GREMLIN Database
JAYE - Putative protein JayE from lambdoid prophage e14 region
UniProt: P75981 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14254
Length: 263 (244)
Sequences: 2240 (1994)
Seq/√Len: 127.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_H253_E3.9531.00
154_E158_T3.7671.00
88_E96_R3.7581.00
89_E92_T3.4461.00
32_T47_A3.4401.00
202_I229_I3.3381.00
250_A253_E3.1591.00
165_G168_A2.9201.00
181_V253_E2.8501.00
203_T207_R2.7771.00
152_P179_R2.6811.00
20_V28_Q2.5251.00
114_V118_K2.4881.00
249_I255_A2.3011.00
35_A42_L2.2561.00
114_V128_T2.2281.00
53_A86_D2.1901.00
199_R203_T2.1211.00
129_Y141_M2.0851.00
29_Y57_A1.9891.00
189_I229_I1.9831.00
213_D216_P1.9721.00
119_E163_H1.9431.00
134_G137_T1.9101.00
62_A77_V1.9081.00
191_V202_I1.9051.00
30_T47_A1.9051.00
237_S246_N1.8901.00
226_S238_H1.8881.00
139_G178_F1.8791.00
220_L255_A1.8751.00
31_T44_V1.8371.00
118_K126_A1.8081.00
120_V160_A1.7761.00
20_V67_T1.7291.00
48_C55_G1.7141.00
20_V30_T1.7021.00
14_K34_D1.7021.00
196_P199_R1.6901.00
117_A140_V1.6621.00
30_T49_S1.6571.00
48_C54_V1.6491.00
46_I81_L1.6491.00
35_A44_V1.6091.00
204_A208_S1.5981.00
142_I160_A1.5851.00
190_R239_Q1.5841.00
158_T162_Q1.5831.00
140_V164_I1.5791.00
197_E201_A1.5781.00
224_R228_A1.5651.00
157_E179_R1.5641.00
21_I31_T1.5601.00
99_E118_K1.5361.00
91_E94_R1.5191.00
90_L93_W1.5161.00
157_E161_R1.5121.00
209_F228_A1.5121.00
161_R165_G1.5081.00
116_W163_H1.4961.00
168_A171_A1.4871.00
210_L257_L1.4851.00
205_E232_A1.4461.00
110_D130_R1.4431.00
223_S226_S1.4361.00
117_A160_A1.4311.00
58_D61_T1.4071.00
56_N84_G1.3981.00
37_S42_L1.3841.00
163_H167_L1.3811.00
23_R27_V1.3581.00
60_G76_G1.3431.00
132_L139_G1.3121.00
144_S156_T1.3071.00
108_G169_P1.3031.00
117_A126_A1.2991.00
27_V55_G1.2951.00
59_D80_T1.2911.00
141_M178_F1.2831.00
37_S40_G1.2771.00
16_T19_S1.2771.00
113_Y138_V1.2691.00
23_R57_A1.2541.00
200_A203_T1.2531.00
153_E156_T1.2491.00
31_T35_A1.2371.00
63_L77_V1.2291.00
18_G30_T1.1920.99
235_E238_H1.1900.99
93_W97_V1.1790.99
11_D37_S1.1780.99
19_S65_L1.1780.99
52_G56_N1.1770.99
113_Y169_P1.1690.99
200_A204_A1.1670.99
19_S31_T1.1600.99
29_Y81_L1.1450.99
142_I157_E1.1380.99
97_V101_Y1.1370.99
140_V177_V1.1310.99
57_A81_L1.1080.99
108_G112_D1.0950.99
223_S230_S1.0930.99
28_Q49_S1.0910.99
184_T256_V1.0890.99
32_T45_P1.0750.99
227_E230_S1.0650.99
114_V127_W1.0630.99
144_S153_E1.0540.98
62_A81_L1.0540.98
185_V220_L1.0500.98
15_V69_V1.0460.98
219_E248_S1.0390.98
117_A120_V1.0310.98
122_G145_S1.0310.98
57_A62_A1.0300.98
232_A235_E1.0300.98
22_Q66_V1.0290.98
219_E249_I1.0290.98
17_A34_D1.0280.98
198_I234_G1.0200.98
21_I65_L1.0190.98
