	182_A	0.663	0.83
37_S	41_V	0.662	0.83
142_I	156_T	0.662	0.83
223_S	238_H	0.660	0.83
185_V	255_A	0.658	0.83
13_L	42_L	0.658	0.83
125_R	215_Y	0.657	0.83
10_S	24_D	0.654	0.82
77_V	81_L	0.653	0.82
140_V	143_A	0.652	0.82
22_Q	28_Q	0.651	0.82
138_V	169_P	0.650	0.82
57_A	61_T	0.648	0.82
15_V	19_S	0.648	0.82
198_I	201_A	0.647	0.82
142_I	177_V	0.647	0.82
31_T	81_L	0.643	0.81
21_I	63_L	0.642	0.81
102_Y	167_L	0.641	0.81
123_I	142_I	0.641	0.81
140_V	160_A	0.640	0.81
244_V	248_S	0.638	0.81
117_A	128_T	0.638	0.81
117_A	142_I	0.638	0.81
181_V	252_N	0.636	0.81
143_A	180_P	0.630	0.80
105_P	112_D	0.628	0.80
201_A	205_E	0.626	0.80
254_L	257_L	0.622	0.79
21_I	75_S	0.622	0.79
95_A	99_E	0.622	0.79
65_L	83_G	0.612	0.78
53_A	91_E	0.612	0.78
144_S	171_A	0.609	0.78
102_Y	111_G	0.609	0.78
113_Y	117_A	0.608	0.78
202_I	228_A	0.607	0.78
197_E	200_A	0.607	0.78
107_G	116_W	0.606	0.77
224_R	237_S	0.605	0.77
116_W	173_S	0.605	0.77
51_A	55_G	0.604	0.77
28_Q	66_V	0.602	0.77
221_K	232_A	0.600	0.77
12_G	40_G	0.599	0.77
116_W	169_P	0.598	0.77
157_E	177_V	0.598	0.77
160_A	177_V	0.598	0.77
98_I	102_Y	0.594	0.76
137_T	176_Y	0.594	0.76
57_A	232_A	0.592	0.76
250_A	256_V	0.592	0.76
144_S	150_P	0.591	0.76
22_Q	26_L	0.589	0.75
73_P	247_I	0.587	0.75
236_Y	240_L	0.583	0.75
182_A	256_V	0.582	0.75
101_Y	141_M	0.580	0.74
23_R	62_A	0.580	0.74
96_R	119_E	0.579	0.74
100_R	103_W	0.577	0.74
33_D	36_T	0.576	0.74
55_G	86_D	0.574	0.74
16_T	31_T	0.574	0.74
218_G	221_K	0.573	0.73
107_G	112_D	0.572	0.73
116_W	119_E	0.571	0.73
93_W	257_L	0.569	0.73
220_L	246_N	0.569	0.73
169_P	180_P	0.565	0.72
225_I	228_A	0.564	0.72
14_K	17_A	0.563	0.72
113_Y	170_V	0.560	0.72
202_I	205_E	0.560	0.72
244_V	247_I	0.560	0.72
111_G	115_V	0.559	0.72
56_N	83_G	0.556	0.71
205_E	208_S	0.555	0.71
136_G	157_E	0.554	0.71
57_A	75_S	0.553	0.71
71_G	122_G	0.551	0.71
188_H	242_A	0.550	0.70
116_W	238_H	0.544	0.70
92_T	194_D	0.544	0.70
134_G	174_D	0.543	0.69
105_P	167_L	0.538	0.69
110_D	126_A	0.537	0.69
154_E	179_R	0.536	0.68
57_A	63_L	0.536	0.68
49_S	129_Y	0.535	0.68
94_R	100_R	0.534	0.68
114_V	140_V	0.532	0.68
208_S	213_D	0.532	0.68
119_E	128_T	0.530	0.68
205_E	235_E	0.529	0.67
208_S	212_R	0.527	0.67
93_W	98_I	0.526	0.67
65_L	74_S	0.524	0.67
161_R	221_K	0.522	0.66
187_F	225_I	0.521	0.66
12_G	37_S	0.521	0.66
23_R	29_Y	0.520	0.66
178_F	225_I	0.520	0.66
100_R	119_E	0.515	0.65
24_D	64_I	0.513	0.65
178_F	252_N	0.513	0.65
143_A	152_P	0.511	0.65
46_I	62_A	0.511	0.65
186_D	189_I	0.511	0.65
43_R	78_A	0.509	0.65
60_G	78_A	0.509	0.65
201_A	234_G	0.508	0.64
107_G	222_V	0.508	0.64
142_I	152_P	0.506	0.64
134_G	145_S	0.505	0.64
55_G	83_G	0.505	0.64
137_T	174_D	0.504	0.64
252_N	256_V	0.504	0.64
194_D	229_I	0.504	0.64
193_P	232_A	0.503	0.64
92_T	95_A	0.503	0.64
13_L	16_T	0.503	0.64
93_W	96_R	0.502	0.63
44_V	75_S	0.501	0.63
109_A	115_V	0.501	0.63
130_R	137_T	0.501	0.63
90_L	94_R	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3h2tA	2	0.5665	98.3	0.825	Contact Map
3laxA	1	0.384	41.2	0.936	Contact Map
1mdbA	1	0.7376	18.8	0.946	Contact Map
4mt1A	3	0.7262	17.9	0.946	Contact Map
1zpvA	3	0.3346	14.4	0.948	Contact Map
2v7bA	1	0.6768	9.9	0.952	Contact Map
2d1sA	1	0.6464	7.9	0.954	Contact Map
4isbA	2	0.749	7.7	0.954	Contact Map
2pzzA	2	0.2928	7	0.955	Contact Map
1v25A	2	0.5475	6.7	0.956	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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