GREMLIN Database
COHE - Putative lambdoid prophage e14 repressor protein C2
UniProt: P75974 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14249
Length: 224 (197)
Sequences: 6334 (4829)
Seq/√Len: 344.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_R40_M4.5861.00
177_R190_L4.1441.00
142_E190_L3.0211.00
98_V164_I2.8121.00
144_R147_D2.7461.00
100_A134_V2.7291.00
15_L19_V2.6911.00
23_S27_T2.4421.00
184_Q198_Y2.4321.00
131_I148_M2.3531.00
137_D194_W2.3331.00
149_I175_F2.2871.00
141_D192_P2.2441.00
179_I188_K2.1831.00
166_L206_S2.1181.00
23_S33_P2.0571.00
66_W70_E2.0011.00
97_W135_I1.9831.00
131_I150_F1.9401.00
181_D186_Y1.8971.00
92_V131_I1.8271.00
188_K196_E1.8261.00
161_D210_T1.8161.00
128_M153_P1.7921.00
39_F46_K1.7891.00
137_D193_N1.7331.00
168_H204_N1.7031.00
175_F211_V1.6911.00
157_A163_V1.6901.00
29_I59_C1.6831.00
28_M59_C1.6791.00
14_K18_G1.6251.00
21_G24_S1.6161.00
134_V149_I1.6131.00
34_T38_R1.6091.00
24_S28_M1.6041.00
22_N33_P1.5871.00
33_P37_S1.5621.00
32_E35_Q1.5521.00
179_I186_Y1.5321.00
38_R43_G1.5301.00
174_T189_A1.5201.00
134_V143_Y1.5041.00
143_Y162_D1.4711.00
52_M55_H1.4621.00
13_R40_M1.4251.00
176_K189_A1.4131.00
24_S27_T1.4051.00
133_R148_M1.3881.00
15_L18_G1.3841.00
130_Y153_P1.3661.00
140_I144_R1.3651.00
165_A187_L1.3581.00
119_Y122_P1.3421.00
136_G145_P1.3411.00
138_S176_K1.3401.00
25_F36_T1.3341.00
22_N40_M1.3301.00
151_V211_V1.3281.00
165_A178_L1.3091.00
38_R44_A1.3061.00
162_D177_R1.2601.00
186_Y198_Y1.2581.00
39_F52_M1.2481.00
19_V61_D1.2431.00
134_V175_F1.2311.00
98_V132_L1.2191.00
57_E62_L1.2151.00
117_E120_P1.2141.00
31_R35_Q1.2101.00
63_P66_W1.1961.00
22_N37_S1.1961.00
32_E38_R1.1941.00
174_T197_P1.1861.00
128_M154_E1.1681.00
16_R20_G1.1641.00
35_Q38_R1.1571.00
15_L60_F1.1401.00
31_R36_T1.1381.00
36_T39_F1.1351.00
55_H58_K1.1351.00
101_G176_K1.1341.00
149_I211_V1.1251.00
186_Y196_E1.1061.00
199_I205_C1.0961.00
99_Q103_W1.0921.00
39_F56_I1.0851.00
35_Q39_F1.0851.00
44_A47_N1.0801.00
37_S41_G1.0781.00
31_R52_M1.0761.00
34_T37_S1.0701.00
15_L62_L1.0701.00
31_R39_F1.0671.00
141_D190_L1.0621.00
26_A29_I1.0581.00
166_L208_I1.0561.00
68_D71_H1.0551.00
20_G24_S1.0331.00
25_F56_I1.0281.00
187_L197_P1.0101.00
16_R25_F1.0041.00
127_E152_D1.0001.00
64_V68_D0.9911.00
129_T153_P0.9891.00
19_V28_M0.9791.00
66_W69_Q0.9791.00
39_F47_N0.9781.00
129_T212_I0.9771.00
57_E67_L0.9761.00
151_V164_I0.9751.00
181_D184_Q0.9751.00
16_R22_N0.9731.00
67_L71_H0.9721.00
62_L66_W0.9571.00
65_G68_D0.9541.00
129_T150_F0.9511.00
163_V178_L0.9501.00
97_W133_R0.9471.00
94_V131_I0.9441.00
177_R188_K0.9381.00
164_I175_F0.9251.00
120_P123_V0.9221.00
13_R17_D0.9151.00
115_T119_Y0.9151.00
54_R64_V0.9121.00
150_F213_F0.9101.00
136_G176_K0.9011.00
116_A119_Y0.8981.00
75_N79_K0.8961.00
54_R58_K0.8841.00
189_A196_E0.8841.00
98_V175_F0.8801.00
142_E162_D0.8711.00
62_L67_L0.8591.00
19_V60_F0.8591.00
44_A51_S0.8451.00
57_E65_G0.8441.00
72_Q81_D0.8431.00
135_I145_P0.8371.00
42_D46_K0.8351.00
51_S55_H0.8321.00
163_V210_T0.8231.00
167_M199_I0.8201.00
143_Y214_S0.8201.00
167_M172_E0.8141.00
101_G136_G0.8131.00
26_A33_P0.8131.00
75_N78_K0.8101.00
29_I52_M0.8071.00
82_V86_N0.8061.00
142_E177_R0.8051.00
115_T118_T0.8031.00
72_Q75_N0.7991.00