115_V119_E1.0180.98
221_K237_S1.0140.98
106_Q112_D1.0050.98
27_V50_S1.0030.98
222_V246_N1.0000.98
33_D45_P0.9850.98
57_A77_V0.9840.98
170_V173_S0.9820.98
187_F210_L0.9470.97
205_E228_A0.9440.97
212_R216_P0.9440.97
224_R227_E0.9430.97
209_F225_I0.9410.97
76_G80_T0.9340.97
113_Y116_W0.9330.97
161_R175_L0.9310.97
191_V235_E0.9290.97
123_I126_A0.9230.96
156_T160_A0.9200.96
106_Q109_A0.9200.96
65_L69_V0.9200.96
249_I253_E0.9150.96
14_K36_T0.9120.96
207_R257_L0.9050.96
188_H241_L0.9000.96
155_S159_A0.8960.96
108_G116_W0.8950.96
113_Y173_S0.8890.96
101_Y104_T0.8810.95
15_V72_L0.8790.95
112_D115_V0.8770.95
139_G176_Y0.8720.95
222_V226_S0.8690.95
151_I182_A0.8670.95
21_I77_V0.8650.95
152_P157_E0.8650.95
133_M139_G0.8540.95
139_G252_N0.8530.95
29_Y77_V0.8490.94
202_I232_A0.8480.94
194_D236_Y0.8480.94
118_K125_R0.8390.94
222_V240_L0.8370.94
112_D116_W0.8330.94
15_V37_S0.8330.94
152_P156_T0.8290.94
54_V86_D0.8280.94
27_V48_C0.8210.93
94_R97_V0.8200.93
209_F214_G0.8170.93
59_D79_D0.8170.93
89_E94_R0.8140.93
111_G114_V0.8080.93
114_V125_R0.8060.93
124_T143_A0.8050.93
218_G224_R0.8050.93
156_T159_A0.8040.93
134_G139_G0.8030.93
183_H249_I0.8010.92
89_E93_W0.7950.92
16_T34_D0.7930.92
168_A175_L0.7920.92
17_A32_T0.7830.92
193_P198_I0.7830.92
124_T145_S0.7760.91
185_V210_L0.7650.91
62_A75_S0.7650.91
205_E231_G0.7650.91
161_R166_P0.7620.91
109_A112_D0.7620.91
132_L137_T0.7610.90
31_T46_I0.7570.90
19_S69_V0.7560.90
30_T33_D0.7550.90
12_G36_T0.7540.90
32_T35_A0.7510.90
20_V49_S0.7460.90
117_A164_I0.7440.89
226_S240_L0.7410.89
120_V163_H0.7400.89
52_G86_D0.7390.89
141_M252_N0.7380.89
143_A150_P0.7340.89
125_R143_A0.7280.88
65_L72_L0.7280.88
10_S13_L0.7250.88
23_R26_L0.7180.88
131_H137_T0.7170.88
108_G113_Y0.7150.88
152_P180_P0.7140.87
224_R230_S0.7140.87
104_T210_L0.7130.87
90_L112_D0.7110.87
132_L141_M0.7100.87
50_S55_G0.7100.87
132_L176_Y0.6990.86
31_T34_D0.6980.86
143_A254_L0.6970.86
16_T35_A0.6940.86
120_V159_A0.6930.86
103_W111_G0.6920.86
59_D78_A0.6910.86
19_S34_D0.6890.86
194_D234_G0.6870.85
21_I62_A0.6850.85
187_F257_L0.6840.85
142_I145_S0.6810.85
157_E160_A0.6790.85
221_K226_S0.6780.85
35_A45_P0.6770.85
209_F213_D0.6720.84
189_I202_I0.6700.84
100_R104_T0.6700.84
193_P199_R0.6700.84
202_I238_H0.6680.84
160_A163_H0.6640.83
227_E231_G0.6640.83
144_S182_A0.6630.83
37_S41_V0.6620.83
142_I156_T0.6620.83
223_S238_H0.6600.83
185_V255_A0.6580.83
13_L42_L0.6580.83
125_R215_Y0.6570.83
10_S24_D0.6540.82
77_V81_L0.6530.82
140_V143_A0.6520.82
22_Q28_Q0.6510.82
138_V169_P0.6500.82
57_A61_T0.6480.82
15_V19_S0.6480.82
198_I201_A0.6470.82
142_I177_V0.6470.82
31_T81_L0.6430.81
21_I63_L0.6420.81
