GREMLIN Database
INTE - Prophage lambda integrase
UniProt: P75969 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12370
Length: 375 (310)
Sequences: 19190 (16395)
Seq/√Len: 931.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
337_E351_L4.8821.00
126_K135_D3.3201.00
132_D135_D2.9971.00
328_T331_E2.8701.00
254_I352_G2.7501.00
224_G336_S2.7251.00
220_A329_F2.7041.00
336_S350_L2.6741.00
227_L330_H2.6571.00
143_Y155_V2.4241.00
234_K283_A2.3351.00
51_I54_E2.3161.00
334_S364_D2.2461.00
85_S120_R2.1111.00
220_A230_I2.1081.00
45_E49_I2.0901.00
140_L156_R2.0881.00
336_S340_Y2.0481.00
88_L162_V2.0251.00
88_L116_V2.0201.00
122_R142_E1.9981.00
257_P350_L1.9731.00
87_W166_A1.9251.00
165_E169_Y1.9191.00
29_R36_G1.9081.00
85_S89_D1.8801.00
89_D120_R1.8711.00
341_K347_T1.8651.00
235_F273_V1.8631.00
266_N270_R1.8621.00
244_H255_A1.8401.00
195_S198_E1.8061.00
87_W128_I1.8041.00
242_H255_A1.8031.00
235_F285_L1.7791.00
127_L130_A1.7561.00
55_A58_R1.7561.00
92_Q113_A1.7341.00
136_I179_A1.7331.00
115_P158_V1.7171.00
357_Q360_D1.7151.00
164_K180_L1.7131.00
225_Q230_I1.7021.00
270_R274_A1.6991.00
266_N269_L1.6951.00
170_G176_Y1.6921.00
150_R154_V1.6761.00
353_H359_T1.6671.00
252_S354_K1.6411.00
44_N47_E1.6261.00
266_N273_V1.6261.00
54_E58_R1.6041.00
113_A117_S1.6011.00
108_T112_K1.5961.00
358_Q361_R1.5891.00
341_K363_H1.5841.00
227_L231_S1.5731.00
85_S125_M1.5611.00
87_W165_E1.5581.00
51_I55_A1.5311.00
31_K36_G1.5041.00
215_N276_C1.4871.00
131_V163_F1.4811.00
234_K284_Y1.4761.00
269_L273_V1.4751.00
214_G218_L1.4691.00
57_T61_E1.4481.00
156_R160_I1.4471.00
340_Y347_T1.4411.00
52_A56_N1.4371.00
199_W221_L1.4331.00
90_R94_I1.4161.00
221_L332_Q1.4121.00
307_T311_S1.4091.00
168_H183_K1.4051.00
229_D254_I1.4031.00
198_E201_K1.4021.00
236_S283_A1.3911.00
355_T360_D1.3901.00
233_M238_I1.3841.00
29_R38_F1.3791.00
137_A169_Y1.3651.00
109_Y113_A1.3641.00
215_N272_V1.3641.00
340_Y345_L1.3581.00
348_Q359_T1.3411.00
173_P176_Y1.3311.00
216_A306_L1.3231.00
92_Q109_Y1.3141.00
269_L272_V1.3111.00
83_T86_T1.2971.00
351_L359_T1.2891.00
201_K205_I1.2891.00
199_W339_L1.2851.00
194_L327_A1.2781.00
337_E347_T1.2751.00
235_F277_R1.2711.00
194_L335_L1.2551.00
216_A230_I1.2501.00
160_I164_K1.2461.00
272_V276_C1.2311.00
140_L144_I1.2311.00
137_A141_D1.2311.00
46_A50_A1.2201.00
111_Q114_K1.2201.00
53_T60_A1.2181.00
203_F218_L1.2131.00
112_K158_V1.2051.00
167_Q172_V1.1981.00
164_K177_N1.1931.00
241_D270_R1.1901.00
194_L202_I1.1901.00
54_E57_T1.1891.00
126_K130_A1.1881.00
