GREMLIN Database
CROE - Putative lambdoid prophage e14 transcriptional regulatory protein
UniProt: P75975 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14414
Length: 66 (57)
Sequences: 5288 (4299)
Seq/√Len: 569.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_G52_A2.6121.00
45_L53_I2.5461.00
45_L55_K2.3611.00
34_Y64_P2.3341.00
15_E53_I2.0611.00
16_L52_A2.0141.00
14_G54_T1.9381.00
30_V46_E1.8521.00
30_V44_K1.6241.00
12_Q54_T1.6221.00
16_L25_G1.5891.00
33_G55_K1.5621.00
32_N44_K1.5601.00
34_Y40_V1.5321.00
27_L49_T1.5201.00
32_N40_V1.4931.00
35_K39_F1.4581.00
17_A31_F1.4311.00
42_A45_L1.3931.00
12_Q56_S1.3671.00
36_K62_I1.2641.00
10_K57_D1.2591.00
36_K64_P1.2331.00
26_Y29_L1.1761.00
48_Y52_A1.1521.00
35_K38_S1.1091.00
15_E31_F1.0811.00
18_G23_T1.0541.00
8_L60_P1.0151.00
18_G25_G1.0121.00
27_L48_Y0.9961.00
47_Q53_I0.9831.00
8_L59_R0.9711.00
19_K24_P0.9691.00
12_Q55_K0.9651.00
12_Q57_D0.9231.00
35_K59_R0.9041.00
19_K22_S0.9011.00
35_K64_P0.8951.00
34_Y38_S0.8851.00
38_S41_L0.8501.00
9_T60_P0.8151.00
13_Q55_K0.8041.00
31_F53_I0.7811.00
40_V44_K0.7711.00
10_K59_R0.7671.00
25_G52_A0.7661.00
13_Q33_G0.7651.00
48_Y51_G0.7601.00
42_A56_S0.7501.00
19_K29_L0.7491.00
27_L47_Q0.7441.00
19_K26_Y0.7441.00
28_R46_E0.7401.00
38_S64_P0.7071.00
33_G58_L0.6961.00
11_E60_P0.6821.00
15_E45_L0.6661.00
9_T12_Q0.6521.00
18_G22_S0.6501.00
8_L11_E0.6471.00
47_Q51_G0.6421.00
15_E47_Q0.6141.00
35_K62_I0.6111.00
39_F42_A0.6081.00
20_V23_T0.6041.00
31_F45_L0.5971.00
29_L47_Q0.5821.00
38_S62_I0.5811.00
31_F51_G0.5781.00
58_L63_Y0.5741.00
22_S25_G0.5731.00
19_K23_T0.5600.99
7_S59_R0.5490.99
9_T59_R0.5470.99
10_K60_P0.5460.99
33_G53_I0.5370.99
7_S56_S0.5340.99
13_Q58_L0.5160.99
26_Y31_F0.5100.99
45_L48_Y0.5080.99
33_G57_D0.5050.99
35_K41_L0.5020.99
35_K61_D0.5010.99
17_A26_Y0.5000.99
37_A61_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ww8A 1 0.8636 99 0.247 Contact Map
3kptA 1 0.9394 98.9 0.272 Contact Map
4p0dA 1 0.9848 98.8 0.302 Contact Map
3phsA 1 1 98.8 0.306 Contact Map
4uzgA 1 1 98.8 0.313 Contact Map
4oq1A 1 1 98.7 0.316 Contact Map
2xtlA 1 0.9848 98.7 0.324 Contact Map
2x9xA 1 0.9848 98.7 0.329 Contact Map
2y1vA 1 0.9848 98.7 0.332 Contact Map
2xi9A 1 0.7576 98.7 0.335 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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