102_Y167_L0.6410.81
123_I142_I0.6410.81
140_V160_A0.6400.81
244_V248_S0.6380.81
117_A128_T0.6380.81
117_A142_I0.6380.81
181_V252_N0.6360.81
143_A180_P0.6300.80
105_P112_D0.6280.80
201_A205_E0.6260.80
254_L257_L0.6220.79
21_I75_S0.6220.79
95_A99_E0.6220.79
65_L83_G0.6120.78
53_A91_E0.6120.78
144_S171_A0.6090.78
102_Y111_G0.6090.78
113_Y117_A0.6080.78
202_I228_A0.6070.78
197_E200_A0.6070.78
107_G116_W0.6060.77
224_R237_S0.6050.77
116_W173_S0.6050.77
51_A55_G0.6040.77
28_Q66_V0.6020.77
221_K232_A0.6000.77
12_G40_G0.5990.77
116_W169_P0.5980.77
157_E177_V0.5980.77
160_A177_V0.5980.77
98_I102_Y0.5940.76
137_T176_Y0.5940.76
57_A232_A0.5920.76
250_A256_V0.5920.76
144_S150_P0.5910.76
22_Q26_L0.5890.75
73_P247_I0.5870.75
236_Y240_L0.5830.75
182_A256_V0.5820.75
101_Y141_M0.5800.74
23_R62_A0.5800.74
96_R119_E0.5790.74
100_R103_W0.5770.74
33_D36_T0.5760.74
55_G86_D0.5740.74
16_T31_T0.5740.74
218_G221_K0.5730.73
107_G112_D0.5720.73
116_W119_E0.5710.73
93_W257_L0.5690.73
220_L246_N0.5690.73
169_P180_P0.5650.72
225_I228_A0.5640.72
14_K17_A0.5630.72
113_Y170_V0.5600.72
202_I205_E0.5600.72
244_V247_I0.5600.72
111_G115_V0.5590.72
56_N83_G0.5560.71
205_E208_S0.5550.71
136_G157_E0.5540.71
57_A75_S0.5530.71
71_G122_G0.5510.71
188_H242_A0.5500.70
116_W238_H0.5440.70
92_T194_D0.5440.70
134_G174_D0.5430.69
105_P167_L0.5380.69
110_D126_A0.5370.69
154_E179_R0.5360.68
57_A63_L0.5360.68
49_S129_Y0.5350.68
94_R100_R0.5340.68
114_V140_V0.5320.68
208_S213_D0.5320.68
119_E128_T0.5300.68
205_E235_E0.5290.67
208_S212_R0.5270.67
93_W98_I0.5260.67
65_L74_S0.5240.67
161_R221_K0.5220.66
187_F225_I0.5210.66
12_G37_S0.5210.66
23_R29_Y0.5200.66
178_F225_I0.5200.66
100_R119_E0.5150.65
24_D64_I0.5130.65
178_F252_N0.5130.65
143_A152_P0.5110.65
46_I62_A0.5110.65
186_D189_I0.5110.65
43_R78_A0.5090.65
60_G78_A0.5090.65
201_A234_G0.5080.64
107_G222_V0.5080.64
142_I152_P0.5060.64
134_G145_S0.5050.64
55_G83_G0.5050.64
137_T174_D0.5040.64
252_N256_V0.5040.64
194_D229_I0.5040.64
193_P232_A0.5030.64
92_T95_A0.5030.64
13_L16_T0.5030.64
93_W96_R0.5020.63
44_V75_S0.5010.63
109_A115_V0.5010.63
130_R137_T0.5010.63
90_L94_R0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h2tA 2 0.5665 98.3 0.825 Contact Map
3laxA 1 0.384 41.2 0.936 Contact Map
1mdbA 1 0.7376 18.8 0.946 Contact Map
4mt1A 3 0.7262 17.9 0.946 Contact Map
1zpvA 3 0.3346 14.4 0.948 Contact Map
2v7bA 1 0.6768 9.9 0.952 Contact Map
2d1sA 1 0.6464 7.9 0.954 Contact Map
4isbA 2 0.749 7.7 0.954 Contact Map
2pzzA 2 0.2928 7 0.955 Contact Map
1v25A 2 0.5475 6.7 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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