273_V276_C1.1881.00
162_V166_A1.1871.00
49_I53_T1.1861.00
348_Q356_Q1.1811.00
133_V168_H1.1761.00
213_M309_N1.1731.00
215_N275_R1.1721.00
237_D246_I1.1721.00
168_H181_A1.1641.00
118_L155_V1.1621.00
335_L339_L1.1601.00
133_V170_G1.1561.00
118_L121_E1.1541.00
104_I112_K1.1541.00
200_K204_D1.1521.00
139_L155_V1.1371.00
234_K237_D1.1361.00
250_T253_K1.1341.00
310_F314_R1.1331.00
123_A139_L1.1331.00
81_A129_S1.1321.00
89_D93_A1.1321.00
355_T358_Q1.1271.00
267_W271_D1.1251.00
106_L110_K1.1221.00
239_W242_H1.1221.00
218_L268_S1.1191.00
216_A286_V1.1151.00
196_L339_L1.1121.00
116_V120_R1.1051.00
20_S23_V1.1001.00
205_I316_L1.0961.00
233_M243_L1.0921.00
81_A127_L1.0851.00
139_L143_Y1.0731.00
28_W51_I1.0711.00
105_R108_T1.0631.00
225_Q245_V1.0631.00
50_A54_E1.0581.00
56_N60_A1.0571.00
227_L303_A1.0571.00
226_R247_Q1.0571.00
144_I152_A1.0531.00
163_F172_V1.0531.00
58_R63_R1.0481.00
342_E366_R1.0401.00
87_W169_Y1.0401.00
245_V248_E1.0371.00
110_K114_K1.0361.00
240_D270_R1.0361.00
337_E359_T1.0331.00
57_T60_A1.0291.00
196_L200_K1.0201.00
84_T162_V1.0111.00
134_R138_Q1.0031.00
227_L329_F1.0011.00
339_L342_E1.0011.00
53_T56_N0.9981.00
219_L269_L0.9961.00
348_Q360_D0.9921.00
337_E341_K0.9911.00
193_R335_L0.9841.00
87_W162_V0.9821.00
309_N312_K0.9811.00
160_I180_L0.9781.00
206_A217_M0.9781.00
219_L230_I0.9771.00
167_Q176_Y0.9731.00
134_R169_Y0.9731.00
118_L146_A0.9641.00
19_Y23_V0.9621.00
338_R363_H0.9601.00
154_V157_S0.9581.00
311_S315_D0.9571.00
104_I109_Y0.9521.00
236_S282_S0.9511.00
205_I317_A0.9491.00
143_Y152_A0.9471.00
233_M285_L0.9411.00
19_Y22_K0.9391.00
163_F179_A0.9341.00
128_I163_F0.9321.00
82_I86_T0.9281.00
243_L247_Q0.9241.00
207_D214_G0.9221.00
163_F178_P0.9211.00
151_M155_V0.9201.00
117_S120_R0.9191.00
148_R151_M0.9191.00
273_V277_R0.9181.00
85_S124_G0.9181.00
107_N110_K0.9151.00
167_Q181_A0.9071.00
136_I159_L0.9061.00
156_R179_A0.9051.00
89_D113_A0.8971.00
219_L286_V0.8951.00
42_G51_I0.8921.00
177_N180_L0.8921.00
122_R138_Q0.8891.00
274_A277_R0.8841.00
106_L109_Y0.8841.00
211_R214_G0.8821.00
53_T57_T0.8801.00
266_N272_V0.8791.00
47_E51_I0.8761.00
228_G232_R0.8751.00
84_T159_L0.8741.00
40_A43_T0.8731.00
132_D173_P0.8711.00
338_R364_D0.8681.00
138_Q142_E0.8671.00
58_R61_E0.8601.00
271_D274_A0.8581.00
84_T88_L0.8581.00
46_A49_I0.8551.00
88_L92_Q0.8531.00
153_Q185_P0.8511.00
331_E334_S0.8451.00
45_E48_A0.8451.00
336_S351_L0.8441.00
50_A53_T0.8441.00
268_S271_D0.8431.00
27_Y40_A0.8401.00
82_I90_R0.8371.00
90_R171_E0.8351.00