118_T122_P0.7991.00
160_G179_I0.7971.00
43_G47_N0.7921.00
20_G40_M0.7891.00
22_N36_T0.7871.00
12_A15_L0.7841.00
143_Y175_F0.7831.00
83_S86_N0.7811.00
36_T40_M0.7811.00
202_N205_C0.7791.00
157_A178_L0.7781.00
159_H179_I0.7781.00
72_Q79_K0.7681.00
166_L169_D0.7651.00
32_E37_S0.7641.00
54_R57_E0.7581.00
12_A40_M0.7571.00
20_G28_M0.7531.00
76_I81_D0.7531.00
162_D190_L0.7521.00
155_V206_S0.7521.00
20_G59_C0.7461.00
94_V133_R0.7421.00
53_A64_V0.7380.99
137_D140_I0.7250.99
31_R34_T0.7230.99
132_L164_I0.7210.99
114_S120_P0.7200.99
92_V129_T0.7170.99
164_I211_V0.7150.99
162_D175_F0.7130.99
16_R19_V0.7110.99
50_D54_R0.7080.99
152_D155_V0.7080.99
66_W72_Q0.7060.99
126_G152_D0.7060.99
178_L187_L0.7050.99
13_R22_N0.6990.99
180_E185_R0.6980.99
78_K81_D0.6980.99
64_V67_L0.6940.99
147_D214_S0.6910.99
25_F29_I0.6890.99
92_V150_F0.6840.99
94_V148_M0.6840.99
63_P67_L0.6810.99
99_Q104_K0.6750.99
65_G71_H0.6750.99
62_L68_D0.6670.99
103_W174_T0.6670.99
158_C161_D0.6650.99
21_G25_F0.6630.99
137_D145_P0.6620.99
114_S118_T0.6620.99
181_D198_Y0.6600.99
16_R21_G0.6590.99
159_H180_E0.6570.99
13_R16_R0.6560.99
75_N81_D0.6560.99
38_R52_M0.6540.99
186_Y195_P0.6500.99
143_Y147_D0.6440.99
129_T152_D0.6430.99
100_A176_K0.6370.99
124_P129_T0.6350.98
169_D172_E0.6340.98
100_A175_F0.6300.98
46_K53_A0.6210.98
76_I80_P0.6190.98
39_F43_G0.6180.98
65_G69_Q0.6160.98
21_G40_M0.6120.98
44_A52_M0.6110.98
119_Y123_V0.6110.98
35_Q52_M0.6100.98
149_I164_I0.6070.98
44_A68_D0.6060.98
132_L173_T0.6050.98
77_T81_D0.6040.98
53_A57_E0.6030.98
117_E123_V0.5980.98
26_A34_T0.5930.98
29_I56_I0.5910.98
119_Y124_P0.5900.98
75_N80_P0.5820.97
113_L116_A0.5800.97
54_R68_D0.5790.97
117_E121_C0.5770.97
29_I39_F0.5750.97
35_Q50_D0.5700.97
57_E63_P0.5690.97
168_H172_E0.5670.97
150_F215_G0.5650.97
38_R42_D0.5650.97
38_R41_G0.5650.97
116_A122_P0.5640.97
183_T201_I0.5610.97
15_L25_F0.5580.97
165_A207_I0.5570.97
53_A68_D0.5570.97
46_K56_I0.5560.97
37_S40_M0.5550.96
65_G70_E0.5540.96
41_G47_N0.5520.96
23_S26_A0.5510.96
76_I79_K0.5500.96
99_Q174_T0.5450.96
72_Q76_I0.5440.96
95_I130_Y0.5420.96
46_K50_D0.5390.96
63_P68_D0.5390.96
151_V209_G0.5370.96
101_G138_S0.5360.96
73_T77_T0.5350.96
106_V173_T0.5330.96
184_Q201_I0.5320.96
99_Q102_A0.5320.96
26_A31_R0.5310.95
38_R45_T0.5300.95
33_P39_F0.5300.95
116_A120_P0.5290.95
91_L118_T0.5290.95
50_D68_D0.5240.95
54_R65_G0.5240.95
39_F44_A0.5230.95
73_T78_K0.5220.95
35_Q44_A0.5220.95
55_H59_C0.5180.95
39_F69_Q0.5180.95
29_I55_H0.5150.95
184_Q203_G0.5140.95
74_T78_K0.5140.95
143_Y149_I0.5130.95
157_A210_T0.5100.94
83_S87_K0.5090.94
114_S119_Y0.5090.94
80_P87_K0.5080.94
34_T46_K0.5050.94
114_S122_P0.5050.94
12_A36_T0.5040.94
15_L66_W0.5020.94
30_D55_H0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bdnA 2 0.9598 100 0.284 Contact Map
1jhfA 2 0.8482 100 0.4 Contact Map
2fjrA 4 0.8304 100 0.403 Contact Map
3k2zA 2 0.8482 100 0.424 Contact Map
2hnfA 1 0.567 99.9 0.522 Contact Map
1umuA 2 0.4688 99.9 0.548 Contact Map
1kcaA 6 0.4241 99.8 0.603 Contact Map
2bnmA 3 0.8214 99.8 0.625 Contact Map
1dw9A 6 0.6205 99.5 0.701 Contact Map
4y42A 6 0.6161 99.3 0.721 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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