137_A140_L0.8341.00
47_E50_A0.8331.00
82_I171_E0.8291.00
202_I217_M0.8271.00
50_A57_T0.8271.00
334_S361_R0.8251.00
141_D144_I0.8251.00
27_Y38_F0.8251.00
54_E61_E0.8231.00
132_D170_G0.8221.00
48_A52_A0.8201.00
111_Q115_P0.8201.00
160_I179_A0.8181.00
217_M332_Q0.8181.00
205_I313_A0.8171.00
271_D275_R0.8131.00
49_I52_A0.8121.00
90_R169_Y0.8101.00
107_N111_Q0.8061.00
268_S272_V0.8051.00
144_I149_P0.8031.00
20_S27_Y0.7981.00
337_E363_H0.7971.00
170_G181_A0.7951.00
211_R215_N0.7951.00
135_D138_Q0.7941.00
231_S303_A0.7941.00
131_V136_I0.7931.00
272_V275_R0.7891.00
237_D247_Q0.7871.00
167_Q177_N0.7851.00
150_R153_Q0.7841.00
355_T359_T0.7761.00
221_L335_L0.7761.00
356_Q360_D0.7761.00
50_A60_A0.7741.00
26_V45_E0.7731.00
284_Y287_H0.7701.00
122_R139_L0.7681.00
134_R170_G0.7681.00
84_T131_V0.7671.00
91_Y165_E0.7641.00
223_T256_I0.7631.00
91_Y161_D0.7621.00
21_R24_N0.7611.00
94_I141_D0.7611.00
288_F297_R0.7601.00
115_P155_V0.7591.00
119_L159_L0.7531.00
128_I166_A0.7531.00
230_I329_F0.7491.00
206_A313_A0.7481.00
28_W52_A0.7441.00
87_W171_E0.7421.00
341_K366_R0.7411.00
225_Q229_D0.7401.00
327_A331_E0.7391.00
163_F167_Q0.7361.00
140_L152_A0.7351.00
167_Q180_L0.7321.00
32_H37_K0.7321.00
337_E348_Q0.7301.00
206_A214_G0.7281.00
212_Y215_N0.7271.00
313_A317_A0.7251.00
304_N307_T0.7231.00
258_L269_L0.7221.00
163_F177_N0.7191.00
88_L120_R0.7181.00
302_K305_T0.7171.00
219_L223_T0.7141.00
83_T127_L0.7101.00
227_L307_T0.7071.00
201_K204_D0.7071.00
190_T193_R0.6961.00
221_L339_L0.6901.00
258_L266_N0.6901.00
307_T329_F0.6891.00
114_K117_S0.6851.00
239_W244_H0.6851.00
311_S321_W0.6841.00
240_D258_L0.6841.00
133_V181_A0.6841.00
269_L276_C0.6831.00
117_S121_E0.6811.00
119_L124_G0.6801.00
86_T90_R0.6791.00
153_Q157_S0.6781.00
305_T308_M0.6761.00
172_V176_Y0.6741.00
194_L198_E0.6731.00
304_N308_M0.6731.00
133_V137_A0.6681.00
226_R330_H0.6631.00
141_D145_A0.6631.00
243_L248_E0.6611.00
310_F332_Q0.6601.00
196_L343_Q0.6591.00
225_Q233_M0.6581.00
268_S273_V0.6581.00
192_Q320_D0.6531.00
166_A172_V0.6511.00
250_T352_G0.6501.00
28_W55_A0.6481.00
111_Q154_V0.6481.00
82_I129_S0.6481.00
104_I108_T0.6471.00
219_L243_L0.6471.00
284_Y300_Q0.6461.00
38_F41_L0.6451.00
39_H42_G0.6441.00
28_W59_L0.6441.00
86_T89_D0.6421.00
191_R328_T0.6391.00
202_I310_F0.6381.00
41_L51_I0.6381.00
308_M312_K0.6371.00
235_F276_C0.6361.00
244_H253_K0.6341.00
112_K115_P0.6341.00
137_A168_H0.6341.00
89_D117_S0.6321.00
266_N276_C0.6271.00
306_L329_F0.6261.00
164_K167_Q0.6261.00
123_A131_V0.6261.00
340_Y350_L0.6251.00
20_S24_N0.6251.00
211_R275_R0.6241.00
156_R182_T0.6231.00
203_F214_G0.6221.00
198_E320_D0.6221.00
164_K181_A0.6221.00
116_V162_V0.6211.00
161_D165_E0.6191.00
162_V165_E0.6171.00
38_F43_T0.6141.00
196_L342_E0.6141.00
222_V266_N0.6131.00
90_R93_A0.6101.00
348_Q358_Q0.6091.00
311_S314_R0.6081.00
348_Q351_L0.6071.00
342_E368_K0.6071.00
44_N48_A0.6051.00
243_L246_I0.6001.00
210_H214_G0.5971.00
118_L143_Y0.5961.00
207_D218_L0.5941.00
240_D266_N0.5901.00
90_R165_E0.5851.00
123_A135_D0.5841.00
141_D169_Y0.5831.00
244_H247_Q0.5801.00
199_W335_L0.5801.00
192_Q198_E0.5781.00
242_H248_E0.5771.00
305_T309_N0.5751.00
218_L222_V0.5751.00
197_E201_K0.5711.00
310_F329_F0.5701.00
225_Q256_I0.5661.00
217_M310_F0.5651.00
203_F222_V0.5651.00
354_K358_Q0.5631.00
159_L179_A0.5631.00
172_V178_P0.5631.00
94_I165_E0.5611.00
120_R124_G0.5611.00
303_A307_T0.5601.00
168_H180_L0.5591.00
356_Q359_T0.5581.00
85_S116_V0.5581.00
240_D274_A0.5541.00
42_G48_A0.5531.00
224_G351_L0.5521.00
360_D363_H0.5521.00
164_K168_H0.5521.00
139_L142_E0.5521.00
82_I127_L0.5511.00
240_D285_L0.5501.00
314_R321_W0.5481.00
56_N59_L0.5471.00
157_S161_D0.5451.00
115_P154_V0.5441.00
108_T111_Q0.5431.00
212_Y276_C0.5431.00
197_E200_K0.5421.00
133_V169_Y0.5411.00
100_K104_I0.5401.00
165_E168_H0.5371.00
116_V158_V0.5361.00
341_K346_D0.5361.00
341_K365_D0.5361.00
90_R138_Q0.5351.00
330_H351_L0.5331.00
143_Y147_G0.5331.00
39_H43_T0.5291.00
192_Q321_W0.5281.00
232_R237_D0.5271.00
19_Y24_N0.5261.00
215_N286_V0.5251.00
87_W90_R0.5241.00
267_W270_R0.5221.00
91_Y112_K0.5211.00
21_R25_K0.5211.00
193_R338_R0.5211.00
100_K103_D0.5201.00
338_R365_D0.5191.00
241_D244_H0.5191.00
222_V268_S0.5181.00
243_L258_L0.5181.00
100_K109_Y0.5161.00
58_R62_Q0.5151.00
160_I177_N0.5151.00
330_H334_S0.5141.00
30_Y37_K0.5131.00
55_A59_L0.5121.00
139_L159_L0.5111.00
153_Q184_Q0.5071.00
136_I163_F0.5061.00
345_L350_L0.5051.00
201_K317_A0.5051.00
312_K316_L0.5011.00
223_T230_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z1bA 3 0.92 100 0.232 Contact Map
1z19A 3 0.744 100 0.315 Contact Map
1a0pA 1 0.6827 100 0.382 Contact Map
2a3vA 3 0.7307 100 0.384 Contact Map
4a8eA 2 0.6773 100 0.432 Contact Map
1xo0A 3 0.7387 100 0.434 Contact Map
1ae9A 4 0.4507 100 0.542 Contact Map
3nkhA 2 0.464 100 0.552 Contact Map
1aihA 2 0.4187 99.9 0.601 Contact Map
4e0gA 2 0.68 99.9 0.646 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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